Identification of chemical constituents and absorbed components in rat serum of (L.) Jacq. by UPLC-Q-exactive-MS.

(L.) Jacq. has anti-inflammatory, analgesic, haemostatic and antioxidant effects, but its pharmacological components are still unclear.

Development and Validation of a GULP-Based Predictive Model for Dehydration in Elderly Patients with Post-Stroke Dysphagia.

The background for establishing and verifying a dehydration prediction model for elderly patients with post-stroke dysphagia (PSD) based on General Utility for Latent Process (GULP) is as follows: For elderly patients with PSD, GULP technology is utilized to build a dehydration prediction model. This aims to improve the accuracy of dehydration risk assessment and provide clinical intervention, thereby offering a scientific basis and enhancing patient prognosis. This research highlights the innovative application of GULP technology in constructing complex medical prediction models and addresses the special health needs of elderly stroke patients.

Three-Plane Calcaneal Osteotomy With Joint Preservation vs Subtalar Arthrodesis to Treat Painful Calcaneal Fracture Malunions.

Background: Calcaneal fracture malunion (CFM) commonly occurs with multiple pathologic changes and progressive pain and difficulty walking. The purpose of this study was to propose a modified 3-plane joint-preserving osteotomy for the treatment of CFM with subtalar joint incongruence, and to compare its efficacy to subtalar arthrodesis.

Methods: A retrospective comparative analysis of the data of 56 patients with CFM admitted from January 2017 to December 2022 was performed.

Caution when using network partners for target identification in drug discovery.

Identifying novel, high-yield drug targets is challenging and often results in a high failure rate. However, recent data indicates that leveraging human genetic evidence to identify and validate these targets significantly increases the likelihood of success in drug development. Two recent papers from Open Targets claimed that around half of FDA-approved drugs had targets with direct human genetic evidence.

The Application of Resolvin D1-Loaded Gelatin Methacrylate in a Rat Periodontitis Model.

To evaluate the drug release, cytocompatibility with periodontal ligament cells (PDLCs), and therapeutic efficacy of GelMA hydrogel loaded with resolvin D1 (RvD1) in treating rat periodontal inflammation and alveolar bone damage. An RvD1 complexed with GelMA was prepared, and its release kinetics and compatibility with PDLCs were assessed. Rats with induced periodontitis were treated weekly with topical applications of vehicle, GelMA, RvD1, or RvD1 complexed with GelMA for four weeks.

The Construction of a Standard Karyotype of Intermediate Wheatgrass and Its Potential Progenitor Species.

The genome composition of intermediate wheatgrass (IWG; (Host) Barkworth and D.R. Dewey; 2n = 6x = 42) is complex and remains to be a subject of ongoing investigation.

Response of Plant Leaf Traits to Environmental Factors in Climax Communities at Varying Latitudes in Karst Regions.

Exploring the changes in plant functional traits and their relationship with the environment in karst climax communities across different latitudes can enhance our understanding of how these communities respond to environmental gradients. In this study, we focus on climax karst climax plant communities in Guizhou Province, China. We selected three sample sites located at varying latitudes and analyzed the variations in functional traits of the plant communities at these latitudes.

Fucoidan Oligosaccharide Supplementation Relieved Kidney Injury and Modulated Intestinal Homeostasis in D-Galactose-Exposed Rats.

A fucoidan oligosaccharide (FOS), a potent compound derived from algae, is known for its diverse biological activities, including prebiotic activity, anticancer activity, and antioxidative properties, and has demonstrated supportive therapeutic effects in treating kidney ailments. This study was conducted to explore the protective influence of FOS on kidney damage due to aging induced by D-galactose in Sprague Dawley (SD) rats. The low-dose FOS group was administered FOS (100 mg/kg) by gavage, and the high-FOS group received FOS (200 mg/kg) by gavage.

Optimization of Mold Heating Structure Parameters Based on Cavity Surface Temperature Uniformity and Thermal Response Rates.

Rapid heating cycle molding technology has recently emerged as a novel injection molding technique, with the uniformity of temperature distribution on the mold cavity surface being a critical factor influencing product quality. A numerical simulation method is employed to investigate the rapid heating process of molds and optimize heating power, with the positions of heating rods as variables. The temperature uniformity coefficient is an indicator used to assess the uniformity of temperature distribution within a system or process, while the thermal response rate plays a crucial role in evaluating the heating efficiency of a heating system.

Advancements in Oral Delivery Systems for Probiotics Based on Polysaccharides.

Probiotics are an essential dietary supplement for intestinal flora balance, inhibition of pathogenic bacteria and immune regulation. However, probiotic inactivation during gastrointestinal transportation remains a big challenge for oral administration. Hence, oral delivery systems (ODSs) based on polysaccharides have been constructed to protect probiotics from harsh environments.

Rhoifolin Suppresses Cell Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells In Vitro and In Vivo.

Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, ranking fifth in terms of fatality with poor prognosis and a low survival rate. Rhoifolin (ROF), a flavonoid constituent, has previously been shown to suppress the proliferation of breast and pancreatic cancer cells. However, its inhibitory effect on HCC has remained unexplored.

Optimization of Video Heart Rate Detection Based on Improved SSA Algorithm.

A solution to address the issues of environmental light interference in Remote Photoplethysmography (rPPG) methods is proposed in this paper. First, signals from the face's region of interest (ROI) and background noise signals are simultaneously collected, and the two signals are processed by a differential to obtain a more accurate rPPG signal. This method effectively suppresses background noise and enhances signal quality.

Co-Optimization Operation of Distribution Network-Containing Shared Energy Storage Multi-Microgrids Based on Multi-Body Game.

Under the carbon peaking and carbon neutrality target background, efficient collaborative scheduling between distribution networks and multi-microgrids is of great significance for enhancing renewable energy accommodation and ensuring stable system operation. Therefore, this paper proposes a collaborative optimization method for the operation of distribution networks and multi-microgrids with shared energy storage based on a multi-body game. The method is modeled and solved in two stages.

Development of a Mobile Laser Measurement System for Subway Tunnel Deformation Detection.

In recent years, mobile laser measurement systems have markedly enhanced the capabilities of deformation detection and defect identification within metro tunnels, attributed to their superior efficiency, precision, and versatility. Nevertheless, challenges persist, including substantial equipment costs, inadequate after-sales support, technological barriers, and limitations in customization. This paper develops a mobile laser measurement system that has been specifically developed for the purpose of detecting deformation in metro tunnels.

Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data.

Developing the capacity to monitor species diversity worldwide is of great importance in halting biodiversity loss. To this end, remote sensing plays a unique role. In this study, we evaluate the potential of Global Ecosystem Dynamics Investigation (GEDI) data, combined with conventional satellite optical imagery and climate reanalysis data, to predict in situ alpha diversity (Species richness, Simpson index, and Shannon index) among tree species.

Correction: Shi et al. A Comprehensive Overview of the Antibiotics Approved in the Last Two Decades: Retrospects and Prospects. 2023, , 1762.

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Study of Ultrasound-Assisted Low-Pressure Closed Acid Digestion Method for Trace Element Determination in Rock Samples by Inductively Coupled Plasma Mass Spectrometry.

In this paper, a method of ultrasound-assisted low-pressure closed acid digestion followed by inductively coupled plasma mass spectrometry (ICP-MS) analysis was proposed for trace element quantification in rock samples. By using 1.5 mL of a binary acid mixture of HNO-HF with a ratio of 2:1, rock powder samples of 50 mg were completely decomposed in 12 h at 140 °C after 4 h of ultrasonic treatment with or without pressure relief procedure.

Research on Constitutive Modeling of DH460 Continuous Casting Steel with the Solidification End Reduction Process.

The constitutive model was commonly used to describe the flow stress of materials under specific strain, strain rate, and temperature conditions. In order to study the thermal-mechanical behavior of DH460 continuous casting steel during the solidification end heavy reduction (HR) process accurately. The high-temperature compression experiment was carried out, and phenomenological constitutive models were established based on the experimental results.

Self-Powered, Flexible, Transparent Tactile Sensor Integrating Sliding and Proximity Sensing.

Tactile sensing is currently a research hotspot in the fields of intelligent perception and robotics. The method of converting external stimuli into electrical signals for sensing is a very effective strategy. Herein, we proposed a self-powered, flexible, transparent tactile sensor integrating sliding and proximity sensing (SFTTS).

Bending Performance of Diamond Lattice Cylindrical Shells.

The Diamond lattice cylindrical shell (Diamond LCS) was proposed by a mapping approach based on the triply periodic minimal surfaces (TPMS). The finite element models were built and their accuracy was verified by experimental results. Parameter studies were carried out to investigate the effect of geometric and loading parameters on the bending properties of the Diamond LCSs by the finite element model.

Cellular Signaling of Amino Acid Metabolism in Prostate Cancer.

Prostate cancer is one of the most common malignancies affecting men worldwide and a leading cause of cancer-related mortality, necessitating a deeper understanding of its underlying biochemical pathways. Similar to other cancer types, prostate cancer is also characterised by aberrantly activated metabolic pathways that support tumour development, such as amino acid metabolism, which is involved in modulating key physiological and pathological cellular processes during the progression of this disease. The metabolism of several amino acids, such as glutamine and methionine, crucial for tumorigenesis, is dysregulated and commonly discussed in prostate cancer.

Molecular Docking Studies and In Vitro Activity of Pancreatic Lipase Inhibitors from Yak Milk Cheese.

Pancreatic lipase serves as a primary trigger for hyperlipidemia and is also a crucial target in the inhibition of hypercholesterolemia. By synthesizing anti-hypercholesterolemic drugs such as atorvastatin, which are used to treat hypercholesterolemia, there were some side effects associated with the long-term use of statins. Based on this idea, in the present study, we identified peptides that inhibited PL by virtual screening and in vitro activity assays.

Genome-Wide Identification of - () Gene Family and the Potential Function of Under Salt Stress in .

is an important medicinal herb known as a "natural antibiotic", which has been used in Southeast Asia for thousands of years. The () gene is an important regulatory factor for plant photoperiod flowering and stress response. However, there is currently no detailed research on the genes of .

Infectious Spleen and Kidney Necrosis Virus ORF093R and ORF102R Regulate Glutamate Metabolic Reprogramming to Support Virus Proliferation by Interacting with c-Myc.

Glutamine metabolism is essential for infectious spleen and kidney necrosis virus (ISKNV) replication. Glutaminase 1 (GLS1), the key enzyme of the glutamine metabolism, and c-Myc positively regulate ISKNV infection, while c-Myc is closely correlated with GLS1. However, the regulatory mechanism among ISKNV, c-Myc and glutamine metabolism remains unclear.

Identification of Downregulated Gene in Parkinson's Disease Through Integrated Transcriptomic Analysis and Validation.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (α-syn) aggregation. Lipid metabolism dysfunction may contribute to PD progression. This study aims to identify lipid metabolism-related genes (LMGs) associated with PD using an integrative transcriptomic analysis of microarray and single-cell RNA sequencing (scRNA-seq) datasets from patients with PD and healthy controls.