Unveiling the impacts of metformin on hepatocellular carcinoma: A bioinformatic exploration in cell lines.

The most common type of liver cancer is hepatocellular carcinoma (HCC), accounting for 75-85% of cases. Despite its associated side effects, sorafenib remains the standard treatment for HCC. Given the critical need to improve therapeutic efficacy while minimizing adverse effects, alternative drugs must be thoroughly investigated.

Promising candidate drug target genes for repurposing in cervical cancer: A bioinformatics-based approach.

Cervical cancer is the fourth most common cancer among women globally, and studies have shown that genetic variants play a significant role in its development. A variety of germline and somatic mutations are associated with cervical cancer. However, genomic data derived from these mutations have not been extensively utilized for the development of repurposed drugs for cervical cancer.

Unveiling the role of dopants in boosting CuS supercapacitor performance: insights from first-principles calculations.

Transition metal sulfides have become famous in high energy density supercapacitor materials owing to their rich redox and high conductivity. While their development has achieved a breakthrough in terms of capacitance, there is little knowledge from the theoretical perspective on how dopants play a role in enhancing their capacitances. In this work, pseudocapacitance and quantum capacitance were evaluated through first-principles calculation to describe their role in transition metal sulfide, which here is represented by copper sulfide (CuS).

High Volumetric Energy Density Supercapacitor of Additive-Free Quantum Dot Hierarchical Nanopore Structure.

The high surface-area-to-volume ratio of colloidal quantum dots (QDs) positions them as promising materials for high-performance supercapacitor electrodes. However, the challenge lies in achieving a highly accessible surface area, while maintaining good electrical conductivity. An efficient supercapacitor demands a dense yet highly porous structure that facilitates efficient ion-surface interactions and supports fast charge mobility.

Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy.

The landscape of cancer therapy has witnessed a paradigm shift with the emergence of innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility, these dendrimers offer a promising avenue for the targeted delivery of therapeutic cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium- based Peptide Dendrimers, unraveling their structural intricacies, mechanisms of action, and advancements that have propelled them from laboratory curiosities to potential clinical champions.

Telepharmacy Implementation to Support Pharmaceutical Care Services during the COVID-19 Pandemic: A Scoping Review.

Background: Telepharmacy was effectively applied for remote pharmaceutical care during the COVID-19 pandemic.

Objectives: To determine the implementation of telepharmacy services to support pharmacists in providing pharmaceutical care during the pandemic.

Data Sources: Seven electronic databases were searched from inception to June 2021: PubMed, Ovid MEDLINE, Excerpta Medica database (Embase), Web of Science, Proquest, Scopus, and the Cochrane Database of Systematic Reviews.

Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment.

Hemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for treatment consist of oral medications, topical applications, or surgery, yet a scarcity of highly effective drugs still exists. Genetic markers provide promising avenues for investigating the treatment of hemorrhoids, as they may reveal intricate biological mechanisms and targeted drug therapies, ultimately enhancing more precise treatment tailored to the patient.

Identifying pathogenic variants related to systemic lupus erythematosus by integrating genomic databases and a bioinformatic approach.

Systemic lupus erythematosus (SLE) is an inflammatory-autoimmune disease with a complex multi-organ pathogenesis, and it is known to be associated with significant morbidity and mortality. Various genetic, immunological, endocrine, and environmental factors contribute to SLE. Genomic variants have been identified as potential contributors to SLE susceptibility across multiple continents.

Identification of druggable genes for multiple myeloma based on genomic information.

Multiple myeloma (MM) is a hematological malignancy. It is widely believed that genetic factors play a significant role in the development of MM, as investigated in numerous studies. However, the application of genomic information for clinical purposes, including diagnostic and prognostic biomarkers, remains largely confined to research.

Leveraging Genomic and Bioinformatic Analysis to Enhance Drug Repositioning for Dermatomyositis.

Dermatomyositis (DM) is an autoimmune disease that is classified as a type of idiopathic inflammatory myopathy, which affects human skin and muscles. The most common clinical symptoms of DM are muscle weakness, rash, and scaly skin. There is currently no cure for DM.

Transcriptomics-driven drug repositioning for the treatment of diabetic foot ulcer.

Diabetic foot ulcers (DFUs) are a common complication of diabetes and can lead to severe disability and even amputation. Despite advances in treatment, there is currently no cure for DFUs and available drugs for treatment are limited. This study aimed to identify new candidate drugs and repurpose existing drugs to treat DFUs based on transcriptomics analysis.

Novel strategy for high-performance supercapacitors through the polyvinylpyrrolidone (PVP)-assisted growth of FeS.

Iron disulfide or pyrite (FeS) has emerged as a promising transition metal sulfide-based supercapacitor owing to its abundance and superb electrochemical properties. However, FeS still faces major hurdles in realizing its full potential, such as a low energy density and poor conductivity. In this study, we report a high-performance FeS supercapacitor synthesized by a direct one-step process with the help of polyvinylpyrrolidone (PVP).

Assessing brand switching level and behaviour of growing-up milk products in Java: A structural equation modeling and multigroup analysis.

The biggest consumers of dairy products for children aged 1-3 years, which are referred to as growing-up milk (GUM), come from the middle and lower socioeconomic classes. More than 90% of Indonesians belong to this segment. In 2020, the proportion of the population living in rural and urban areas will be almost equal, namely 43.

Interface Analysis of LiCl as a Protective Layer of LiAlTi(PO) for Electrochemically Stabilized All-Solid-State Li-Metal Batteries.

Regardless of the superiorities of LiAlTi(PO) (LATP), such as stability against oxygen and moisture, high ionic conductivity, and low activation energy, its practical application in all-solid-state lithium metal batteries is still impeded by the formation of ionic-resistance interphase layers. Upon contact with Li metal, electron migration from Li to LATP causes the reduction of Ti in LATP. As a result, an ionic-resistance layer will be formed at the interface between the two materials.

Potentially Virulent Multi-Drug Resistant Isolated from Inanimate Surface in a Medical University: as an Alternative for Bacterial Virulence Determination.

Multi-drug resistant (MDR) bacteria are becoming a worldwide problem due to limited options for treatment. Moreover, patients infected by MDR with highly virulent accessories are worsening the symptoms, even to the point of causing death. In this study, we isolated bacteria from 14 inanimate surfaces that could potentially be reservoirs for the spread of bacterial infections in the medical university.

Geography and elevation as drivers of cloacal microbiome assemblages of a passerine bird distributed across Sulawesi, Indonesia.

Background: Empirical field studies allow us to view how ecological and environmental processes shape the biodiversity of our planet, but collecting samples in situ creates inherent challenges. The majority of empirical vertebrate gut microbiome research compares multiple host species against abiotic and biotic factors, increasing the potential for confounding environmental variables. To minimize these confounding factors, we focus on a single species of passerine bird found throughout the geologically complex island of Sulawesi, Indonesia.

Multifaceted Social and Environmental Disruptions Impact on Smallholder Plantations' Resilience in Indonesia.

As one of the most productive plantation producers in the world, Indonesia also faces rapid change in both social and environmental systems. These conditions are predicted to become more disruptive to the agricultural sector in the future. Therefore, understanding the impact of social and environmental disruption on smallholder plantations' resilience is vital to formulate a strategy for the sustainability of farmers' livelihoods in this country.

Identification of Potential Treatments for Acute Lymphoblastic Leukemia through Integrated Genomic Network Analysis.

The advancement of high-throughput sequencing and genomic analysis revealed that acute lymphoblastic leukemia (ALL) is a genetically heterogeneous disease. The abundance of such genetic data in ALL can also be utilized to identify potential targets for drug discovery and even drug repurposing. We aimed to determine potential genes for drug development and further guide the identification of candidate drugs repurposed for treating ALL through integrated genomic network analysis.

Integrated genomic analysis to identify druggable targets for pancreatic cancer.

According to the National Comprehensive Cancer Network and the American Society of Clinical Oncology, the standard treatment for pancreatic cancer (PC) is gemcitabine and fluorouracil. Other chemotherapeutic agents have been widely combined. However, drug resistance remains a huge challenge, leading to the ineffectiveness of cancer therapy.

Revealing the synergetic interaction between amino and carbonyl functional groups and their effect on the electronic and optical properties of carbon dots.

Nitrogen and oxygen-based functionalized carbon dot (CDs) surfaces have attracted significant attention due to their ability to tailor the optical and electronic properties of CDs. However, the complex synthesis process and structure of the functionalized CDs hinder an in-depth understanding of their mechanism, limiting their potential applications. Herein, we report CDs functionalized with amino and carbonyl functional groups and reveal the mechanism of interaction between the amino and carbonyl groups and the CDs' optical and electronic properties.