Change Fatigue Among Clinical Nurses and Related Factors: A Cross-sectional Study in Public Hospitals.

Objectives: To investigate the levels of change fatigue among clinical nurses in public hospitals and identify the potential contributing factors.

Design: A cross-sectional, multi-stage sampling study was conducted in accordance with the STROBE guideline.

Methods: This study surveyed 2,228 nurses in China from October to December 2023 using Wen Juan Xing (www.

Lactate Dehydrogenase Indicates Development From Fulminant Myocarditis to Chronic Persistent Myocarditis: A Multicenter Retrospective Cohort Study in China.

Background: Fulminant myocarditis (FM) is a critical manifestation of myocarditis. However, the clinical features and risk factors associated with its adverse outcomes are not fully understood. Given the high mortality and potential for long-term complications, it is crucial to identify factors that could predict the progression of FM to chronic persistent myocarditis.

Residue Depletion and Withdrawal Interval Estimations of Sulfamonomethoxine or Doxycycline Residues in Chinese Taihe Black-Bone Silky Fowls.

Black-bone fowls are rich in melanin and regarded as being rich in nutritional value. However, the metabolism of antibiotics in black-bone fowls remains poorly understood. This study aimed to determine the tissue residue depletion kinetics of Sulfamonomethoxine (SMM) or Doxycycline in Taihe black-bone silky fowls.

Molecular and biological characteristics of two rare bloodstream Candida isolates: Candida nonsorbophila and Candida sonorensis.

Background: The incidence of new infections caused by rare Candida species has been steadily increasing, particularly in immunocompromised patients. This study investigates two rare Candida species responsible for Candida bloodstream infections and explores their molecular characteristics.

Methods: Clinical Candida strains were continuously isolated from the lower respiratory tract and blood specimens of a patient.

Comparative analysis of organoid, air-liquid interface, and direct infection models for studying pathogen-host interactions in endometrial tissue.

The endometrium is a critical component of female reproductive health. Endometritis can significantly affect women's health, leading to complications such as infertility, pregnancy failure, and intrauterine adhesions. Therefore, establishing a reliable and effective model of endometritis is essential for advancing research in female reproductive health.

Nomogram for predicting the postoperative outcomes in cervical spondylotic myelopathy based on apparent diffusion coefficient.

Purpose: To development a nomogram based on clinical features and apparent diffusion coefficient (ADC) of the cervical spinal cord in surgical prognosis in patients with cervical spondylotic myelopathy (CSM).

Methods: Patients with CSM who underwent decompression surgery between March and September 2023 were enrolled. Patients underwent conventional cervical spine MRI and sagittal position ZOOM-DWI before surgery.

Unveiling the Pathogenic Role of Novel CPLANE1 Compound Heterozygous Variants in Joubert Syndrome: Insights Into mRNA Stability and NMD Pathway.

Joubert syndrome (JS) is a rare neurodevelopmental disorder associated with mutations in genes involved in ciliary function. Germline variants in CPLANE1 have been implicated in JS. In this study, we investigated a family with three adverse pregnancies characterised by fetal malformations consistent with JS.

Growth patterns and heat tolerance analysis of dwarf chicken with frizzled feather.

Chickens are covered with feathers, lack sweat glands, and are sensitive to the thermal environment. Previously, our group bred a novel dwarf chicken strain with frizzled feather, named as dwarf chicken with frizzled feather (DFC). The cumulative growth of the chicken body weight and size were analyzed with 3 mathematical models.

Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models.

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade serous ovarian cancer with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within the tumor and microenvironment.

Liquid-bodied antibiofilm robot with switchable viscoelastic response for biofilm eradication on complex surface topographies.

Recalcitrant biofilm infections pose a great challenge to human health. Micro- and nanorobots have been used to eliminate biofilm infections in hard-to-reach regions inside the body. However, applying antibiofilm robots under physiological conditions is limited by the conflicting demands of accessibility and driving force.

Controllable Preparation of Low-Cost Coal Gangue-Based SAPO-5 Molecular Sieve and Its Adsorption Performance for Heavy Metal Ions.

With the advancement of industrial production and urban modernization, pollution from heavy metal ions and the accumulation of solid waste have become critical global environmental challenges. Establishing an effective recycling system for solid waste and removing heavy metals from wastewater is essential. Coal gangue was used in this study as the primary material for the synthesis of a fully coal gangue-based phosphorus-silicon-aluminum (SAPO-5) molecular sieve through a hydrothermal process.

Tricuspid Regurgitation in Tuberculous Constrictive Pericarditis Underwent Pericardiectomy.

Background: The presence of constrictive pericarditis (CP) in conjunction with tricuspid regurgitation (TR) and the worsening of TR following pericardiectomy are associated with a reduction in patient survival. The purpose of this study was to investigate the prevalence of tuberculous CP in conjunction with TR, the incidence of worsening regurgitation following pericardiectomy, and the analysis of associated factors.

Methods: Seventy-five consecutive patients who underwent pericardiectomy for tuberculous CP at the institution between January 2021 and December 2023 were retrospectively analyzed.

Prevalence of scoliosis and congenital heart disease based on school screening in Jinghong City, Yunnan Province.

Objective: To investigate the prevalence of scoliosis and congenital heart disease (CHD) in the same area and to explore the relationship between them according to a joint school screening.

Methods: All students aged 6-15 years in 20 schools in Jinghong City, Yunnan Province, China was screened for scoliosis and CHD. Scoliosis screening completed through the Adam's forward bending test with scoliometer measurement, and CHD screening completed through auscultation combined with portable echocardiography (ECHO).

A Prospective Observational Study to Evaluate the Actual Use of 1% Pimecrolimus in Chinese Patients with Mild-to-Moderate Atopic Dermatitis Affecting Sensitive Skin Areas.

Introduction: Atopic dermatitis (AD) is a common inflammatory skin disorder that affects both children and adults, characterized by pruritus and scaly, dry eczematous lesions. This study aimed to gather knowledge on the actual use and effectiveness of Pimecrolimus (PIM) in Chinese patients with mild-to-moderate AD affecting sensitive skin areas in routine clinical practice.

Methods: This multicentre and non-interventional study included 130 subjects from China, divided into two age groups (2-12 years and ≥12 years).

Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor.

Inflammatory myofibroblastic tumor (IMT) is a rare spindle-cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of IMT formed an "Expert consensus on the diagnosis and treatment of inflammatory myofibroblastic tumor".

Analysis of the current status and characteristics of osteoporosis in adult hemophilia patients based on high-resolution peripheral quantitative computed tomography: a case control study.

Background: Current research on osteoporosis (OP) in hemophilia is insufficient. The suitability of high-resolution peripheral quantitative computed tomography (HR-pQCT) for evaluating osteoporosis in hemophilia remains unclear.

Aim: To investigate the current status of osteoporosis and the applicability of HR-pQCT in adult hemophilia patients.

Early prediction of invasive fungal infection risk in acute-on-chronic liver failure: a prediction model based on admission indicators.

Background: Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome, and the incidence of invasive fungal infection (IFI) among hospitalized patients with ACLF is steadily increasing. The aim of this study is to develop a diagnostic nomogram to assist in the identification of IFI in these patients.

Methods: A retrospective study included 705 patients from January 1, 2019, to October 31, 2023, randomly divided into training (n = 493) and validation (n = 212) cohorts.

Body Composition Differentiates Prediabetes Phenotype Clusters in the Diabetes Prevention Program Study.

Context: Type 2 diabetes (T2D) remains a significant public health program, and current approaches to risk reduction fail to adequately prevent T2D in all individuals.

Objective: The purpose of this study was to apply clustering methods that include metabolic risk factors and body composition measures to identify and characterize prediabetes phenotypes and their relationships with treatment arm and incident T2D.

Design: Secondary analysis of the Diabetes Prevention Program clinical trial.

Targeted Lipidomics and Transcriptomics Unveil Aberrant Lipid Metabolic Remodeling in Visceral and Subcutaneous Adipose Tissue under ER Stress.

Endoplasmic reticulum (ER) stress is known to impair the function of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), disrupting lipid metabolism. Despite the crucial role lipid plays in regulating adipose tissue function, the specific lipidomic alterations in VAT and SAT under ER stress remain unclear. In this study, ER stress was induced in VAT and SAT, and targeted lipidomic and transcriptomic approaches were used to analyze lipid metabolism and gene expression profiles.

Integrative metabolomics and microbiomics analysis reveals distinctive microbiota-metabolites interactions in gastric carcinogenesis.

Gastric microbiota and metabolites may interact and play collaborative roles in the carcinogenesis process. This study aims to investigate differential metabolites and microbes, as well as the possible roles of microbe-metabolite interactions in gastric cancer (GC) development. Targeted metabolomics assays and 16S rRNA sequencing were performed to compare metabolic and microbial profiles in gastric tissues from subjects with superficial gastritis/chronic atrophic gastritis (SG/CAG), intestinal metaplasia/low-grade intraepithelial neoplasia (IM/LGIN) and GC.

An Olefin Radical Based Thiele's Hydrocarbon Derivative and Macrocyclic Tetraradical.

A persistent Thiele's hydrocarbon derivative, containing two five-membered dioxoborocyclic monoradical units bridged by a p-phenylene, was generated. It exhibits an open-shell singlet ground state with a large singlet-triplet energy gap. A macrocyclic molecule, composed of two units of the Thiele's hydrocarbon derivative, was also prepared.

Pesticide-fertilizer synergistic alginate-based hydrogel for enhanced pesticide retention and nutrient optimization against apple Valsa canker.

The prevalence of apple Valsa canker (AVC) poses a significant threat to the vitality of apple trees, jeopardizing the progress of the apple industry. Current strategies have proven inadequate in managing the disease effectively due to challenges such as extended duration and frequent relapses, especially low-adhesion vertical target. Herein, we introduce a pesticide-fertilizer synergistic alginate-based hydrogel (P&F-Gel) to enhance long-term pesticide retention and offer nutrient supplementation without labor-intensive practices.

Epidemiological and Clinical Characteristics of Human Metapneumovirus-Associated Acute Respiratory Tract Infection Cases in the Pudong New Area, Shanghai, from 2014 to 2023.

Background: This study characterized Human metapneumovirus (HMPV) infection epidemiology and clinical features in patients with acute respiratory infections (ARIs) in Pudong New Area, Shanghai, China, compared by pre- and post-COVID-19 periods.

Methods: Between January 2014 and December 2023, the basic and clinical information, as well as respiratory tract specimens from ARIs, were collected at 14 sentinel hospitals in Shanghai Pudong. Specimens were tested for HMPV and other respiratory pathogens.

The Compensatory Effect of S375F on S371F Is Vital for Maintaining the Infectivity of SARS-CoV-2 Omicron Variants.

The emergence of Omicron variants dramatically changed the transmission rate and infection characteristics compared to previously prevalent strains, primarily due to spike protein mutations. However, the impact of individual mutations remained unclear. Here, we used virus-like particle (VLP) pseudotyped to investigate the functional contributions by 12 common mutations in the spike protein.

LvWRKY75 enhances the transcription of LvMYB5 and promotes anthocyanin biosynthesis in lily petals during the blooming phase.

Anthocyanin accumulation plays a crucial role in enhancing Lilium petal colouration; however, breeding efforts are hindered by our lack of understanding of the complex molecular mechanism behind the pigment's synthesis. This study explores the potential role of the WRKY family gene WRKY75 in anthocyanin synthesis in lilies. Contrary to the inhibitory effect observed in Arabidopsis thaliana, both transient silencing and overexpression analyses of LvWRKY75 indicate that the gene positively regulates anthocyanin synthesis in lilies.