Sensitive characterization of complex chemical reactions in black garlic preparation based on on-line extraction electrospray ionization mass spectrometry.

Changes in chemical composition during food processing and handling are crucial for the alteration of food flavor and function, and accurate characterization of key chemical reaction pathways in complex food matrices is one of the core challenges in food chemistry research. Here, this study attempts to establish a strategy for sensitive characterization of chemical reactions during food processing based on on-line extraction electrospray ionization mass spectrometry (oEESI-MS). The process of making garlic into black garlic, a traditional global flavor food, was chosen as an exemplary research template.

High-risk factors and predictive models for hemorrhagic chronic radiation proctitis.

Introduction: Hemorrhagic chronic radiation proctitis (CRP) is a common and challenging complication after pelvic radiation therapy. Identifying high-risk factors, predicting its occurrence, and optimizing radiotherapy plans are key to preventing hemorrhagic CRP. This study retrospectively examined potential risk factors and developed a nomogram to predict its onset.

Building Bilayer MoS with Versatile Morphologies via Etching-And-Growth Coexisting Method.

The etch-engineering is a feasible avenue to tailor the layer number and morphology of 2D layered materials during the chemical vapor deposition (CVD) growth. However, less reports strengthen the etch-engineering used in the fabrication of high-quality transition metal dichalcogenide (TMD) materials with tunable layers and desirable morphologies to improve their prominent performance in electronic and optoelectronic devices. Here, an etching-and-growth coexistence method is reported to directly synthesize high-quality, high-symmetric MoS bilayers with versatile morphologies via CVD.

Geographical origins of Angelica sinensis using functional compounds and multielement with machine learning-based fusion approaches.

Ensuring food traceability is essential for maintaining safety and authenticity. Angelica sinensis (Oliv.) Diels (AS), a medicinal food prized for its rich nutritional value and tonic effects, is frequently vulnerable to geographic origin fraud.

Shell Dependence of Highly Tunable Circular Dichroism in Chiral Hybrid Plasmonic Nanomaterials for Chiroptical Applications.

Chiral plasmonic nanomaterials with fascinating physical and chemical properties show emerging chirality-dependent applications in photonics, catalysis, and sensing. The capability to precisely manipulate the plasmonic chirality in a broad spectral range plays a crucial role in enabling the applications of chiral nanomaterials in diverse and complex scenarios; however, it remains a challenge yet to be addressed. Here we demonstrate a strategy to significantly enhance the tunability of circular dichroism (CD) spectra of chiral nanomaterials by constructing core-shell hybrid metal-semiconductor structures with tailored shells.

A generalist medical language model for disease diagnosis assistance.

The delivery of accurate diagnoses is crucial in healthcare and represents the gateway to appropriate and timely treatment. Although recent large language models (LLMs) have demonstrated impressive capabilities in few-shot or zero-shot learning, their effectiveness in clinical diagnosis remains unproven. Here we present MedFound, a generalist medical language model with 176 billion parameters, pre-trained on a large-scale corpus derived from diverse medical text and real-world clinical records.

Head pose-assisted localization of facial landmarks for enhanced fast registration in skull base surgery.

In skull base surgery, the method of using a probe to draw or 3D scanners to acquire intraoperative facial point clouds for spatial registration presents several issues. Manual manipulation results in inefficiency and poor consistency. Traditional registration algorithms based on point clouds are highly dependent on the initial pose.

Noninvasive Oral Hyperspectral Imaging-Driven Digital Diagnosis of Heart Failure With Preserved Ejection Fraction: Model Development and Validation Study.

Background: Oral microenvironmental disorders are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF). Hyperspectral imaging (HSI) technology enables the detection of substances that are visually indistinguishable to the human eye, providing a noninvasive approach with extensive applications in medical diagnostics.

Objective: The objective of this study is to develop and validate a digital, noninvasive oral diagnostic model for patients with HFpEF using HSI combined with various machine learning algorithms.

First Experience With a Novel Self-Expandable Valve for Mitral Annular Calcification Guided by Three-Dimensional Printing.

Transcatheter mitral valve replacement (TMVR) may emerge as a surgical alternative for high-risk patients with severe mitral annular calcification (MAC), yet several questions remain to be addressed. We present the case of a 67-year-old high-risk female patient with severe MAC (MAC score = 8) and mitral stenosis (effective orifice area = 121.3 mm).

Identification of a mitophagy-related gene signature for predicting overall survival and response to immunotherapy in rectal cancer.

Background: Rectal cancer is a highly heterogeneous gastrointestinal tumor, and the prognosis for patients with treatment-resistant and metastatic rectal cancer remains poor. Mitophagy, a type of selective autophagy that targets mitochondria, plays a role in promoting or inhibiting tumors; however, the importance of mitophagy-related genes (MRGs) in the prognosis and treatment of rectal cancer is unclear.

Methods: In this study, we used the differentially expressed genes (DEGs) and MRGs from the TCGA-READ dataset to identify differentially expressed mitophagy-related genes (MRDEGs).

Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis.

Pulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes. Pulpotomy is categorized into partial pulpotomy (PP), the removal of a partial segment of the coronal pulp tissue, and full pulpotomy (FP), the removal of whole coronal pulp, which is followed by applying the biomaterials onto the remaining pulp tissue and ultimately restoring the tooth.

Extraction, detection, bioactivity, and product development of luteolin: A review.

Luteolin is a kind of natural flavonoid, widely existing in a variety of plants, has been revealed to have a wide range of biological activities. In recent years, the research results of luteolin are abundant. Here we review the latest research results of luteolin in order to provide new ideas for further research and development of luteolin.

Small-Scale Soft Terrestrial Robot with Electrically Driven Multi-Modal Locomotion Capability.

Small-scale soft robots, despite their potential for adaptability in unknown environments, often encounter performance constraints due to inherent limitations within soft actuators and compact bodies. To address this problem, we proposed a fast-moving soft robot driven by electroactive materials. The robot combines the advantages of dielectric elastomer actuators (DEAs) and shape memory alloy (SMA) spring actuators, enabling its high-performance multi-modal locomotion in a small and lightweight design.

Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system.

Drug resistance to chemotherapy in treating cancers becomes an increasingly serious challenge, which leads to treatment failure and poor patient survival. Drug-resistant cancer cells normally reduce intracellular accumulation of drugs by controlling drug uptake and promoting drug efflux, which severely limits the efficacy of chemotherapy. To overcome this problem, a membrane fused drug delivery system (MF-DDS) was constructed to treat cisplatin (DDP)-resistant lung cancer (A549-DDP) by delivering DDP via membrane fusion using a complementary coiled-coil forming peptides (CPK/CPE).

Interfacial modulation with homogeneous gallium phosphide protective layer enables dendrite-free and superior stable sodium metal anode.

Sodium metal is heralded as a premier anode candidate poised to supplant lithium in next-generation rechargeable batteries due to its abundant availability, cost-effectiveness, and superior energy density. Due to the highly reactive nature of metallic sodium, an unstable solid electrolyte interphase (SEI) forms spontaneously on the Na metal anode. This instability leads to non-uniform sodium deposition during cycling, promoting dendrite growth and the accumulation of "dead" sodium.

Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study.

Heavy alcohol consumption is a known risk factor for type 2 diabetes (T2D), However, the moderating effect of fasting plasma glucose (FPG) levels remains unclear. This study explores the relationship between alcohol intake and T2D risk across FPG strata in a Japanese cohort. Data from 15,453 participants in the NAGALA cohort were analyzed over 5.

Estimating forest aboveground carbon sink based on landsat time series and its response to climate change.

Accurately estimating forest carbon sink and exploring their climate-driven mechanisms are critical to achieving carbon neutrality and sustainable development. Fewer studies have used machine learning-based dynamic models to estimate forest carbon sink. The climate-driven mechanisms in Shangri-La have yet to be explored.

Ubiquitination of OsCSN5 by OsPUB45 activates immunity by modulating the OsCUL3a-OsNPR1 module.

The COP9 signalosome (CSN) is a highly conserved protein complex in eukaryotes, with CSN5 serving as its critical catalytic subunit. However, the role of CSN5 in plant immunity is largely unexplored. Here, we found that suppression of in rice enhances resistance against the fungal pathogen and the bacterial pathogen pv.

Analysis of user behavior and satisfaction under the elderly adaptation mode of an APP based on the fuzzy-IPA model.

With the rapid advancement of technologies like the Internet, big data, and AI, various apps have impacted the daily lives of the elderly, widening the generational "digital divide." Adapting apps for elderly users is crucial to addressing this issue. To address this challenge, we first focused on the middle-aged and elderly population, verifying the reliability and validity of the survey results.

Experiment and numerical analysis of prestressed unequal-walled rectangular concrete-filled steel box beams.

When long-span beams undergo large, the strength of the beam material cannot be fully utilized. To solve this problem, a prestressed unequal-walled rectangular concrete-filled steel box (PURCFSB) beam is proposed in this paper. The prestressing is added to the concrete-filled steel tubular (CFST) beam and the section is designed.

Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation.

Glucose deprivation, a hallmark of the tumor microenvironment, compels tumor cells to seek alternative energy sources for survival and growth. Here, we show that glucose deprivation upregulates the expression of mitochondrial-cytochrome c oxidase II (MT-CO2), a subunit essential for the respiratory chain complex IV, in facilitating glutaminolysis and sustaining tumor cell survival. Mechanistically, glucose deprivation activates Ras signaling to enhance MT-CO2 transcription and inhibits IGF2BP3, an RNA-binding protein, to stabilize MT-CO2 mRNA.

Lignosulfonate as a versatile regulator for the mediated synthesis of Ag@AgCl nanocubes.

The remarkable catalytic activity, optical properties, and electrochemical behavior of nanomaterials based on noble metals (NM) are profoundly influenced by their physical characteristics, including particle size, morphology, and crystal structure. Effective regulation of these parameters necessitates a refined methodology. Lignin, a natural aromatic compound abundant in hydroxyl, carbonyl, carboxyl, and sulfonic acid groups, has emerged as an eco-friendly surfactant, reducing agent, and dispersant, offering the potential to precisely control the particle size and morphology of NM-based nanomaterials.

Expert consensus on apical microsurgery.

Apical microsurgery is accurate and minimally invasive, produces few complications, and has a success rate of more than 90%. However, due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists, many clinical problems remain to be overcome. The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.

In-depth site-specific glycoproteomic analysis reveals ER-resident protein PDI regulating wheat yellow mosaic virus infection.

N-glycosylation is crucial in the process of wheat yellow mosaic virus (WYMV) infection, but changes in site-specific N-glycosylation of proteins during WYMV infection have not been well studied. In this study, we employed an intact glycopeptide approach to analyze mock- and WYMV-infected wheat plants. We found that most glycoproteins have N-glycans containing paucimannose or complex/hybrid chains.

Identification of human cranio-maxillofacial skeletal stem cells for mandibular development.

Compared with long bone that arises from the mesoderm, the major portion of the maxillofacial bones and the front bone of the skull are derived from cranial neural crest cells and undergo intramembranous ossification. Human skeletal stem cells have been identified in embryonic and fetal long bones. Here, we describe a single-cell atlas of the human embryonic mandible and identify a population of cranio-maxillofacial skeletal stem cells (CMSSCs).