Publications by authors named "Karthik"

Advancing next-generation battery technologies requires a thorough understanding of the intricate phenomena occurring at anodic interfaces. This focused review explores key interfacial processes, examining their thermodynamics and consequences in ion transport and charge transfer kinetics. It begins with a discussion on the formation of the electro chemical double layer, based on the GuoyChapman model, and explores how charge carriers achieve equilibrium at the interface.

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  • Niosomes are vesicular systems that utilize nonionic surfactants for effective topical and transdermal drug delivery, offering targeted release while reducing systemic toxicity.
  • Recent research emphasizes the importance of nonionic surfactants and cholesterol in enhancing the stability and drug entrapment capacity of niosomes, making them beneficial for treating various dermatological and systemic disorders.
  • The potential applications of niosomes extend to cancer therapies and immunization, leading to improved efficacy, reduced side effects, and better patient outcomes in drug delivery.
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We describe the case of a girl in her middle childhood who presented with signs of heterosexual precocious puberty in the form of axillary and pubic hair growth, acne and clitoromegaly. Investigations showed elevated androgens and autonomous cortisol excess, suggesting an adrenal source. CT imaging confirmed a left adrenal mass and multiple colonic polyps.

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Nanoparticles play a significant role in enhancing crop yield and reducing nutrient loss through precise nutrient delivery mechanisms. However, it is imperative to ascertain the specific plant physiology altered by these nanoparticles. This study investigates the effects of green-synthesized nanoparticles, specifically boron nitride and sulphur, on sunflower yield, seed quality, and physiological activities.

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This case report describes an adult man in his 50s with a history of type 2 diabetes and previously well-controlled hypertension, who presented with uncontrolled hypertension, muscle weakness and fatigue. Biochemical testing revealed hypokalaemia. There was no evidence of renal/renovascular disease.

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Breast cancer remains one of the most prevalent malignancies among women globally. Despite advances in therapeutic options, the prognosis often remains challenging. Breast cancer typically originates in the epithelial lining of glandular tissue ducts (85%) or lobules (15%).

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Background: In endemic COVID-19, immunocompromised children are vulnerable until vaccinated but the optimal primary vaccination regime and need for booster doses remains uncertain.

Methods: We recruited 19 immunocompromised children (post-solid organ transplantation, have autoimmune disease or were on current or recent chemotherapy for acute lymphoblastic leukemia), and followed them from the start of primary vaccination with BNT162b2 mRNA SARS-CoV-2 until 1-year post-vaccination. We investigated the quality of vaccine immunogenicity, and longevity of hybrid immunity, in comparison to healthy children.

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serovar Hvittingfoss, a member of the non-typhoidal group, is an important foodborne serovar most frequently identified in regions (Australia, Belgium, and the United States) with active surveillance systems. This serovar has been implicated in outbreaks of foodborne illness. Soft cheese, crab cocktail, beef, and rock melon are commonly involved in these outbreaks.

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Background: Neuronal ceroid lipofuscinoses (NCLs) are progressive, autosomal recessive lysosomal storage disorders primarily affecting children, marked by seizures, cognitive decline, motor regression, and visual impairment. Limited genetic data exist for South Asian populations, with most studies relying on enzymatic assays or electron microscopy. This study explores the genetic spectrum of NCL and genotype-phenotype correlations in a cohort from South India.

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Since the seminal report by Adachi and co-workers in 2012, there has been a veritable explosion of interest in the design of thermally activated delayed fluorescence (TADF) compounds, particularly as emitters for organic light-emitting diodes (OLEDs). With rapid advancements and innovation in materials design, the efficiencies of TADF OLEDs for each of the primary color points as well as for white devices now rival those of state-of-the-art phosphorescent emitters. Beyond electroluminescent devices, TADF compounds have also found increasing utility and applications in numerous related fields, from photocatalysis, to sensing, to imaging and beyond.

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  • Pseudomonas aeruginosa is highly resistant to antibiotics due to intrinsic and acquired mechanisms, primarily utilizing Pseudomonas-derived cephalosporinase (PDC) and serine Ambler class C β-lactamases through the AmpC gene system.
  • * A study analyzed 111 P. aeruginosa isolates from India, identifying the ESAC allele PDC-447 as the most prevalent variant, particularly among carbapenem-resistant strains, while also noting other significant variants like PDC-398 and PDC-397.
  • * Genetic mutations in the PDC enzyme, such as T105A in the H-helix region, were linked to increased antibiotic resistance, emphasizing the complexity of resistance mechanisms and
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Background: The Halba tribe owes its nomenclature term "Hal" which locally means plowing or farming. Bastariya Halba is Dravidian tribe from Warangal. They speak Indo-European language Halbi.

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Transforming growth factor beta 1 (TGF-β1), a multifunctional cytokine, induces the expression of bone remodeling gene matrix metalloproteinase-13 (MMP-13). CREB-binding protein (CBP), a co-activator and runt-related transcription factor 2 (Runx2), a bone transcription factor, play critical roles in regulating bone-remodeling genes. Recent advances in non-coding RNAs have revealed the significance of microRNAs (miRNAs) and their target genes in bone physiology.

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There is a growing need to better characterise senescent cells in the CNS and retina. The recently published SenMayo gene panel was developed to identify transcriptomic signatures of senescence across multiple organ systems, but the retina was not included. While other approaches have identified senescent signatures in the retina, these have largely focused on experimental models in young animals.

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  • - Bilateral upper lobe pulmonary agenesis is a rare birth defect typically discovered incidentally in adults, with non-specific and subtle findings on traditional x-rays.
  • - Diagnosis is often missed on regular radiography, but chest CT scans performed for other reasons can reveal this condition.
  • - Contrast-enhanced CT is the best method for diagnosing and detailing the features of pulmonary agenesis, and understanding related pulmonary anomalies is crucial in treating patients with congenital heart issues.
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Ayurveda has unique and relevant methods in nosology, symptomatology, and drug selection. These methods need a novel and effective way of presentation for convenient comprehension and implementation. 'Clinical algorithms' is one such way, wherein a large amount of data is simplified, conceptual intricacies abstracted, and clinical application made easier.

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  • The study reveals that microplastics in the Eastern Arabian Sea are mainly sourced from land-based activities, highlighting the relevance of global marine plastic pollution.
  • Quantification of microplastic concentrations and the use of hydrodynamic models aid in tracking their movement in coastal areas, providing valuable data for environmental analysis.
  • An Environmental Decision Support System (EDSS) was developed to guide policy decisions and integrated coastal zone management, aligning with international sustainability goals and emphasizing the need for effective waste management strategies.
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The development of eco-friendly materials is a challenging one in the research field. Natural fibers are more accessible, biodegradable, inexpensive, and less dense. They offer fewer health risks and are eco-friendly compared to synthetic fibers.

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In the present study, we determine the synergistic activity of ertapenem with cefazolin and flucloxacillin against type A beta-lactamase producing Methicillin susceptible Staphylococcus aureus isolate. In the time kill assay, at standard inoculum, ertapenem with cefazolin showed >1 log kill and ertapenem with flucloxacillin demonstrated >2 log kill. When tested at high inoculum, both combinations achieved >1 log kill at 1x MIC.

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Four distinct neural models were used to evaluate the efficiency of a V-trough solar water heater (VTSWH) equipped with square-cut twisted tape (SCTT) and V-cut twisted tape (VCTT) at two different twist ratios, 3 and 5. The objective of this study was the use of ANFIS (Adaptive Neuro-Fuzzy Inference System), G.L.

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Introduction: This work focuses on the Dengue-viremia ABC (Atangana-Baleanu Caputo) fractional-order differential equations, accounting for both symptomatic and asymptomatic infected cases. Symptomatic cases are characterized by higher viremia levels, whereas asymptomatic cases exhibit lower viremia levels. The fractional-order model highlights memory effects and other advantages over traditional models, offering a more comprehensive representation of dengue dynamics.

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Background Diabetic foot ulcers (DFUs) are common complications in diabetes patients, often leading to sepsis and leg amputation. Methicillin-resistant Staphylococcus aureus (MRSA) infections in DFUs pose challenges due to methicillin resistance with and genes. This study aims to assess the prevalence of MRSA in clinical isolates from DFUs, analyze the antibiogram of MRSA isolates, and detect the presence of the and genes among MRSA isolates.

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  • Lumbar spine surgeries often cause significant post-op pain, and two regional anesthesia methods, Erector Spinae Plane Block (ESPB) and Thoracolumbar Interfascial Plane Block (TLIPB), are being compared for their effectiveness in pain management.
  • In a study with 60 patients, results showed that patients receiving the ESPB technique consumed more opioids and experienced higher pain scores compared to those receiving TLIPB, which also provided a quicker analgesic effect.
  • Overall, while both techniques are effective, TLIPB may reduce opioid use and is quicker to provide relief, but ESPB may last longer in terms of pain management, calling for further research to confirm these findings.
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The development of photocatalysts must be meticulous, especially when they are designed to degrade hazardous dyes that cause mutagenesis and carcinogenesis. In this meticulous approach, Ni-based metal-organic frameworks with different ligands, including terephthalic acid (NTP), 2-aminoterephthalic acid (NATP), and their composite with g-CN (NTP/GCN, and NATP/GCN) have been synthesized using hydrothermal method. Structural analysis by XRD and ATR-IR revealed synergistic properties due to robust chemical interactions between the NATP-MOFs and GCN systems.

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