Publications by authors named "Laxmikant"

The most frequent infantile tumor is a hemangioma, and its most common complication is ulceration. A quickly progressing ulcer called a hemangioma can also result in secondary infection. The mechanism of ulcer formation is unknown but is thought to develop during the rapid growth phase.

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Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder of hyperglycemia has close link with obesity and insulin resistance. Standard approaches in T2DM management are lifestyle management and Pharmacotherapy. Dietary management in T2DM was found to be safe and effective.

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Pharmaceutical design has made significant advancements in recent years, leading to the development of novel therapeutics with unprecedented efficacy and safety profiles. This review highlights the potential of these innovations to revolutionize healthcare and improve patient outcomes. The application of cutting-edge technologies like artificial intelligence, machine learning, and data mining in drug discovery and design has made it easier to find potential drug candidates.

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In Volume 46 of the Journal of Biosciences, in the article titled 'A cost-effective and efficient approach for generating and assembling reagents for conducting real-time PCR' by Ridim D Mote, V Shinde Laxmikant, Surya Bansi Singh, Mahak Tiwari, Hemant Singh, Juhi Srivastava, Vidisha Tripathi,Vasudevan Seshadri, Amitabha Majumdar and Deepa Subramanyam, published on 27 November 2021 (https://doi.org/10.1007/s12038-021- 00231-w), the second author's name was incorrectly set as V Shinde Laxmikant.

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Real-time PCR is a widely used technique for quantification of gene expression. However, commercially available kits for real-time PCR are very expensive. The ongoing coronavirus pandemic has severely hampered the economy in a number of developing countries, resulting in a reduction in available research funding.

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Malaria is one of the major infectious diseases that remains a constant challenge to human being mainly due to the emergence of drug-resistant strains of parasite and also the availability of drugs, which are non-specific for their pharmacodynamic activity and known to be associated with multiple side effects. The disease has acquired endemic proportions in tropical countries where the hygienic conditions are not satisfactory while the environmental conditions favor the proliferation of parasite and its transmission, particularly through the female anopheles. It is obvious that to square up the problems, there is a need for designing and development of more effective drugs, which can combat the drug-resistant strains of the parasite.

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Article Synopsis
  • The ineffectiveness of current nematicides and the significant damage caused by nematodes highlight the need for natural solutions to control these pests.
  • The pigment extracted from Serratia marcescens demonstrated effectiveness against juvenile stages of nematodes like Radopholus similis and Meloidogyne javanica, requiring lower concentrations than traditional treatments like copper sulfate.
  • Analysis confirmed that the pigment contains prodigiosin, a bioactive compound, suggesting that microbial secondary metabolites may offer a promising approach for nematode management.
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