Electron transfer tuning for persulfate activation via the radical and non-radical pathways with biochar mediator.

Electron mediator-based in-situ chemical oxidation (ISCO) offers a novel strategy for groundwater remediation due to diverse reaction pathways. However, distinguishing and further tuning the reaction pathway remains challenging. Herein, biochar as an electron mediator targeted active peroxysulphate (PDS) via the radical or non-radical pathway.

Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities.

Background: DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear.

Methods: Utilizing data from The Cancer Genome Atlas, we conducted a comprehensive analysis of sex-related DNAm effects in nine non-reproductive cancers, compared to paired normal adjacent tissues (NATs), and validated the results using independent datasets. First, we assessed the extent of sex differential DNAm between cancers and NATs to explore how sex-related DNAm differences change in cancerous tissues.

Clinical decision support tool-guided, selective intensive induction strategy of ustekinumab in patients with Crohn's disease: A multicenter cohort study.

Objectives: We aimed to evaluate the effectiveness and safety of clinical decision support tool (CDST)-guided initial selective intensive induction therapy (IIT) for patients with Crohn's disease (CD) who were treated with ustekinumab (UST) and to identify those most likely to benefit from IIT.

Methods: Patients with active CD were included in this multicenter retrospective study and were categorized as low-, intermediate-, and high-probability responders according to the UST-CDST. IIT was defined as intensive induction by two or three initial doses of weight-based intravenous UST administration.

Successful treatment of tumor lysis syndrome associated with hepatic artery infusion chemotherapy in a patient with hepatocellular carcinoma: a case report.

Background: Tumor lysis syndrome is a life-threatening complication in the treatment of cancer. However, it rarely occurs in solid tumors, especially in hepatocellular carcinoma.

Case Presentation: We present a 52-year-old male Asian patient with advanced hepatocellular carcinoma treated with hepatic artery infusion chemotherapy that resulted in tumor lysis syndrome.

Optimising the paradigms of human AI collaborative clinical coding.

Automated clinical coding (ACC) has emerged as a promising alternative to manual coding. This study proposes a novel human-in-the-loop (HITL) framework, CliniCoCo. Using deep learning capacities, CliniCoCo focuses on how such ACC systems and human coders can work effectively and efficiently together in real-world settings.

A dataset for N natural abundance of soil ammonia volatilization.

Investigating the sources of ammonia (NH) in the atmosphere and the contribution of each source is essential for environmental pollution control. The presented dataset aims to provide N natural abundance (δN) data collected from different controlled treatments to fill the knowledge gap between insufficient data of soil δN-NH and accurately identifying atmospheric NH source apportionments. Our results showed that the overall δN-NH values emitted from soil ranged from -46.

Chemogenetic Modulation of Preoptic Neurons Decreases Body Temperature and Heart Rate.

The preoptic area of the hypothalamus is critical for regulation of brain-body interaction, including circuits that control vital signs such as body temperature and heart rate. The preoptic area contains approximately 70 molecularly distinct cell types. The gene is expressed in a subset of preoptic area cell types.

Electronic tuning of platinum cocatalysts over g-CN nanosheets through the linker engineering for photocatalytic hydrogen evolution.

The strong metal-support interactions (SMSI) can profoundly affect the electronic state of platinum (Pt) cocatalysts, which plays a dominant role for photocatalytic activity in the supported photocatalysts. However, the conventional Pt/g-CN photocatalysts usually shows negligible SMSI effect because of the lack of the reducible species. Herein, we demonstrate that the linker engineering of UiO66-type MOFs can effectively strengthen the SMSI and optimize the electron density of Pt nanoparticles on g-CN nanosheets.

Chinese medicine as comprehensive therapy for psoriasis: A case report.

Rationale: Psoriasis is an immune-mediated, chronic, relapsing, inflammatory disease induced by a combination of genetic and environmental factors. It can be comorbid with other systemic diseases and severely affects patient's quality of life. This case report describes the therapeutic role of traditional Chinese medicine (TCM) in patient with psoriasis.

Primary dedifferentiated liposarcoma of the gallbladder: a case report and literature review.

Background: Liposarcoma (LPS) is a kind of malignancy of soft tissue usually found in the retroperitoneal, limb, or neck region, and some may be detected with delayed symptoms (pain or palpable mass), and less frequently occurs in organs of the digestive system. In contrast, Dedifferentiated liposarcoma (DDLPS) is a common histological subtype of LPS. The present study reported a case of dedifferentiated liposarcoma originating in the gallbladder.

Enhanced fractional-order total variation regularization-based velocity field reconstruction for CUP-VISAR diagnostic system.

The fusion of a velocity interferometer system for any reflector with compressed ultrafast photography systems in recent literature can achieve two-dimensional spatiotemporal diagnosis of shock wave velocities. Addressing the limitations posed by 7 × 7 coded aperture sampling, this study introduces an enhanced three-dimensional reconstruction algorithm grounded in fractional-order total variation regularization (E-3DFOTV). Simulated reconstructions and analysis were conducted on 80 frames of 350 × 800 fringes.

Cognitive frailty as a predictor of hospitalisation among older adults: a systematic review and meta-analysis.

To examine whether cognitive frailty serves as a predictor of hospitalisation in older adults. PubMed, Web of Science, Embase, Scopus and Cochrane Library databases were systematically searched from inception to February 6, 2024. The reviewers independently selected studies, extracted data and evaluated the quality of studies.

Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization.

Schizophrenia (SCZ) is a complex psychiatric disorder presenting challenges for characterization. The current study aimed to identify and evaluate disease-responsive essential genes (DREGs) to enhance the molecular characterization of SCZ. RNA-sequencing data from PsychENCODE (536 SCZ patients, 832 controls) and peripheral blood transcriptome data from 144 recruited subjects (59 SCZ patients, 6 non-SCZ psychiatric patients, 79 controls) are analyzed.

Stability analysis of electromagnetic suspension systems coupled with flexible frames: Modeling, control, analysis and experimentation.

The stability of the suspension is a key challenge for the application and promotion of electromagnetic suspension technology, especially when it operates in conjunction with a flexible structure, which significantly increases the system's complexity. This paper abstracts the characteristics of the coupling conditions between an electromagnetic suspension system and a flexible structure and designs and constructs an experimental apparatus that includes an electromagnet and a simulated flexible structure with adjustable stiffness and inertia. Based on the Lyapunov method, the central manifold theorem, and the Poincaré method, the stability of the electromagnetic suspension system and the conditions for Hopf bifurcations are derived.

Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma.

Objectives: To investigate the value of vascular morphology on high frame rate contrast-enhanced ultrasound (H-CEUS) and CEUS Li-RADS in predicting microvascular invasion (MVI), Ki-67 expression and recurrence of hepatocellular carcinoma (HCC).

Methods: This retrospective study enrolled 78 patients with single HCC diagnosed by postoperative pathology between January 1, 2021, and June 30, 2022. All patients underwent ultrasound and H-CEUS examination before operation.

Fibroblast growth factor 10 alleviates LPS-induced acute lung injury by promoting recruited macrophage M2 polarization.

Acute lung injury (ALI) is characterized by damage to the alveoli and an overabundance of inflammation. Representing a serious inflammatory condition, ALI lacks a precise treatment approach. Despite the recognized benefit impacts of Fibroblast growth factor-10 (FGF10) on ALI, the underlying mechanisms remain unelucidated.

Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease.

Background: Quercetin (QCT) is a bioflavonoid derived from vegetables and fruits that has anti-inflammatory and anti-ferroptosis effects against various diseases. Previous studies have shown that QCT modulates the production of cellular inflammatory factors in asthma models and delays the development of chronic airway inflammation. However, the regulatory mechanism of QCT, a traditional Chinese medicine, in the treatment of asthma has not been elucidated.

Antioxidant 1,2,3,4,6-Penta--galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors.

1,2,3,4,6-penta--galloyl-β-D-glucose (PGG) is the main phenolic active ingredient in , which is commonly used for the treatment of osteoporosis (OP). PGG is a potent natural antioxidant, and its effects on OP remain unknown. This study aimed to investigate the effects of PGG on promoting bone formation and explore its estrogen receptor (ER)-related mechanisms.

Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis.

Loganin (LOG), a bioactive compound derived from Cornus officinalis Siebold & Zucc, has been understudied in the context of osteoarthritis (OA) treatment. In this study, we induced an inflammatory response in chondrocytes using lipopolysaccharide (LPS) and subsequently treated these cells with LOG. We employed fluorescence analysis to quantify reactive oxygen species (ROS) levels and measured the expression of NLRP3 and nuclear factor erythropoietin-2-related factor 2 (NRF2) using real-time quantitative polymerase chain reaction (qRT-PCR), Western blotting, and immunofluorescence (IF) techniques.

Thermal Ablation for Papillary Thyroid Carcinoma.

Importance: Image-guided thermal ablation has been administered for patients with T1N0M0 papillary thyroid carcinoma (PTC) who elect to not undergo surgery or receive active surveillance. Considering the indolent nature of PTC, long-term outcomes of ablation are needed.

Objective: To investigate l0-year outcomes of thermal ablation in treating T1N0M0 PTC.

Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells.

Exosomal microRNAs (miRNAs) in circulation were recognized as potential biomarkers for the diagnosis of multiple diseases. However, its potential as a diagnostic hallmark for tuberculosis (TB) has yet to be explored. Here, we comprehensively analyze miRNA profiles in exosomes derived from the plasma of active TB patients and healthy persons to evaluate its efficacy in TB diagnosis.

Urea/Thiourea Imine Linkages Provide Accessible Holes in Flexible Covalent Organic Frameworks and Dominates Self-Adaptivity and Exciton Dissociation.

Unraveling the robust self-adaptivity and minimal energy-dissipation of soft reticular materials for environmental catalysis presents a compelling yet unexplored avenue. Herein, a top-down strategy, tailoring from the unique linkage basis, flexibility degree, skeleton electronics to trace-guest adaptability, is proposed to fill the understanding gap between micro-soft covalent organic frameworks (COFs) and photocatalytic performance. The thio(urea)-basis-dominated linkage within benzotrithiophene-based COFs induce the framework contraction/swelling (intralayer micro-flexibility) in response to tetrahydrofuran or water.

Photobiomodulation therapy at 650 nm enhances osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells through modulating autophagy.

Background: Photobiomodulatiom therapy (PBMT) has biostimulatory effects on bone marrow mesenchymal stem cells (BMSCs), which takes a pivotal role in maintaining bone mass and avoiding osteoporosis (OP). Autophagy is an important regulator for cell survival and homeostasis. Previous researchers found that BMSCs derived from osteoporotic rats (OP-BMSCs) were with the feature of reduced osteogenic differentiation and autophagy dysfunction.

Multi-omics Graph Knowledge Representation for Pneumonia Prognostic Prediction.

Early prognostic prediction is crucial for determining appropriate clinical interventions. Previous single-omics models had limitations, such as high contingency and overlooking complex physical conditions. In this paper, we introduced multi-omics graph knowledge representation to predict in-hospital outcomes for pneumonia patients.