Psychological Status and its Influencing Factors of Staff in a District of Shenzhen: A Retrospective Study.

Background: Anxiety, depression, and sleep disorders, as psychological and emotional diseases, have serious impact on people's physical and mental health, and receive increasing academic attention. This study aimed to examine anxiety, depression, and sleep disorder of staff in a district of Shenzhen and to provide the basis for the development of targeted intervention measures to improve the psychological status of cadres.

Methods: Based on the psychological evaluation data of staff cadres in a district of Shenzhen City obtained from January to December 2020, a stratified sampling method was adopted to randomly select two streets and three communities in each street.

Advances in Exercise and Dietary Interventions for Peripheral Arterial Disease.

Peripheral arterial disease(PAD)is a common atherosclerotic cardiovascular disease.The patients with this disease experience pain during exercise,which is relieved after rest.Exercise interventions,dietary interventions,and combined interventions can treat PAD via different mechanisms.

Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration.

Bone defect repair remains a great challenge in the field of orthopedics. Human body essential trace element such as copper is essential for bone regeneration, but how to use it in bone defects and the underlying its mechanisms of promoting bone formation need to be further explored. In this study, by doping copper into mesoporous bioactive glass nanoparticles (Cu-MBGNs), we unveil a previously unidentified role of copper in facilitating osteoblast mitophagy and mitochondrial dynamics, which enhance amorphous calcium phosphate (ACP) release and subsequent biomineralization, ultimately accelerating the process of bone regeneration.

HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses.

Histone deacetylase HDAC6 has been implicated in regulating antiviral innate immunity. However, its precise function in response to DNA virus infection remains elusive. Herein, we find that HDAC6 deficiency promotes the activation of cGAS-STING signaling and type I interferon (IFN) production, both in vitro and in vivo, resulting in a decrease in HSV-1 infection.

Photocatalytic Oxidative Coupling of Methane to Ethane Using CO as a Soft Oxidant over the Au/TiO-V Nanosheets.

Photocatalytic oxidative coupling of methane (OCM) offers an appealing route for converting greenhouse gas into valuable C hydrocarbons. However, O as the most commonly used oxidant, tends to result in inevitable overoxidation and waste of methane feedstock. Herein, we first report a photocatalytic OCM using CO as a soft oxidant for CH production under mild conditions, where an efficient photocatalyst with unique interface sites is designed and constructed to facilitate CO adsorption and activation, while concurrently boosting CH dissociation.

Distinct knee phenotype variation: a comparative analysis of medial and lateral unicompartmental knee arthroplasty.

Purpose: Lateral unicompartmental knee arthroplasty (UKA) is relatively less common than medial UKA. There has been no comparative analysis of the constitutional phenotypes of knees that underwent medial and lateral UKA. Therefore, this study aimed to compare the Coronal Plane Alignment of the Knee (CPAK) classification of knees that underwent medial and lateral UKA.

Trace amount of taurine leveling agent for stable Zn anode.

Aqueous zinc-ion batteries are highly praised for their cost-effectiveness, environmental friendliness, and high safety, making them an ideal choice for next-generation energy storage systems. However, the practical application of Zn metal anodes is constrained by well-known challenges such as dendrite growth and significant interfacial side reactions. This study introduces a trace amount of taurine (TAU) as a leveling additive into the electrolyte to optimize the microstructure of the electrolyte and the anode interface chemistry.

Utilization of 3D-Printed Customized Uncemented Stem Prostheses for Revision of Aseptic Loosening in the Distal Femoral Cemented Prostheses: Case Series and Literature Review.

Objective: Aseptic loosening (AL) is a common mechanical complication following reconstruction of the distal femoral cemented prosthesis (DFCP), often resulting in severe bone loss, which complicates prosthesis revision. 3D-printed personalized implants represent an emerging solution for the reconstruction of complex bone defects. This study aimed to investigate the early therapeutic effects of using a 3D-printed, customized, uncemented stem prosthesis for revising aseptic AL in DFCP.

Management of Bone Defects and Complications After Bone Tumor Resection Using Ilizarov Method.

Objective: Ilizarov technology is highly effective in addressing complex orthopedic challenges. This study aims to describe our experience with distraction osteogenesis in managing bone tumors in the lower extremity, focusing on composite bone defects and associated complications.

Methods: A retrospective clinical study was conducted to analyze patients with primary bone tumors who underwent distraction osteogenesis using the Ilizarov method from 2010 to 2020.

The complete telomere-to-telomere sequence of a mouse genome.

The current reference genome of , GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled the telomere-to-telomere genome of mouse haploid embryonic stem cells. The results reveal more than 7.

Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study.

Purpose: Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease that primarily affects the large intestine. Coagulation abnormalities have been detected in UC patients. This study aimed to evaluate coagulation-related parameters in patients with UC.

Evaluating the diagnostic performance of [F]ALF-NOTA-FAPI-04 PET/CT in gastric cancer: a comparative study with [F]FDG PET/CT.

Purpose: To compare the diagnostic value of [F]ALF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) and F-fluorodeoxyglucose (FDG) PET/CT in gastric cancer.

Methods: This single-center retrospective analysis included 65 patients with gastric cancer who received both [F]FDG and [F]ALF-NOTA-FAPI-04 PET/CT for initial staging or restaging. Histopathological manifestations, typical imaging manifestations, follow-up imaging, and comprehensive clinical assessment were used as reference criteria.

Electrospinning of recombinant human-like collagen-reinforced PCL nanofibrous membranes using benign solvents for periodontal regeneration.

Periodontal tissue defects are a leading cause of tooth loss in adults. Guided tissue regeneration (GTR) has emerged as an effective clinical approach for promoting periodontal regeneration. In this study, we employed a green electrospinning technology to combine recombinant human-like collagen (RHC) with polycaprolactone (PCL) to fabricate RHC/PCL membranes for periodontal regeneration.

Monophasic hyaluronic acid-silica hybrid hydrogels for articular cartilage applications.

Hyaluronic acid (HA), an FDA-approved natural polymer and important component of the extracellular matrix (ECM), has been widely used to develop hydrogels for cartilage regeneration. However, HA hydrogels often exhibit poor mechanical properties and unsuitable degradability, limiting their capability to support cell growth in cartilage. To overcome these challenges, this study modifies HA with a silica precursor and the coupling agent (3-Glycidyloxypropyl) trimethoxysilane (GPTMS) to develop a monophasic organic-inorganic hybrid HA-silica hydrogel.

Manual Therapy Exerts Local Anti-Inflammatory Effects Through Neutrophil Clearance.

Manual therapy (MT) has been widely used in China to treat local tissue inflammation for a long time. However, there is a lack of scientific evidence for using MT in anti-inflammatory therapy, and its anti-inflammatory mechanism needs further clarification. We utilized MT to treat cardiotoxin (CTX) injury-induced skeletal muscle inflammation in C57BL6/J mice.

Efficacy and safety of acupuncture treatment for stiff neck: A systematic review and meta-analysis.

Background: Stiff neck is a common acute musculoskeletal condition that significantly affects the quality of life of patients. Acupuncture is recommended as an effective method for alleviating pain and restoring neck mobility in patients with stiff neck, but there is currently a lack of scientific evidence supporting its efficacy and safety. The purpose of this study was to investigate the efficacy and safety of acupuncture in the treatment of stiff neck.

Ultrasound-Guided "Cross Injection" Technique for Mouth Corner Lift with Botulinum Toxin Type A.

Background: Drooping mouth corner may lead to a sad, tired or aging appearance, which could be corrected by injection of botulinum neurotoxin. In the article, we describe a novel "cross injection" technique for mouth corner lift with botulinum neurotoxin injection guided by ultrasound.

Methods: Patients with drooping mouth corner were treated with botulinum neurotoxin injection using ultrasound-guided "cross injection" technique.

Effect of the HCT Gene on Lignin Synthesis and Fiber Development in Gossypium barbadense.

As one of the key enzymes in the metabolic pathway of phenylpropane, shikimate hydroxycinnamoyl transferase (HCT) is mainly involved in the biosynthesis of the plant secondary cell wall, which is closely related to cotton fiber quality. In this study, whole-genome identification and bioinformatics analysis of the HCT gene family were performed in G. barbadense.

MBG/BSA Bone Grafts Immunomodulate Bone Regeneration by Releasing Bioactive Ions in Inflammatory Bone Defects.

Since the diseases that cause bone defects are mostly inflammatory diseases, the current bone grafts are unable to effectively regulate osteoimmune activity, leading to the impaired osteogenesis and unfavorable bone regeneration. In this study, inspired by bone composition, biomimetic mesoporous bioactive glass nanoparticle (MBG)/bovine serum albumin (BSA) bone grafts are designed for inflammatory bone defects. Systematically, MBG/BSA bone grafts are evaluated for characterization, bioactivity, anti-inflammatory, antioxidant activity, and osteogenic activity.

SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice.

Statins therapy is efficacious in diminishing the risk of major cardiovascular events in diabetic patients. However, our research has uncovered a correlation between the prolonged administration of statins and an elevated risk of myocardial dysfunction in patients with type II diabetes mellitus (TIIDM). Here, we report the induction of sterol regulatory element-binding protein 1 (SREBP1) activation, associated lipid peroxidation, and the consequent diabetic myocardial dysfunction after statin treatment and explored the underlying mechanisms.

The primary stability of ultrashort residual proximal femur fixed with triangular fixation stem prosthesis: a comparative biomechanical study based on sawbones models.

Background: Tumor resection near the proximal end of the femur and revision surgery of the distal femoral prosthesis may result in a very short bone segment remaining at the proximal end of the femur, known as ultrashort residual proximal femur (URPF). In this study, we propose a triangular fixation stem (TFS) prosthesis to improve the fixation of URPF. The aim of this research is to investigate the biomechanical properties of the TFS prosthesis and compare it with the conventional stem (CS) prosthesis through biomechanical experiments, providing preliminary biomechanical evidence for prosthetic fixation of URPF.

Integrated analysis of bulk and single-cell RNA sequencing reveals the impact of nicotinamide and tryptophan metabolism on glioma prognosis and immunotherapy sensitivity.

Background: Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis metabolism and signal transduction functions. However, their comprehensive impact on the prognosis and the tumor immune microenvironment of glioma is still unclear. The purpose of this study was to investigate the association of nicotinamide and tryptophan metabolism with prognosis and immune status of gliomas and to develop relevant models for predicting prognosis and sensitivity to immunotherapy in gliomas.