Kisspeptin stimulates oestradiol biosynthesis by upregulating steroidogenic transcripts and proliferation markers in the bubaline granulosa cells in vitro.

Kisspeptin (Kp), an upstream regulator of GnRH release, is essential for the development and function of reproductive axis. Previously, we demonstrated the localization of Kp and its receptor (Kiss1r) in the active follicle in the bubaline ovary. Present study aimed to determine the effect of Kp on granulosa cell (GCs) functions, especially oestradiol (E ) and progesterone (P ) production, and differential expression of genes regulating the proliferation, apoptosis and steroidogenesis in the buffalo.

Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi.

Background: Vitamin D deficiency and anemia are clinical conditions that coexist during pregnancy. A high prevalence of Vitamin D deficiency ranging from 50 to 94% is seen throughout the country. The aim of the study was to discover the association between Vitamin D status and iron deficiency anemia during pregnancy.

Experiences with the Introduction of AI-based Tools for Moderation Automation of Voice-based Participatory Media Forum.

Voice-based discussion forums where users can record audio messages which are then published for other users to listen and comment, are often moderated to ensure that the published audios are of good quality, relevant, and adhere to editorial guidelines of the forum. There is room for the introduction of AI-based tools in the moderation process, such as to identify and filter out blank or noisy audios, use speech recognition to transcribe the voice messages in text, and use natural language processing techniques to extract relevant metadata from the audio transcripts. We design such tools and deploy them within a social enterprise working in India that runs several voice-based discussion forums.

Application of Machine Learning Algorithm on MEMS-Based Sensors for Determination of Helmet Wearing for Workplace Safety.

Appropriate use of helmets as industrial personal protective gear is a long-standing challenge. The dilemma for any user wearing a helmet is thermal discomfort versus the chances of head injuries while not wearing it. Applying helmet microclimate psychrometry, we propose a logistic regression- (LR) based machine learning (ML) algorithm coupled with low-cost and readily available MEMS sensors to determine if a helmet was worn (W) or not worn (NW) by a human user.

Correlation of Buccal Micronucleus with Disease Activity Score Using Buccal Micronucleus Cytome Analysis (BMCA) in Systemic Lupus Erythematosus.

Background: A disease activity score obtained by using systemic lupus erythematosus disease activity index (SLEDAI) has traditionally been a reliable method to assess the SLE status of patients. More recently, a buccal micronucleus cytome assay (BMCA) has been developed for use as a biomarker of DNA damage in patients with SLE. There has been a very limited number of studies pertaining to the oral lesions in Arab population suffering from SLE in Asir region.

The diabetes clinic: Creating an illusion of time.

Diabetes care is challenging task, both for both the person with diabetes, and for the diabetes care provider. One of the challenges is the pressure to see a huge case load in limited time. This leads to poor patient satisfaction, and result in suboptimal outcome.

Peripheral Gangrene Complicating Systemic Lupus Erythematosus in a Patient with Spina Bifida: A Case Report.

An adolescent girl, a known case of spina bifida with systemic lupus, presented with bluish discolouration of three toes of the right foot. She had thrombosis of bilateral popliteal arteries. She underwent percutaneous transluminal angioplasty (PTA) of both legs and Chopart amputation of the right foot.

Deconstructing Pretest Risk Enrichment to Optimize Prediction of Psychosis in Individuals at Clinical High Risk.

Importance: Pretest risk estimation is routinely used in clinical medicine to inform further diagnostic testing in individuals with suspected diseases. To our knowledge, the overall characteristics and specific determinants of pretest risk of psychosis onset in individuals undergoing clinical high risk (CHR) assessment are unknown.

Objectives: To investigate the characteristics and determinants of pretest risk of psychosis onset in individuals undergoing CHR assessment and to develop and externally validate a pretest risk stratification model.

Diagnostic Dilemma in Appendiceal Mucormycosis: A Rare Case Report.

Appendiceal mucormycosis is a rare life-threatening infection seen in immunocompromised patients. It is usually seen in chemotherapy induced neutropenia in patients with hematological malignancies. Clinically, the symptoms and signs may be masked due to ongoing corticosteroids.

"Potential health benefits of lunasin: a multifaceted soy-derived bioactive peptide".

Bioactive peptides are small protein fragments derived from enzymatic hydrolysis of food proteins, fermentation with proteolytic starter cultures, and gastrointestinal digestion. These peptides have positive impacts on a number of physiological functions in living beings. Lunasin, a soy-derived bioactive peptide, is one of the most promising among them.

Dental health status among sensory impaired and blind institutionalized children aged 6 to 20 years.

Background: This study was planned to assess the dental caries status among disabled children as dental health is an integral part of general body health and this group is deprived of health care needs.

Materials & Methods: A sample of 310 disabled children was gathered including 195- Hearing impaired, 115 - blind. Of which 226 were males and 84 were females.

Analysis and development of fourth order LCLC resonant based capacitor charging power supply for pulse power applications.

A fourth order (LCLC) resonant converter based capacitor charging power supply (CCPS) is designed and developed for pulse power applications. Resonant converters are preferred t utilize soft switching techniques such as zero current switching (ZCS) and zero voltage switching (ZVS). An attempt has been made to overcome the disadvantages in 2nd and 3rd resonant converter topologies; hence a fourth order resonant topology is used in this paper for CCPS application.

Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines.

Cycloaddition of C-imidazolyl-N-phenylnitrones with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E.