Pelvic venous disorders (PeVD) are not well represented in obstetrics and gynaecology journals.

Background: Pelvic venous disorders (PeVD), previously "Pelvic congestion syndrome (PCS)" is usually defined as a female health problem. However, it is our impression that gynaecologists rarely recognise this condition, and most of the research interest appears to be by vascular and venous surgeons, and radiologists. The aim of this study was to investigate if there was evidence to support this view.

Effect of human chorionic gonadotropin on oocyte maturation and developmental competence in buffalo.

We hypothesized that human chorionic gonadotropic (hCG) could replace LH in the maturation media for buffalo oocytes, and hCG administration before ovum pick-up (OPU) enhances in-vitro development of buffalo oocytes. Objectives were 1) to investigate the effect of hCG supplementation on nuclear maturation, oocyte development, and granulosa cell mRNA abundance of genes related to growth and antioxidant pathways and 2) to determine the effect of hCG administration before OPU on in-vitro oocyte development. In Experiment 1, buffalo oocytes retrieved from slaughterhouse ovaries were maturated in the media supplemented with 0.

Correction: On distance-based topological indices and co-indices of fractal-type molecular graphs and their respective graph entropies.

[This corrects the article DOI: 10.1371/journal.pone.

TNF alpha Inhibitors in Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis.

Background: Recent studies have focused on treating cardiac sarcoidosis (CS) with corticosteroids primarily mitigating symptoms and reducing the risk of mortality and other cardiovascular complications. A promising new treatment approach involves tumor necrosis factor (TNF) alpha inhibitors.

Methodology: A systematic search was conducted on PubMed, the Cochrane Library, and Elsevier's Science Direct databases to identify studies comparing TNF alpha inhibitors with other drugs in CS patients who had heart failure.

Correction: Molecular surveillance based on anaplasmosis in domestic small ruminants: First report on zoonotic Anaplasma capra and phylogenetic insights from Faisalabad, Pakistan.

[This corrects the article DOI: 10.1371/journal.pone.

In Vitro Hydroxyapatite Nucleation in Cationically Cured Epoxy Composites with Pulverized Date Seed.

Recently, driven by a growing focus on environmental sustainability and cost-effectiveness, researchers have shown a keen interest in creating useful materials from bio-wastes, particularly for their potential applications in the biomedical field. Current research has been conducted on the impact of date seed powder (DSP) on hydroxyapatite (HA) formation, specifically in relation to the promotion of bone health and regeneration. HA is an essential component of bone tissue and plays a crucial role in maintaining bone strength and structure.

Catalytic-assisted remediation and phytotoxicity evaluations of organic pollutants in the presence of metal-doped BiO-based NPs catalyst.

The chemical co-precipitation method was used to synthesize a variety of pure BiO and substituted BiCoCdO NPs (x = 0.0-0.8) and doping influences were evaluated based on the optical, photocatalytic, morphological, and structural characteristics.

Next-generation vaccines for influenza B virus: advancements and challenges.

To battle seasonal outbreaks of influenza B virus infection, which continue to pose a major threat to world health, new and improved vaccines are urgently needed. In this article, we discuss the current state of next-generation influenza B vaccine development, including both advancements and challenges. This review covers the shortcomings of existing influenza vaccines and stresses the need for more-effective and broadly protective vaccines and more-easily scalable manufacturing processes.

Automated estimation of individualized organ-specific dose and noise from clinical CT scans.

Radiation dose and diagnostic image quality are opposing constraints in x-ray CT. Conventional methods do not fully account for organ-level radiation dose and noise when considering radiation risk and clinical task. In this work, we develop a pipeline to generate individualized organ-specific dose and noise at desired dose levels from clinical CT scans.

Investigation of and gene polymorphisms and their association with susceptibility to colorectal cancer.

Background: This study investigates the association of single nucleotide polymorphism in glutathione S transferase P1 (rs1695 and rs1138272) and phosphatase and TENsin homolog (rs701848 and rs2735343) with the risk of colorectal cancer (CRC).

Patients And Methods: In this case-control study, 250 healthy controls and 200 CRC patients were enrolled. All subjects were divided into 3 groups: healthy control, patients, and overall (control + patients).

Trends in Iatrogenic Error-Related Mortality in the US From 1999 to 2020: Age-Period-CohortAnalysis.

Introduction: There is a noticeable lack of information on iatrogenic error (IE)-related deaths in the United States. To address this, we conducted a retrospective analysis examining temporal, regional, urbanization, and age-related trends in IE-related mortality from 1999 to 2020.

Methods: Utilizing the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research database, we identified crude and age-adjusted mortality rates (AAMR) per 100,000 persons.

Optimization of nonlinear properties of COLi-doped alkalides group I/III doping for unprecedented charge transfer and advancements in optoelectronics.

The design and synthesis of nonlinear optical (NLO) materials are rapidly growing fields in optoelectronics. Considering the high demand for newly designed materials with superior optoelectronic characteristics, we investigated the doping process of Group-IIIA elements (namely, B, Al and Ga) onto alkali metal (AM = Li, Na and K)-supported COLi (AM@COLi) complexes to enhance their NLO response. The AM-COLi complexes retained their structural features following interaction with the Group-IIIA elements.

A computational approach to drug design for multiple sclerosis via QSPR modeling, chemical graph theory, and multi-criteria decision analysis.

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system with an unknown etiology. While disease-modifying therapies can slow progression, there is a need for more effective treatments. Quantitative structure-activity relationship (QSAR) modeling using topological indices derived from chemical graph theory is a promising approach to rationally design new drugs for MS.

Level of cognitive functioning among elderly patients in urban area of Bangladesh: A cross-sectional study.

Bangladesh is experiencing rapid urbanization and a growing elderly population, particularly in urban areas. Cognitive decline, ranging from mild cognitive impairment to dementia, is a prevalent issue among elderly populations globally. Understanding the current state of cognitive functioning in this demographic is essential for informing effective healthcare plans and programs.

Analyzing HIV/AIDS dynamics with a novel Caputo-Fabrizio fractional order model and optimal control measures.

In this manuscript, we present a novel mathematical model for understanding the dynamics of HIV/AIDS and analyzing optimal control strategies. To capture the disease dynamics, we propose a new Caputo-Fabrizio fractional-order mathematical model denoted as SEIEUPIATR, where the exposed class is subdivided into two categories: exposed-identified EI and exposed-unidentified EU individuals. Exposed-identified individuals become aware of the disease within three days, while exposed-unidentified individuals remain unaware for more than three days.

Modeling the supply chain sustainability imperatives in the fashion retail industry: Implications for sustainable development.

The resilience of established business strategies has been tested in the wake of recent global supply chain upheavals triggered by events like the COVID-19 pandemic, Russia-Ukraine combat, Hamas-Israel war, and other geopolitical conflicts. Organizations are compelled to integrate sustainable practices into their supply chains to navigate the complexities of the post-COVID-19 era and mitigate the far-reaching consequences of such disruptions. However, exploring supply chain imperatives from sustainability dimensions still remains underexplored, presenting a significant research gap, particularly in the fashion retail sector.

Insights into adult worker foraging dynamics within a Bombus terrestris (Hymenoptera: Apidae) colony.

Bombus terrestris, an important eusocial insect, plays a vital role in providing pollination services for both wild plants and greenhouse crops. For the development of the colonies, the workers must leave the hives to collect nectar and pollen. However, limited findings about the foraging behavior of B.

Identification of a biallelic MMUT variant (p.Thr230Arg) and its global perspective on clinical management.

Background: Methylmalonic acidemia (MMA), type mut (0) is a rare type of genetic inborn error of metabolism (IEM) that is caused by aberrant malonyl-CoA mutase activity. Diagnosing IEM can be challenging due to its inherited onset and varying degrees of severity.

Methods And Results: In the present study, a consanguineous Pakistani family suspected of IEM was genetically analyzed using whole exome sequencing.

Antimicrobial Activity of Tea and Agarwood Leaf Extracts Against Multidrug-Resistant Microbes.

Emerging multidrug-resistant (MDR) strains are the main challenges to the progression of new drug discovery. To diminish infectious disease-causing pathogens, new antibiotics are required while the drying pipeline of potent antibiotics is adding to the severity. Plant secondary metabolites or phytochemicals including alkaloids, phenols, flavonoids, and terpenes have successfully demonstrated their inhibitory potential against the drug-resistant pathogens.

Design, synthesis and biological evaluation of ethyl 5-(1-benzyl-1H-indol-5-yl)isoxazole-3-carboxylates as antimycobacterial agents.

The continued prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains, particularly against first-line antitubercular (anti-TB) drugs, presents an impending public health threat that necessitates the exploration and development of New Chemical Entities (NCEs). In search of new anti-TB leads, a library of ethyl 5-(1-benzyl-1H-indol-5-yl)isoxazole-3-carboxylates were generated through a strategy of scaffold hopping from the proven isoxazole-3-carboxylate-based anti-TB pharmacophore. We evaluated their antibacterial potential against a panel of pathogenic bacteria and MtbH37Rv strains.

Evaluation of Photoaging and Sun Protection Behavior in Children With Xeroderma Pigmentosum, Group C: A Prospective Analysis.

Thirteen children with xeroderma pigmentosum variant C were evaluated using the Dermoscopic Photoaging Assessment Scale (DPAS), the Glogau scale, and the Sun Protection Behavior Scale (SPBS). Most patients exhibited signs of epidermal photoaging, with pigmentary and vascular changes and poor sun protection behavior (mean SPBS score: 18.92 ± 5.

A hybrid encryption framework leveraging quantum and classical cryptography for secure transmission of medical images in IoT-based telemedicine networks.

In the era of the Internet of Things (IoT), the transmission of medical reports in the form of scan images for collaborative diagnosis is vital for any telemedicine network. In this context, ensuring secure transmission and communication is necessary to protect medical data to maintain privacy. To address such privacy concerns and secure medical images against cyberattacks, this research presents a robust hybrid encryption framework that integrates quantum, and classical cryptographic methods.

Seed-specific expression of AtWRI1 enhanced the yield of cotton seed oil.

The WRINKLED1 (WRI1) transcription factor controls carbon flow in plants through regulating the expression of glycolysis and fatty acid biosynthesis genes. The role of Gossypium hirsutum WRINKLED1 (GhWRI1) in seed-oil accumulation still needs to be explored. Multiple sequence alignment of WRI1 proteins confirmed the presence of two conserved AP2 domains.