A Universal Multi-Epitope Vaccine Design Against Porcine Reproductive and Respiratory Syndrome Virus via Bioinformatics and Immunoinformatics Approaches.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive disorders in sows and severe pneumonia in piglets, alongside immunosuppressive effects on the host. It poses a significant global threat to the swine industry, with no effective control measures currently available due to its complex pathogenesis and high variability. Conventional inactivated and attenuated vaccines provide inadequate protection and carry biosafety risks.

Enhance the Surface Insulation Properties of EP Materials via Plasma and Fluorine-Containing Coupling Agent Co-Fluorinated Graphene.

Epoxy resin (EP) is an outstanding polymer material known for its low cost, ease of preparation, excellent electrical insulation properties, mechanical strength, and chemical stability. It is widely used in high- and ultra-high-voltage power transmission and transformation equipment. However, as voltage levels continue to increase, EP materials are gradually failing to meet the performance demands of operational environments.

Mapping the knowledge landscape: A bibliometric analysis of exosome research in osteoarthritis (2004-2023).

Exosomes have emerged as a crucial focus in advancing the diagnosis and treatment of osteoarthritis (OA). However, there are limited bibliometric studies on this topic. This study aimed to delineate the literature landscape on exosomes in OA, identifying global research trends and key areas.

Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/β-catenin signaling.

Liver fibrosis is a critical stage in the progression of various chronic liver diseases to cirrhosis and liver cancer. Early inhibition of liver fibrosis is crucial for the treatment of liver disease. Hepatectomy, a common treatment for liver-related diseases, promotes liver regeneration.

Continuous worsening of population emotional stress globally: universality and variations.

Background: Understanding emotional stress stability in populations is crucial because stress is a key factor in causing depression, and it worsens well-being.

Method: In this study, using repeated cross-sectional data from 149 countries from 2007 to 2021 (N = 2,450,043), we examined time trends of psychological stress in populations worldwide.

Results: Over half of the population experienced emotional stress in 20 countries, and 85% of the countries reported worse psychological stress in 2020 compared with 2008.

Modeling and Simulation of Micron Particle Agglomeration in a Turbulent Flow: Impact of Cylindrical Disturbance and Particle Properties.

The fly ash generated by coal combustion is one of the main sources of PM2.5, so the particulate matter removal technology of coal-fired boilers is receiving increasing attention. Turbulent agglomeration has emerged as a powerful tool for improving the efficiency of removing fine particulates from environments, sparking interest in its study.

Point-of-care testing diagnosis of African swine fever virus by targeting multiple genes with enzymatic recombinase amplification and CRISPR/Cas12a System.

African swine fever virus (ASFV) infection is causing devastating outbreaks globally; pig farming has suffered severe economic losses due to the ASFV. Currently, strict biosecurity control measures can mitigate the incidence of ASF. Rapid, cost-effective, and sensitive detection of ASFV can significantly reduce disease transmission and mortality.

Effect of exercise based on ACSM recommendations on blood pressure and heart rate in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials.

Numerous studies have demonstrated the positive effects of exercise as a non-pharmacological treatment for hypertensive patients. However, there was a relative lack of research analyzing the effects of different exercise doses on hypertensive individuals. Therefore, the primary objective of this study was to evaluate the impact of different exercise doses on blood pressure (BP) and heart rate (HR) in hypertensive patients through a systematic review and meta-analysis.

Inhibition of CCR2 attenuates NLRP3-dependent pyroptosis after myocardial ischaemia-reperfusion in rats via the NF-kB pathway.

Myocardial infarction (MI) is a leading cause of mortality worldwide, contributing significantly to long-term cardiac dysfunction and heart failure. Effective therapeutic strategies are urgently needed to mitigate the extensive damage caused by MI and subsequent ischemia-reperfusion (I/R) injury. This study investigates the role of the Chemokine receptor 2 (CCR2) in regulating NLRP3-dependent cardiomyocyte pyroptosis following myocardial ischemia-reperfusion (MIR), elucidating its molecular mechanisms.

The receptor binding mechanism of mouse sPLA2 group IIE.

Secreted phospholipase A2s (sPLA2s) participate in physiological function by their enzyme and receptor binding activity. Muscle-type phospholipase A2 receptor (M-type PLA2R) is the sPLA2 binding protein with the highest affinity so far, and also inhibits the enzyme activity of sPLA2. There is species specificity and pH dependence for the binding of M-type PLA2R to sPLA2.

Synthetic Breast Ultrasound Images: A Study to Overcome Medical Data Sharing Barriers.

The vast potential of medical big data to enhance healthcare outcomes remains underutilized due to privacy concerns, which restrict cross-center data sharing and the construction of diverse, large-scale datasets. To address this challenge, we developed a deep generative model aimed at synthesizing medical data to overcome data sharing barriers, with a focus on breast ultrasound (US) image synthesis. Specifically, we introduce CoLDiT, a conditional latent diffusion model with a transformer backbone, to generate US images of breast lesions across various Breast Imaging Reporting and Data System (BI-RADS) categories.

The lingering menace: How legacy organochlorine pesticides still threaten our rivers and food chains.

The bioaccumulation of organochlorine pesticides (OCPs) in aquatic organisms has been extensively explored in recent years due to associated ecological risks and potential threats to human health through food. This study aims to assess the bioaccumulation of organochlorine pesticides (OCPs) in 18 freshwater fish species from the Pearl River Delta, China. The observed OCP concentrations ranged from 0.

Mechanistic Study of Purple Sweet Potato Anthocyanins: Multifaceted Anti-Fibrotic Effects and Targeting of PDGFRβ in Liver Fibrosis.

The purple sweet potato anthocyanins (PSPA) are known for their diverse health benefits, yet their hepatoprotective effects and the mechanisms by which they combat liver fibrosis have not been thoroughly investigated. This study aimed to elucidate these effects by employing a carbon tetrachloride (CCl)-induced mouse model of liver fibrosis. We conducted a comprehensive analysis of the effects of PSPA on liver injury, oxidative stress, inflammation, and fibrosis-related signaling pathways.

Single-cell sequencing reveals transcriptional dynamics regulated by ERα in mouse ovaries.

Context: Estrogen receptor α (ERα) is a key regulator of reproductive function, particularly in ovarian development and function, yet the specifics of its role at the molecular level remain unclear.

Aims: The study aims to elucidate the molecular mechanisms of ERα-regulated transcriptional dynamics in ovarian cells using ERα knockout (αERKO) mice created via CRISPR/Cas9.

Methods: Single-cell RNA sequencing (scRNA-seq) was used to compare transcriptomes from individual ovarian cells in both wild type and αERKO mice.

Effects of carbon nanotube and alumina doping on the properties of para-aramids: A DFT and molecular dynamics study.

Because of its superior mechanical and electrical insulation qualities, paramamid insulating paper is frequently used in the electrical industry. However, a significant barrier preventing it from taking a more prominent role is its low heat conductivity. This research modifies aramid by doping it with carbon nanotubes and alumina to balance its insulating qualities and increase its thermal conductivity.

Relationship between stratigraphic overlap and sedimentary facies evolution of the Junggar Basin, Northwest China.

The interaction between the topography of the slope zone on the edge of the basin and the distribution of sediments is crucial for accurately predicting sediment distribution, but few studies emphasize the impact of stratigraphic overlap on the spatial evolution of sedimentary facies. The tectonic movement and sedimentary environment of Hala'alat Mountain in the northwest margin of the Junggar Basin are complex, and the sedimentary model of the whole Cretaceous system is still unclear. This article uses lithology, logging, and seismic data to explain the evolution process and sedimentary model of the Cretaceous system.

Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function.

Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex, recruiting the 40S small ribosome subunit, and scanning the 5' untranslated region (5' UTR) for the start codon. eIF4A1 and eIF4A2, two isoforms of eIF4A, are highly conserved and exchange freely within eIF4F complexes. The understanding of their biological and molecular functions remains incomplete if not fragmentary.

Succession of microbial community structure in fermented grains during the fermentation of strong-flavor Baijiu and its impact on the metabolism of acids, alcohols, and esters.

The study clarified the succession of microbial community structures in fermented grains (FG) and their association with flavor compounds, along with their potential metabolic functions. The community diversity, functional genera and metabolites in FG were investigated by polyphasic detecting approaches. There are 13 dominant microorganisms in FG (relative abundance > 1%).

Ru single-atom nanozymes targeting ROS-ferroptosis pathways for enhanced endometrial regeneration in intrauterine adhesion therapy.

Intrauterine adhesion (IUA) presents a significant challenge in gynecology, characterized by excessive fibrosis and compromised reproductive function, leading to severe infertility. Although biocompatible hydrogels integrated with stem cells offer a promising approach for IUA therapy, clinical applications remain limited. Recent studies have highlighted the role of ferroptosis and reactive oxygen species (ROS) in IUA pathogenesis, yet strategies targeting ferroptosis through antioxidant stress are underexplored.