Design and Study of Pulsed Eddy Current Sensor for Detecting Surface Defects in Small-Diameter Bars.

The design and study of pulsed eddy current sensors for detecting surface defects in small-diameter rods are highly significant. Accurate detection and identification of surface defects in small-diameter rods may be attained by the ongoing optimization of sensor design and enhancement of detection technologies. This article presents the construction of a non-coaxial differential eddy current sensor (Tx-Rx sensor) and examines the detection of surface defects in a small diameter bar.

Research on Wireless Passive Ultrasonic Thickness Measurement Technology Based on Pulse Compression Method.

Fixed-point thickness measurement is commonly used in corrosion detection within petrochemical enterprises, but it suffers from low detection efficiency for localized thinning, limitations regarding measurement locations, and high equipment costs due to insulation and cooling layers. To address these challenges, this paper introduces a wireless passive ultrasonic thickness measurement technique based on a pulse compression algorithm. The research methodology encompassed the development of mathematical and circuit models for single coil and wireless energy transmission, the proposal of a three-terminal wireless energy mutual coupling system, and the establishment of a finite element model simulating the ultrasonic body wave thickness measurement and wireless energy transmission system.

A Comprehensive Psychometric Evaluation of the Future Self-Continuity Questionnaire.

Future self-continuity is the relationship between an individual's perception of their present and future selves and is attracting intense interest from researchers in psychology and health. This study aimed to psychometrically evaluate the Future Self-Continuity Questionnaire (FSCQ), a tool designed to measure an individual's future self-continuity, in New Zealand's unique sociocultural context. In Phase 1 we tested the reliability (internal consistency) of the 10 item FSCQ and its three subscales and attempted to replicate the three-factor structure reported previously.

Disease burden and trends of lung cancer attributable to nickel among Chinese and global population: a cross-sectional study.

Background: Nickel is a well-established carcinogen, and China stands as a significant producer of nickel compounds. Nickel-associated lung cancer is increasingly acknowledged as a pressing public health concern. This study presents a comprehensive analysis at temporal, spatial, and population levels utilizing the most recent data from GBD 2019 to estimate the disease burden of nickel-associated lung cancer from 1990 to 2019, and make predictions to 2035.

The role of universal stress protein Usp1413 in meropenem adaptive resistance and environmental stress responses in .

Although various mechanisms of carbapenem-resistance have been identified in the nosocomial pathogen , the critical process of resistance evolution and the factors involved in are not well understood. Herein, we identified a universal stress protein Usp1413 which played an important role in adaptive resistance of to meropenem (MEM). Based on RNA-Seq and genome sequencing, Usp1413 was not only one of the most downregulated USPs, but also the bare one having mutation of tyrosine and glycine inserted at the site of 229-230 (YG229-230) under the stimulation of MEM.

Rapid identification of horse oil adulteration based on deep learning infrared spectroscopy detection method.

As a natural oil, horse oil has unique biological activity ingredients and therapeutic characteristics, which has important application value and market potential in healthcare, food, skin care and other fields. However, fraud is rampant in the horse oil market, and traditional methods such as chemical analysis and physical property detection are time-consuming, costly, and have low accuracy in detecting adulteration. Excessive adulteration may cause health risks, skin problems, and economic losses.

Flexible Passive Wireless Sensing Platform with Frequency Mapping and Multimodal Fusion.

As one of the core parts of the Internet-of-things (IOTs), multimodal sensors have exhibited great advantages in fields such as human-machine interaction, electronic skin, and environmental monitoring. However, current multimodal sensors substantially introduce a bloated equipment architecture and a complicated decoupling mechanism. In this work we propose a multimodal fusion sensing platform based on a power-dependent piecewise linear decoupling mechanism, allowing four parameters to be perceived and decoded from the passive wireless single component, which greatly broadens the configurable freedom of a sensor in the IOT.

Study on the spatial and temporal evolution of ecosystem service value based on land use change in Xi'an City.

Ecosystem service value (ESV) is essential for understanding regional ecological benefits and resources. This study utilizes the fourth phase of land use data from the Resource and Environment Science Data Centre of the Chinese Academy of Sciences. We corrected the ESV coefficient using the equivalent factor method for value per unit area and integrated the biomass factor of farmland ecosystems in Shaanxi Province.

Multimodal prehabilitation to improve functional abilities and reduce the chronic inflammatory response of frail elderly patients with gastric cancer: A prospective cohort study.

Background: Population ageing and cancer burden are important global public health problems that pose unprecedented threats to health systems worldwide. Frailty is a common health problem among elderly patients with cancer. In recent years, the use of prehabilitation to improve frailty has received widespread attention.

Design, synthesis, and biological evaluation of Ponatinib-based N-Phenylpyrimidine-2-amine derivatives as novel fibroblast growth factor receptor 4 (FGFR4) selective inhibitors.

Fibroblast growth factor receptor 4 (FGFR4) has been proven to be a promising target for FGFR-driven HCC therapy. Great efforts have been devoted to the discovery of FGFR4 inhibitors. In this article, a new class of Ponatinib-based N-phenylpyridine-2-amine derivatives was designed and synthesized as covalent and irreversible FGFR4 selective inhibitors through a rational drug design strategy.

Multi-omics analysis and experiments uncover the function of cancer stemness in ovarian cancer and establish a machine learning-based model for predicting immunotherapy responses.

Background: The heterogeneity of cancer makes it challenging to predict its response to immunotherapy, highlighting the need to find reliable biomarkers for assessment. The sophisticated role of cancer stemness in mediating resistance to immune checkpoint inhibitors (ICIs) is still inadequately comprehended.

Methods: Genome-scale CRISPR screening of RNA sequencing data from Project Achilles was utilized to pinpoint crucial genes unique to Ovarian Cancer (OV).

Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease: a network pharmacology and experimental approach.

There is currently no effective treatment for Alzheimer's disease (AD). This research explored Shenzhiling Oral Liquid (SZLD) against AD by pinpointing crucial elements and understanding its molecular mechanisms through network pharmacology and in vitro experiment. First, we used network pharmacology to screen the main targets and mechanisms of SZLD to improve AD.

Multi-omics decipher the immune microenvironment and unveil therapeutic strategies for postoperative ovarian cancer patients.

Background: Ovarian cancer (OC) is a highly aggressive and often fatal disease that frequently goes undetected until it has already metastasized. The classic treatment for OC involves surgery followed by chemotherapy. However, despite the effectiveness of surgery, relapse is still a common occurrence.

Polo-like kinase 4 accelerates glioma malignant progression and vasculogenic mimicry by phosphorylating EphA2.

Vasculogenic mimicry (VM), which involved the formation of vascular-like structures by highly invasive tumor cells, had been identified as one of the mechanisms contributing to resistance against anti-angiogenic therapy in patients with glioblastoma (GBM). Therefore, inhibition of VM formation may serve as an effective therapeutic strategy against angiogenesis resistance. Polo-like kinase 4 (PLK4), a protein kinase, had been linked to the progression of glioblastoma and was associated with an unfavorable prognosis.

Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth.

Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuroendocrine neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar tumor with a propensity for invading the hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate the molecular pathology, clinical manifestations, and transcriptomic profiles of papillary craniopharyngioma.

Adaptive Strategy of the Perennial Halophyte Grass to Long-Term Salinity Stress.

Salinity stress influences plants throughout their entire life cycle. However, little is known about the response of plants to long-term salinity stress (LSS). In this study, , a perennial halophyte grass, was exposed to 300 mM NaCl for two years (completely randomized experiment design with three biological replicates).

Preclinical development of lentiviral vector gene therapy for Diamond-Blackfan anemia syndrome.

Diamond-Blackfan anemia syndrome (DBAS) is an inherited bone marrow failure disorder caused by haploinsufficiency of ribosomal protein genes, most commonly RPS19. Limited access to patient hematopoietic stem/progenitor cells (HSPCs) is a major roadblock to developing novel therapies for DBAS. We developed a novel self-inactivating third-generation RPS19-encoding lentiviral vector (LV), termed "SJEFS-S19", for DBAS gene therapy.

Palmitoleic acid inhibits Pseudomonas aeruginosa quorum sensing activation and protects lungs from infectious injury.

Background: Unsaturated fatty acids targeting quorum sensing (QS) system have shown potential application in reducing bacterial virulence. We aim to investigate the effect of palmitoleic acid (PMA) on P. aeruginosa QS activation, and its impact on infection-induced lung injury.

Vaginal colonization of Lactobacilli: Mechanism and function.

Traditional antibiotics exhibit numerous limitations in addressing female reproductive tract infections associated with vaginal microbiota disturbances. In recent years, the application of vaginal probiotics, notably lactobacilli, has demonstrated significant therapeutic benefits. In this article, we summarize the adhesion and colonization mechanisms of female vaginal lactobacilli, influencing factors, functions, and the current status of lactobacillus applications.

Controllable reverse energy flow in the focus of tightly focused hybrid vector beams.

We demonstrate analytically and numerically that the reverse energy flow is able to appear around the optical axis in the focal region of tightly focused hybrid vector beams. Theoretically, we derive and obtain the general expression of the longitudinal component of the Poynting vector in the focal plane for hybrid vector beams having circular polarization mapping tracks on the Poincaré sphere under xy basis vectors. Following from the obtained expression and the numerical simulation results, the on-axis and near-axis reverse energy flow behaviors are proved.