NMR-based metabolic profiling and antioxidant activity of ethanol extract.

The metabolite profile of the ethanol extract from was assessed using the 1D NMR approach amalgamated with 2D NMR. an indigenous plant found in Indonesia, possesses considerable promise as a raw material for medicinal products. We examined the antioxidant capacity of the extract using DPPH and ABTS methods.

Optimization of microwave-assisted extraction on polyphenol metabolite from (Mill.) urb. bulbs using response surface methodology.

bulbs, an endemic plant in Indonesia, have enormous potential as raw materials for pharmaceutical products. Therefore, it is necessary to strengthen and develop extraction methods that are easy, rapid, and efficient to enrich targeted secondary metabolites. This study aims to optimize the microwave-assisted extraction (MAE) method conditions for polyphenol metabolite from bulbs.

A 5-year evaluation of chemoprophylactic treatment in elementary school children with subclinical leprosy.

Subclinical leprosy is an infectious disease in which the immune system remains infected with (). The progress of subclinical leprosy to clinical cases within 1 year of infection is 1.5%, with an increase to 6% in the following 4 years.

Congenital diplopodia-A rare case of duplicated lower limb: A case report.

Introduction And Importance: Diplopodia is an extremely rare case in medical history, with an even fewer cases being reported in literature. We intended to enrich the literature about diplopodia with our own case report.

Case Presentation: We present a case about A boy, aged one year and four months old brought by his mother to the hospital with a chief complaint of a duplicated foot in his right lower leg.

Effect of supplementation of Rhodomyrtus tomentosa fruit juice in preventing hypercholesterolemia and atherosclerosis development in rats fed with high fat high cholesterol diet.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Nutraceuticals, mainly based on natural products, have been proven to control the risk factors of CVDs effectively. Rhodomyrtus tomentosa is an underutilized fruit that is rich in phenolic compounds and has antioxidant activities.

Religious schema and tolerance towards alienated groups in Indonesia.

National discourses that are acceptable by the alienated groups determine the level of public tolerance towards those groups. This study thus examined the relationships between religious schema and tolerance of two alienated groups in Indonesia, namely, the atheists and believers in indigenous faiths. Additionally, the study explored the differences in tolerance of these two groups across university cohorts encompassing discrete social climates and curricula.

Leprosy transmission in endemic and non-endemic areas based on the profile of antibody response of PGL-1 and PCR detection of DNA from nasal swab among healthy children of East Java, Indonesia.

Background: East Java has become one of the provinces that have higher prevalence of leprosy, especially in the coastal region. Environment has also influenced for leprosy transmission and early detection could reduce the incidence rate of new leprosy cases. Epidemiological studies of leprosy in children can give an illustration of the important aspects of the environment.

Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division.

Protein phosphatase PstP is conserved throughout the Actinobacteria in a genetic locus related to cell wall synthesis and cell division. In many Actinobacteria it is the sole annotated serine threonine protein phosphatase to counter the activity of multiple serine threonine protein kinases. We used transcriptional knockdown, electron microscopy and comparative phosphoproteomics to investigate the putative dual functions of PstP as a specific regulator of cell division and as a global regulator of protein phosphorylation.

SP.S-11 PHAGOCYTOTIC ACTIVITY ON IN DIFFERENT NUTRIENT CONDITIONS.

Background: () is a pathogenic bacterium that causes leprosy. The presence of in the environment is supported by microorganisms that act as the new host for . 's potential to be a host of in the environment.

Lucio phenomenon of leprosy LL type on pregnancy: A Rare Case.

Introduction: Lucio phenomenon is a rare type of reaction in untreated, diffusely infiltrative form of lepromatous leprosy type, characterised with ulcerative type of skin lesions.

Case: A 29 year old Indonesian female, 7th months primigravida with a four-month history of painful scarlet spots that darken and ulcerate on both of her hands and legs. The patient was experiencing fever.

Expression profile of Rab5, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae.

Objective/background: Phagolysosome process in macrophage of leprosy patients' is important in the early phase of eliminating Mycobacterium leprae invasion. This study was to clarify the involvement of Rab5, Rab7, and trytophan aspartate-containing coat protein (TACO) from host macrophage and leprae lipoarabinomannan (Lep-LAM) and phenolic glycolipid-1 (PGL-1) from M. leprae cell wall as the reflection of phagolysosome process in relation to 16 subunit ribosomal RNA (16S rRNA) M.

Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.

The influenza A virus NS1 protein affects virulence through several mechanisms, including the host's innate immune response and various signaling pathways. Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype continue to evolve through reassortment and mutations. Our recent phylogenetic analysis identified a group of HPAI H5N1 viruses with two characteristic mutations in NS1: the avian virus-type PDZ domain-binding motif ESEV (which affects virulence) was replaced with ESKV, and NS1-138F (which is highly conserved among all influenza A viruses and may affect the activation of the phosphatidylinositol 3-kinase [PI3K]/Akt signaling pathway) was replaced with NS1-138Y.