Publications by authors named "Hong Fu"
Peripheral Nerve Block Combined with Low-Dose General Anaesthesia in Elderly Patients Receiving Hip Arthroplasty.
J Coll Physicians Surg Pak
January 2025
The study assessed the effectiveness and safety of nerve block combined with low-dose general anaesthesia in elderly hip arthroplasty patients, conducted by a meta-analysis of RCTs. Six trials involving 403 patients were identified from databases such as Cochrane, MEDLINE, and PubMed. The results demonstrated a statistically significant difference in pain scores at postoperative 12hours (95% CI, -2.
View Article and Find Full Text PDFBackground: Neutrophil-to-lymphocyte ratio (NLR) is a promising prognostic marker for patients undergoing hepatectomy for colorectal liver metastases (CRLM). However, its prognostic value in patients receiving neoadjuvant therapy (NAT) has not been sufficiently addressed.
Methods: From 2013 to 2023, a cohort of 692 patients with CRLM receiving hepatectomy were enrolled in five centers.
Enhancing university students' engagement in studying assistive technology by case-based active learning: a pilot study in Hong Kong.
Disabil Rehabil Assist Technol
January 2025
Assistive technology (AT) professionals are in pressing need with nowadays growing aged/disabled population, so as well-designed higher education programs in this field. This study designed and implemented a case-based active learning approach within an undergraduate course related to AT in Hong Kong, and assessed its impact on enhancing student engagement over two academic years. A total of twelve multimedia patient case dossiers on six major physical disabilities were created.
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- Radiotherapy resistance significantly impacts the treatment outcomes for esophageal squamous cell carcinoma (ESCC), highlighting the need to understand its underlying mechanisms.
- Researchers identified GPR37 as a crucial factor that enhances radiosensitivity in ESCC, noting its low expression in radioresistant tumors correlating with worse patient prognosis.
- GPR37 functions by interacting with ATP1A1 to promote its degradation, inhibiting the AKT/mTOR signaling pathway, and can also be transferred to other cells via exosomes to reduce their malignant behavior, making it a promising therapeutic target to improve radiotherapy effectiveness.
Article Synopsis
- A new series of chalcone derivatives were created, specifically those containing 1,2,4-triazole and pyridine, and their effectiveness against tobacco mosaic virus (TMV) was tested.
- S7 showed particularly strong antiviral activity with a lower effective concentration (EC = 89.7 μg/mL) compared to ningnanmycin (NNM: EC = 201.7 μg/mL).
- Molecular studies revealed that S7 binds more effectively to the TMV coat protein (TMV-CP) than NNM, suggesting it enhances disease resistance in tobacco plants by improving chlorophyll content and reducing plant damage.
Background: A large number of pathogenic fungi have caused serious damage to the global crop yield, and drug resistance is always a topic that cannot be avoided for traditional fungicides. Therefore, finding efficient, green, and low-toxic fungicides is our primary task, which brings opportunities for the development of natural product green pesticides.
Results: Twenty chalcone derivatives containing 1,2,3,4-tetrahydroquinoline were designed and synthesized, and the compounds were tested for their fungicidal effects against eight plant pathogenic fungi in vitro.
Article Synopsis
- Carbon dioxide (CO) drive is effective for tertiary oil recovery in high water content oil fields, but its low viscosity hampers oil extraction efficiency.
- Introducing viscosity enhancers, like acetate scCO tackifier PVE, can improve fluid dynamics and enhance oil recovery.
- A study using molecular dynamics simulations revealed that increasing the proportion of vinyl acetate in viscosity enhancers enhances the viscosity of CO systems, enabling better oil extraction.
Article Synopsis
- The study aimed to analyze factors affecting changes in corneal tissue structure after the smooth incision lenticular keratomileusis (SILK) procedure using the ELITA Femtosecond Laser System.
- It involved testing various surgical parameters on 71 porcine and 6 human cadaver eyes, with measurements taken using confocal microscopy to observe and quantify the disrupted tissue interface.
- Results showed that the thickness of the disrupted interface was primarily influenced by laser pulse energy, scan overlap, and mechanical manipulation, with ELITA SILK producing minimal disruption compared to other methods, highlighting its potential for better surgical outcomes in refractive surgery.
Aim: To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid (α-KG) on scleral collagen expression.
Methods: Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness (ChT) during myopia. The establishment of a hypoxic myopia model (HYP) for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia and α-KG on collagen expression were demonstrated by Sirius red staining.
Article Synopsis
- Cognitive dysfunction in older adults is influenced by depression and adverse childhood experiences (ACEs) related to deprivation, which can impose significant economic burdens.
- Research aimed to explore how depression mediates the relationship between these deprivation-related ACEs and cognitive function using data from a large national survey.
- The findings revealed that both deprivation-related ACEs and depression are negatively correlated with cognitive function, and depression plays a significant mediating role, suggesting that addressing childhood deprivation could help reduce cognitive dysfunction through improved mental health.
Leukemia remains a fatal disease for most affected patients, and a simple and effective therapeutic strategy is urgently needed. Targeted delivery chemo-drugs to leukemia cells shows promise, but the diverse subtypes of leukemia make single-ligand nanomedicine often ineffective. Herein, a dual-aptamer decorated, reduction-responsive dimeric prodrug-based nanoparticle (NP), termed SXP-NPs, was developed using the two leukemia-specific aptamers Sgc8c and XQ-2d, a reduction-responsive podophyllotoxin (POD) dimeric prodrug, and DSPE-PEG2000.
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- The paper tackles the issue of low detection accuracy of grape clusters due to scale differences, lighting variations, and occlusion in complex scenes.
- It introduces a new YOLOv7 network with four key enhancements: a Multi-Scale Feature Extraction Module to improve small target detection, a Receptive Field Augmentation Module using dilated convolution to better capture objects of different sizes, a Spatial Pyramid Pooling Cross Stage Partial Concatenation Faster module for effective multi-scale feature integration, and a Residual Global Attention Mechanism to focus on important regions.
- Experimental results show a significant improvement in detection performance, achieving a mean Average Precision (mAP) of 93.29% on the GrappoliV2 dataset, outperforming YOLOv
Article Synopsis
- Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication after ERCP procedures, and this study evaluates the role of topical epinephrine in preventing PEP.
- A review of 10 studies, including 7 randomized controlled trials (RCTs) and 3 retrospective cohort studies (RCSs) with a total of 5683 patients, found that epinephrine alone did show some promise in reducing PEP incidence compared to controls, but overall, it did not significantly prevent PEP or improve its severity.
- Additionally, while the use of epinephrine combined with nonsteroidal anti-inflammatory drugs (NSAIDs) showed some reduction in mild PEP
Article Synopsis
- The delta opioid receptor (δOR) influences human sensation and emotion and is a promising target for drug development due to its lower risk of causing drug dependence compared to the Mu opioid receptor.
- The study uses cryo-electron microscopy to analyze the δOR-G complex when interacting with the small-molecule agonist ADL5859, and investigates receptor-ligand interactions and signaling biases.
- Findings reveal a connection between δOR’s β-arrestin recruitment and effects like analgesic tolerance and altered gastrointestinal motility, enhancing understanding of δOR's role in drug discovery.
Article Synopsis
- * Researchers analyzed data from 295 pertussis patients and 295 with other respiratory infections, utilizing various algorithms and tests to identify key features for diagnosis.
- * The XGBoost machine learning model outperformed other models, achieving a high accuracy rate of 92.3% and could significantly improve pertussis diagnosis for doctors.
Article Synopsis
- Myopia rates are rising globally due to lifestyle changes, causing significant public health concerns and affecting quality of life.
- High myopia can lead to serious eye diseases due to changes in the sclera, emphasizing the need for effective prevention strategies.
- Collagen is essential for maintaining scleral integrity, and enhancing its expression or mechanical properties can potentially slow the progression of myopia.
Cord blood vitamin A and vitamin D levels in relation to physical growth in exclusively breastfed infants aged 0-6 months.
Front Endocrinol (Lausanne)
August 2024
Article Synopsis
- Vitamins A and D are crucial for pregnant women and infants, but their impact on the growth of exclusively breastfed infants remains unclear.
- This study involved 140 mother-infant pairs to investigate the relationship between the levels of these vitamins in umbilical cord blood and the physical growth of infants aged 0-6 months using various growth measurements.
- The findings revealed that higher vitamin A levels positively affected head circumference growth, while vitamin D levels were linked to both negative and positive impacts on length and BMI growth, respectively.
Article Synopsis
- Low-permeability reservoirs (less than 10 mD) face challenges such as high injection difficulty and low gas recovery, making CO a preferred method for development to ease these issues and reduce carbon emissions.
- The study examines the effectiveness of two CO-soluble foaming agents (CG-1 and CG-2) in improving gas displacement and recovery in fractured rock with low permeability (around 0.25 mD).
- Results indicated that CG-1 performed well under various conditions, achieving an 83.7% blocking rate and a 12.02% improvement in recovery when optimized for injection at 0.6 mL/min and 2.80% concentration.
Round ligament varicosities (RLV) are a very rare cause of an inguinal mass, which is very similar to an inguinal hernia, and should be taken seriously by women, especially in mid-pregnancy. Ultrasound can confirm the diagnosis of the RLV and can prevent unnecessary interventions. We report a case of a patient with bilateral RLV: the primigravida was 31 years old, GP, gestation 30w.
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- The study assessed how higher-order wavefront aberrations change after the Smooth Incision Lenticular Keratomileusis (SILK) procedure for correcting myopia and astigmatism using the ELITA femtosecond laser.
- Results showed a significant improvement in mean refractive spherical equivalent from preoperative readings to 9-month follow-ups, indicating effective correction.
- While higher-order aberrations increased post-surgery, there was no significant difference in certain aberrations at follow-up visits, supporting the procedure's predictability and effectiveness.
Article Synopsis
- Efficient and stable hydrogen evolution electrocatalysts are crucial for advancing hydrogen production, but current methods face limitations due to separate use of interface and phase engineering.* -
- The newly proposed CoMo/CoTe electrocatalyst features an amorphous CoMo layer encapsulating a crystalline CoTe array, which significantly enhances catalytic performance through optimized electronic structures.* -
- Experimental findings and theoretical calculations indicate that this interface-engineered catalyst improves intermediate adsorption and lowers kinetic barriers, demonstrating excellent performance in various water environments.*
In-situ revealed inhibition of WC to excessive oxidation of CoOOH for high-efficiency alkaline overall water splitting.
J Colloid Interface Sci
December 2024
Article Synopsis
- Developing low-cost and efficient catalysts to replace expensive noble metals is a key challenge in catalysis.
- The Co-WC dual-component catalytic system exhibits impressive performance in hydrogen and oxygen evolution reactions, with specific overpotentials of 63 mV and 259 mV, respectively, and achieves overall water splitting at 1.53 V.
- This performance is enhanced by electronic changes at the WC/Co interface, which improves the energetics for hydroxyl and hydrogen species, while the core-shell structure helps stabilize the material during reactions.
Article Synopsis
- The review discusses the integration of artificial intelligence in soft robotics, highlighting their ability to sense, think, and interact with humans.
- Design strategies for soft robotics are summarized, covering materials, structures, technologies, and potential uses.
- The text also presents future considerations and possibilities for the development of soft robots.
Article Synopsis
- The study highlights that early identification of high-risk factors is crucial for improving outcomes in patients with severe acute pancreatitis (SAP).
- Researchers analyzed clinical data from patients and identified key predictors of SAP, including age, BMI, non-hypertriglyceridemic acute pancreatitis, white blood cell count, procalcitonin, serum calcium levels, and computed tomography severity index.
- The findings suggest that these factors can aid in early screening and intervention efforts to better manage patients at risk of progressing to SAP.