Sesquiterpenoid isolated from derived from : isolation, structure elucidation, and biological activity.

The aim of this research was isolation, structure elucidation, and biological activities of terpenoids from endophytic fungus obtained from . An endophytic fungus, , was isolated from the roots of was cultivated and extracted to give the crude extract. The crude extract was fractionated using vacuum liquid chromatography followed by separation and purification with column chromatography to obtain a terpenoid derivative (12.

Hair regeneration in androgenetic alopecia using secretome of adipose-derived stem cells (ADSC) and minoxidil: a comparative study of three groups.

Androgenetic alopecia is one of the most common cause of hair loss disorder. This hereditary and androgen-dependent disorder tends to progress into partial or even complete baldness Several therapeutic options are now available for AGA, including conventional medications such as finasteride, dutasteride, and minoxidil. However, side effects of these medications are also commonly reported.

Study on the development of nanoparticles based on levan for oral insulin delivery.

Oral insulin administration has gained attention as a promising alternative to injections. However, its effectiveness is hindered by the major challenge of degradation by gastric acid. Biopolymer-based nanocarriers have been explored as a solution to address this challenge.

The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis.

Vaginal dryness and dyspareunia are frequent complaints among postmenopausal women. Studies have shown that isoflavones reduce the severity of menopausal symptoms. This study aimed to evaluate the effects of isoflavones on vaginal dryness and dyspareunia in postmenopausal women.

A Discussion on Sensitivity Optimization in Reflective-Mode Phase-Variation Permittivity Sensors Based on Semi-Lumped Resonators.

Typically, the operating frequency in single-frequency reflective-mode phase-variation permittivity sensors based on semi-lumped resonators (e.g., step-impedance resonators-SIRs) is set to the resonance frequency of the sensing resonator when it is loaded with the so-called reference (REF) material, .

Effect of Low-Load Blood Flow Restriction Training and High-Load Resistance Training on Quadriceps Strength, Dynamic Stability, and Functional Performance.

Objective: Blood flow restriction (BFR) is a method used to affix a pneumatic cuff to the uppermost part of a leg. Blood flow restriction is often combined with low load-blood flow restriction training (LL-BFRt) to enhance strength and promote muscle hypertrophy. Therefore, this research aimed to examine the effect of LL-BFRt, sham LL-BFRt, and high load-resistance training (HL-Rt) on quadriceps strength (QS), dynamic stability, and functional performance.

Nucleic acid amplification-lateral flow immunoassay (NAA-LFIA) for the rapid differentiation of Trypanosoma evansi and Trypanosoma equiperdum.

Trypanosoma evansi and Trypanosoma equiperdum are very difficult to distinguish morphologically. However, molecular identification algorithms sequentially using Mini and Maxi primers can distinguish the two species. Duplex polymerase chain reaction (dPCR) facilitates simultaneous amplification but is difficult to visualize with gel electrophoresis because it produces overlapping amplicons.

Genome-wide association study of genetic markers of coat color patterns in Sumatran native cattle.

Background And Aim: Coat color is a phenotypic trait that is affected by many functional genes. In addition, coat color is an important characteristic of breeds in livestock. This study aimed to determine functional genes for coat color patterns in Sumatran native cattle in Indonesia using a genome-wide association study method.

Exploring the promising therapeutic benefits of iodine and radioiodine in breast cancer cell lines.

Iodine has an anti-proliferative effect on cancer cells; however, its effects have not been explored adequately. The aim of this study was to evaluate the therapeutic potential of iodine and radioiodine by assessing their effects on the viability of various breast cancer cell lines: MCF7, SKBR3, and MDA-MB231. The viability of cells was measured in treated cells exposed to six doses of iodine (5, 10, 20, 40, 60, 80 µM) and two doses of radioiodine (3.

COL3A1 Gene Polymorphism and Its Impact on Female Pelvic Organ Prolapse.

Pelvic organ prolapse (POP) is a women's health problem in both developed and developing countries. Various studies have found that the occurrence of POP is related to the supporting structures of the pelvic floor, including type III collagen levels. Most studies reported no correlation between collagen 3 alpha 1 (COL3A1) rs1800255 gene polymorphism and the occurrence of POP.

Bridging gaps in medication therapy management at community health centers: A mixed-methods study on patient perceptions and pharmacists' preparedness.

Background: The primary goals of Medication Therapy Management (MTM) are to avoid pharmaceutical mistakes, facilitate accessible therapy, and encourage patients to actively participate in their health management.

Objectives: This study aimed to determine patients' perceptions of MTM services, evaluate the knowledge, attitudes, and practices (KAP) of Community Health Center (CHC) pharmacists regarding MTM services, and develop strategies to improve MTM services in CHCs.

Methods: A mixed-method approach was designed in three parts.

Overview of ICU Nurses' Knowledge and Need Assessment for Instrument to Detect Sick Building Syndrome.

Introduction: Nurses in intensive care units (ICUs) are vulnerable to sick building syndrome (SBS), which can affect their health, performance, and patient safety. Understanding SBS is crucial in healthcare to protect both staff and patients. However, many ICU nurses lack knowledge about this condition and the necessary detection tools.

Effectiveness of Fractional CO2 Laser and Topical Combination Therapy in Striae Distensae (Stretch Marks).

Striae distensae (SD) are a skin disorder characterized by linear atrophic depression of the dermis due to stretching of the skin. There are various SD therapy modalities, namely topical therapy, peeling, microneedling, platelet-rich plasma, and laser. Until now, there has been no standard therapy for SD, but several therapeutic modalities can reduce clinical symptoms, so knowledge about the current management of SD is needed.

Development of inulin nanocarrier for effective oral delivery of insulin: synthesize, optimization, characterization, and biophysical study.

The susceptibility of insulin against gastric acid degradation presents a major challenge for oral insulin delivery. The potential of biopolymer-based nanocarriers was investigated in order to address this issue. Inulin, a biopolymer produced by the halophilic bacterium Salinivibrio sp.

Comparing paper-based and mobile application for rank-based peer assessment in interprofessional education: before, during, and after the COVID-19 pandemic.

Background: Education was affected during the COVID-19 pandemic, and there was a need to adapt the learning approaches to the situation. At the University of Gadjah Mada, many essential soft skills of healthcare professionals are taught using the interprofessional education (IPE) approach on-site. Our university responded to this crisis by offering online classes and similar types of training.

Positive effect of fermented sorghum on productivity, jejunal histomorphology, and tight junction gene expression in broiler chickens.

This study aimed to investigate the effects of dietary fermented sorghum (FS) as a substitute for corn on growth performance, jejunal histomorphology, cecal short-chain fatty acid (SCFA) levels, and gene expression of tight junctions in broiler chickens. A total of 240 one-day-old male New Lohmann Indian River chicks were randomly divided into five groups, with each group receiving different dietary treatments: a control group (CTRL) with a basal diet, groups supplemented with 10% (NFS10) and 20% (NFS20) non-fermented sorghum, and groups supplemented with 10% (FS10) and 20% (FS20) fermented sorghum. Each group was further divided into six replications, with eight birds per replicate.

Inter-atrial Septum Stenting in Congenital Heart Disease Patient: A Case Series in Indonesia.

Background: Inter-atrial septum (IAS) stenting in duct-dependent congenital heart disease patient has shown to be an effective way to maintain inter-atrial blood flow, however it is still considered a high risk procedure and inter-atrial septum stenting remains a low-frequency procedure.

Method: A single-center observational cohort study was carried out at the National Cardiovascular Center Harapan Kita (NCCHK) between April 2019 and April 2023. This study included duct-dependent congenital heart disease patients.

Bovine umbilical mesenchymal stem cell-conditioned medium increased expression of GLUT-4 in pancreas of diabetic rats induced by nicotinamide-streptozotocin.

Background: Diabetes is a degenerative disease associated with metabolic disorders. The majority of people have type 2 diabetes mellitus (DM) insulin resistance due to an unhealthy lifestyle. The development of DM treatment is also growing, one of which is using conditioned medium.

Comparison among Intense Pulsed Light, Alexandrite, and Long-Pulsed Neodymium-Doped Yttrium Aluminum Garnet 1064 Nm Lasers for Lower Leg Hair Removal: Case Series.

Lower leg hair removal is the method of reducing unwanted lower leg hair. Various technologies for lower leg hair removal include Intense Pulsed Light (IPL), alexandrite laser, and neodymium-doped yttrium aluminum garnet (Nd: YAG) laser. Conventional techniques are abandoned because effectiveness of the latest technological therapies has a longer period with minimal side effects.

Dietary jack bean ( L.) supplementation enhanced intestinal health by modulating intestinal integrity and immune responses of broiler chickens.

This study investigated the influence of supplementing with jack beans on jejunal morphology, cecal short-chain fatty acids production, gene expression both of pro- and anti-inflammatory cytokines and tight junctions. Four treatment groups including 288 Indian River chicks that were one day old were randomized at random. While the treatment groups received jack bean supplementation at levels of 5 %, 10 %, and 15 %, the control group (0 %) was given a basal diet.

Molecular identification of new Trypanosoma evansi type non-A/B isolates from buffaloes and cattle in Indonesia.

Trypanosoma evansi is reportedly divided into two genotypes: types A and B. The type B is uncommon and reportedly limited to Africa: Kenya Sudan, and Ethiopia. In contrast, type A has been widely reported in Africa, South America, and Asia.

Decision making for people living with HIV/AIDS using the theory of innovation diffusion model at the Western Provident Association Turen Foundation.

Objectives: To describe how people living with HIV/AIDS (PLWHA) make decisions using the diffusion of innovation theory model. Decisions occur when individual decision makers engage in activities that guide choices to adopt or reject a particular innovation.

Methods: This is a descriptive analysis research using a survey method.