Publications by authors named "Kohei Kobatake"
Background: Urothelial carcinoma (UC) is a common type of malignant disease; however, the diagnostic and prognostic markers of upper urinary tract urothelial cancer (UTUC) remain poorly understood because of its rarity.
Methods: To clarify the clinicopathological significance of granulocyte-colony stimulating factor (G-CSF) in UTUC, we analyzed the expression and distribution of G-CSF in 112 upper tract urothelial carcinoma (UTUC) samples with immunohistochemistry.
Results: In normal urothelium, G-CSF expression was weak or absent, whereas high expression of G-CSF was observed in UTUC tissues, both in tumor cells (TCs) and stromal cells (SCs).
Article Synopsis
- - Utilizing a multidisciplinary team meeting (MDTM) before robot-assisted radical prostatectomy (RARP) for pT2 prostate cancer significantly reduces the rate of positive surgical margins (PSM), indicating improved surgical outcomes.
- - In cases reviewed by the MDTM, the PSM rate was notably lower (11.1%) compared to those that weren't evaluated (24.0%), with key predictors for PSM including PSA levels and nerve-sparing procedures.
- - The MDTM's effectiveness in lowering PSM rates appears consistent regardless of the surgeon's experience level, suggesting that collaborative evaluation before surgery is beneficial for patient outcomes.
Article Synopsis
- The genome faces constant DNA damage from both internal and external sources, requiring precise regulation of repair mechanisms to maintain integrity.
- After exposure to ionizing radiation (IR), the modification of histone H3 (H3K4me3) shows a decrease shortly after and an increase later, indicating the dynamic response of chromatin to DNA damage in both human and mouse cells.
- PTIP, a critical component of a histone methyltransferase complex, is necessary for the upregulation of H3K4me3 and helps induce cell cycle arrest by activating the PRDM1 cell cycle inhibitor, with its reduced expression linked to acute myeloid leukemia.
Objectives: This study aimed to elucidate the clinical characteristics and predictors of long-term postoperative urinary incontinence (PUI) after robot-assisted radical prostatectomy (RARP).
Methods: This study included patients who underwent RARP at our institution and were stratified into PUI (≥1 pad/day) and continence (0 pad/day) groups at 60 months after RARP. A propensity score-matched analysis with multiple preoperative urinary status (Expanded Prostate Cancer Index Composite urinary subdomains, total International Prostate Symptom Score (IPSS), and IPSS-quality of life scores) was performed to match preoperative urinary status in these groups.
Objective: To assess the association among preoperative total testosterone levels, postoperative sexual function, and prognosis after robot-assisted radical prostatectomy.
Methods: Patients who underwent robot-assisted radical prostatectomy in our institution were included in the study. Based on preoperative total testosterone levels, they were divided into low (<3.
Article Synopsis
- - Recent research indicates the need to understand how hydronephrosis (HN) affects muscle-invasive bladder cancer (MIBC), as previous studies showed mixed results regarding its significance and molecular characteristics.
- - An analysis of 108 MIBC patients revealed that those with HN had a higher occurrence of the luminal papillary subtype and increased FGFR3 mutations compared to those without HN.
- - Ultimately, while MIBC with HN shows increased FGFR3 mutations, it's the reduced renal function, not HN itself, that is linked to poor overall survival in patients.
Background: Vagococcal infections are extremely rare in humans. There are limited studies on the optimal methods for identification, antimicrobial susceptibility testing, and clinical manifestations of vagococcal infections. Herein, we report a patient with a urinary tract infection who had Vagococcus fluvialis in the urine.
View Article and Find Full Text PDFIntroduction: Nuclear envelope spectrin repeat protein (Nesprin) 1 encoded by SYNE1, crucially regulates the morphology and functions of the cell. Mutations in the SYNE1 gene are associated with various diseases; however, their significance in renal cell carcinoma (RCC) remains unknown. In this study, we have investigated the association of SYNE1/Nesprin1 with the progression and prognosis of clear cell RCC (ccRCC).
View Article and Find Full Text PDFTo propose the centrality angle (C-angle) as a novel simple nephrometry score for the evaluation of tumor complexity and prediction of perioperative outcomes in nephron-sparing surgery (NSS) for renal tumors. The analysis was based on 174 patients who underwent robot-assisted partial nephrectomy retrospectively. C-angle was defined as the angle occupied by the tumor from the center of the kidney in the coronal CT images.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the modified 5-item frailty index's effectiveness in predicting outcomes for patients undergoing radical nephroureterectomy for upper tract urothelial carcinoma.
- It categorizes patients into high and low frailty index groups, finding that those with higher scores experienced more severe complications and poorer survival rates.
- The results highlight the modified frailty index as a crucial tool for assessing surgical risk and predicting postoperative outcomes in these patients.
Objective: Comprehensive genomic profiling testing using a hybrid-capture next-generation sequencing is commonly used in clinical practice to employ precision medicine in cancer treatment worldwide. In this study, we aimed to analyze the profiles obtained using comprehensive genomic profiling testing that was performed in Japanese castration-resistant prostate cancer patients and to discuss the genetic findings in a real-world setting.
Methods: A total of 60 cases and 57 castration-resistant prostate cancer patients underwent comprehensive genomic profiling testing between 1 January 2021 and 31 December 2022.
Purpose: Upper tract urothelial carcinoma (UTUC) can be divided into renal pelvis tumor (RPT) and ureteral tumor (UT) based on the tumor origin. This study aimed to evaluate the efficacy of neoadjuvant chemotherapy with gemcitabine and cisplatin (NAC-GC) in terms of the pathological outcomes and oncological prognoses in patients with UTUC. We also compared its efficacy between RPT and UT.
View Article and Find Full Text PDFObjectives: This study aimed to investigate the characteristics of patients who report improvement in quality of life (QOL) related to urinary status after undergoing robot-assisted radical prostatectomy (RARP) for localized prostate cancer.
Methods: We retrospectively reviewed the patients who underwent RARP between May 2010 and May 2021 at our institution and were preoperatively unsatisfied with their urinary status. Patients were grouped as Group 1 (improved patients: "satisfied" with urinary status based on international prostate symptom score QOL [IPSS-QOL] = 0-2 at 12 months after RARP) and Group 2 (unimproved group: "unsatisfied"-IPSS-QOL 3-6).
Article Synopsis
- - The study investigates the long-term effectiveness of low-intensity extracorporeal shock wave therapy (LIESWT) for penile rehabilitation in patients recovering from robot-assisted radical prostatectomy (RARP), comparing it with traditional treatments like phosphodiesterase type 5 inhibitors (PDE5i) and no treatment.
- - Results show that patients receiving LIESWT had significantly better sexual function and potency scores than those in the control group, and the outcomes were comparable to those who used PDE5i.
- - This research suggests that LIESWT could be a promising alternative treatment for erectile dysfunction after RARP, though the study's limitations include being conducted at a single institution.
We report a case of bloodstream infection due to () associated with pelvic abscess in a 74-year-old female patient undergoing radiotherapy for cervical cancer. Gram staining of positive anaerobic blood cultures revealed short chains of gram-positive cocci. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry was performed directly on the blood culture bottle, and 16S rRNA sequencing identified the bacterium as .
View Article and Find Full Text PDFBackground: We previously reported preoperative radiological morphology (RM) as an independent predictor for pathological upstaging after partial nephrectomy in patients with T1 renal cell carcinoma (RCC).
Purpose: To investigate the prognostic importance of RM in all stages and the molecular characteristics underlying the differences between each type of RM in patients with clear cell RCC (ccRCC).
Design Setting And Participants: The Cancer Imaging Archive datasets (TCIA), comprising CT images and RNA-sequencing data, were used (n = 163).
Article Synopsis
- * The study involved 223 UTUC patients, revealing that those with HV had a higher likelihood of advanced disease characteristics and significantly worse survival rates across several metrics, including progression-free survival (PFS) and overall survival (OS).
- * HV and lymphovascular invasion (LVI) were identified as independent risk factors, leading to a classification of patients into low, intermediate, and high-risk groups based on these factors, which displayed significant differences in survival outcomes over time.
Article Synopsis
- Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, and one rare subtype is chromophobe RCC (ChRCC) with sarcomatoid differentiation, which lacks clear treatment protocols.
- This study presents two cases of ChRCC with sarcomatoid differentiation, where one patient was treated with nivolumab after sunitinib failure, and the other received ipilimumab-nivolumab as a first-line treatment.
- Both therapeutic approaches were effective, but the patients faced immune-related side effects like interstitial nephritis and colitis, suggesting that immune checkpoint therapy can be beneficial for these specific cases.
Article Synopsis
- The study investigates the link between oxidative stress responses (OSRs) and the development of clear cell renal cell carcinoma (ccRCC), highlighting that OSRs are crucial for cancer progression.
- BACH1, a key transcription factor for OSRs, is shown to be associated with worse patient prognosis and higher serum inflammation markers in ccRCC, particularly when its expression is elevated in tumors.
- Findings suggest that BACH1 enhances tumor invasion and migration through pathways like epithelial-mesenchymal transition (EMT) and other OSR-related processes, indicating its significant role in the cancer's pathogenesis and worsening outcomes.
Our purpose was to evaluate the efficiency of manual bladder washout (MBW) for bladder retention by blood clot formation using urinary catheters. Three types of 22 Fr urinary catheters, a rounded tip Foley catheter (FC) with the standard two eyes, an open-ended Nelaton catheter (NC) with a side hole, and an open-ended Foley catheter (OEFC) with a side hole closer to the tip than NC, were evaluated. An automatic irrigation device that could perform a predetermined procedure mimicking MBW under constant velocity was fabricated.
View Article and Find Full Text PDFBackground: Histologic tumor necrosis (TN) is a well-established independent prognostic indicator in patients treated surgically for clear cell renal cell carcinoma (ccRCC). However, the precise mechanisms by which TN alters disease progression remain unknown. The DEAD-box protein DDX41, a member of a large family of helicases, has been characterized as a pattern recognition receptor against an array of double-stranded (ds)DNA produced from bacteria, dsDNA viruses, and nearby cells that have released dsDNA fragments through necrosis.
View Article and Find Full Text PDFIntroduction: BK virus-associated hemorrhagic cystitis is a significant complication of hematopoietic stem cell transplantation. Although severe BK virus-associated hemorrhagic cystitis is associated with treatment-related mortality, sufficient evidence regarding its management is lacking.
Case Presentation: A 14-year-old boy presented with BK virus-associated hemorrhagic cystitis and bladder clot retention after hematopoietic stem cell transplantation.
Article Synopsis
- Multi-parametric magnetic resonance imaging (mpMRI) combined with ultrasonography for prostate biopsy improves diagnosis accuracy but still produces false-positive results.
- A study of 322 patients identified 105 false-positive lesions and compared histological characteristics (atrophy, hyperplasia, lymphocyte infiltration) between low and high PI-RADS lesions.
- Results showed that high PI-RADS lesions had significantly more hyperplasia and lymphocyte infiltration than low PI-RADS lesions, suggesting that histopathological changes contribute to false positives.
Kinesin family member C1 (), a minus end-directed motor protein, is reported to play an essential role in cancer. This study aimed to analyze expression and examine involvement in cisplatin resistance in bladder cancer (BC). Immunohistochemistry showed that 37 of 78 (47.
View Article and Find Full Text PDFIntroduction: Metastatic urothelial carcinomas are common in lung, liver, and lymph nodes. We present rare secondary tumor of the prostate metastasized from upper tract urothelial carcinoma.
Case Presentation: An 87-year-old man was diagnosed as urothelial carcinoma of left upper tract and bladder.