Precise engineering of gene expression by editing plasticity.

Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledge is fundamental for advancing genetic engineering and improving crop traits.

Results: We here demonstrate that CREs can be accurately predicted and utilized to precisely regulate gene expression beyond the range of natural variation.

Micronuclear battery based on a coalescent energy transducer.

Micronuclear batteries harness energy from the radioactive decay of radioisotopes to generate electricity on a small scale, typically in the nanowatt or microwatt range. Contrary to chemical batteries, the longevity of a micronuclear battery is tied to the half-life of the used radioisotope, enabling operational lifetimes that can span several decades. Furthermore, the radioactive decay remains unaffected by environmental factors such as temperature, pressure and magnetic fields, making the micronuclear battery an enduring and reliable power source in scenarios in which conventional batteries prove impractical or challenging to replace.

Adjunctive aspiration technique for the surgical management of deep orbital cavernous hemangioma.

To propose a needle aspiration technique for the surgical removal of orbital cavernous hemangioma. In this retrospective case series, we enrolled 13 patients with orbital cavernous hemangioma, who underwent excisional surgery assisted with needle aspiration technique from June 2013 to April 2022. Preoperative symptoms, clinical examination, and imaging features were recorded.

Thorium Cluster Synthesized by a Solvent-Free Flux Approach: The Richest Coordination Diversity and Application Exploration.

The renaissance of research interests in actinide oxo clusters in the past decade arises from both the concerns of radioactive contamination and their potential utility as nanoscale materials. Compared to the uranium cluster, the thorium (Th) cluster shows less coordination variation. Herein, we presented a unique Th cluster () that exhibits the most diverse coordination chemistry found within a single Th cluster via a solvent-free flux synthesis approach.

An Integrated Clinical and Computerized Tomography-Based Radiomic Feature Model to Separate Benign from Malignant Pleural Effusion.

Introduction: Distinguishing between malignant pleural effusion (MPE) and benign pleural effusion (BPE) poses a challenge in clinical practice. We aimed to construct and validate a combined model integrating radiomic features and clinical factors using computerized tomography (CT) images to differentiate between MPE and BPE.

Methods: A retrospective inclusion of 315 patients with pleural effusion (PE) was conducted in this study (training cohort: n = 220; test cohort: n = 95).

Realizing Low-Temperature Graphite-based Rechargeable Potassium-Ion Full Battery.

Graphite (Gr) has been considered as the most promising anode material for potassium-ion batteries (PIBs) commercialization due to its high theoretical specific capacity and low cost. However, Gr-based PIBs remain unfeasible at low temperature (LT), suffering from either poor kinetics based on conventional carbonate electrolytes or K -solvent co-intercalation issue based on typical ether electrolytes. Herein, a high-performance Gr-based LT rechargeable PIB is realized for the first time by electrolyte chemistry.

The synthesis and application of crystalline-amorphous hybrid materials.

Crystalline-amorphous hybrid materials (CA-HMs) possess the merits of both pure crystalline and amorphous phases. Abundant dangling bonds, unsaturated coordination atoms, and isotropic structural features in the amorphous phase, as well as relatively high electronic conductivity and thermodynamic structural stability of the crystalline phase simultaneously take effect in CA-HMs. Furthermore, the atomic and bandgap mismatch at the CA-HM interface can introduce more defects as extra active sites, reservoirs for promoted catalytic and electrochemical performance, and induce built-in electric field for facile charge carrier transport.

A diagnostic approach integrated multimodal radiomics with machine learning models based on lumbar spine CT and X-ray for osteoporosis.

Introduction: The aim of this analysis is to construct a combined model that integrates radiomics, clinical risk factors, and machine learning algorithms to diagnose osteoporosis in patients and explore its potential in clinical applications.

Materials And Methods: A retrospective analysis was conducted on 616 lumbar spine. Radiomics features were extracted from the computed tomography (CT) scans and anteroposterior and lateral X-ray images of the lumbar spine.

Low-temperature anode-free potassium metal batteries.

In contrast to conventional batteries, anode-free configurations can extend cell-level energy densities closer to the theoretical limit. However, realizing alkali metal plating/stripping on a bare current collector with high reversibility is challenging, especially at low temperature, as an unstable solid-electrolyte interphase and uncontrolled dendrite growth occur more easily. Here, a low-temperature anode-free potassium (K) metal non-aqueous battery is reported.

Photochromic Uranyl-Based Coordination Polymer for Quantitative and On-Site Detection of UV Radiation Dose.

A highly sensitive detection of ultraviolet (UV) radiation is required in a broad range of scientific research, chemical industries, and health-related applications. Traditional UV photodetectors fabricated by direct wide-band-gap inorganic semiconductors often suffer from several disadvantages such as complicated manufacturing procedures, requiring multiple operations and high-cost instruments to obtain a readout. Searching for new materials or simple strategies to develop UV dosimeters for quantitative, accurate, and on-site detection of UV radiation dose is still highly desirable.

In Situ Self-Elimination of Defects via Controlled Perovskite Crystallization Dynamics for High-Performance Solar Cells.

Understanding and controlling crystallization is crucial for high-quality perovskite films and efficient solar cells. Herein, the issue of defects in formamidinium lead iodide (FAPbI ) formation is addressed, focusing on the role of intermediates. A comprehensive picture of structural and carrier evolution during crystallization is demonstrated using in situ grazing-incidence wide-angle X-ray scattering, ultraviolet-visible spectroscopy and photoluminescence spectroscopy.

Assembling a Heterobimetallic Actinide Metal-Organic Framework by a Reaction-Induced Preorganization Strategy.

Periodically arranging coordination-distinct actinides into one crystalline architecture is intriguing but of great synthetic challenge. We report a rare example of a heterobimetallic actinide metal-organic framework (An-MOF) by a unique reaction-induced preorganization strategy. A thorium MOF (SCU-16) with the largest unit cell among all Th-MOFs was prepared as the precursor, then the uranyl was precisely embedded into the MOF precursor under oxidation condition.

Radiolytic Water Splitting Sensitized by Nanoscale Metal-Organic Frameworks.

High-energy radiation that is compatible with renewable energy sources enables direct H production from water for fuels; however, the challenge is to convert it as efficiently as possible, and the existing strategies have limited success. Herein, we report the use of Zr/Hf-based nanoscale UiO-66 metal-organic frameworks as highly effective and stable radiation sensitizers for purified and natural water splitting under γ-ray irradiation. Scavenging and pulse radiolysis experiments with Monte Carlo simulations show that the combination of 3D arrays of ultrasmall metal-oxo clusters and high porosity affords unprecedented effective scattering between secondary electrons and confined water, generating increased precursors of solvated electrons and excited states of water, which are the main species responsible for H production enhancement.

Removing Lead from Contaminated Sediment Using Indium-Based Perovskite Precursor.

Heavy metal pollution in river and lake sediments seriously damages river ecological safety and indirectly affects human health. The existing research mainly focuses on how to adsorb pollutants and repair sediment, and how the reuse of these pollutants may be a new technology to control sediment pollutants. The rapid development of perovskite solar cells in recent years has attracted a lot of attention, among which lead (Pb) halide perovskites have very excellent photoelectric performance.

Organic-Inorganic Lead Halide Perovskite Single Crystal: From Synthesis to Applications.

Organic-inorganic lead halide perovskite is widely used in the photoelectric field due to its excellent photoelectric characteristics. Among them, perovskite single crystals have attracted much attention due to its lower trap density and better carrier transport capacity than their corresponding polycrystalline materials. Owing to these characteristics, perovskite single crystals have been widely used in solar cells, photodetectors, light-emitting diode (LED), and so on, which have greater potential than polycrystals in a series of optoelectronic applications.

Enhanced Xe/Kr separation the pore size confinement effect of a microporous thorium-based metal-organic framework.

A three-dimensional microporous thorium-based metal-organic framework (Th-BPYDC-I) that features a suitable pore size for Xe was prepared. The pore confinement effect enables high Xe uptake (2.15 mmol g) and good Xe/Kr selectivity (7.

Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis.

The association of IFN-γ receptor 1 (IFNGR1) gene polymorphisms with tuberculosis (TB) susceptibility has not been systematically studied. We therefore conducted a meta-analysis to assess their association. Literature search was conducted in PubMed, EMBASE, Web of Science, and the Cochrane Library.

Working Aqueous Zn Metal Batteries at 100 °C.

Reliable power supplies at extremely high temperatures are urgently needed to broaden the application scenarios for electric devices. Aqueous zinc metal batteries (ZMBs) with intrinsic safety are a promising alterative for high-temperature energy storage. However, the reversibility and long-term cycling stability of aqueous ZMBs at extremely high temperatures (≥100 °C) have rarely been explored.

Dynamic Biomolecular "Mask" Stabilizes Zn Anode.

Zn anode is confronted with serious Zn dendrite growth and water-induced parasitic reactions, which severely hinders the rapid development and practical application of aqueous zinc metal batteries (AZMBs). Herein, inspired by sodium hyaluronate (SH) biomolecules in living organisms featured with the functions of water retention, ion-transport regulation, and film-formation, the SH working as a dynamic and self-adaptive "mask" is proposed to stabilize Zn anode. Benefiting from the abundant functional groups with high hydrophilicity and zincophilicity, SH molecule can constrain active water molecules on the Zn-electrolyte interface and participate in Zn solvation structure to suppress parasitic reactions.

K extraction induced phase evolution of KFeO.

Orthorhombic KFeO has a unique structure where K cations can migrate inside the Fe-O skeleton, thus making it a promising material for heterogeneous catalysis and electrochemical energy storage devices. However, KFeO is sensitive to conditions such as moisture and carbon dioxide, which would trigger severe phase evolution and consequently deteriorate the performance. In this work, we investigated the phase evolution using freshly prepared KFeO and KFeO after exposure to ambient air and after immersion in water, respectively.

Predictive value of neutrophil to lymphocyte ratio on acute kidney injury after on-pump coronary artery bypass: a retrospective, single-center study.

Objective: To investigate the predictive value of preoperative neutrophil to lymphocyte ratio (NLR) on acute kidney injury (AKI) after on-pump coronary artery bypass (ONCAB).

Methods: Patients who underwent elective ONCAB for coronary heart disease were included. NLR was calculated according to the results of preoperative routine blood test, patients were divided into non-AKI and AKI groups, and the differences in clinical baseline data between the two groups were compared.

Boosting the Optoelectronic Performance by Regulating Exciton Behaviors in a Porous Semiconductive Metal-Organic Framework.

Exciton behaviors including exciton formation and dissociation dynamics play an essential role in the optoelectronic performance of semiconductive materials but remain unexplored in semiconductive metal-organic frameworks (MOFs). Herein, we reveal that the exciton behaviors in semiconductive MOFs can be regulated by framework-guest interactions, a feature often not achievable in traditional inorganic or organic semiconductors. Incorporation of the electron-deficient molecule within the pores of a terbium-based semiconductive MOF (TbL·4HO·6DMF, L = TATAB, 4,4',4″--triazine-1,3,5-triyltri--aminobenzoate, DMF = ,-dimethylformamide) results in efficient energy transfer from the MOF skeleton to molecular acceptors, with a yield of up to 77.

Flexible Electron-Rich Ion Channels Enable Ultrafast and Stable Aqueous Zinc-Ion Storage.

Aqueous zinc-ion batteries (ZIBs) are regarded as a promising candidate for ultrafast charge storage owing to the high ionic conductivity of aqueous electrolytes and high theoretical capacity of zinc metal anodes. However, the strong electrostatic interaction between high-charge-density zinc ions and host materials generally leads to sluggish ion-transport kinetics and structural collapse of rigid cathode materials during the charge/discharge process, so searching for suitable cathode materials for ultrafast and long-term stable ZIBs remains a great challenge. Herein, flexible electron-rich ion channels enabling fast-charging and stable aqueous ZIBs have been demonstrated.

Preparation of Crystalline LaFeO Nanoparticles at Low Calcination Temperature: Precursor and Synthesis Parameter Effects.

Substantial effort has been devoted to fabricating nanocrystalline lanthanum ferrite (LaFeO), and calcination is the crucial process of crystallization in both high-temperature strategies and wet chemical methods. Lowering the calcination temperature gives the ability to resist the growth and agglomeration of nanoparticles, therefore contributing to preserve their unique nanostructures and properties. In this work, we prepared crystalline LaFeO nanoparticles with a calcination process at 500 °C, lower than the calcination temperature required in most wet chemistry methods.

2,3-diaminophenazine as a high-rate rechargeable aqueous zinc-ion batteries cathode.

Organic materials are attracting extensive attention as promising cathodes for rechargeable aqueous zinc-ion batteries (ZIBs). However, most of them fail to implement the requirement of batteries with combined high-rate and long-cycle performance. Herein, we report a flexible organic molecule 2,3-diaminophenazine (DAP) which exhibits ultrahigh rate performance up to 500C and high capacity retention of 80% after 10,000 cycles at 100C (25.