1700030J22RIK is essential for sperm flagellar function and male fertility in mice.

Spermiogenesis is an indispensable process occurring during the later stages of spermatogenesis. Despite multiple proteins being associated with spermiogenesis, the molecular mechanisms that control spermiogenesis remain poorly characterized. In this study, we show that 1700030J22RIK is exclusively expressed in the testis of mice and investigate its roles in spermiogenesis using genetic and proteomic approaches.

Casein-grape seed proanthocyanidins complexes stabilized Pickering emulsion gels based on Lycium Barbarum seed oil with excellent mechanical properties and oxidation resistance.

Pickering emulsion gels received extensive attention in encapsulating fat-soluble substances such as Lycium barbarum seed oil (LBSO). However, the gels presented poor mechanical properties, otherwise, their physical encapsulation cannot inhibit lipid peroxidation. Herein, grape seed proanthocyanidins (OPCs) and casein (CAS) complexes interacted through hydrogen and covalent bonds were proposed to build Pickering emulsion gels and encapsulate LBSO, which changed the secondary structures of CAS and further enhanced emulsifying ability, oxidation resistance, and gelling performance.

Development and validation of a risk prediction model for dyslipidemia in community-dwelling middle-aged and older adults in China: a nationwide survey.

Background: The incidence of dyslipidemia as a risk factor for many serious diseases is increasing year by year. This study aimed to construct and visualize a risk prediction model for dyslipidemia in middle-aged and older adults.

Method: The subjects of our study are derived from CHARLS.

Gut microbiota regulate insomnia-like behaviors via gut-brain metabolic axis.

Sleep interacts reciprocally with the gut microbiota. However, mechanisms of the gut microbe-brain metabolic axis that are responsible for sleep behavior have remained largely unknown. Here, we showed that the absence of the gut microbiota can alter sleep behavior.

Investigating the Bromoform Membrane Interactions Using Atomistic Simulations and Machine Learning: Implications for Climate Change Mitigation.

Methane emissions from livestock contribute to global warming. Seaweeds used as food additive offer a promising emission mitigation strategy because seaweeds are enriched in bromoform─a methanogenesis inhibitor. Therefore, understanding bromoform storage and production in seaweeds and particularly in a cell-like environment is crucial.

Bushen Huoxue decoction improves the reproduction of endometriosis-associated infertility by regulating Homeobox A10 and αlpha(v)beta(3) integrin expression.

Objective: To investigate the mechanism of Bushen Huoxue decoction (, BSHXD) to treat endometriosis-induced infertility.

Medhods: The main compounds of BSHXD were determined by high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). The effect of BSHXD on Homeobox A10 (HOXA10) and alpha(v)beta(3) (αvβ3) integrin expression of Ishikawa cells, mouse model, and endometriosis-associated infertility women was evaluated by using Western blot analysis, immunohistochemistry and Real-Time quantitative polymerase chain reaction (RT-qPCR).

Brain-clinical pattern alterations after treatment in schizophrenia.

Discovering meaningful brain-clinical patterns would be a significant advancement for elucidating the pathophysiology underlying schizophrenia. In the present study, we analyzed associations between functional brain characters (average functional connectivity strength and its fluctuations) and clinical features (age onset, illness duration, and positive, negative, disorganized, excited, and depressed) using partial least squares. Also, we analyzed the brain-clinical relationship changes after 6-wk of treatment.

Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report.

Aim: To examine the immune responses in patients diagnosed as grade C periodontitis during orthodontic treatment.

Materials And Methods: Our study included seven orthodontic patients with grade C periodontitis and measured their levels of inflammatory cytokines in gingival crevicular fluid and plasma before orthodontic treatment, during the alignment and levelling phase, and during the detailing and finishing phase. The key signal pathways in the orthodontic process of patients with periodontitis were detected by KEGG analysis.

Sintilimab Plus Lenvatinib with or Without Radiotherapy for Advanced Hepatocellular Carcinoma with Pulmonary Metastasis.

Background: Hepatocellular carcinoma (HCC) with pulmonary metastasis (PM) significantly worsens prognosis, and current treatment options remain limited.

Methods: A retrospective study was conducted on HCC patients treated with sintilimab combined with lenvatinib at three hospitals in China between 2020 and 2021. Progression-free survival (PFS), overall survival (OS), and tumor response based on RECIST 1.

Influencing factors and preventive measures of infectious complications after intestinal resection for Crohn's disease.

The incidence of Crohn's disease (CD) has increased in recent years, with most patients requiring intestinal resection. Complications after intestinal resection for CD can lead to poor prognosis and recurrence, among which infectious complications are the most common. This study aimed to investigate the common risk factors, including medications, preoperative nutritional status, surgery-related factors, microorganisms, lesion location and type, and so forth, causing infectious complications after intestinal resection for CD, and to propose corresponding preventive measures.

miR-PC-3p-241582_34 Contributes to the Infection of by Regulating the Expression of in .

is a recurring pest in the maize seedling stage under the wheat-maize no-tillage direct seeding system in China's summer maize region. Our previous research identified a highly pathogenic to , which spore wall protein plays an important role in the infection process. However, the regulatory mechanism of this spore wall protein is still unclear.

Phenotypic variability observed in a Chinese patient cohort with biallelic variants in the genes.

Purpose: The neuronal ceroid lipofuscinoses (NCLs) comprise a group of inherited neurodegenerative disorders with thirteen NCL-disease causing genes ceroid lipofuscinosis neuronal ( identified. The purpose of this study was to describe the genetic and clinical characteristics of a cohort of Chinese patients harboring biallelic variants in the genes.

Methods: We recruited 14 patients from 13 unrelated families who carried biallelic variants in the genes.

AAPM task group report 314: Fault recovery in external beam radiation therapy.

Task Group (TG) 314 of the American Association of Physicists in Medicine (AAPM) was charged to develop guidance for recovering from fault states in radiation therapy, specifically regarding the delivery of photon or electron beams using a linear accelerator (linac) including ancillary systems. The fault conditions addressed may involve software, hardware, or a combination of causes. The report provides detailed recommendations for the proactive steps to be taken before a fault, the actions to be taken at the time of a fault, and the safety steps before returning a linac to clinical service, as well as the activities that device manufacturers and standard organizations can do to prevent and resolve the faults.

Effect of ocean dynamic processes on the temporal-spatial pattern of persistent organic pollutants (PCB-153 and BDE-47) in the shelf seas.

Field observations of persistent organic pollutants (POPs) in shelf seas presented abnormal phenomena such as high-concentration patches in offshore areas and different vertical profiles of POPs at the same location. We assumed that these phenomena were associated with the presence of bottom cold water mass (BCWM) in shelf seas and used a hydrodynamic-ecosystem-POP coupled model to confirm this hypothesis. Based on model results, with the formation of BCWM during summer, POPs accumulated inside BCWM due to their transport across the thermocline by the sorption to sinking particles.

Comprehensive analysis of psychological symptoms and quality of life in early patients with IBD: a multicenter study from China.

Objective: To investigate the prevalence and risk factors of psychological symptoms and quality of life (QoL) in early patients with inflammatory bowel disease (IBD).

Methods: From September 2021 to May 2022, a unified questionnaire was developed to collect clinical data from early patients with IBD from 42 tertiary care hospitals. The influencing factors of psychological symptoms and poor QoL are screened by logistic regression analysis for constructing model in predicting poor QoL.

An accurate measurement method for serum homocysteine measurement by ID-LC/MS/MS and the application of external quality assessment.

Background: Serum homocysteine (Hcy) measurement accuracy is essential for detecting and diagnosing cardio-cerebrovascular illnesses. Although many different methods have been developed to determine the concentration of Hcy, those different assays showed nonequivalent results. This study aimed to develop an accurate and precise isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC/MS/MS) method for serum homocysteine (Hcy) and assign values for reference materials used in external quality assessment (EQA) programs.

Effects of positive psychological control intervention on sleep and psychology of officers and soldiers working at sea.

Background: The working environment of submarine crews is also very special. They are in a closed, high-temperature, high-noise, high-vibration and narrow working and living space for a long time, and they suffer from physical discomfort caused by seasickness, which will affect the mental health of officers and soldiers. American psychologists have achieved positive results in psychological resilience training for officers and soldiers from the perspective of positive psychology.

Mesoscale Reorganization of the Depolymerized Aluminosilicate into Single-Crystalline Hierarchical Zeolite.

Controllable synthesis of hierarchical zeolites from natural aluminosilicate minerals is considered an efficient and eco-friendly approach for the production of high-performance zeolites, but its synthesis mechanism is still obscure. Herein, we take the synthesis of a single-crystalline hierarchical NaA zeolite using submolten salt depolymerized kaolin (SMS-K) as the sole source of silicon and aluminum via a mesoscale reorganization strategy as an example to elucidate the reorganization process. Comprehensive morphological and structural analyses reveal that sodium-rich voids in SMS-K facilitate concurrent assembly both within the interior and at the interface of the amorphous gel, leading to the formation of numerous nanoparticles with short-range order which assemble into single-crystal nanocube NaA zeolites with intracrystalline mesopores.