The Role of Rapid Maxillary Expansion in the Management of Obstructive Sleep Apnoea: Monitoring Respiratory Parameters-A Systematic Review and Meta-Analysis.

Obstructive sleep apnoea (OSA) is a sleep-related breathing condition that involves the presence of episodic disruptions to the sleeping pattern due to partial or complete airway obstruction. There are a range of treatment options that exist to alleviate the symptoms of this condition including CPAP, mandibular advancement, and maxillary expansion techniques. This systematic review and meta-analysis of published articles aims to determine if rapid maxillary expansion ("RME") is an effective treatment option in the management of OSA, using quantitative parameters of AHI and SpO.

Toward non-clinical validation of fractional flow reserve simulation software: A generic coronary artery geometry.

Medical image-based diagnostic techniques have become increasingly common in the clinic. Estimating fractional flow reserve in coronary stenoses from medical image data is among the most prominent examples. The modeling techniques used in these clinical tools require rigorous experimental validation yet there is currently no standardized, public toolset to help assess model credibility.

Factors Associated with Pediatric Drowning-Associated Lung Injury.

Objective: To identify risk factors for clinically-important drowning-associated lung injury (ciDALI) in children.

Study Design: This was a cross-sectional study of children (0 through18 years) who presented to 32 pediatric emergency departments (EDs) from 2010 through 2017. We reviewed demographics, comorbidities, prehospital data, chest radiographs reports, and ED course from emergency medical services, medical, and fatality records.

Outcome and Cost Evaluation of Hip Fractures in Elderly Patients at a Tertiary Care Hospital in the Caribbean.

Introduction Hip fractures in the elderly are considered one of the most common types of orthopedic injuries, associated with increased morbidity and mortality. The incidence has been increasing over the years, and its management has also caused a significant economic burden for most countries worldwide. This study aimed to determine the outcomes and economic costs associated with hip fractures in elderly patients at a tertiary care institution in Trinidad and Tobago.

Impact of kidney allocation system 250 policy on 1-year graft loss.

A new deceased donor kidney allocation system (KAS250) was implemented in March 2021 that prioritizes recipients within a 250-nautical mile radius of the donor hospital. KAS250 was implemented to reduce geographic disparities in access to kidney transplantation. Studies have shown an increase in cold ischemia time (CIT) after KAS250 implementation but the impact on graft outcomes is unknown.

New Onset Diabetes in Pancreatic Adenocarcinoma Does Not Correlate With Molecular Subtype.

Background And Objectives: Studies show that new onset diabetes mellitus (DM) (NOD) predates the diagnosis of PDAC by up to 2 years. Two tumor-intrinsic molecular subtypes of PDAC that are prognostic and predictive of chemotherapy response have been described and validated. We hypothesize that patients with NOD may have different molecular subtypes and prognoses.

Genetic and allelic heterogeneity in 248 Indians with skeletal dysplasia.

Skeletal dysplasias are a clinically and genetically heterogeneous group of rare disorders. Studies from large cohorts are essential to provide insights into the disease epidemiology, phenotypic spectrum, and mutational profiles. Here we enumerate additional 248 Indians from 197 families with a skeletal dysplasia, following a similar study earlier.

Imperatorin, a natural furanocoumarin alleviates chronic neuropathic pain by targeting GABAergic tone in an animal model of spinal cord injury.

Chronic neuropathic pain (CNP) caused by spinal cord injury (SCI) has long-term implications, that result in functional deficit. In this study, we explored imperatorin, a natural furanocoumarin isolated from the dried pulp of L. Imperatorin (10 mg/kg, i.

Qualitative study on the influence of mealtime screen exposure on children's feeding practices: perspectives from paediatricians and speech-language pathologists in Chennai, Tamil Nadu.

Objective: This qualitative research study investigates perspectives on the influence of mealtime screen exposure (MTSE) on feeding practices in children through semi-structured interviews with paediatricians and speech-language pathologists (SLPs).

Design: This study used a constructivist paradigm and a qualitative research approach, employing thematic analysis, to understand the research objectives from the lens of practitioners. The researchers used transcripts from semistructured interviews to generate themes.

K channel-dependent electrical signaling links capillary pericytes to arterioles during neurovascular coupling.

The brain has evolved mechanisms to dynamically modify blood flow, enabling the timely delivery of energy substrates in response to local metabolic demands. Several such neurovascular coupling (NVC) mechanisms have been identified, but the vascular signal transduction and transmission mechanisms that enable dilation of penetrating arterioles (PAs) remote from sites of increased neuronal activity are unclear. Given the exponential relationship between vessel diameter and blood flow, tight control of arteriole membrane potential and diameter is a crucial aspect of NVC.

Modeling Heterogeneous Catalysis Using Quantum Computers: An Academic and Industry Perspective.

Heterogeneous catalysis plays a critical role in many industrial processes, including the production of fuels, chemicals, and pharmaceuticals, and research to improve current catalytic processes is important to make the chemical industry more sustainable. Despite its importance, the challenge of identifying optimal catalysts with the required activity and selectivity persists, demanding a detailed understanding of the complex interactions between catalysts and reactants at various length and time scales. Density functional theory (DFT) has been the workhorse in modeling heterogeneous catalysis for more than three decades.

Determination of MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.

Defining the substrates of Resistance-Nodulation-Division (RND) systems is often complicated by the presence of multiple systems in a single bacterial species. Using a major efflux knockout strain, we developed a system that enables controlled expression of MexXY-OprM in the absence of background efflux complexes with overlapping substrate profiles. This system identified three groups of potential substrates: substrates, partial substrates, and nonsubstrates, and defined trimethoprim as a new substrate for MexXY-OprM.

Diagnosis and Management of Orthopaedic Conditions Associated With Hereditary Sensory Autonomic Neuropathies.

Hereditary sensory and autonomic neuropathies (HSANs) encompass a diverse group of inherited neuropathies characterized by notable sensory and autonomic involvement that affects musculoskeletal structures and systemic function. There are 8 recognized types of HSAN. The orthopaedic manifestations of HSAN are complex and diverse, including spinal deformity, Charcot arthropathy, osteomyelitis, fractures, osteonecrosis, osteoporosis, and skeletal deformities.

Managing multisystem parechovirus infection in a neonate - an experience from rural Australia.

Human parechovirus (HPeV) infections in neonates and infants have been linked to outbreaks in regions including Australia, Northern Europe, and the US, resulting in long-term neurological complications. HPeV symptoms range from mild gastroenteritis and respiratory issues to severe systemic illness, including seizures and neurological damage. Human parechovirus type 3 (HPeV3) has emerged as a significant cause of sepsis-like illness in infants aged less than 3 months.

Improving current understanding of cognitive impairment in patients with a spinal cord injury: A UK-based clinician survey.

Context: Emerging data suggests that patients with a spinal cord injury (SCI) have a higher risk of developing cognitive impairment. The true incidence of cognitive impairment in this group is unclear due to the difficulty in administering commonly used assessment tools, which are dependent on functional abilities e.g.

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.

Background: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.

Role of crosslinkers in advancing chitosan-based biocomposite scaffolds for bone tissue engineering: A comprehensive review.

Bone tissue engineering (BTE) aims to repair and regenerate damaged bone tissue by combining cells, scaffolds, and signaling molecules. Various macromolecules, including natural polymers like chitosan (CS), collagen, hyaluronic acid, and alginate, as well as synthetic polymers such as polyethylene glycol and polylactic acid, are used in scaffold fabrication. Among these, CS holds significant potential in BTE due to its biocompatibility, biodegradability, and other features.

A View on the Emerging Concern of Oropouche Fever in Brazil and Its Diagnosis.

Oropouche fever has gained prominence due to its outbreaks and health consequences, particularly in Latin American countries. In addition to the more common symptoms of fever and nausea, Oropouche has been reported to cause neurological and gastrointestinal problems. However, Oropouche remains a neglected disease that needs improved detection methods.

Transmission dynamics of fractional order SVEIR model for African swine fever virus with optimal control analysis.

Understanding the dynamics of the African swine fever virus during periods of intense replication is critical for effective combatting of the rapid spread. In our research, we have developed a fractional-order SVEIR model using the Caputo derivatives to investigate this behaviour. We have established the existence and uniqueness of the solution through fixed point theory and determined the basic reproduction number using the next-generation matrix method.

The Role of Artificial Intelligence in Accelerating Vaccine Development: Challenges and Opportunities in Pandemic Preparedness.

Artificial intelligence (AI) has been studied and applied to medicines and vaccine development. However, there is still a need to understand the processes used and improve them. With this letter, we draw attention to AI use as a tool in vaccine production, supporting scientists and enabling optimization in this process.