Role of advanced imaging in primary hepatic neuroendocrine tumor with borderline raised AFP and negative chromogranin staining: A case report.

Background: Primary hepatic neuroendocrine tumors (PHNETs) are rare, accounting for approximately 0.3 % of all neuroendocrine tumors (NETs) and are often difficult to diagnose due to their nonspecific symptoms and imaging features. Standard diagnostic and treatment protocols are lacking due to their rarity, but imaging and immunohistochemistry (IHC) remain key tools for diagnosis.

COMPARISON OF POSTOPERATIVE ATRIAL FIBRILLATION IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT WITH AND WITHOUT LONG CPB TIME.

Background: Postoperative atrial fibrillation (POAF) is frequently observed after cardiac surgery, and duration of Bypass Time (CPB) is an independent risk factor for postoperative atrial fibrillation (POAF). The main objective of the current study was to compare new onset Postoperative Atrial Fibrillation (POAF) in patients undergoing coronary artery bypass graft with and without long CPB time.

Methods: A prospective comparative study design was used and conducted at the Cardiac Surgery Department in Bahawalpur- Pakistan which is a tertiary care health centre for the period of April 2020 to February 2021, a total of 110 patients were enrolled after getting institutional approval and informed consent from patients.

Passive and Active Exoskeleton Solutions: Sensors, Actuators, Applications, and Recent Trends.

Recent advancements in exoskeleton technology, both passive and active, are driven by the need to enhance human capabilities across various industries as well as the need to provide increased safety for the human worker. This review paper examines the sensors, actuators, mechanisms, design, and applications of passive and active exoskeletons, providing an in-depth analysis of various exoskeleton technologies. The main scope of this paper is to examine the recent developments in the exoskeleton developments and their applications in different fields and identify research opportunities in this field.

Assessing the relationship between mental workload and work fatigue among oil and gas workers in PT X, Jambi Province, Indonesia: PLS-SEM analysis.

Occupational fatigue among oil and gas workers can have perilous consequences related to safety, health, economy, and wellbeing. This makes it necessary to discover major factors related to fatigue and implement appropriate prevention programs and education. Therefore, this study aimed to investigate the relationship between mental workload, sleep quality, and occupational fatigue in oil and gas office workers in Jambi Province, Indonesia.

Amyloid pathology and cognitive impairment in hAβ-KI and APP-KI mouse models of Alzheimer's disease.

The hAβ-KI and APP-KI are two amyloid models that harbor mutations in the endogenous mouse App gene. Both hAβ-KI and APP-KI mice contain a humanized Aβ sequence, and APP-KI mice carry three additional familial AD mutations. We herein report that the Aβ levels and Aβ42/Aβ40 ratio in APP-KI homozygotes are dramatically higher than those in hAβ-KI homozygotes at 14 months of age.

Role of oral hypoglycaemic drugs in preventing complication in non-alcoholic fatty liver disease with type 2 diabetes mellitus.

Objective: To determine the prevalence of non-alcoholic fatty liver disease, and the effect of oral hypoglycaemic drugs and lifestyle modifications in reducing fatty liver changes and liver enzymes in these patients.

Methods: The comparative, observational study was conducted at the Department of Pharmacology, Sohail University, Karachi, from October 2022 to October 2023, and comprised patients of either gender having elevated liver enzymes and ultrasound finding of fatty liver changes along with raised glycated haemoglobin, transaminases, total cholesterol and triglycerides. The participants were prescribed oral hypoglycaemic agents by endocrinologists.

Phytochemical Analysis and Antimicrobial Potential of Parthenium hysterophorous and Lantana camara.

Background: Parthenium hysterophorous and Lantana camara are notable for their significant phytochemical and antimicrobial properties. Advancements in phytochemical research have led to the development of novel formulations and products derived from P. hysterophorus and L.

In vitro characterization of probiotic potential of Lactobacillus plantarum CM49 against selected cattle mastitogens.

Background: Bovine mastitis results in significant economic losses for the dairy industry globally due to milk production losses and decreased herd efficiency. This research aimed to isolate, select, and characterize indigenous lactobacilli with probiotic properties. A total of 40 lactobacilli were isolated from healthy milk samples of cattle and identified at the species level through 16S rDNA sequencing.

Constipation and DIOS: Diagnosis, differential diagnosis, and management.

Cystic Fibrosis (CF) is a complex disorder that requires multidisciplinary expertise for effective management. The GALAXY study estimated the prevalence of constipation to be about 25% among People with Cystic Fibrosis (PwCF), identifying it as one of the common gastrointestinal (GI) symptoms within this patient population. Quality of Life (QoL) assessments uncovered high patient dissatisfaction, highlighting the imperative need for enhanced treatment strategies.

Enhancing sequencing batch reactors for efficient wastewater treatment across diverse applications: A comprehensive review.

This review explores recent progress in sequencing batch reactors (SBRs) and hybrid systems for wastewater treatment, emphasizing their adaptability and effectiveness in managing diverse wastewater compositions. Through extensive literature analysis from 1985 to 2024, the integration of advanced technologies like photocatalysis within hybrid systems is highlighted, showing promise for improved pollutant removal efficiencies. Insights into operational parameters, reactor design, and microbial communities influencing SBR performance are discussed.

Comparison of Various Therapeutic Approaches to Manage Infertility in Polycystic Ovarian Syndrome.

Objective: To compare the efficacies of common therapeutic regimens and their combinations, used in polycystic ovarian syndrome (PCOS) to improve fertility in reproductive-age women.

Study Design: A descriptive study. Place and Duration of the Study: Department of Obstetric Gynaecologist, Medicare Cardiac and General Hospital, Karachi, Pakistan, from November 2022 to July 2023.

Bioprospecting of Metabolites from Actinomycetes and their Applications.

Actinomycetes are present in various terrestrial and aquatic habitats, predominantly in the soil rhizosphere, encompassing marine and freshwater ecosystems. These microorganisms exhibit characteristics that resemble both bacteria and fungi. Numerous actinomycetes exhibit a mycelial existence and undergo significant morphological transformations.

Prospects of Plant Derived Bioactive Compounds as Nanoparticles for Biotechnological Applications.

Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles produced from the medicinal plant extracts are identified as an exceptional applicant in nanomedicine, cosmetics, and agriculture for the treatment of diseases as antimicrobial, antioxidant and anticancer agents, etc. Plant extracts actually have bioactive metabolites that provide therapeutic potential against a variety of diseases.

Outcomes of extracranial stereotactic body radiation therapy for induced oligometastatic non-small cell lung cancer on novel systemic therapy.

Background: Stereotactic body radiation therapy (SBRT) is often delivered in patients with oligometastatic disease (OMD). However, the specific subset of patients with polymetastatic non-small cell lung cancer (NSCLC) on novel systemic therapies who develop induced oligopersistant disease (OpersisD) or oligoprogressive disease (OprogD), as defined by the European Organisation for Research and Treatment of Cancer (EORTC) OMD classification, has not been well described. This study explores the outcomes of patients treated with this strategy.

Thorough examination of the potential biological implications of the cuproptosis-related gene LIPT2 in the prognosis and immunotherapy in pan-cancer.

Objectives: To elucidate the expression levels and prognostic value of the Lipoyltransferase 2 (LIPT2) gene in a pan-cancer view.

Methodology: Our study comprehensively investigated the role of LIPT2 in pan-cancer, combining bioinformatics analyses with experimental validations.

Results: Analysis of LIPT2 mRNA expression across various cancers revealed a significant up-regulation in 18 tumor types and down-regulation in 8 types, indicating its diverse involvement.

Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia.

Coronary artery ectasia (CAE) is defined as abnormal dilation of a coronary artery with a diameter exceeding that of adjacent normal arterial segment by >1.5 times. CAE is a pathological entity of the coronary arteries and characterized as a variant of coronary atherosclerosis.

Medicinal Plants in the Treatment of Respiratory Diseases and their Future Aspects.

The utilization of medicinal plants in the treatment of respiratory diseases has a rich history dating back centuries. This study delves into the diverse range of plant species known for their therapeutic properties, with a specific focus on their applications in respiratory health. Medicinal plants have played a crucial role as a source of ingredients for medications and the synthesis of drugs.

Fabry Disease in Women: Genetic Basis, Available Biomarkers, and Clinical Manifestations.

Fabry Disease (FD) is a rare lysosomal storage disorder caused by mutations in the gene on the X chromosome, leading to a deficiency in α-galactosidase A (AGAL) enzyme activity. This leads to the accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), in vital organs such as the kidneys, heart, and nervous system. While FD was initially considered predominantly affecting males, recent studies have uncovered that heterozygous Fabry women, carrying a single mutated gene, can manifest a wide array of clinical symptoms, challenging the notion of asymptomatic carriers.

Influence of Smart Sensors on Structural Health Monitoring Systems and Future Asset Management Practices.

Recent developments in networked and smart sensors have significantly changed the way Structural Health Monitoring (SHM) and asset management are being carried out. Since the sensor networks continuously provide real-time data from the structure being monitored, they constitute a more realistic image of the actual status of the structure where the maintenance or repair work can be scheduled based on real requirements. This review is aimed at providing a wealth of knowledge from the working principles of sensors commonly used in SHM, to artificial-intelligence-based digital twin systems used in SHM and proposes a new asset management framework.

Validation of reference gene stability for miRNA quantification by reverse transcription quantitative PCR in the peripheral blood of patients with COVID-19 critical illness.

The COVID-19 pandemic has created an urgency to study the host gene response that leads to variable clinical presentations of the disease, particularly the critical illness response. miRNAs have been implicated in the mechanism of host immune dysregulation and thus hold potential as biomarkers and/or therapeutic agents with clinical application. Hence, further analyses of their altered expression in COVID-19 is warranted.

Transfersome, an ultra-deformable lipid-based drug nanocarrier: an updated review with therapeutic applications.

The application of nanotechnology with integration of chemical sciences is increasing continuously in the management of diseases. The drug's physicochemical and pharmacological characteristics are enhanced by application of nanotechnological principles. Several nanotechnology-based formulations are being investigated to improve patient compliance.