Kerr-lens mode-locked GHz-repetition-rate Yb:CYA laser with 11-W average power.

We demonstrate on a high-power 1-GHz Kerr-lens mode-locked (KLM) ytterbium (Yb):CYA laser delivering 149-fs pulses with an average power of 11.1 W. The corresponding single-pulse energy and peak power are 10.

Memory-based consensus control for multi-agent systems with time-varying topology and communication constraints.

This paper focuses on the design of event-triggered observer-based heterogeneous memory controllers for leader-following multi-agent systems with time-varying topology. In order to save limited on-board resources, a novel adaptive event-triggered strategy based on the nonlinear transformation law of the estimation error is proposed in this paper, which can effectively reduce some unnecessary data transmission due to small fluctuations after the estimation error converges. Then, a more general topology structure described by an interval type-2 fuzzy model is adopted, which contains both nonlinear time-varying law and uncertain parameters.

MSDG: Multi-Scale Dynamic Graph Neural Network for Industrial Time Series Anomaly Detection.

A large number of sensors are typically installed in industrial plants to collect real-time operational data. These sensors monitor data with time series correlation and spatial correlation over time. In previous studies, GNN has built many successful models to deal with time series data, but most of these models have fixed perspectives and struggle to capture the dynamic correlations in time and space simultaneously.

Adaptive window adjustment with boundary DoU loss for cascade segmentation of anatomy and lesions in prostate cancer using bpMRI.

Accurate segmentation of prostate anatomy and lesions using biparametric magnetic resonance imaging (bpMRI) is crucial for the diagnosis and treatment of prostate cancer with the aid of artificial intelligence. In prostate bpMRI, different tissues and pathologies are best visualized within specific and narrow ranges for each sequence, which have varying requirements for image window settings. Currently, adjustments to window settings rely on experience, lacking an efficient method for universal automated adjustment.

Mechanism of ginsenoside Rb against OGD/R damage based on metabonomic and PCR array analyses.

In order to study the mechanisms of ginsenoside Rb (G-Rb) against oxygen-glucose deprivation/reoxygenation (OGD/R) injury in HT22 cells based on metabolomics and PCR array, HT22 cells were randomly divided into control group, model group, G-Rb high-dose group (10 µmol/l) and G-Rb low-dose group (5 µmol/l). Except for the control group, which was left untreated, the remaining groups were incubated with 10 mmol/l NaSO in sugar-free DMEM medium for 2 h and then replaced with serum-free high-sugar DMEM medium for 2 h in order to replicate OGD/R model. Trypan blue staining was used to detect the cell viability; flow cytometry was used to detect apoptosis; western blotting was used to detect the protein expression levels of Bax, Bcl-2 and caspase-3.

Metabolomics-Based Study of the Protective Effect of 4-Hydroxybenzyl Alcohol on Ischemic Astrocytes.

Ischemic stroke is a common and dangerous disease in clinical practice. Astrocytes (ASs) are essential for maintaining the metabolic balance of the affected regions during the disease process. 4-Hydroxybenzyl alcohol (4HBA) from Bl.

Development of an Indirect ELISA to Distinguish between Porcine Sapelovirus-Infected and -Vaccinated Animals Using the Viral Nonstructural Protein 3AB.

Porcine sapelovirus (PSV) is a new pathogen that negatively impacts the pig industry in China. Affected pigs experience severe diarrhea and even death. Vaccination is used to control disease outbreaks, and sensitive diagnostic methods that can distinguish infected animals from vaccinated animals (DIVA) are essential for monitoring the effectiveness of disease control programs.

The impact of high-altitude migration on cardiac structure and function: a 1-year prospective study.

Introduction: The trend of human migration to terrestrial high altitudes (HA) has been increasing over the years. However, no published prospective studies exist with follow-up periods exceeding 1 month to investigate the cardiac change. This prospective study aimed to investigate the changes in cardiac structure and function in healthy young male lowlanders following long-term migration to HA.

Downregulating miR-432-5p exacerbates adriamycin-induced cardiotoxicity via activating the RTN3 signaling pathway.

Background: Adriamycin (ADR) is a widely used chemotherapy drug in clinical practice and it causes toxicity in the myocardium affecting its clinical use. miR-432-5p is a miRNA primarily expressed in myocardial cells and has a protective effect in the myocardium. We aim to explore the protective effect of miR-432-5p on ADR-caused impaired mitochondrial ATP metabolism and endoplasmic reticulum stress (ERs).

Tunable temperature-responsive photonic ionogels with dual signals output.

Photonic ionogels with dual electrical and optical output have been intensively studied. However, tunable temperature-responsive photonic ionogel assembled by thermosensitive nanogels has not been studied yet. Herein, an innovative approach to fabricate photonic ionogels has been developed for smart wearable devices with tunable temperature sensitivity and structural color.

Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetic kidney disease in mice via inhibiting the SGLT2/glycolysis pathway.

Ethnopharmacological Relevance: Fufang Zhenzhu Tiaozhi (FTZ) capsule is a hospital preparation of a patented traditional Chinese medicine compound. FTZ has been clinically used for nearly 13 years in the treatment of diabetes and glycolipid metabolic diseases. With the significant benefits of SGLT2 inhibitor in patients with diabetic kidney disease (DKD), it provides a research avenue to explore the mechanism of FTZ in treating this disease based on glycolysis pathway.

[Effects of " Air Pollution Prevention and Control Action Plan " on PM and Chemical Compositions in Zhengzhou in Polluted Winters].

The Air Pollution Prevention and Control Action Plan （APPCAP） was promulgated in China in 2013. To explore the effectiveness of APPCAP on PM in winter in Zhengzhou, PM samples were collected in Zhengzhou Monitoring Center during December 2013 and December 2018. The chemical composition of PM was analyzed, including EC, OC, water soluble ions, and metal elements.

Magnetic compression anastomosis to restore biliary tract continuity after obstruction following major abdominal trauma: A case report.

Background: The combination of magnetic compression anastomosis (MCA) and endoscopy has been used to treat biliary stricture after liver transplantation. However, its use for the treatment of complex biliary obstruction after major abdominal trauma has not been reported. This case report describes the successful use of MCA for the treatment of biliary obstruction resulting from major abdominal trauma.

[Retracted] STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.

[This retracts the article DOI: 10.3892/ol.2017.

Relationships Among Serological Indicators and In Vitro High-Throughput Drug Sensitivity Screening Results in Patients with Hepatocellular Carcinoma.

Aim: The purpose of this study was to analyze the relationship between serum indicators and high-throughput drug screening (HDS) results, aiming to achieve specific therapy for hepatocellular carcinoma (HCC).

Methods: This study recruited patients with HCC who underwent surgical resection at the Hepatobiliary Surgery Center of the First Affiliated Hospital of Chongqing Medical University from December 2019 to December 2021. HCC tissues were obtained from patients during surgery and subjected to in vitro cell culture, and then HDS testing was performed on the cultured tissue samples.

NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.

() has a potential zoonotic risk, with a high proportion of co-infection occurring with () and other diarrheal pathogens. Despite its high prevalence, the cellular mechanism of pathogenesis is ill-defined. Previous proteomics analyses have revealed that the differentially expressed protein NOD-like receptor X1 (NLRX1) located in the mitochondria participates in several important antiviral signaling pathways in infection, which are closely related to mitophagy.

Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors.

Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a critical role for SmD2, a core component of the spliceosome machinery, in modulating DNA damage in HCC through its impact on BRCA1/FANC cassette exons and expression. Our findings reveal that SmD2 depletion sensitizes HCC cells to PARP inhibitors, expanding the potential therapeutic targets.

4,4'-methylenediphenol reduces Aβ-induced toxicity in a model of Alzheimer's disease.

Introduction: is a widely used medicinal and edible herb with a rich chemical composition. Moreover, prescriptions containing are commonly used for the prevention and treatment of cardiovascular, cerebrovascular, and aging-related diseases. Recent pharmacological studies have confirmed the antioxidant and neuroprotective effects of , and, in recent years, this herb has also been used in the treatment of Alzheimer's disease (AD) and other neurodegenerative disorders.

Containment control for fractional-order networked system with intermittent sampled position communication.

This paper investigates containment control for fractional-order networked systems. Two novel intermittent sampled position communication protocols, where controllers only need to keep working during communication width of every sampling period under the past sampled position communication of neighbors' agents. Then, some necessary and sufficient conditions are derived to guarantee containment about the differential order, sampling period, communication width, coupling strengths, and networked structure.