Publications by authors named "Ling-Cai"
Article Synopsis
- - ClpA is an important protease in bacteria that influences how they cause disease, particularly in a specific pathogen affecting melon plants, where deletion of ClpA reduced its virulence and abilities like motility and antioxidant defense.
- - The study found that ClpA regulates virulence-related genes differently, negatively impacting some and positively affecting others, indicating a complex role in the pathogen's behavior.
- - Experiments showed that ClpA interacts with another protein, RepA, and after removing the ClpA gene, the pathogen lost its ability to cause disease but increased its ability to form biofilms, highlighting ClpA's crucial role in bacterial virulence.
Antibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing systemic exposure and therefore toxicity. ADCs are complex molecules that require careful attention to various components.
View Article and Find Full Text PDFThere are more diversified isoforms of the hepcidin gene that exist in fishes than in mammals, and elucidating the differences between these isoforms should provide insight into the functioning of hepcidin in fishes. In our study, AS-hepc2 and AS-hepc6 hepcidin isoforms from black porgy were characterized for their in vivo expression patterns following bacterial challenge, and their in vitro antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi. As a result, two isoforms were observed to be widely distributed in all the tissues tested.
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