Physico-Chemical Properties of Magnetic Dicationic Ionic Liquids with Tetrahaloferrate Anions.

A series of imidazolium-based symmetrical and asymmetrical dicationic ionic liquids (DcILs) with alkyl spacers of different length and with [FeCl Br] as counter ion have been synthesized. The synthesized DcILs are characterized by using FTIR and Raman spectroscopy as well as mass spectrometry, along with single-crystal XRD analysis. Physicochemical properties such as solubility, thermal stability and magnetic susceptibility are also measured.

Structural characterization and antileishmanial activity of newly synthesized organo-bismuth(V) carboxylates: experimental and molecular docking studies.

In a quest to discover new formulations for the treatment of various parasitic diseases, a series of heteroleptic triorganobismuth(V) biscarboxylates of type [BiR(OCR')], where R=CH for 1-4 and p-CHCH for 5-8, were synthesized, characterized and evaluated for their biological potential against L. tropica. All the synthesized complexes were fully characterized by elemental analysis, FT-IR, multinuclear (H and C) NMR spectroscopy and X-ray crystallography.

Synthesis, characterization and urease inhibition, in vitro anticancer and antileishmanial studies of Ni(II) complexes with N,N,N'-trisubstituted thioureas.

A series of N,N,N'-trisubstituted thioureas (1-12) and their Ni(II) complexes (1a-12a) were synthesized and characterized by multinuclear ((1)H and (13)C) NMR, FT-IR spectroscopy and LC-MS techniques in combination with elemental analysis. The crystal structures of both ligands and Ni(II) chelates of type Ni(L-O, S)2 were determined by single crystal X-ray diffraction analysis. All the complexes were adopted to have square planar geometry, where the N,N,N'-trisubstituted thioureas showed bidentate mode of coordination at nickel centre through oxygen and sulfur atoms.

Novel approaches to screening guanidine derivatives.

Introduction: Compounds containing guanidine moiety, originating both from natural and synthetic sources, have found potential applications in both synthetic and medicinal chemistry. Indeed, guanidine functionality can be found in many natural and pharmaceutical products as well as in cosmetic ingredients produced by synthetic methods.

Areas Covered: This review covers the latest developments in the research undertaken for the therapeutic application of newly synthesized guanidine derivatives including: small peptides and peptidomimetics.

Solution-phase microwave assisted parallel synthesis of N,N'-disubstituted thioureas derived from benzoic acid: biological evaluation and molecular docking studies.

An efficient and facile microwave-assisted solution phase parallel synthesis for a 26-member library of N,N'-disubstituted thiourea analogs were accomplished successfully. The reaction time for synthesis of analogs was drastically reduced from a reported 8-12 h to only 10 min. Compounds were more than 95% pure, as characterized by modern analytical techniques, i.

1-Benzoyl-3-(4-n-butyl-phen-yl)thio-urea.

The dihedral angle between the benzoyl and phenyl groups in the title compound, C(18)H(20)N(2)OS, is 30.57 (4)°. The crystal packing is characterized by N-H⋯O hydrogen bonds.

1-Benzoyl-3-(2,4,5-trichloro-phen-yl)thio-urea.

The benzene and phenyl rings in the title compound, C(14)H(9)Cl(3)N(2)OS, form a dihedral angle of 40.98 (6)°. The mol-ecule exists in the thione form with typical thio-urea C-S [1.

2-[2-(1,3-Dioxoisoindolin-2-yl)acetamido]-acetic acid.

The title mol-ecule, C(12)H(10)N(2)O(5), is non-planar with dihedral angles of 89.08 (7) and 83.21 (7)° between the phthalimide and acetamide mean planes, and the acetamide and acetic acid mean planes, respectively.

catena-Poly[[triphenyl-tin(IV)]-μ-2-(cyclo-hexyl-amino-carbon-yl)benzoato-κO:O].

In the title polymeric complex, [Sn(C(6)H(5))(3)(C(14)H(16)NO(3))](n), adjacent triphenyl-tin cations are bridged by the N-cyclo-hexyl-phthalamate anion through the carboxyl-ate and carbonyl O atoms, forming a helical chain running along the b axis. The amide N atom is a hydrogen-bond donor to the uncoordinated carboxyl-ate O atom. The geometry at the five-coordinate Sn atom is trans-C(3)SnO(2) trigonal-bipyramidal.

catena-Poly[[triphenyl-tin(IV)]-μ(2)-[3-(cyclo-hexyl-carbamo-yl)propanoato-κO:O]].

The Sn atom in the polymeric title compound, [Sn(C(6)H(5))(3)(C(10)H(16)NO(3))](n), is five-coordinated within a trans-C(3)O(2) donor set that defines an approximate trigonal-bipyramidal geometry. The carboxyl-ate ligand is monodentate and the amide O atom bridges a symmetry-related Sn atom, generating a chain along [010] with a linear topology. An intra-molecular carboxyl-ate-carbonyl N-H⋯O hydrogen bond is responsible for the curved conformation within the carboxyl-ate ligand.

Germatranyl substituted organotin (IV) carboxylates: synthesis spectroscopic characterization and biological activities.

Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)3GeCH(R1)CH2COO](4-n)SnR(2)n, where n= 2, R(2) = C2H5 (1-5); R(1) = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R(2) = CH2C6H5 (6-8), R(1) = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (1H, 13C, 119Sn) NMR, 119mSn Mössbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.

Synthesis, structural characterization and in vitro cytotoxicity and anti-bacterial activity of some copper(I) complexes with N,N'-disubstituted thioureas.

A series of copper(I) complexes of N,N'-disubstituted thioureas, [C(6)H(5)CONHCSNHR]Cu(I)Cl where R=C(6)H(5) (1a), 2-ClC(6)H(4) (2a), 3-ClC(6)H(4) (3a), 4-ClC(6)H(4) (4a), 2,3-Cl(2)C(6)H(3) (5a), 2,4-Cl(2)C(6)H(3) (6a), 2,5-Cl(2)C(6)H(3) (7a), 2,6-Cl(2)C(6)H(3) (8a), 3,4-Cl(2)C(6)H(3) (9a) and 3,5-Cl(2)C(6)H(3) (10a) have been synthesized. These complexes (1a-10a) have been characterized by elemental analyses, IR, (1)H and (13)C NMR spectroscopy, cyclic voltammetry and single crystal XRD for 1a and 8a, and for ligand 7. The X-ray crystal structures reveal that the complexes 1a and 8a are mononuclear in the solid state in which the copper atoms adopt a distorted tetrahedral geometry.

[Bis-(diphenyl-phosphino)methane-κP,P']dichloridopalladium(II).

The title complex, [PdCl(2)(C(25)H(22)P(2))], is a slightly distorted square-planar bis-(diphenyl-phosphino)methane cis-complex of PdCl(2). The structure of a polymorph of the title compound has been described earlier, but the arrangement of the mol-ecules observed in the current structure is distinctively different from that previously reported [Steffen & Palenik (1976 ▶). Inorg.

In vitro anti-leishmanial activities of germatranyl and Silicon incorporated diorganotin derivatives: synthesis and spectroscopic properties.

A series of germanium and silicon incorporated diorganotin derivatives of general formula [N(OCH2CH2)3GeCH(R(1)CH2CO2]2 SnR2(2) where R1 = H3C, C6H5, p-CH3C6H4, p-FC6H4; R2 = H2CSi(CH3)2C6H5, H2CC6H5, p-CH3C7H7 were synthesized by the reaction of appropriate diorganotin dichlorides and germatranyl (substituted) propionic acid in 1:2 mole ratio, respectively. The evidence regarding their structure is mainly based on spectroscopic data obtained by multinuclear (1H, 13C, 29Si, 119Sn) NMR and 119mSn Mössbauer, IR and mass spectral studies in combination with melting points and elemental analyses. The compounds have been screened for in vitro anti-leishmanial activity against promastigotes of Leishmania major and the results offer potent activities which are better than the standard drug, pentamidine, for one compound.

Dicyclo-hexyl-ammonium thio-cyanate.

In the crystal structure of the title compound, C(12)H(24)N(+)·NCS(-), the anions and cations are linked through N-H⋯N and N-H⋯S hydrogen bonds, resulting in a chain along the a axis.

Lower homologues (methyl, ethyl) of diorganotin derivatives of germyl (substituted) propanoic acids: spectroscopic elucidations and biological studies.

Some novel lower homologues of diorganotin derivatives of germyl substituted propanoic acids with general formula [Ar(3)GeCH(R(1))CH(R(2))COO](2)SnR(2)(3), where Ar = p-CH(3)C(6)H(4), C(6)H(5), R(1) = p-CH(3)C(6)H(4), p-CH(3)OC(6)H(4), o-CH(3)OC(6)H(4), C(6)H(5), R(2) = H, CH(3), R(3) = CH(3), C(2)H(5) have been prepared by the condensation reaction of dialkyltin oxide and triarylgermyl(substituted) propanoic acid in 1 : 2 M ratio, respectively, and were characterized by IR, multinuclear ((1)H, (13)C, (119)Sn) NMR, (119 m)Sn Mössbauer spectroscopy. The synthesized compounds were also screened for their toxicity and possible antibacterial, antifungal activities and found some encouraging results.

Derivatives of substituted 3-trichlorogermylpropionic acid.

The central Ge atoms in the structures of 3-(2-fluorophenyl)-3-(triphenylgermyl)propionic acid, [Ge(C(6)H(5))(3)(C(9)H(8)FO(2))], 3-(2-tolyl)-3-(tri-4-tolylgermyl)propionic acid, [Ge(C(7)H(7))(3)(C(10)H(11)O(2))], and 3-(4-tolyl)-3-(tribenzylgermyl)propionic acid, [Ge(C(7)H(7))(3)(C(10)H(11)O(2))], are four-coordinate with slightly distorted tetrahedral geometry. The Ge-Csp(3) distances [1.970 (3)-1.