Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing suitability of different dry coating processes.

Recent work showed that contrary to conventional wisdom, fine surface engineered excipients outperform their larger counterparts in blends of highly loaded blends of cohesive drug powders in terms of their packing, flowability and tablet tensile strength. Here, two continuous devices, fluid-energy mill (FEM) and conical mill (Comil), are compared with LabRAM, a batch device used in previous work, for nano-silica dry coating of microcrystalline cellulose (MCC) excipients, 20 and 30 μm. Coated MCCs from all three devices had higher bulk densities and flow function coefficients (FFCs) compared with Avicel PH-102.

Broad-Spectral-Response Photocatalysts for CO Reduction.

The poor conversion efficiency of carbon dioxide photoreduction has hindered the practical application at present, and one of the prime reasons for this obstacle is the inefficient solar energy utilization of photocatalysts. Generally speaking, it is contradictory for a photocatalyst to concurrently possess the broad-spectral response and appropriate band-edge positions for coinstantaneous carbon dioxide reduction and water oxidation. In this Outlook, we summarize a series of strategies for realizing visible-light and IR-light-driven carbon dioxide photoreduction under the guarantee of suitable band-edge positions.

Studying Workflow and Workarounds in Electronic Health Record-Supported Work to Improve Health System Performance.

Clinical workflow is the enactment of a series of steps to perform a clinical activity. The transition from paper to electronic health records (EHRs) over the past decade has been characterized by profound challenges supporting clinical workflow, impeding frontline clinicians' ability to deliver safe, efficient, and effective care. In response, there has been substantial effort to study clinical workflow as well as workarounds-exceptions to routine workflow-in order to identify opportunities for improvement.

Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.

Scope: The development of novel compounds that trigger non-apoptotic cell death may represent alternative therapeutic strategies for esophageal squamous cell carcinoma (ESCC) treatment. Cellular senescence suppresses tumorigenesis by halting the proliferation of tumor cells, implying the induction of senescence as a promising anticancer strategy, especially when combined with senolytic agents that specially kill senescent cells. This study is designed to screen novel anti-ESCC compounds from a natural product resource and identify its mechanism-of-action.

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated T17/T balance.

Immunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (T17) cells and regulatory T cells (T cells) is involved in ulcerative colitis (UC) pathogenesis. Dendritic cells (DCs) are able to induce T cell differentiation.

A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients.

Background: With the recent emergence of immune checkpoint inhibitors, microsatellite instability (MSI) status has become an important biomarker for immune checkpoint blockade therapy. There are growing technical demands for the integration of different genomic alterations profiling including MSI analysis in a single assay for full use of the limited tissues.

Methods: Tumor and paired control samples from 64 patients with primary colorectal cancer were enrolled in this study, including 14 MSI-high (MSI-H) cases and 50 microsatellite stable (MSS) cases determined by MSI-PCR.

GCNCDA: A new method for predicting circRNA-disease associations based on Graph Convolutional Network Algorithm.

Numerous evidences indicate that Circular RNAs (circRNAs) are widely involved in the occurrence and development of diseases. Identifying the association between circRNAs and diseases plays a crucial role in exploring the pathogenesis of complex diseases and improving the diagnosis and treatment of diseases. However, due to the complex mechanisms between circRNAs and diseases, it is expensive and time-consuming to discover the new circRNA-disease associations by biological experiment.

iCDA-CGR: Identification of circRNA-disease associations based on Chaos Game Representation.

Found in recent research, tumor cell invasion, proliferation, or other biological processes are controlled by circular RNA. Understanding the association between circRNAs and diseases is an important way to explore the pathogenesis of complex diseases and promote disease-targeted therapy. Most methods, such as k-mer and PSSM, based on the analysis of high-throughput expression data have the tendency to think functionally similar nucleic acid lack direct linear homology regardless of positional information and only quantify nonlinear sequence relationships.

Electronic Medical Record Search Engine (EMERSE): An Information Retrieval Tool for Supporting Cancer Research.

Purpose: The Electronic Medical Record Search Engine (EMERSE) is a software tool built to aid research spanning cohort discovery, population health, and data abstraction for clinical trials. EMERSE is now live at three academic medical centers, with additional sites currently working on implementation. In this report, we describe how EMERSE has been used to support cancer research based on a variety of metrics.

Anti-inflammatory properties of uvaol on DSS-induced colitis and LPS-stimulated macrophages.

Background: leaves are used as a kind of phytomedicine and the main ingredient in some traditional Chinese medicine products for the relief of colitis. To understand the bioactive constituents of L., we did a phytochemistry study and investigated anti-Inflammatory effects of compounds and explored the underlying mechanisms.

Multi-targeted B and Co co-doped 45S5 bioactive glasses with angiogenic potential for bone regeneration.

Many elements, such as copper, cobalt (Co), strontium, magnesium and boron (B) have been used for single or multiple doping of bioactive glasses to promote angiogenesis during bone regeneration. However, few works have focused on promoting angiogenesis through stimulating several different signalling pathways which can be called a multi-target approach. In this study, 45S5 bioactive glass (BG) co-doped with B and Co was prepared by conventional melt quenching method.

Classical and non-classical melatonin receptor agonist-directed micellization of bipyridinium-based supramolecular amphiphiles in water.

The addition of molecular recognition units into structures of amphiphiles is a means by which soft matter capable of undergoing template-directed micellization can be obtained. These supramolecular amphiphiles can bind with molecular templates using non-covalent bonding interactions, forming host-guest complexes that hold the amphiphiles together as they undergo micellization. In most cases, such templates are synthesized and designed for a specific molecular recognition motif.

Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer.

Colon cancer is the third most common cancer, with a high incidence and mortality. Construction of a specific and sensitive prediction model for prognosis is urgently needed. In this study, profiles of patients with colon cancer with clinical and gene expression data were downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA).

An investigation of the positive effects of doping an Al atom on the adsorption of CO on BN nanosheets: a DFT study.

Nowadays, climate problems caused by greenhouse gases are becoming more and more serious. Motivated by reducing carbon dioxide emissions from fossil fuel power generation, scientists are devoting themselves to developing novel materials or technologies for capturing carbon dioxide. Nanostructure materials, which show great potential for this application, have come to the attention of scientists.

Migrating from One Comprehensive Commercial EHR to Another: Perceptions of Front-line Clinicians and Staff.

As healthcare organizations continue to grow and evolve, migrations from one commercial electronic health record (EHR) system to another are likely to become more common. However, little is known about front-line clinicians' and staff's perceptions of such changes. Our study addresses this gap through an organization-wide survey of employees immediately prior to the transition to a new commercial EHR.

A Superconducting Binary Encoder with Multigate Nanowire Cryotrons.

Many classic and quantum devices need to operate at cryogenic temperatures, demanding advanced cryogenic digital electronics for processing the input and output signals on a chip to extend their scalability and performance. Here, we report a superconducting binary encoder with ultralow power dissipation and ultracompact size. We introduce a multigate superconducting nanowire cryotron (nTron) that functions as an 8-input OR gate within a footprint of approximately 0.

Correction to: Anti-HSV-1 activity of Aspergillipeptide D, a cyclic pentapeptide isolated from fungus Aspergillus sp. SCSIO 41501.

Following publication of the original article [1], we have been notified that there is a typo in the title of this article.

Arsenopyrite weathering in sodium chloride solution: Arsenic geochemical evolution and environmental effects.

In situ electrochemical techniques and surface analysis were used to investigate the weathering behavior of arsenopyrite in chlorine-containing brine. Cyclic voltammetry measurements showed that arsenopyrite weathering releases S°, As (III) and Fe (II) during the initial step, even contains different concentrations of H and Cl, and terminal transformation into SO, As (V) and Fe (III), respectively. Cl ions promote the arsenopyrite weathering through diffusion control or adsorption control when Cl- ions are at low or high concentrations.

Influence of Cytochrome P450 2D6 Polymorphisms on the Efficacy of Oral Propranolol in Treating Infantile Hemangioma.

Objective: The aim of this study is to evaluate the association of genetic polymorphisms in Cytochrome P450 2D6(CYP2D6) and the change in VEGF levels with the response to propranolol in patients with Infantile hemangiomas (IH).

Methods: IH patients who underwent over six months of propranolol therapy and received oral propranolol only were enrolled. The target dose of propranolol was 1 mg kgday.

Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities.

Mesoporous bioactive glass nanoparticles (MBGNs) are emerging biomaterials for bone repair/regeneration, considering their favorable pro-osteogenic and proangiogenic activities. To further improve their therapeutic effects, the endowment of MBGNs with additional antioxidant properties is of particular interest to target oxidative stress related to bone remodeling and diseases. To this end, we developed antioxidant cerium-containing MBGNs (Ce-MBGNs) (particle size of 100-300 ​nm) by using a postimpregnation strategy to incorporate Ce, through which the shape, pore structure, and dispersity of the nanoparticles were preserved.

Paraneoplastic Encephalitis and Enteric Neuropathy Associated With Anti-Hu Antibody in a Patient Following Immune-checkpoint Inhibitor Therapy.

Paraneoplastic neurological syndromes (PNSs) are uncommon complications of immune-checkpoint inhibitor (ICI) therapy. This article reports a case of paraneoplastic encephalitis and enteric neuropathy associated with anti-Hu antibody in a patient with advanced small cell lung cancer. Symptoms presented in the third week after the second dose of sintilimab therapy and manifested as focal seizures and intestinal pseudo-obstruction.