To Determine the Role of Human Papillomavirus in Oral Cancer-A Prospective Study.

Introduction: Human papillomavirus (HPV) has been implicated in several studies pertaining to oral squamous cell carcinoma (OSCC) in the last several decades. Infection with human papillomavirus (HPV), particularly HPV16 and 18, is the leading cause of squamous cell carcinoma of the neck (SCCHN).

Methodology: We selected an adequate number of subjects with the same parameters for both the case and the controls based on detailed case histories, specifically taking into account the adverse habits (tobacco in any form and alcohol) that each subject had recorded.

Replication kinetics, morphogenesis and interaction of shrimp parvovirus Penaeus stylirostris penstyldensovirus (PstDV1) in PmLyO-Sf9 cells.

Penaeus stylirostris penstyldensovirus (PstDV1) is one of the significant shrimp parvovirus which causes runt deformity syndrome in shrimps. In the current study, we attempted to elucidate the replication cycle of the virus in PmLyO-Sf9 cells. PstDV1 needs 4-5 h to complete replication in the cell line and release.

In vitro propagation of infectious hypodermal hematopoietic necrosis virus (Penaeus stylirostris penstyldensovirus) in PmLyO-Sf9 cells.

Infectious hypodermal hematopoietic necrosis virus (IHHNV/PstDVI) was isolated and propagated in the hybrid shrimp-insect cell line PmLyO-Sf9. A few hours after inoculation with an infected tissue extract or virus suspension, cytopathic changes could be observed in the cell line, including clustering, enlargement, syncytium formation, granulation, vacuole formation, tapering, irregularities in the plasma membrane with extended tails, detachment, cell death, and accumulation of cellular debris. Expression of viral genes, the presence of virions, and cytological changes observed using transmission electron microscopy suggested replication of the virus in these cells.

Dentistry students' opinion toward Biochemistry course and its relevance in clinical practice in Chennai, India.

Biochemistry is a subject that is essential to understand the molecular basis of a disease, its diagnosis, and prognosis. However, study of biochemistry in dentistry at the undergraduate level is considered to be much teacher-oriented and the students show a lackluster attitude toward the subject. This questionnaire study is carried out to understand the perception of dental students in studying biochemistry and its relevance in dental practice.

How does clinical profile and outcome differ in patients with Chronic Kidney Disease undergoing percutaneous coronary revascularization according to the severity of CKD? - CHANNEL Study.

Background: Chronic kidney disease (CKD) is an independent risk factor for the development of coronary artery disease. We evaluated outcomes amongst patients of CKD undergoing percutaneous coronary intervention (PCI) as assessed on severity of CKD based on estimated glomerular filtration rate (eGFR) at the time of PCI.

Method And Materials: We analyzed 100 consecutive CKD patients who underwent PCI and were followed up for 1 year; an observational, prospective, open-label study.

Prediction of the individual multileaf collimator positional deviations during dynamic IMRT delivery priori with artificial neural network.

Purposes: Multileaf collimator (MLC) positional accuracy during dynamic intensity modulation radiotherapy (IMRT) delivery is crucial for safe and accurate patient treatment. The deviations of individual leaf positions from its intended positions can lead to errors in the dose delivered to the patient and hence may adversely affect the treatment outcome. In this study, we propose a state-of-the-art machine learning (ML) method based on an artificial neural network (ANN) for accurately predicting the MLC leaf positional deviations during the dynamic IMRT treatment delivery priori using log file data.

Lour. mitigates oxidative stress and inflammation in acute pyelonephritic rats.

The current study evaluates the efficacy of methanolic extract of Lour. (MERA) against inflammatory changes associated with acute pyelonephritis. The antioxidant enzymes such as SOD, CAT, GPx, GR and oxidative stress markers like GSH content, malondialdehyde (MDA) level, nitrate level, reactive oxygen species (ROS) level and renal toxicity markers were evaluated in this study.

Protective Role of (Gaertn.) Roxb Fruits Against CCl Induced Oxidative Stress and Liver Injury in Rodent Model.

Abstract: The medicinal plant, (Gaertn.) Roxb. is widely used in the traditional Indian system of medicine like Ayurveda for centuries in the treatment of various ailments owing to it's rejuvenating as well as health promoting effects.

Acute oral toxicity and anti-inflammatory evaluation of methanolic extract of Rotula aquatica roots in Wistar rats.

Background: The plant Rotula aquatica Lour. was traditionally well known due to its large number of pharmacological action and medicinal uses. The plant is a necessary component of many Ayurvedic drug preparations since historical times.

Studies on biofilm formation and virulence factors associated with uropathogenic Escherichia coli isolated from patient with acute pyelonephritis.

The current study aims to the detection of pathogenic potential and virulence factor identification of uropathogenic Escherichia coli BRL-17 isolated from patients urine. The organism was isolated from the patient with chronic pyelonephritis. The identification of organism was done by analyzing gram staining, biochemical, 16S rDNA analysis, Raman microscopy and SEM analysis.

Terminalia bellirica (Gaertn.) Roxb fruit exerts anti-inflammatory effect via regulating arachidonic acid pathway and pro-inflammatory cytokines in lipopolysaccharide-induced RAW 264.7 macrophages.

Terminalia bellirica (Gaertn.) Roxb. (Family: Combretaceae), known as Bhibhitaki in Sanskrit and locally known as Behera in India, has been used for centuries in Ayurveda, a universal system of medicine in India.

The influence of tissue antioxidant enzymes and inflammatory cascade in pathology of cystitis: An experimental rat model.

We evaluate the role of antioxidant enzyme status and inflammatory cascade in disease progression of cystitis in a rat model. The animals were injected with clinically isolated Uropathogenic Escherichia coli (UPEC) and study the effect of various antioxidant enzymes and inflammatory markers in disease pathology on the 0 day, 12 h and 7 day of infection. The antioxidant status of bladder tissue was decreased during the 7 day of infection.

Ethyl acetate fraction of Terminalia bellirica (Gaertn.) Roxb. fruits inhibits proinflammatory mediators via down regulating nuclear factor-κB in LPS stimulated Raw 264.7 cells.

Inflammation has been considered as a major risk factor for various kinds of human diseases. Macrophages play substantial roles in host defense against infection. It can be activated by lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria.

A one-dimensional search method with stable 1-norm solution for linear prediction.

In this paper a simple iterative algorithm that is guaranteed to produce a stable all-pole filter when minimizing the 1-norm of the linear prediction error signal is proposed. The approach works for both the autocorrelation and covariance frameworks, involves only a one-dimensional search at each step, and obviates the need for linear programming based methods. Based on simulation studies, it was observed that the performance of the algorithm is nearly optimal, i.

Role of antioxidant defence, renal toxicity markers and inflammatory cascade in disease progression of acute pyelonephritis in experimental rat model.

Urinary tract infections are the most common bacterial infections affecting millions of people each year worldwide. The animal model provides an excellent and suitable system for studying cystitis and pyelonephritis caused by Escherichia coli and other uropathogens. Using this established model, we evaluate the role of antioxidant defence system, renal injury markers, and blood parameters in the diseases progression during Escherichia coli infection on 0 day, 12h and 7 day.

Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products.

After screening marine actinomycetes isolated from sediment samples collected from the Arctic fjord Kongsfjorden for potential anticancer activity, an isolate identified as Streptomyces artemisiae MCCB 248 exhibited promising results against the NCI-H460 human lung cancer cell line. H460 cells treated with the ethyl acetate extract of strain MCCB 248 and stained with Hoechst 33342 showed clear signs of apoptosis, including shrinkage of the cell nucleus, DNA fragmentation and chromatin condensation. Further to this treated cells showed indications of early apoptotic cell death, including a significant proportion of Annexin V positive staining and evidence of DNA damage as observed in the TUNEL assay.

In vivo toxicity evaluation of aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb. fruit.

Terminalia bellirica (Gaertn.) Roxb. (Family: Combretaceae), known as Bhibhitaki in Sanskrit and locally known as Behera in India is one of the oldest medicinal plants which has widely been used in the traditional system of medicine, especially in Ayurveda for centuries.

Delayed intramedullary abscess in operated case of spinal lipoma.

Intramedullary abscess is a rare condition with high rate of mortality and morbidity. We are presenting a case of delayed intramedullary abscess in an operated case of spinal lipoma, after 2 years of primary surgery. To best of our knowledge this only second case of intramedullary abscess in a case of spinal lipoma without dermal sinus.

Analysis of the curve of Spee and the curve of Wilson in adult Indian population: A three-dimensional measurement study.

Statement Of Problem: When reconstructing the occlusal curvatures dentists often use a 4-inch radii arc as a rough standard based on Monson spherical theory. The use of an identical radius for the curve of Spee for all patients may not be appropriate because each patient is individually different. The validity of application of this theory in the Indian population and the present study has been undertaken.

Association of matrix metalloproteinase 1 gene promoter mutation and residual ridge resorption in edentulous patients of South Indian origin.

Background: Matrix metalloproteinase (MMP) are involved in bone transformation at the extraction site postdental extraction. We examined the genetic association between single nucleotide polymorphisms of MMP-1 and continuous atrophy of edentulous mandible.

Methods: Buccal cells from 33 edentulous patients were collected using sterile wooden spatula and were suspended in 15 ml falcon tubes containing 1.

Subjective Visual Vertical in Various Vestibular Disorders by Using a Simple Bucket Test.

Subjective Visual Vertical (S.V.V.