Biomechanical evaluation of the modified proximal femoral nail for the treatment of reverse obliquity intertrochanteric fractures.

The best treatment method for reverse obliquity intertrochanteric fractures (ROIFs) is still under debate. Our team designed the modified proximal femoral nail (MPFN) specially for treating such fractures. The objective of this research was to introduce the MPFN device and compare the biomechanical properties with Proximal Femoral Nail Antirotation (PFNA) and InterTAN nail via finite element modelling.

Comprehensive evaluation of antibiotic pollution in a typical tributary of the Yellow River, China: Source-specific partitioning and fate analysis.

The partitioning and migrating of antibiotic residues pose a considerable pollution to the river environment. However, a source-specific approach for quantifying the fate of antibiotics is lacking. To further elucidate the migration behavior of antibiotics from different pollution sources in aquatic environments, we introduced a source-specific partition coefficient (S-Kp) based on Positive Matrix Factorization (PMF) model to improve the multimedia model.

Design and Study of a Novel P-Type Junctionless FET for High Performance of CMOS Inverter.

In this paper, a novel p-type junctionless field effect transistor (PJLFET) based on a partially depleted silicon-on-insulator (PD-SOI) is proposed and investigated. The novel PJLFET integrates a buried N+-doped layer under the channel to enable the device to be turned off, leading to a special work mechanism and optimized performance. Simulation results show that the proposed PJLFET demonstrates an I/I ratio of more than seven orders of magnitude, with I reaching up to 2.

Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD.

Objectives: The current study aimed to investigate the structural and functional connectivity of the subregions of the amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid with Oppositional Defiant Disorder (ODD).

Methods: A total of 354 children with ADHD-only, 161 children with ADHD and ODD (ADHD + ODD), and 100 healthy controls were enrolled. The Child Behavior Checklist (CBCL) and the Behavior Rating Inventory of Executive Function (BRIEF) were filled out by caregivers.

A missing link: The interdependence between sugar-sweetened beverage and cigarette consumption from China.

Sugar-sweetened beverages (SSBs) and cigarettes are addictive substances and addictive substances are often related in consumption with each other. However, the potential interdependence between SSB and cigarette consumption has not been explored in the literature. As SSB and cigarette consumption have posed a great threat to individual health, the knowledge of such interdependence is critical for policymakers to design and coordinate government interventions.

A comprehensive review on anti-allergic natural bioactive compounds for combating food allergy.

Food allergy poses a great challenge to food safety and public health worldwide. Currently, clinical symptoms are primarily managed with medications, which can lead to drug resistance, adverse effects, and disruptions in gut flora balance. As a result, there has been a focus on researching safe and effective anti-allergic natural ingredients.

In vitro culture of the parasitic stage larvae of hematophagous parasitic nematode Haemonchus contortus.

Current research on common parasitic nematodes is limited because their infective stages cannot be propagated in vitro. Here, we report a culture system for developing L4s of Haemonchus contortus, a blood-feeding nematode of ruminants. Our results demonstrated that a proportionate mixture of NCTC-109 to Luria-Bertini (1:2) media promoted the formation of early L4s and then into late L4s upon inclusion of 12.

Phonon Involved Photoluminescence of Mn Ions Doped CsPbCl Micro-Size Perovskite Assembled Crystals.

Mn ions doped CsPbCl perovskite nanocrystals (NCs) exhibit superiority of spin-associated optical and electrical properties. However, precisely controlling the doping concentration, doping location, and the mono-distribution of Mn ions in the large-micro-size CsPbCl perovskite host is a formidable challenge. Here, the micro size CsPbCl perovskite crystals (MCs) are reported with uniform Mn ions doping by self-assembly of Mn ions doped CsPbCl perovskite NCs.

Fluorinated multifunctional polymer vesicles for enhanced ocular surface penetration and synergistic treatment of dry eye disease.

Current pharmacotherapy for DED is limited by a vicious inflammatory cycle in which reactive oxygen species (ROS) play a critical role. Additionally, topical eye drop therapy for DED often suffers from poor ocular availability due to multiple ocular surface barriers. Considering the key role of the ROS-NLRP3-IL-1β signaling axis in DED, in this investigation, fluorinated multifunctional polymer vesicles were developed for enhanced ocular surface penetration and synergistic DED therapy by combining ROS scavenging and immunomodulation.

Combined Transcriptomics and C Metabolomics Analysis Reveals and Genes Involved in the Regulation of Efficient Cytidine Synthesis in .

The development of an engineered strain for efficient cytidine production holds significant value for both research and industrial applications. In this study, the and genes were knocked out to reveal their roles involved in the regulation of efficient cytidine synthesis in . The results showed that after 36 h of shaking flask fermentation, the knockout strain NXBG-14 produced a cytidine concentration of 2.

Estimating target population treatment effects in meta-analysis with individual participant-level data.

Meta-analysis of randomized controlled trials is commonly used to evaluate treatments and inform policy decisions because it provides comprehensive summaries of all available evidence. However, meta-analyses are limited to draw population inference of treatment effects because they usually do not define target populations of interest specifically, and results of the individual randomized controlled trials in those meta-analyses may not generalize to the target populations. To leverage evidence from multiple randomized controlled trials in the generalizability context, we bridge the ideas from meta-analysis and causal inference.

Influences of multi-pass friction stir alloying on characterization of AZ91D alloy-based dual reinforcement bio-ceramic nano-composites.

In current study, microstructural, mechanical and corrosion behaviour were investigated with incorporation of dual reinforced AZ91D surface composites. This research was carried out for enhancement of the bio-degradability in biological environment. The surface composites were successfully fabricated by friction stir processing method with a rotation speed of 800 rpm, travel speed of 80 mm/min and 2.

Population pharmacokinetic modeling and exposure-response analysis of anrikefon: insights and implications in clinical analgesia.

Background: Anrikefon (HSK21542), a potent and selective peripheral kappa opioid receptor (KOR) agonist developed by Haisco, effectively blocks pain and itch signals.

Aim: To develop a population pharmacokinetic (PK) model for anrikefon and conduct exposure-response (E-R) analysis for safety and efficacy in postoperative pain patients.

Method: The Population PK analysis uses NONMEM software with data from six trials.

Generation of induced pluripotent stem cell line from a patient with long COVID.

Long COVID, or post-acute sequelae of SARS-CoV-2 infection, leads to vascular dysfunction, which contributes to the chronic multi-organ damage often seen in affected patients. Long COVID, a global health concern is associated with increased thrombotic risk, also known as COVID-19-associated coagulopathy (CAC). Here, we derived an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of a long COVID patient.

Emotion regulation strategy and its relationship with emotional dysregulation in children with attention-deficit/hyperactivity disorder: behavioral and brain findings.

Important associations between emotional dysregulation (ED) and ADHD have been identified in adults, with a key manifestation of this being differential use of emotion regulation strategies: reduced use of cognitive reappraisal (CR), but elevated expressive suppression (ES). These associations have been observed at both behavioral and neuroimaging levels. The present study aims to explore the use of CR and ES in children with ADHD, and their relationship to ED.

Integrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease.

To explore the pharmacological mechanism of Changpu-Yizhi-Wan (CYW) in the treatment of Alzheimer's disease (AD) from the perspective of ferroptosis based on network pharmacology and experimental verification. The Encyclopedia of Traditional Chinese Medicine 2.0 (ETCM2.

Optimizing natural human-derived decellularized tissue materials for periodontal bone defect repair.

Periodontal disease is a major contributor to tooth loss worldwide in adults. Particularly, periodontal bone defect is a common clinical condition, yet current therapeutic strategies exhibit limited effectiveness. Recently, natural bone graft materials have attracted considerable interest for enhancing bone defect repair due to their superior biocompatibility and osteogenic capabilities.

Feasibility, Acceptability, and Preliminary Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents in China: A Pilot Study.

Currently, there is a lack of cost-effective and accessible intervention resources for Chinese adolescents with emotional disorders. The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A), which aims to apply transdiagnostic treatment principles to target core dysfunctions across a range of emotional disorders with a single protocol, could fill this gap. We first modified the UP-A for use in the Chinese cultural context and then assessed its feasibility, acceptability, and preliminary efficacy using a single-arm design.

Strong coupling FeVO nanoparticles/3D N-doped interconnected porous carbon derived from MOFs by confined adsorption-assembly-pyrolysis for greatly boosting oxygen reduction.

Low-cost and effective electrocatalysts are critical for energy storage and conversion. Herein, iron(III) and vanadium(III) acetylacetonates were first adsorbed and confined in porous zeolitic imidazolate framework-8 (ZIF-8), which further cross-linked together by the methanol-induced-assembly. Following the pyrolysis, the FeVO nanoparticles were efficiently encapsulated within three-dimensional (3D) N-doped interconnected porous carbon, termed FeVO/NIPC.

The smallest plant from the Lower Devonian of South China and the divergent life-history strategies in zosterophyllopsids.

Plants have evolved different life-history strategies to overcome limited amounts of available resources; however, when and how divergent strategies of sexual reproduction evolved in early land plants are not well understood. As one of the notable and vital components of early terrestrial vegetation, the Zosterophyllopsida and its type genus reached maximum species diversity during the Pragian (Early Devonian; 410.8-407.

Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy.

The fat mass and obesity-associated protein (FTO) is an RNA demethylase required for catalytic demethylation of -methyladenosine (mA); it is highly expressed and functions as an oncogene in acute myeloid leukemia (AML). Currently, the overarching objective of targeting FTO is to precisely inhibit the catalytic activity. Meanwhile, whether FTO degradation also exerts antileukemic effects remains unknown.

Automatic segmentation model and machine learning model grounded in ultrasound radiomics for distinguishing between low malignant risk and intermediate-high malignant risk of adnexal masses.

Objective: To develop an automatic segmentation model to delineate the adnexal masses and construct a machine learning model to differentiate between low malignant risk and intermediate-high malignant risk of adnexal masses based on ovarian-adnexal reporting and data system (O-RADS).

Methods: A total of 663 ultrasound images of adnexal mass were collected and divided into two sets according to experienced radiologists: a low malignant risk set (n = 446) and an intermediate-high malignant risk set (n = 217). Deep learning segmentation models were trained and selected to automatically segment adnexal masses.

Reversible light-responsive protein hydrogel for on-demand cell encapsulation and release.

The design of biomaterials that can reconfigure on-demand in response to external stimuli is an emerging area in materials research. However, achieving reversible assembly of protein-based biomaterials by light input remains a major challenge. Here, we present the engineering of a new protein material that is capable of switching between liquid and solid state reversibly, controlled by lights of different wavelengths.

Efficacy of internet-based cognitive behavioral therapy for medicated adults with attention-deficit/hyperactivity disorder (ADHD): A randomized controlled trial.

Background: Cognitive behavioral therapy (CBT) is an effective treatment for adults with attention-deficit/hyperactivity disorder (ADHD), but its use is limited by poor accessibility and time constraints-barriers that internet-based CBT (iCBT) may help overcome. This trial aimed to explore the short- and long-term efficacy of iCBT in medicated adults with ADHD.

Methods: Eighty-six adults with ADHD were randomized into two groups: the iCBT combined with medication group (iCBT+M, n = 43) and the medication-only group (n = 43).