Publications by authors named "Herlina"

Background And Purpose: Many studies have been performed to identify new sources, their optimal isolation, and the biological activities of flavonoids due to nutraceutical, pharmaceutical, and cosmeceutical properties.

Experimental Approach: This review describes the method for flavonoid isolation and characteristic from the genus and their biological activities with the indication of the most active ones. To perform a comprehensive review, a thorough literature review using Google Scholar, Scopus, and Science Direct was performed with keyword alone or in combination with other words.

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Purpose: This study aimed to evaluate the potency of 471 flavonoids from the genus as potential acetylcholinesterase (AChE) inhibitors and free radical scavengers through computational studies to develop Alzheimer's disease (AD) therapies from natural products.

Methods: A total of 471 flavonoids from the genus were subjected to molecular docking against AChE, followed by toxicity screening. The potential AChE inhibitors with the least toxic profile were subjected to further investigation through molecular dynamics (MD) simulations, density functional theory (DFT) study, and in silico pharmacokinetic predictions.

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Introduction: , a medical plant found in sub-Saharan Africa and the Western Ghats of India, shows promise as a potential source of bioactive compounds to treat cancer. In our ongoing research on folk medical plants, we report the isolation of flavonoid compound from the stem bark of along with its cytotoxic activity against breast cancer (MCF-7 and T47D), and cervical cancer (HeLa) cell lines.

Purpose: This study aimed to isolate secondary metabolite from the stem bark of and evaluate its cytotoxic activity to support the use of folk medicinal plants as alternative therapy against cancer.

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Background: Local wisdom food ingredients in North Sumatra, Indonesia, are a source of phenolics which have antioxidant, antihyperlipidemia, neuronal survival, and growth. Administering products with antioxidant properties can provide a supporting effect in preventing inflammation and neurodegenerative process.

Objective: The main objective of this study was to analyze the formulation of red palm oil ( Jacq), koja bay leaves ( L Spreng), and passion fruit seeds ( Sims) to improve lipid profile, antioxidant activity, Brain-Derived Neurotrophic Factor (BDNF), and lipase enzyme activity of Sprague-Dawley rats.

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A Pro-Gly-typed cyclopeptide, cyclosenegalin A, was firstly isolated from Annona senegalensis and Annona scleroderma. In this study, we reported synthesis the cycloheptapeptide with a combination of solid- and solution-phase synthetic methods. This study also compared the effectiveness of β-turn inducer type I and II in cyclosenegalin A to facilitate the cyclization process.

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Purpose: This study aimed to screen potential drug candidates from the flavonoids of the genus for the Corona Virus Disease 2019 (COVID-19) treatment.

Patients And Methods: A comprehensive screening was conducted on the structures of 473 flavonoids derived from the genus , focusing on their potential toxicity and pharmacokinetic profiles. Subsequently, flavonoids that were non-toxic and possessed favorable pharmacokinetic properties underwent further analysis to explore their interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, employing molecular docking and molecular dynamics simulations.

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The emergence of antimicrobial resistance due to the widespread and inappropriate use of antibiotics has now become the global health challenge. Flavonoids have long been reported to be a potent antimicrobial agent against a wide range of pathogenic microorganisms in vitro. Therefore, new antibiotics development based on flavonoid structures could be a potential strategy to fight against antibiotic-resistant infections.

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Background: Phytase supplementation in rations can reduce their phytic acid composition in order to enhance their nutritional value. Aspergillus niger is a fungus that can encode phytase. This study aims to determine the characteristics of its DNA sequences and amino acid composition that encode the phytase enzyme, as well as to determine the primer designs.

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Utilizing the bioactive compounds found in pigmented rice might significantly reduce the risk of breast cancer. This study aims to systematically review existing literature on the benefit of Asian pigmented rice bioactive compounds and their implication in breast cancer. Searches of the literature were conducted in two databases (Scopus and PubMed) for a systematic review.

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Previous studies have shown that the confirmed cases drive investor sentiment, reflecting the stock's return. Based on this, the vaccination growth is also expected to drive the investor's sentiment, which can be reflected in the return of the stock market in ASEAN.  Therefore, this study explores the vaccination impact on stock returns in ASEAN countries.

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Plants in the genus Erythrina is a potential source of chemical constituents, one of which is flavonoids, which have diverse bioactivities. To date, literature on the flavonoids from the genus Erythrina has only highlighted the phytochemical aspects, so this review article will discuss isolation techniques and strategies for the first time. More than 420 flavonoids have been reported in the Erythrina genus, which are grouped into 17 categories.

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Background: In Indonesia, around 400 health workers died due to Covid-19 between June-July 2021, therefore the health workers need to be given further immunity. Health workers were among the first to get a booster shoot. However, they may experience side effects after vaccination.

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Chisocarpene A () is a new tirucallane-type triterpenoid together with odoratone () and 24-methylenecycloartanol (), isolated from the stem bark of . The chemical structures of compounds were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay.

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Article Synopsis
  • Two new compounds, dysoticans A and B, and three dimers, dysoticans C-E, were discovered in the stem bark of Dysoxylum parasiticum in West Java, Indonesia, by using detailed spectroscopic techniques.
  • Dysoticans A and B are novel cadinanes with slight modifications, while C and D are unique pseudo-sesquiterpenoid dimers, and E is a sesquiterpenoid dimer consisting of an eudesmane-germacrene hybrid.
  • The compounds A, B, and C, as well as E, showed moderate anti-cancer activity against certain human cancer cell lines, while D exhibited strong targeted cytotoxicity against cervical cancer cells.
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Two new dammarane-type triterpenoid fatty acid ester derivatives, 3β-oleate-20-hydroxydammar-24-en () and 3β-oleate-20,24-epoxy-25-hydroxydammarane () with a known dammarane-type triterpenoid compound, such as 20-hydroxydammar-24-en-3-on (), were isolated from the stem bark of (C.DC.) Blume.

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Flavonoids are a secondary metabolite group with various bioactivities, such as antioxidants. They are rich in the genus , such as . This research aims to isolate and characterize flavonoids from the twigs of and determine their antioxidant properties through in silico and in vitro assays.

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<b>Background and Objective:</b> Aluminum (Al) is widely used in many aspects of daily life, such as food packaging, cooking utensil components, food additives, cosmetics and water distillation. This study aimed to evaluate the protective role of nanocurcumin on the cerebral cortex of one and two-month-old mice exposed to 200 mg kg<sup></sup><sup>1</sup> b.wt.

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This study aimed to investigate the motivation of participating in exercise and the impact on the quality of life among the elderly during the Covid-19 pandemic. This study used a mixed-method (quantitative and qualitative) and included 109 respondents (72 women and 37 men) to answer the questionnaires. In addition, the study included 15 participants for the qualitative phase, consisting of 8 women and 5 men from the elderly group, 1 village official, and 1 youth leader.

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Cervical cancer is the second most lethal cancer in Indonesia, behind breast cancer. One of the reasons cancer cells are difficult to treat is that the immune system is sometimes unable to recognise them as foreign. Cytokinin therapy is carried out so that the immune system can strengthen its response to cancer cells, with the aim of slowing or stopping the development of malignant cells.

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<b>Background and Objective:</b> Andaliman is a wild plant in Indonesia and it has been used for centuries as traditional medicine. This study aimed to evaluate the effect of methanol extract of andaliman on apoptosis cancer cells via cytochrome c protein. <b>Materials and Methods:</b> The rats are divided into 5 groups.

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In this study, acute toxicity of kenikir leaf ( HBK) ethanolic extract was conducted on Wistar white male rats with fixed dose procedure. The extraction method used was maceration using 70% ethanol. A dose of 2000 mg/kgBW was determined as the starting dose based on the preliminary test result.

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Functional cotton fabric incorporated with antibacterial microcapsules of lime () essential oil (LO) was prepared. The coacervation method, employing two biopolymers of alginate and gelatin as the shells, was preferentially selected to produce the LO microcapsules, whereas immobilization of the LO microcapsules onto the fabric was done using the pad-dry-cure method using various concentrations of citric acid binder. The antibacterial inhibition zone of the functional fabric was subsequently analysed using the Kirby Bauer method.

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Background: is Gram-positive bacteria that contribute to caries. Many antibacterial agents are resistant against bacteria so that the discovery of new antibacterial agents is a crucial issue. Mechanism of antibacterial agents by disrupting cell wall bacteria is a promising target to be developed.

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The present study was intended to prepare and optimize the mucoadhesive buccal patch of gambier leaf extract using chitosan (CH) and tapioca starch (TS) composite as the polymer complexes. The patch formulation was designed based on 2 factorial design in order to optimize the composition of CH and TS. The physical and chemical characteristics of the prepared patches, including mass and thickness uniformity, folding endurance, surface pH, swelling index, percent of elongation, and mucoadhesive time were successfully evaluated.

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Thymic stromal lymphopoietin (TSLP) is known to be associated with allergic diseases. It is also suggested that TSLP has a role in autoimmune diseases such as psoriasis; however, the associated pathways remain unknown. There is currently little information on TSLP in psoriasis vulgaris.

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