Publications by authors named "Li Zhigang"

Herpes virus entry mediator (HVEM) is a novel costimulatory molecule which mediates stimulatory or inhibitory signals in immune responses which makes it an attractive target in cancer therapeutics. However, the role of tumor cell intrinsic HVEM on tumor biology remains largely unknown. In this study, We demonstrated that CK+HVEM+ tumor correlates with better survival using Multiplex immuno histochemistry (mIHC) in Human Lung Adenocarcinoma Tissue microarray.

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Objective: To investigate the clinical features, pathological phenotype, treatment and prognosis of idiopathic multicenter Castleman disease (iMCD)in children.

Methods: From January 2017 to September 2023, basic information, laboratory tests, treatment and prognosis of children diagnosed with iMCD who attended Beijing Children's Hospital of Capital Medical University were collected.

Results: A total of 9 children were enrolled, with a median age of onset of median 11 (2-15) years, 6 males and 3 female.

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Background: Glioblastoma multiforme (GBM) is a highly aggressive brain cancer with poor prognosis and limited treatment options. Despite advances in understanding its molecular mechanisms, effective therapeutic strategies remain elusive due to the tumor's genetic complexity and heterogeneity.

Methods: This study employed a comprehensive analysis approach integrating 113 machine learning algorithms with Mendelian Randomization (MR) analysis to investigate the molecular underpinnings of GBM.

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Efficient, non-destructive and real-time meat freshness assessment has always been a hot research topic. This paper presents a novel approach for detecting lamb meat freshness using a flexible optoelectronic sensing system combined with an integrated learning model. We developed a flexible impedance sensing system and a flexible optical sensing system through laser direct writing and transfer technology.

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Traffic-related air pollution (TRAP) has been linked with numerous respiratory diseases. Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of TRAP exposure on lung microbiome are rarely explored.

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In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes-associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correlation between PANX1 mRNA and core Hippo components, Yes-associated protein 1 [YAP], Transcriptional coactivator with PDZ-binding motif [TAZ], and Hippo scaffold, Ras GTPase-activating-like protein IQGAP1 [IQGAP1], in invasive cutaneous melanoma and breast carcinoma. Furthermore, we demonstrated that PANX1 expression is upregulated in invasive melanoma cell lines and is associated with increased YAP protein levels.

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Currently, lithium-ion batteries (LIBs) are at the forefront of energy storage technologies. Silicon-based anodes, with their high capacity and low cost, present a promising alternative to traditional graphite anodes in LIBs, offering the potential for substantial improvements in energy density. However, the significant volumetric changes that silicon-based anodes undergo during charge and discharge cycles can lead to structural degradation.

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DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. Its diverse functions in cancer progression and viral infections have attracted considerable attention. DDX21 exerts a pivotal function through ribosomal DNA (rDNA) transcription and rRNA processing.

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Since elevated amounts of chlorine disinfectant were discharged into surface water, more attention should be paid to the reactions between dissolved organic matter (DOM) and chlorine under sunlight. However, disinfection byproducts (DBPs) formed from DOM by solar photolysis of chlorine, and changes of cytotoxicity during this process remain unclear. In this study, it was found that solar photolysis of chlorine significantly promoted the formation of aliphatic chlorinated DBPs and aromatic chlorinated DBPs (including chlorobenzoquinone) by 44.

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Iodinated X-ray contrast media (ICM) are commonly detected at considerable concentrations in aquatic environments. The long-term pollution trends in ICM at the whole lake/river scale have not yet been investigated; therefore, the risks associated with ICM and the influences of environmental factors remain understudied. Herein, the occurrence and distribution of ICM in the surface water of Taihu Lake were comprehensively investigated.

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Breast cancer stem cells (BCSCs) are the main cause of breast cancer recurrence and metastasis. While the ubiquitin-proteasome system contributes to the regulation of BCSC stemness, the underlying mechanisms remain unclear. Here, we identified ubiquitin-conjugating enzyme E2T (UBE2T) as a pivotal ubiquitin enzyme regulating BCSC stemness through systemic screening assays, including single-cell RNA sequencing (scRNA-seq) and stemness-index analysis.

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The stabilization and structural integrity of DNA architectures remain significant challenges in their biomedical applications, particularly when inserting functional units into the genome using long single-stranded DNA (lssDNA). To address these challenges, a site-specific photo-cross-linking method is employed. Single-stranded oligonucleotides, containing one or two photosensitive cyanovinylcarbazole nucleoside (K) molecules, are precisely incorporated and cross-linked at the specific sites of ssDNA through base-pairing, followed by rapid UV irradiation at 365 nm.

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Background: Several studies have shown that combining immune checkpoint inhibitors (ICIs) with antiangiogenic tyrosine kinase inhibitors is effective for solid tumors, including esophageal squamous cell carcinoma (ESCC). However, most of these studies were focused on immunotherapy-naive patients. This retrospective real-world study offers insights into the efficacy and safety of combining anlotinib with ICIs in locally advanced/metastatic ESCC patients who progressed on prior ICI.

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Background: Previous studies have revealed the impact of heavy metals (HMs) on gut microbiota and intestinal structure. However, the relationship between HMs and fecal incontinence (FI) remains unclear. Therefore, this study aims to evaluate the association between blood HMs exposure and FI.

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Droplet rebound on nonwetting surfaces is a common phenomenon. However, the underlying physics regulating the contact time remains unclear. In this work, we investigate droplet impacts on superamphiphobic surfaces through experiments and theoretical analyses.

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Thoracogastric airway fistula (TGAF) is a rare but devastating complication that may occur following esophagectomy. The most effective method for repairing the defect between the airway and digestive tract is the interposition of a pedicled soft tissue in situ. However, this approach is associated with a high risk and remains challenging for surgeons.

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Traffic-related air pollution (TRAP) contains a plethora of hazardous pollutants, and is associated with a multitude of adverse health effects. However, up to now, no early biomarkers that can quickly reflect the health damage induced by TRAP. We conducted a randomized crossover trial in 35 healthy adults.

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The application of upconversion nanomaterials relies heavily on the ability to produce bright upconversion luminescence (UCL) or high upconversion quantum yields (UCQYs) at low power density excitation. Herein, we synthesized silica-coated NaYF:Yb@NaGdF:Tm@NaYF:Tb upconversion nanoparticles (UCNPs) and CsPbI perovskites quantum dots (PeQDs) nanocomposites by the slow hydrolysis of (3-aminopropyl)triethoxysilane. The energy transfer (ET) of Gd→Tb accelerates the five-photon upconversion process of Yb-Tm and the design of the core@shell@shell layer effectively mitigates the energy jumps between Gd ions.

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Article Synopsis
  • Traumatic brain injury (TBI) is a common and serious issue in infants and toddlers, often resulting from falls or traffic incidents; due to ethical constraints, piglet heads are used in place of human children for research purposes.* -
  • A detailed finite element (FE) model of a 4-week-old piglet head was created to study its mechanical properties and validate the model through various tests, including quasi-static compression and dynamic impact tests.* -
  • The simulation results demonstrated high accuracy, with average errors of 12.9% for contact force and 8.9% for intracranial pressure, indicating that the piglet head model is reliable for predicting the effects of TBI.*
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Introduction: Type 2 diabetes (T2D) is a metabolic disorder marked by disruptions in glucolipid metabolism, with numerous signaling pathways contributing to its progression. The liver, as the hub of glycolipid metabolism, plays a pivotal role in this context. Mulberry leaf (ML), a staple in traditional Chinese medicine, is widely utilized in the clinical management of T2D.

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Object: Carotenoids represent a class of bioactive compounds with potential implications for gut health. However, the relationship between dietary carotenoid intake (DCI) and fecal incontinence (FI) remains unclear. This study aims to elucidate the association between DCI and the risk of FI.

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Article Synopsis
  • Polyethylene terephthalate (PET) is a common plastic used in items like bags, bottles, and clothing, but its waste breaks down into harmful microplastics (MPs) that can infiltrate the environment and human bodies.
  • This study examined the male reproductive toxicity of PET MPs by exposing male mice to varying doses for 42 days, observing significant damage to testicular tissues and sperm quality, driven by oxidative stress and activation of the p38 signaling pathway.
  • Treatments with N-acetylcysteine (NAC) and SB203580 showed that blocking oxidative stress and the p38 pathway significantly reduced reproductive damage, highlighting the need for better public health strategies regarding microplastics.
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Clarifying how soil microbial communities respond to shrub introduction after overgrazing in desert steppe and their potential functions is crucial for understanding the biogeochemical processes involved in vegetation transformation and sustainability of desert grasslands. However, the dynamics of microbial communities remain poorly understood. We selected enclosed grasslands (20a), overgrazed grasslands, and shrublands (6a, 15a, and 25a) to explore how shrubs introduced influence soil microbial structure and functional groups over the long term after desert grassland degradation.

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The detection of latent fingerprints plays a crucial role in criminal investigations and biometrics. However, conventional techniques are limited by their lack of depth-resolved imaging, extensive area coverage, and autonomous fingerprint detection capabilities. This study introduces an object-driven optical coherence tomography (OD-OCT) to achieve rapid, autonomous and ultra-large-area detection of latent fingerprints.

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