Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma.

Background: Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. Despite numerous transcriptomics studies to understand its molecular basis, the impact of population-specific differences on this disease remains unexplored.

Aims: This study aimed to investigate the population-specific differences in gene expression patterns among ESCC samples obtained from six distinct global populations, identify differentially expressed genes (DEGs) and their associated pathways, and identify potential biomarkers for ESCC diagnosis and prognosis.

F-Radiolabeling and Preliminary Evaluation of a HSP ligand.

Purpose: With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP ligand.

Methods: A precursor containing methoxymethyl ethers protecting groups and a tosyl as leaving group was synthesized. The target compound was labeled with nucleophilic F-fluoride and the protecting groups was subsequently removed with hydrochloric acid before purification.

Coagulanolide modulates hepatic glucose metabolism in C57BL/KsJ-db/db mice.

Increased hepatic glucose output is one of the major causes of fasting hyperglycemia in diabetic patients. In this study, we investigated the mechanism of action of coagulanolide on hepatic glucose, regulating enzymes in type 2 diabetic C57BL/KsJ-db/db (db/db) mice. Coagulanolide is an active component of Withania coagulans fruit.

Idiopathic periscapular tumoral calcinosis mimicking and presenting as extraskeletal chondromatous tumor.

Tumoral calcinosis is a rare, benign condition of extra-osseous calcification. The term tumoral calcinosis has been liberally and imprecisely used to describe any massive collection of periarticular calcification.It is important to diagnose and differentiate it from other similar conditions causing extra-osseous calcification.

Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.

One new withanolide, (17S,20S,22R)-14alpha,15alpha,17beta,20beta-tetrahydroxy-1-oxowitha-2,5,24-trienolide) named coagulanolide (4) along with four known withanolides 1-3 and 5 have been isolated from Withania coagulans fruits and their structures were elucidated by spectroscopic techniques. The compounds 1-5 showed significant inhibition on postprandial rise in hyperglycemia post-sucrose load in normoglycemic rats as well as streptozotocin-induced diabetic rats. The compound 5 also showed significant fall on fasting blood glucose profile and improved the glucose tolerance of db/db mice.