Background & Objective: Timely intervention for Acute coronary syndrome (ACS) could effectively reduce the mortality rate of ACS patients. This study aimed to investigate the clinical significance of miR-30c-5p for ACS and to provide a convenient biomarker for diagnosing of ACS.
Methods: Baseline information was collected from a total of 173 subjects (98 ACS subjects and 65 healthy subjects).
Colloids Surf B Biointerfaces
December 2024
Traditional design approaches for nanozymes typically rely on empirical methods and trial-and-error, which hampers systematic optimization of their structure and performance, thus limiting the efficiency of developing innovative nanozymes. This study leverages machine learning techniques supported by high-throughput computations to effectively design nanozymes with multi-enzyme activities and to elucidate their reaction mechanisms. Additionally, it investigates the impact of dopants on the microphysical properties of nanozymes.
View Article and Find Full Text PDFIn this Letter, we demonstrate a micro-displacement sensor based on a balloon-shaped fiber surface nanoscale axial photonic (SNAP) microresonator. The SNAP microresonator is fabricated by fiber bending to introduce nanoscale effective radius variations (ERVs) on the fiber surface. Displacement measurement based on the balloon-shaped SNAP microresonator is realized based on the ERV modulation resulting from the change in the bending radius of the balloon-shaped structure.
View Article and Find Full Text PDFAnn Lab Med
November 2024
Background: Quantitative detection of glucose-6-phosphate dehydrogenase (G6PD) is commonly done to screen for G6PD deficiency. However, current reference intervals (RIs) of G6PD are unsuitable for evaluating G6PD-activity levels with local populations or associating variants with hemolysis risk to aid clinical decision-making. We explored appropriate RIs and clinical decision limits (CDLs) for G6PD activity in individuals from Guangzhou, China.
View Article and Find Full Text PDFIntroduction: With continuously increasing labor costs, an urgent need for automated apple- Qpicking equipment has emerged in the agricultural sector. Prior to apple harvesting, it is imperative that the equipment not only accurately locates the apples, but also discerns the graspability of the fruit. While numerous studies on apple detection have been conducted, the challenges related to determining apple graspability remain unresolved.
View Article and Find Full Text PDFAccuFFRivus is an alternative to fractional flow reserve (FFR) based on intravascular ultrasound (IVUS) images for functional assessment of coronary stenosis. However, its prognostic impact in patients undergoing percutaneous coronary intervention (PCI) is still unclear. This retrospective study aimed to investigate the capability of AccuFFRivus in predicting prognosis.
View Article and Find Full Text PDFIn wearable robots, the application of surface electromyography (sEMG) signals in motion intention recognition is a hot research issue. To improve the viability of human-robot interactive perception and to reduce the complexity of the knee joint angle estimation model, this paper proposed an estimation model for knee joint angle based on the novel method of multiple kernel relevance vector regression (MKRVR) through offline learning. The root mean square error, mean absolute error, and R2_score are used as performance indicators.
View Article and Find Full Text PDFIn this Letter, we demonstrate a high-sensitivity vector bend sensor based on a fiber directional coupler. The fiber directional coupler is composed of two parallel waveguides inscribed within a no-core fiber (NCF) by a femtosecond laser. Since the two written waveguides have closely matched refractive indices and geometries, the transmission spectrum of the fiber directional coupler possesses periodic resonant dips.
View Article and Find Full Text PDFCurrently the clinical efficacy of colorectal cancer (CRC) which is the most common malignant tumors over the world has not reached an ideal level. Cetuximab, the monoclonal antibody targeting the extracellular domain of EGFR, has shown its great efficacy in the promotion of apoptosis and the inhibition of tumor cells-like characteristics in numerous cancers. However certain KRAS wild-type CRC patients unexpectedly show cetuximab resistance and the specific mechanism remains unclear.
View Article and Find Full Text PDFSensors (Basel)
August 2022
Deep learning is widely used in modern orchard production for various inspection missions, which helps improve the efficiency of orchard operations. In the mission of visual detection during fruit picking, most current lightweight detection models are not yet effective enough to detect multi-type occlusion targets, severely affecting automated fruit-picking efficiency. This study addresses this problem by proposing the pioneering design of a multi-type occlusion apple dataset and an augmentation method of data balance.
View Article and Find Full Text PDFUnsupervised deep learning methods have shown great success in jointly estimating camera pose and depth from monocular videos. However, previous methods mostly ignore the importance of multi-scale information, which is crucial for pose estimation and depth estimation, especially when the motion pattern is changed. This article proposes an unsupervised framework for monocular visual odometry (VO) that can model multi-scale information.
View Article and Find Full Text PDFBackground: Preeclampsia (PE), which has a high incidence rate worldwide, is a potentially dangerous syndrome to pregnant women and newborns. However, the exact mechanism of its pathogenesis is still unclear. In this study, we used bioinformatics analysis to identify hub genes, establish a logistic model, and study immune cell infiltration to clarify the physiopathogenesis of PE.
View Article and Find Full Text PDFFruit yield estimation is crucial to establish fruit harvesting and marketing strategies. Recently, computer vision and deep learning techniques have been used to estimate citrus fruit yield and have exhibited a notable fruit detection ability. However, computer-vision-based citrus fruit counting has two key limitations: inconsistent fruit detection accuracy and double-counting of the same fruit.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a serious impact on the world. In this study, small RNAs from the blood of COVID-19 patients with moderate or severe symptoms were extracted for high-throughput sequencing and analysis. Interestingly, the levels of a special group of tRNA-derived small RNAs (tsRNAs) were found to be dramatically upregulated after SARS-CoV-2 infection, particularly in coronavirus disease 2019 (COVID-19) patients with severe symptoms.
View Article and Find Full Text PDFIn recent years, deep-learning-based fruit-detection technology has exhibited excellent performance in modern horticulture research. However, deploying deep learning algorithms in real-time field applications is still challenging, owing to the relatively low image processing capability of edge devices. Such limitations are becoming a new bottleneck and hindering the utilization of AI algorithms in modern horticulture.
View Article and Find Full Text PDFBackground: The ketogenic diet (KD)has been considered an effective treatment for epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported that the KD feeding increased Neuregulin 1 (NRG1) expression in the hippocampus; disruption of NRG1 signaling by genetically deleting its receptor-ErbB4 abolished KD's effects on inhibitory synaptic activity and seizures. However, it is still unclear about the mechanisms underlying the effect of KD on NRG1 expression and whether the effects of KD require ErbB4 kinase activity.
View Article and Find Full Text PDFSmall heat shock proteins (sHSPs), a family of the ubiquitous stress proteins in plants acting as molecular chaperones to protect other proteins from stress-induced damage, have been implicated in plant growth and development as well as plant response to environmental stress, especially heat stress. In this study, a chloroplast-localized sHSP, AsHSP26.8, was overexpressed in creeping bentgrass (Agrostis stolonifera L.
View Article and Find Full Text PDFBackground: The ketogenic diet (KD) has been recognized as a potentially effective therapy to treat neuropsychiatric diseases, including epilepsy. Previous studies have indicated that KD treatment elevates γ-Amino butyric acid (GABA) levels in both human and murine brains, which presumably contributes to the KD's anti-seizure effects. However, this has not been systematically investigated at the synaptic level, and the underlying molecular mechanisms remain to be elucidated.
View Article and Find Full Text PDFBackground: Identification of genetic diversity in heat tolerance and associated traits is of great importance for improving heat tolerance in cool-season grass species. The objectives of this study were to determine genetic variations in heat tolerance associated with phenotypic and physiological traits and to identify molecular markers associated with heat tolerance in a diverse collection of perennial ryegrass (Lolium perenne L.).
View Article and Find Full Text PDFAppl Radiat Isot
September 2020
Radioactive noble-gas monitoring is necessary in nuclear facilities. A NaI(Tl)-based radioactive noble-gas monitoring system was developed. In order to increase the amount of air to be measured, the sample vessel of this system was larger than that of other systems, and was pressurized to about 5 × 10 Pa.
View Article and Find Full Text PDFIEEE Trans Image Process
January 2020
In this paper, we propose a novel network block, dubbed as second-order spectral transform block, for 3D shape retrieval and classification. This network block generalizes the second-order pooling to 3D surface by designing a learnable non-linear transform on the spectrum of the pooled descriptor. The proposed block consists of following two components.
View Article and Find Full Text PDFMarjolin's ulcer is a type of skin cancer that generated from chronic nonhealing trauma. For years, its pathogenesis mechanisms remain unclear. Regarding this situation, the authors retrospectively analyze the patients admitted to their department from 2005 to 2019 to present several representative cases and examine the expression patterns of survivin and its role in this process.
View Article and Find Full Text PDFZinc removal from basic oxygen steelmaking filter cake was studied by tablet testing and in a millipot under different conditions. The results from tablet testing show that coke and metallic iron in filter cake play the role of reductants to remove zinc during sintering. Zinc removal increased with increasing temperature and decreasing partial pressure of oxygen.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
November 2018
Male genital injuries are rare and only few of them are total penoscrotal degloving injuries. Though this kind of injury is not life-threatening, it could be psychologically devastating to patients if not treated appropriately. This report presents a case of total male genitalia degloving injury treated by sliding flap and skin graft, assisted by Vacuum Sealing Drainage.
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