Elevated Lipid Concentrations in Seminal Plasma Can Reduce Sperm Motility in Simmental Bulls.

Sperm motility is a key factor influencing male fertility and is associated with metabolic and lipid profiles across species. The aim of this study was to investigate the relationship between sperm motility and the seminal plasma lipid profile in Simmental bulls, and to identify key lipids potentially influencing sperm motility. Semen samples were collected from 26 healthy Simmental bulls with an average age of 4.

The Moral Psychological Justification of Anger: An Exploration of Self-Respect and Recognition.

In the field of moral psychology, traditional perspectives often evaluate anger based on its consequences, either validating or condemning it for its perceived benefits or harms. This paper argues for a shift in focus from the outcomes of anger to its moral and psychological foundations. By integrating insights from psychological research, this study posits that the fundamental nature of anger is intrinsically linked to the quest for recognition.

SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.

Purpose: Targeting mitochondrial ferroptosis presents a promising strategy for mitigating myocardial ischemia-reperfusion (I/R) injury. This study aims to evaluate the efficacy of the mitochondrial-targeted ferroptosis inhibitor SS-31@Fer-1 (elamipretide@ferrostatin1) in reducing myocardial I/R injury.

Methods: SS-31@Fer-1 was synthesized and applied to H9C2 cells subjected to hypoxia/reoxygenation (H/R) to assess its protective effects.

BTG3 inhibits porcine epidemic diarrhea virus replication by promoting viral S2 protein degradation through the autophagy and proteasome pathways.

BTG3, which belongs to the BTG/Tob gene family, is involved in various physiological processes. Infection with porcine epidemic diarrhea virus (PEDV), an alphacoronavirus, is associated with high mortality rates among piglets, contributing to major economic losses. This study elucidated a novel mechanism through which BTG3 suppresses PEDV replication.

RNASEK interacting with PEDV structural proteins facilitates virus entry via clathrin-mediated endocytosis.

Porcine epidemic diarrhea virus (PEDV), as a type of Alphacoronavirus causing acute diarrhea and high death rate among sucking piglets, poses great financial damage to the swine industry. Nevertheless, the molecular mechanism whereby PEDV enters host cells is unclear, limiting the development of PED vaccines and anti-PEDV agents. The present study found that the host protein ribonuclease kappa (RNASEK) was regulated by USF2, a transcription factor, and facilitated the PEDV replication.

The ant that may well destroy a whole dam: a systematic review of the health implication of nanoplastics/microplastics through gut microbiota.

Since the widespread usage of plastic materials and inadequate handling of plastic debris, nanoplastics (NPs) and microplastics (MPs) have become global hazards. Recent studies prove that NPs/MPs can induce various toxicities in organisms, with these adverse effects closely related to gut microbiota changes. This review thoroughly summarized the interactions between NPs/MPs and gut microbiota in various hosts, speculated on the potential factors affecting these interactions, and outlined the impacts on hosts' health caused by NPs/MPs exposure and gut microbiota dysbiosis.

Genotypic and phenotypic characteristics of ADGRV1 mutations in four children and functional validation in a zebrafish model.

Mutations in ADGRV1 can cause seizures, but the mechanism remains unclear. The zebrafish model can be used to assess the functions of human ADGRV1 and its variant alleles during embryonic development. In this study, we summarized the phenotypic and genotypic characteristics of four children with ADGRV1 variation and based on this, we validated the ADGRV1 loss phenotype in an adgrv1-knockout zebrafish model.

Identification of novel xanthine oxidase inhibitory peptides from Takifugu obscurus: Peptidomic analysis, molecular docking, and dynamics simulation.

Hyperuricemia, caused by abnormal purine metabolism, is commonly treated with xanthine oxidase (XOD) inhibitors, uricosuric, and dietary adjustments. Recently, marine-derived bioactive peptides have gained attention as potential functional food ingredients due to their therapeutic potential. Takifugu obscurus, an economically significant offshore fish rich in crude proteins was explored in this study as a source of XOD inhibitory peptides.

A spherical vector-based adaptive evolutionary particle swarm optimization for UAV path planning under threat conditions.

Unmanned aerial vehicle (UAV) path planning is a constrained multi-objective optimization problem. With the increasing scale of UAV applications, finding an efficient and safe path in complex real-world environments is crucial. However, existing particle swarm optimization (PSO) algorithms struggle with these problems as they fail to consider UAV dynamics, resulting in many infeasible solutions and poor convergence to optimal solutions.

The healthy eating index may not be an appropriate indicator for assessing dietary quality in breast cancer survivors: results from NHANES 2005-2018.

Background: Evidence on the relationship between the Healthy Eating Index (HEI) and mortality in breast cancer (BC) survivors remains inconclusive. Moreover, rare studies have explored the effect of individual HEI components on survival in this population. This study explored the association between the HEI-2020, including total and 13 component scores, and mortality in BC survivors.

Relational Victimization, Coping Styles and Depressive Symptoms: A Test of Bidirectional Associations in Adolescence.

Although evidence from previous studies suggests that adolescents with negative coping styles who experienced victimization are more likely to exhibit depressive symptoms, these associations have not yet been disentangled to separate between-person differences from within-person effects. To investigate the within-person bidirectional relationships among relational victimization, coping styles and depressive symptoms, this study conducted a four-wave random intercept cross-lagged panel model analysis. The final sample consisted of 1506 adolescents, 72.

SchNet_IIA: Potential Energy Surface Fitting by Interatomic Interactions Attention Based on Transfer Learning Analysis.

Machine learning methods for fitting potential energy surfaces and molecular dynamics simulations are becoming increasingly popular due to their potentially high accuracy and savings in computational resources. However, existing application models often rely on basic architectures like artificial neural networks (ANNs) and multilayer perceptron (MLP), lagging behind cutting-edge technologies in the machine learning domain. Furthermore, the complexity of current machine learning frameworks leads to reduced interpretability and challenges for improvement.

Summer heatwave, ozone pollution and ischemic stroke mortality: An individual-level case-crossover study.

Background: Although the association of short-term ozone and heatwave exposure with cerebrovascular disease has been well documented, it remains largely unknown whether their co-exposure could synergistically trigger ischemic stroke (IS) mortality.

Methods: We performed an individual-level, time-stratified case-crossover analysis utilizing province-wide IS deaths (n = 59079) in warm seasons (May-September) during 2016-2019, across Jiangsu, eastern China. Heatwave was defined according to a combination of multiple temperature thresholds (90-97.

Insights into the zearalenone degradation performance and pathway by Gordonia hydrophobica HAU421 and characterization of a novel lactonohydrolase involved.

Zearalenone (ZEN) is a harmful macrolide mycotoxin, posing a serious hazard to human health. In this study, a highly efficient ZEN-degrading bacterium Gordonia hydrophobica HAU421 was isolated from soil by using spiramycin (SPM)-containing selective medium. Mass spectrometry analysis revealed that strain HAU421 could transform ZEN into hydrolyzed zearalenone (HZEN), zearalenol (ZEL), and hydrolyzed zearalenol (HZEL).

Hidden domain boundary dynamics toward crystalline perfection.

A central paradigm of nonequilibrium physics concerns the dynamics of heterogeneity and disorder, impacting processes ranging from the behavior of glasses to the emergent functionality of active matter. Understanding these complex mesoscopic systems requires probing the microscopic trajectories associated with irreversible processes, the role of fluctuations and entropy growth, and the timescales on which nonequilibrium responses are ultimately maintained. Approaches that illuminate these processes in model systems may enable a more general understanding of other heterogeneous nonequilibrium phenomena, and potentially define ultimate speed and energy cost limits for information processing technologies.

Effect of TiO Coating on Structure and Electrochemical Performance of LiNiCoMnO Cathode Material for Lithium-Ion Batteries.

High-nickel ternary LiNiCoMnO (NCM622) is a promising cathode material for lithium-ion batteries due to its high discharge-specific capacity and energy density. However, problems of NCM622 materials, such as unstable surface structure, lithium-nickel co-segregation, and intergranular cracking, led to a decrease in the cycling performance of the material and an inability to fully utilize high specific capacity. Surface coating was the primary approach to address these problems.

dFCExpert: Learning Dynamic Functional Connectivity Patterns with Modularity and State Experts.

Characterizing brain dynamic functional connectivity (dFC) patterns from functional Magnetic Resonance Imaging (fMRI) data is of paramount importance in neuroscience and medicine. Recently, many graph neural network (GNN) models, combined with transformers or recurrent neural networks (RNNs), have shown great potential for modeling the dFC patterns. However, these methods face challenges in effectively characterizing the modularity organization of brain networks and capturing varying dFC state patterns.

[The Factors Related to Treatment Failure in Children with Acute Lymphoblastic leukemia--Analysis of Multi-Center Data from Real World in Fujian Province].

Objective: To analyze the related factors of treatment failure in children with acute lymphoblastic leukemia (ALL) in real-world.

Methods: The clinical data of 1414 newly diagnosed children with ALL admitted to five hospital in Fujian province from April 2011 to December 2020 were retrospectively analyzed. Treatment failure was defined as relapse, non-relapse death, and secondary tumor.

Superconductivity in an ultrathin multilayer nickelate.

We report the appearance of superconductivity in single-unit-cell NdNiO, exhibiting a transition temperature similar to that of thicker films. In situ synchrotron x-ray scattering performed during growth of the parent phase, NdNiO, shows that the necessary layer-by-layer deposition sequence does not follow the sequence of the formula unit but an alternate order due to the relative stability of the perovskite unit cell. We exploit this insight to grow ultrathin NdNiO heterostructures and conduct in situ studies of topotactic reduction, finding that formation of the square-planar phase occurs rapidly and is highly sensitive to reduction temperature, with small deviations from the optimum condition leading to inhomogeneity and the loss of superconductivity.

Response of ZmPHO1 family members to low phosphorus stress and association of natural variation in ZmPHO1;2a reveal the role of low phosphorus tolerance.

Phosphorus (Pi) is an essential nutrient for plants to sustain normal life processes. In this study, we found that the ZmPHO1 proteins had similar molecular weights and the same conserved domain. Phylogenetic and cis-acting element analysis showed that ZmPHO1s were divided into 4 subgroups, in which ZmPHO1;2a and ZmPHO1;2b were closely phylogenetic with OsPHO1;2b, and the promoter region of ZmPHO1s contained abundant abiotic stress-related elements.

Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study.

Aims: This study examined the association of gravida C-peptide with progeny islet function and insulin sensitivity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS).

Methods: Pregnancy 3rd trimester oral glucose tolerance test (OGTT), cord blood, and offspring OGTT glucose, C-peptide and insulin at age 10-14 years were analyzed for 4,121 mother-child dyads. Gravida fasting and 1-hour C-peptide concentration correlations with cord blood and childhood C-peptide, insulin, insulinogenic index and insulin sensitivity, and insulin resistance [HOMA-IR]), were assessed by multiple linear regression.

SegCSR: Weakly-Supervised Cortical Surfaces Reconstruction from Brain Ribbon Segmentations.

Deep learning-based cortical surface reconstruction (CSR) methods heavily rely on pseudo ground truth (pGT) generated by conventional CSR pipelines as supervision, leading to dataset-specific challenges and lengthy training data preparation. We propose a new approach for reconstructing multiple cortical surfaces using from brain MRI ribbon segmentations. Our approach initializes a midthickness surface and then deforms it inward and outward to form the inner (white matter) and outer (pial) cortical surfaces, respectively, by jointly learning diffeomorphic flows to align the surfaces with the boundaries of the cortical ribbon segmentation maps.

Enantioselective disruption of circadian rhythm behavior in goldfish (Carassius auratus) induced by chiral fungicide triadimefon at environmentally-relevant concentration.

The pollution of triadimefon (TDF) fungicides significantly hinders the "One Health" frame achievement. However, the enantioselective effects of chiral TDF on the circadian rhythm of fish remained unclear. Herein, TDF enantiomers (R(-)-TDF and S(+)-TDF) and racemic Rac-TDF were selected to investigate their enantioselective effects and mechanisms on circadian rhythm of goldfish (Carassius auratus) at an environmentally-relevant concentration (100 µg L⁻¹).