Publications by authors named "Heenam Yoon"

Introduction: Recent studies have investigated the autonomic modulation method using closed-loop vibration stimulation (CLVS) as a novel strategy for enhancing sleep quality. This study aimed to explore the effects of CLVS on sleep quality, autonomic regulation, and brain activity in individuals with poor sleep quality.

Methods: Twenty-seven participants with poor sleep quality (Pittsburgh sleep quality index >5) underwent two experimental sessions using polysomnography and a questionnaire, one with CLVS (STIM) and the other without (SHAM).

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Sleep is an essential part of our lives and daily sleep monitoring is crucial for maintaining good health and well-being. Traditionally, the gold standard method for sleep monitoring is polysomnography using various sensors attached to the body; however, it is limited with regards to long-term sleep monitoring in a home environment. Recent advancements in wearable and nearable technology have made it possible to monitor sleep at home.

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Among the various sleep modulation methods for improving sleep, three methods using noninvasive stimulation during sleep have been reviewed and summarized. The first method involves noninvasive direct brain stimulation to induce a current directly in the brain cortex. Electrically or magnetically applied stimulations trigger electrical events such as slow oscillations or sleep spindles, which can also be recorded by an electroencephalogram.

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Various stimulation systems to modulate sleep structure and function have been introduced. However, studies on the time spent in sleep initiation (TSSI) are limited. This study proposes a closed-loop auditory stimulation (CLAS) to gradually modulate respiratory rhythm linked to the autonomic nervous system (ANS) activity directly associated with sleep.

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Vital signs provide important biometric information for managing health and disease, and it is important to monitor them for a long time in a daily home environment. To this end, we developed and evaluated a deep learning framework that estimates the respiration rate (RR) and heart rate (HR) in real time from long-term data measured during sleep using a contactless impulse radio ultrawide-band (IR-UWB) radar. The clutter is removed from the measured radar signal, and the position of the subject is detected using the standard deviation of each radar signal channel.

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Cooperation in the cardiorespiratory system helps maintain internal stability. Various types of system interactions have been investigated; however, the characteristics of the interactions have mostly been studied using data collected in well-defined physiological states, such as sleep. Furthermore, most analyses provided general information about the interaction, making it difficult to quantify how the systems influenced one another.

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This paper proposes a robust method to screen patients with sleep apnea syndrome (SAS) using a single-lead electrocardiogram (ECG). This method consists of minute-by-minute abnormal breathing detection and apnea-hypopnea index (AHI) estimation. Heartbeat interval and ECG-derived respiration (EDR) are calculated using the single-lead ECG and used to train the models, including ResNet18, ResNet34, and ResNet50.

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The increased demand for well-being has fueled interest in sleep. Research in technology for monitoring sleep ranges from sleep efficiency and sleep stage analysis to sleep disorder detection, centering on wearable devices such as fitness bands, and some techniques have been commercialized and are available to consumers. Recently, as interest in digital therapeutics has increased, the field of sleep engineering demands a technology that helps people obtain quality sleep that goes beyond the level of monitoring.

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Background: Narcolepsy is marked by pathologic symptoms including excessive daytime drowsiness and lethargy, even with sufficient nocturnal sleep. There are two types of narcolepsy: type 1 (with cataplexy) and type 2 (without cataplexy). Unlike type 1, for which hypocretin is a biomarker, type 2 narcolepsy has no adequate biomarker to identify the causality of narcoleptic phenomenon.

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This paper presents an automatic algorithm for the detection of respiratory events in patients using electrocardiogram (ECG) and respiratory signals. The proposed method was developed using data of polysomnogram (PSG) and those recorded from a patch-type device. In total, data of 1,285 subjects were used for algorithm development and evaluation.

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Manual scoring of sleep stages from polysomnography (PSG) records is essential to understand the sleep quality and architecture. Since the PSG requires specialized personnel, a lab environment, and uncomfortable sensors, non-contact sleep staging methods based on machine learning techniques have been investigated over the past years. In this study, we propose an attention-based bidirectional long short-term memory (Attention Bi-LSTM) model for automatic sleep stage scoring using an impulse-radio ultra-wideband (IR-UWB) radar which can remotely detect vital signs.

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Background: Environmental crisis challenges the human race harder than ever before. Ecologists have produced a massive amount of data to cope with the crisis. Accordingly, many national scale ecological database systems have been developed worldwide to manage and analyse these datasets.

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Article Synopsis
  • The study explored how aging and Alzheimer’s disease (AD) differently impact sleep patterns and daily activity rhythms in a diverse group of participants aged 20 to 90.
  • While older adults without AD maintained good sleep quality and a regular daily rhythm, preclinical AD showed earlier circadian phases but clinical AD resulted in later rhythms and longer sleep durations.
  • Overall, the research suggests that normal aging promotes a consistent activity rhythm without affecting sleep length, while AD progression alters these patterns, emphasizing the distinct effects of age and disease on sleep.
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Sleep is a unique behavioral state that affects body functions and memory. Although previous studies suggested stimulation methods to enhance sleep, a new method is required that is practical for long-term and unconstrained use by people. In this study, we used a novel closed-loop vibration stimulation method that delivers a stimulus in interaction with the intrinsic heart rhythm and examined the effects of stimulation on sleep and memory.

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Nocturnal pulse oximetry has been proposed as a tool for diagnosing sleep apnea. We established criteria in determining previous occurrences of apnea events by extracting quantitative characteristics caused by apnea events over the duration of changes in blood oxygen saturation values in our previous studies. In addition, the apnea-hypopnea index was estimated by regression modeling.

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Sleep stage scoring is the first step towards quantitative analysis of sleep using polysomnography (PSG) recordings. However, although PSG is a gold standard method for assessing sleep, it is obtrusive and difficult to apply for long-term sleep monitoring. Further, because human experts manually classify sleep stages, it is time-consuming and exhibits inter-rater variability.

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Sleep plays a primary function for health and sustains physical and cognitive performance. Although various stimulation systems for enhancing sleep have been developed, they are difficult to use on a long-term basis. This paper proposes a novel stimulation system and confirms its feasibility for sleep.

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Human physiological systems have a major role in maintenance of internal stability. Previous studies have found that these systems are regulated by various types of interactions associated with physiological homeostasis. However, whether there is any interaction between these systems in different individuals is not well-understood.

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We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI).

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Objective: Cardiorespiratory interactions have been widely investigated in different physiological states and conditions. Various types of coupling characteristics have been observed in the cardiorespiratory system; however, it is difficult to identify and quantify details of their interaction. In this study, we investigate directional coupling of the cardiorespiratory system in different physiological states (sleep stages) and conditions, i.

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Sleep apnea-hypopnea event detection has been widely studied using various biosignals and algorithms. However, most minute-by-minute analysis techniques have difficulty detecting accurate event start/end positions. Furthermore, they require hand-engineered feature extraction and selection processes.

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Objectives: Obstructive sleep apnea (OSA) is a major sleep disorder that causes insufficient sleep, which is linked with daytime fatigue and accidents. Long-term sleep monitoring can provide meaningful information for patients with OSA to prevent and manage their symptoms. Even though various methods have been proposed to objectively measure sleep in ambulatory environments, less reliable information was provided in comparison with standard polysomnography (PSG).

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The objectives of this study are to investigate heart rate variability (HRV) in major depressive disorder patients (MDD) and healthy controls during different sleep stages, and to examine the association of HRV during sleep and depression severity. Polysomnography was recorded from 15 depressive patients with a higher beck depression inventory index (BDI > 25, H-BDI-D), 15 depressive patients with a lower BDI index (BDI ≤ 25, L-BDI-D) and 15 healthy controls. HRV was calculated during the first three rapid eye movements (REM) periods and non-REM stages (i.

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Amyotrophic lateral sclerosis (ALS) patients whose voluntary muscles are paralyzed commonly communicate with the outside world using eye movement. There have been many efforts to support this method of communication by tracking or detecting eye movement. An electrooculogram (EOG), an electro-physiological signal, is generated by eye movements and can be measured with electrodes placed around the eye.

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