Influence of propranolol and acebutolol on isoprenaline-induced changes in heart rate and peripheral blood flow in man.

The authors studied the variations in the effects of isoprenaline hydrochloride on heart rate (beta 1) and on peripheral blood flow of the upper extremity (beta 2), determined by plethysmography, in a group of 5 men with a mean age of 31 +/- 3 years. The trial was conducted on a single-blind cross-over basis, each subject being infused over 30 min with propranolol (30 microgram/kg), acebutolol (150 microgram/kg) or a placebo (isotonic glucose solution) with at least an 8-day interval between each administration. At the end of the infusion they received isoprenaline (0.

Foot and mouth disease virus production on microcarrier-grown cells.

The industrial usefulness of the production of foot and mouth disease virus with microcarrier grown cells has been tested at a large scale. The vaccines, intended for pigs, prepared with such virus give a good level of immunity against virulent challenges. They are stable and free from side effects.

[Sero-immunological research by immunofluorescence of rats bilharziosis in Guandeloupe. Epidemiological interest, comparative studies in various biotopes (author's transl)].

A sero-immunological survey by immunofluorescnece has been conducted on 94 rats (R. rattus and R. norvegicus) captured in Guadeloupe, in there different biotopes where the presence of S.

[Detection of schistosomiasis in rats using micro blood sampling and immunofluorescence during an epidemiologic study].

For a study of rat parasitism with Schistosoma mansoni in Guadeloupe, we used a technique of microbloodsampling followed by an immunofluorescence test. This method makes it possible to take the blood of the rats, the latter being then marked and set loose. It informs us of the presence of the parasite, the time of infestation, and the rats' movements relative to waterspots.

[Aspects of rats schistosomiasis in the non-salted mangrove swamps and the backmangrove area in the island of Grande-Terre (Guadeloupe) (author's transl)].

The study of parasitism by Schistosoma mansoni among rats (Rattus rattus and Rattus norvegicus) has been carried on in Guadeloupe. Over half the rats caught in the non-salted mangrove swamps and the back-mangrove area of the island of Grande-Terre are parasitized. It seems possible diagrammatize the characteristics of these sites, where the cycle of rats schistosomiasis develops.

[Experimental trichinasis (IV), study of the action of cyclophosphamide on the transplantation of 18 days old adults of T. spiralis (author's transl)].

The survival and the transplantation of adult trichinae collected in cyclophosphamide treated and untreated mice were studied. 1) The worms'burden harbored by treated mice on the 18th day after the infestation is from 4 to 5 times higher than in untreated ones. The sex ratio is here around one instead of 1/2 in the control lot of mice.

[Characteristics of viruses multiplying in cell lines in suspension and their correspondent vaccines].

The characteristics of the viruses produced from cell lines developed in suspension and the vaccines for which they are used should be judged by methods which allow to ensure in all cases their innocuity and efficacity. Innocuity is essentially dependent upon the purity of the viral preparation which should contain a minimum of foreign proteins (due either to the cell or the culture medium) and certain antibiotics. Furthermore, the absence of oncogenic properties of the inactivated viral suspensions should be shown, in addition to their specific innocuity.