Belimumab versus telitacicept in sequential treatment after rituximab for refractory lupus nephritis: a real-world multicentre study.

Objective: Both belimumab and telitacicept are recognised blockers for B lymphocyte activation, both of which have been approved as add-on therapies for SLE in China. The aim of this study is to compare the efficacy of rituximab (RTX) followed by belimumab or telitacicept in a real-world cohort.

Methods: A total of 49 refractory lupus nephritis patients were enrolled from four independent centres, subsequently categorised into two treatment groups: belimumab group (n=35) and telitacicept group (n=14) based on their treatment following RTX.

Analyzing the adverse events of NK-1 receptor antagonists: a pharmacovigilance study from the FAERS database.

Background: NK-1 receptor antagonists (NK-1RAs) are proven to be successful in preventing chemotherapy-induced nausea and vomiting (CINV). The safety profile of NK-1RAs has not been systematically analyzed in the real world. This pharmacovigilance study investigated the differences in adverse events (AEs) between NK-1RAs.

HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo-YAP pathway activation.

Background: Sleep apnea syndrome (SAS) is associated with hypertension and vascular remodeling. Hypoxia-inducible factor-1α (HIF-1α) and the Hippo-YAP pathway are implicated in these processes, but their specific roles remain unclear. This study investigated the HIF-1α/Hippo-YAP pathway in SAS-related hypertension.

Prevalence, Patterns, and Nomogram Model of Intimate Partner Violence Against Mothers During the Child-Rearing Stage: A Family System Analysis in China for Targeted Prevention Strategies.

Intimate partner violence (IPV) is a significant public health issue affecting many women worldwide. While extensive research exists on IPV during pregnancy and postpartum, there is limited information on IPV against mothers during the critical child-rearing stage, specifically the first three years following childbirth. This study examines the prevalence and patterns of IPV among mothers in China during this stage, identifying associated factors across four family subsystems: individual, husband-and-wife, mother-child, and family context, to guide the development of tailored prevention strategies.

Different association of HDL-C, apoA-I, and HDL-C/apoA-I with multiple outcomes in HFrEF patients.

Background: High-density lipoprotein-cholesterol (HDL-C) has been considered a cardioprotective factor for several decades. However, its association with outcomes in patients with heart failure with reduced ejection fraction (HFrEF) remains controversial. We aimed to investigate the association of HDL-C, apolipoprotein A-I (apoA-I), and the HDL-C/apoA-I ratio with multiple outcomes of HFrEF patients and establish prognostic models using machine learning methods.

Programmable ultrasound-mediated swarms manipulation of bacteria-red blood cell microrobots for tumor-specific thrombosis and robust photothermal therapy.

Despite the excellent advantages of biomicrorobots, such as autonomous navigation and targeting actuation, effective penetration and retention to deep lesion sites for effective therapy remains a longstanding challenge. Here, we present dual-engine cell microrobots, which we refer to as PR-robots, created by conjugating photosynthetic bacteria (PSB) with red blood cells (RBCs). The robots penetrate the tumor interior in swarms through combined hypoxic traction and ultrasound actuation (UA).

Relationship between prenatal ultrasound signs and genetic abnormalities for fetal malformations of cortical development.

To explore the relationship between ultrasound signs of suspected fetal malformation of cortical development (MCD) and genetic MCD.The retrospective study involved fetuses with one of the following 10 neurosonography (NSG) signs: (A) abnormal development of the Sylvian fissure; (B) delayed achievement of cortical milestones; (C) premature or aberrant appearance of sulcation; (D) irregular border of the ventricular wall or irregular shape of the ventricle; (E) abnormal shape or orientation of the sulci; (F) hemispheric asymmetry; (G) non-continuous cerebral cortex; (H) intraparenchymal echogenic nodules; (I) persistent ganglionic eminence (GE) or GE cavitation; (J) abnormal cortical lamination.95 fetuses were included in the study.

Awareness regarding human papillomavirus and willingness for vaccination among college students with or without medical background in Guizhou Province.

This cross-sectional epidemiological study aimed to investigate awareness regarding human papillomavirus (HPV) and willingness for vaccination among college students with or without medical background in Guizhou Province, China. A logistic regression model was used for univariate and multivariate analyses of cognition to determine factors influencing willingness for vaccination. In total, 2,540 questionnaires were collected, of which 2,360 were valid.

Commercially Applicable One-Step Method to Construct Homogeneous Anode/Electrolyte Interface and Cathode/Electrolyte Interface Layers in All-Solid-State Lithium-Sulfur Batteries.

Using a solid electrolyte is considered to be the most effective strategy to solve the shuttle effect in lithium-sulfur batteries. However, the practical application of solid-state lithium-sulfur batteries (SLSBs) is still far from being realized. This is because SLSBs, like all other solid-state battery systems, also face the dilemma of interface degradation (including both the anode and cathode interfaces), in addition to terrible kinetics due to the nonliquid solid-state electrolytes infiltrating the nonconductive sulfur particles inside the cathode.

Phyllospheric fungal diversity in decomposing larch leaf litter: a comparative study of epiphytic and endophytic fungi.

Introduction: Epiphytic and endophytic fungi are primary decomposers of forest litter due to their complex species composition and metabolic functions. To clarify the community diversity of phyllospheric fungi and to explore nutrient loss and the role of fungal decomposition, we conducted a study on the decomposition of leaf litter during the 1-year decomposition of in the cold temperate zone.

Methods: Fungal diversity data were characterized via Single Molecule Sequencing (based on the Sequel II Sequencing System) and statistical analyses in R.

Changes in the Structure, Function, and Fat Content of the Heart in Patients with Obesity After Bariatric Surgery-A Prospective Magnetic Resonance Imaging Study.

Background: Changes in myocardial fat in addition to changes in cardiac structure and function have not been accurately evaluated in obese patients following surgery.

Materials And Methods: Forty-four obese patients who underwent sleeve gastrectomy and completed preoperative and postoperative cardiac magnetic resonance imaging (CMR) before surgery and at 1, 3, and 6 months after surgery were enrolled, and their clinical and laboratory data were collected. The differences and correlations between clinical, laboratory, and CMR parameters between the preoperative and postoperative groups were analysed.

The ultrastructural and proteomic analysis of mitochondria-associated endoplasmic reticulum membrane in the midbrain of a Parkinson's disease mouse model.

Recent studies indicated that the dysregulation of mitochondria-associated endoplasmic reticulum membrane (MAM) could be a significant hub in the pathogenesis of Parkinson's disease (PD). However, little has been known about how MAM altered in PD. This study was aimed to observe morphological changes and analyze proteomic profiles of MAM in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse models.

Bioorthogonal oncolytic-virus nanovesicles combined bio-immunotherapy with CAR-T cells for solid tumors.

Various oncolytic viruses (OVs) have been adopted as therapeutic tools to increase the efficacy of chimeric antigen receptor (CAR)-T cells against solid tumors. However, the therapeutic effect of OVs has been limited by pre-existing neutralizing antibodies and poor targeting delivery for systemic administration. Herein, we propose using bioorthogonal OV nanovesicles to boost the antitumor effects of CAR-T cells in solid tumors by reshaping the tumor microenvironment.

Application of platelet transcriptomics for assessing treatment effectiveness and predicting long-term platelet counts recovery in aplastic anemia.

Background: Aplastic anemia (AA) is a bone marrow failure disease for which the means of assessing and predicting the therapeutic effectiveness are still relatively limited. Thrombocytopenia is often the earliest and most severe symptom in patients newly diagnosed with AA. While clinical consideration is usually given to the quantitative changes in platelets during treatment, there is little focus on the resolution of the molecular characteristics of platelets in AA.

Incorporation of polyvinyl alcohol in bacterial cellulose/polypyrrole flexible conductive films to enhance the mechanical and conductive performance.

The integration of polypyrrole (PPy) into bacterial cellulose (BC) has provided significant conductivity and cost benefits. However, this combination has led to a reduction in mechanical properties, particularly in terms of elongation at break and tensile strength. This study investigated the enhancement of BC/PPy composite films by incorporating polyvinyl alcohol (PVA).

Utilization of Tea Polyphenols as Color Developers in Reversible Thermochromic Dyes for Thermosensitive Color Change and Enhanced Functionality of Polyester Fabrics.

Thermochromic textiles possess the capability to indicate ambient temperature through color changes, enabling real-time temperature monitoring and providing temperature warnings for body heat management. In this study, three thermochromic dyes-blue, red, and yellow-were synthesized using crystalline violet lactone (CVL), 6'-(diethylamino)-1',3'-dimethyl-fluoran (DDF), and 3',6'-dimethoxyfluoran (DOF) as leuco dyes, respectively, with biomass tea polyphenol serving as the color developer and tetradecanol as the phase change material. The chemical structures of these dyes were characterized using UV spectroscopy, infrared spectroscopy, Raman spectroscopy and H NMR.

Application and Challenge of Metalloporphyrin Sensitizers in Noninvasive Dynamic Tumor Therapy.

Dynamic tumor therapies (mainly including photodynamic therapy (PDT) and sonodynamic therapy (SDT)) offer new approaches to cancer treatment. They are often characterized by their noninvasive nature, high selectivity, and low toxicity. Sensitizers are crucial for dynamic therapy.

A real-world adverse events study of rimegepant from the FAERS database.

Background: The primary objective of this research is to conduct an exhaustive evaluation of rimegepant with the Food and Drug Administration Adverse Event Reporting System (FAERS) repository.

Research Design And Methods: This study downloaded the reporting files related to rimegepant from the second quarter of 2020 to the first quarter of 2024. Disproportionality analysis was utilized to explore the relationship between rimegepant and adverse drug events (ADEs).

The longitudinal relationships between problematic mobile phone use symptoms and negative emotions: a cross-lagged panel network analysis.

Background: The association between problematic mobile phone use (PMPU) and negative emotions in university students is not well understood in terms of causality and directionality. This study aims to clarify whether negative emotions trigger PMPU or whether the PMPU itself leads to increased negative emotions over time.

Methods: A two-wave longitudinal study was conducted involving 5568 Chinese freshmen who were surveyed at baseline and followed up after one academic year.

The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease.

Background: Overactivated microglia are a key contributor to Parkinson's disease (PD) by inducing neuroinflammation. CD200R1, a membrane glycoprotein mainly found on microglia, is crucial for maintaining quiescence with its dysregulation linked to microglia's abnormal activation. We and other groups have reported a decline in CD200R1 levels in several neurological disorders including PD.