Primary localized bladder amyloidosis with negative postoperative Congo red staining: A case report.

Localized bladder amyloidosis is a rare disorder mimicking bladder tumor, with merely over 200 reported cases. Here, we report a case of a 67-year-old female presented with painless gross hematuria. A positive Congo red staining of the cystoscopy biopsy raised suspicion of bladder amyloidosis, and transurethral resection of the mass was performed.

Preliminary application of EPID three-dimensional dose reconstruction in in vivo dose verification of breast cancer intensity-modulated radiation therapy.

A preliminary study was conducted using electronic portal imaging device (EPID) based dose verification in pre-treatment and in vivo dose reconstruction modes for breast cancer intensity-modulated radiation therapy (IMRT) technique with known repositioning set-up errors. For 43 IMRT plans, the set-up errors were determined from 43 sets of EPID images and 258 sets of cone beam computed tomography images. In-house developed Edose software was used to reconstruct the dose distribution using the pre-treatment and on-treatment (in vivo) EPID acquired fluence maps.

A nomogram predicting the risk of venous thromboembolism in patients following urologic surgeries.

There are inconsistent results pertaining to risk factors for venous thromboembolism (VTE) in patients following urologic surgeries. We attempted to establish a visualization model to shed further light upon this topic. Consequently, a total of 436 patients who were tested for VTE following urologic surgeries were retrospectively enrolled.

Unveiling the Mystery of Precision Catalysis: Dual-Atom Catalysts Stealing the Spotlight.

In the era of atomic manufacturing, the precise manipulation of atomic structures to engineer highly active catalytic sites has become a central focus in catalysis research. Dual-atom catalysts (DACs) have garnered significant attention for their superior activity, selectivity, and stability compared to single-atom catalysts (SACs). However, a comprehensive review that integrates geometric and electronic factors influencing DAC performance remains limited.

AI-directed formulation strategy design initiates rational drug development.

Rational drug development would be impossible without selecting the appropriate formulation route. However, pharmaceutical scientists often rely on limited personal experiences to perform trial-and-error tests on diverse formulation strategies. Such an inefficient screening manner not only wastes research investments but also threatens the safety of clinical volunteers and patients.

Reproductive toxicity and molecular mechanisms of benzo[a]pyrene exposure on ovary, testis, and brood pouch of sex-role-reversed seahorses (Hippocampus erectus).

As a flagship taxa for marine ecosystems, seahorses possess a unique reproductive strategy of "male pregnancy". They are severely threatened by marine petroleum-based pollution but the molecular mechanism involved remains unclear. We evaluated the toxic effects and mechanisms of sub-acute exposure to benzo[a]pyrene (BaP), a representative polycyclic aromatic hydrocarbon (PAH), at three environmental related dosages (0.

Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer.

Background: Pancreatic adenocarcinoma (PDAC) exhibits a complex microenvironment with diverse cell populations influencing patient prognosis. Single-cell RNA sequencing (scRNA-seq) was used to identify prognosis-related cell types, and DNA methylation (DNAm)-based models were developed to predict outcomes based on their cellular characteristics.

Methods: We integrated scRNA-seq, bulk data, and clinical information to identify key cell populations associated with prognosis.

Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation.

Rhabdomyolysis (RM)-induced acute kidney injury (AKI) involves the release of large amounts of iron ions from excess myoglobin in the kidneys, which mediates the overproduction of reactive species with the onset of iron overload via the Fenton reaction, thus inducing ferroptosis and leading to renal dysfunction. Unfortunately, there are no effective treatments for AKI other than supportive care. Herein, we developed a multifunctional nanoplatform (MPD) by covalently bonding melanin nanoparticles (MP NPs) to deferoxamine.

In situ blockade of TNF-TNFR2 axis via oncolytic adenovirus improves antitumor efficacy in solid tumors.

Tumor necrosis factor (TNF) has been recognized as an immune activation factor in tumor immunotherapy. Our study demonstrated that TNF blockade markedly enhanced the antitumor efficacy of oncolytic adenovirus (AdV) therapy. To minimize systemic side effects, we engineered a recombinant oncolytic AdV encoding a TNF inhibitor (AdV-TNFi) to confine TNF blockade within the tumor microenvironment (TME).

Electrospun 11β-HSD1 Inhibitor-Loaded Scaffolds for Accelerating Diabetic Ulcer Healing.

Diabetic ulcers (DUs) are a common and severe complication of diabetes, characterized by impaired wound healing due to a complex pathophysiological mechanism. Elevated levels of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) in wounds have been demonstrated to modulate glucocorticoid activity, leading to delayed skin cell proliferation and restricted angiogenesis, ultimately hindering wound healing. In this study, we propose an electrospun poly(ε-caprolactone) (PCL) nanofiber scaffold doped with the 11β-HSD1 inhibitor BVT2733 (BPs) to prevent 11β-HSD1 activity during the diabetic wound healing process.

GhRAP2.4 enhances drought tolerance by positively regulating the strigolactone receptor GhD14 expression in cotton (Gossypium hirsutum L.).

Drought poses significant challenges to crop productivity, necessitating a deeper understanding of plant adaptive mechanisms. Strigolactones (SLs), a class of phytohormones, have been recognized as crucial regulators in plant responses to drought, yet the specific role of SL receptor in drought tolerance in cotton (Gossypium hirsutum L.) remains underexplored.

Seeing the unseen: NIR probes for reactive nitrogen species biosensing and bioimaging.

Reactive nitrogen species (RNS) play a crucial role in both health and disease, making their accurate and sensitive detection essential. However, their transient nature (∼milliseconds), high reactivity, and low abundance (nM-μM) in complex biological environments present significant challenges. Near-infrared (NIR) fluorescent probes have emerged as a promising solution for in vivo RNS imaging due to their enhanced sensitivity, spatiotemporal resolution, and deep tissue penetration.

Retrospective Analysis of Coronavirus SARS-CoV-2 Antibody Levels in COVID-19 Convalescent Plasma From Blood Donors.

To detect and analyze coronavirus SARS-CoV-2 antibody levels in convalescent plasma from donors who have recovered from COVID-19. Plasma samples from 88 donors aged 20-54 years who were diagnosed with COVID-19 and who were eligible to donate from Zhejiang Province, China, were collected as the experimental group, and 56 samples from healthy blood donors were used as controls. Anti-SARS-CoV-2 antibodies, including Ab and IgM, were detected via chemiluminescent immunoassay, and neutralizing antibodies were measured via the microneutralization method.

The Effect of Metformin on Radiation-Induced Lung Fibrosis in Mice.

Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Metformin has been suggested to have a radioprotective effect. This study explored the radioprotective effects of metformin on RILF and its mechanisms.

The effect of omega-3 Polyunsaturated Fatty Acid (PUFA) prescription preparations on the prevention of clinical cardiovascular disease: a meta-analysis of RCTs.

Importance: Evidence from systematic reviews of the cardioprotective effect of omega-3 polyunsaturated fatty acid (PUFA) remains controversial, and interventions including PUFAs dietary supplements or prescription medications cannot accurately reflect the role of PUFA RX in cardiovascular disease (CVD) prevention.

Objective: We conducted a meta-analysis of randomized clinical trials (RCTs) to evaluate the efficacy of PUFA prescription medication in preventing CVD.

Methods: Two reviewers conducted a literature search of Embase, MEDLINE/PubMed, and the Cochrane Library from their inception to September 2023.

The impact of setup errors on dose distribution in cervical cancer radiotherapy and the margin from CTV to PTV.

Purpose: This study calculates the needed margin from clinical target volume (CTV) to planning target volume (PTV) in IMRT for cervical cancer. It also assesses the impact of setup errors on target and organ at risk (OAR) dose distribution.

Methods: We retrospectively analyzed 50 cervical cancer patients who underwent IMRT, with 210 CBCT scans.

Dosimetric effects of prone immobilization devices on skin in intensity-modulated radiation therapy for gynecologic cancer: a retrospective study.

Objective: The dose perturbation effect of immobilization devices is often overlooked in intensity-modulated radiation therapy (IMRT) for gynecologic cancer. This retrospective study assessed the dosimetric effects of a prone immobilization device combined with a belly board (PIDBB) on the skin.

Methods: We recruited 63 women with gynecologic cancer undergoing postoperative IMRT at our institute.

SLAM Algorithm for Mobile Robots Based on Improved LVI-SAM in Complex Environments.

The foundation of robot autonomous movement is to quickly grasp the position and surroundings of the robot, which SLAM technology provides important support for. Due to the complex and dynamic environments, single-sensor SLAM methods often have the problem of degeneracy. In this paper, a multi-sensor fusion SLAM method based on the LVI-SAM framework was proposed.

Phosphorus addition severely exacerbates the inhibitory effect of the increased diurnal temperature range on the invasive plant Solidago canadensis.

This study investigates how variations in diurnal temperature and phosphorus concentration affect the growth of native Artemisia argyi and invasive Solidago canadensis under intraspecific and interspecific competition. We conducted factorial experiments to assess the impacts of warming, including an increased diurnal temperature range (DTRinc), a symmetric increase in diurnal temperature range (DTRsys), a decreased diurnal temperature range (DTRdec) and phosphorus application (5 g and 10 g P m yr) on both intra- and inter-specific competition among plants. The results indicated that (1) the DTRsys for A.

Analysis on acoustic modes and Brillouin gain spectra of backward stimulated Brillouin scattering in W-type acoustic waveguide optical fibers.

The acoustic Helmholtz equations of W-type acoustic waveguide fibers, including WI- and WII-type acoustic velocity of vl < vl < vl and vl < vl < vl, separately are solved by using the method of separation of variables, and their characteristic equations are derived according to the boundary condition and the acoustic Helmholtz equations. The distribution and cut-off of acoustic modes are analyzed by introducing acoustic normalized frequencies. The dependence of the acoustic inner core radius, the acoustic velocities in the acoustic inner and acoustic outer core on acoustic modes, and Brillouin gain spectra (BGS) is investigated.

Annual winter wheat mapping dataset in China from 2001 to 2020.

Winter wheat is a major staple food grown worldwide. China contributes about 19% of the winter wheat production in the world. Therefore, quickly and accurately acquiring winter wheat distribution in China over long time periods is critical to achieve grain safety and understand the spatiotemporal patterns of winter wheat.

A probable ancient nearshore zone in southern Utopia on Mars unveiled from observations at the Zhurong landing area.

The Chinese Mars rover Zhurong successfully landed in southern Utopia Planitia on Mars in May 2021. Previous research suggested a Hesperian ocean may have existed in the northern lowland on Mars. Recent research observed water-related features at the Zhurong landing site from in situ data.