Sodium balance during acute diarrhoea in malnourished children.

Forty-six male children 12-59 months old (27 malnourished and 19 with normal nutrition) admitted for acute water diarrhoea of less than 48 hours' duration were studied. Using a metabolic balance and separate collections of urine and stools over each 6-hour period, balance studies were carried out up to 48 hours. Blood, stool, and urine samples were analysed for sodium and potassium levels.

Effect of cholera toxin on L-[14C]glycine uptake and intestinal cell enzymes in rabbit.

The uptake of L-[14C]glycine and the activities of intracellular marker enzymes of enterocytes were studied in ligated small intestinal segments of rabbits during experimental cholera induced by intra-intestinal injection of pure cholera toxin (CT). No significant difference was observed in the active uptake of L-[14C]glycine between the CT-injected small intestinal segments and the saline-injected control segments, indicating that there is an intact active transport system for intestinal absorption of L-[14C]glycine during experimental cholera in rabbits. Apart from a significant increase in the activity of a brush border marker enzyme (alkaline phosphatase), there was no significant difference between the activities of marker enzymes for lysosomes (acid phosphate), microsomes (glucose-6-phosphatase), mitochondria (succinate dehydrogenase), and a cytosol enzyme (proteinase) in mucosal homogenates of CT-injected small intestinal segments compared to controls.