Tardigrade Dsup: Interactions with DNA and protection of cells from oxidative stress.

The remarkable capability of Tardigrade to survive under extreme conditions has been partially attributed to Dsup, an intrinsically disordered, highly positively charged protein. Dsup has been shown to bind to DNA in vitro, a property that has been associated with the capability of Dsup to exhibit stress-protective effects when expressed in mammalian cells. However, DNA binding of Dsup has not been visualized in living cells and expression of Dsup in different cell types was associated with either protective or detrimental effects.

[Research progress of mechanism of acupuncture and moxibustion on prevention and treatment of Alzheimer's disease based on the neuronal cell cycle re-entry].

Alzheimer's disease (AD) is the most common type of dementia. Studies have shown that neuronal cell cycle re-entry is an abnormal change in the early stage of AD, and it is also one of the key reasons for mediating neuronal death. The mechanism of acupuncture and moxibustion in treating AD may be related to the regulation of abnormal cell cycle.

A visual electrochemiluminescence sensor based on the combination of distance-readout strategy and nanozymes catalyzing precipitation.

Background: Nanozyme is a kind of biomimetic enzyme with unique properties and catalytic function of nanomaterials. Various nanozymes have been applied in the development of visual biosensors because of its excellent stability and availability. Nevertheless, the current applications of nanozymes primarily focus on colorimetric sensing based on color changes, which is susceptible to external factors interference including sample solution color and ambient light.

Non-destructive determination of ginsenosides in ginseng by combined hyperspectral and X-ray techniques based on ensemble learning.

The potential of hyperspectral imaging and X-ray techniques for the non-destructive determination of the ginsenosides Rg1 + Re and Rb1 in ginseng was investigated. The random forest (RF) models were established using spectral information extracted from hyperspectral data to predict ginsenosides content. The RF model was optimized by data pre-processing methods and feature screening methods.

Dapagliflozin suppressed gastric cancer growth via regulating OTUD5 mediated YAP1 deubiquitination.

Gastric cancer (GC) is a common malignant disease that has a fifth highest incidence and fourth highest mortality worldwide. The Warburg effect is a common phenomenon observed in tumors, which suggests that tumor cells would enhance glucose uptake by overexpressing multiple glucose transporters. Sodium glucose transporter 2 (SGLT2) is one of glucose transporters which highly expressed in several cancers, but its role in gastric cancer is still unclear.

Exogenous strigolactone alleviates post-waterlogging stress in grapevine.

With global climate change, the frequent occurrence of intense rainfall and aggravation of waterlogging disasters have severely threatened the plant growth and fruit quality of grapevines, which are commercially important fruit crops worldwide. There is accordingly an imperative to clarify the responses of grapevine to waterlogging and to propose appropriate remedial measures. Strigolactone (SL) is a phytohormone associated with plant abiotic stress tolerance, while, its function in plant responses to waterlogging stress remain undetermined.

Synthesis and Antifungal Evaluation of Cinnamic Acid-Geraniol Hybrids as Potential Fungicides.

Cinnamic acid and geraniol are two well-known antifungal natural products and widely applied in food and cosmetics industries. To discover novel natural product-based fungicide candidates with more potent activity and good ecological compatibility for the management of plant diseases, a series of cinnamic acid-geraniol hybrids were prepared by means of molecular hybridization and their chemical structures were well confirmed by spectral analysis. The antifungal activities of the target compounds against three phytopathogenic fungi Fusarium graminearum, Gaeumannomyces graminis (Sacc.

Enhanced cellular longevity arising from environmental fluctuations.

Cellular longevity is regulated by both genetic and environmental factors. However, the interactions of these factors in the context of aging remain largely unclear. Here, we formulate a mathematical model for dynamic glucose modulation of a core gene circuit in yeast aging, which not only guided the design of pro-longevity interventions but also revealed the theoretical principles underlying these interventions.

Rapid and non-destructive identification of Panax ginseng origins using hyperspectral imaging, visible light imaging, and X-ray imaging combined with multi-source data fusion strategies.

The geographical origin of Panax ginseng significantly influences its nutritional value and chemical composition, which in turn affects its market price. Traditional methods for analyzing these differences are often time-consuming and require substantial quantities of reagents, rendering them inefficient. Therefore, hyperspectral imaging (HSI) in conjunction with X-ray technology were used for the swift and non-destructive traceability of Panax ginseng origin.

Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome.

Melanoma showcases a complex interplay of genetic alterations and intra- and inter-cellular morphological changes during metastatic transformation. While pivotal, the role of specific mutations in dictating these changes still needs to be fully elucidated. Telomerase promoter mutations (TERTp mutations) significantly influence melanoma's progression, invasiveness, and resistance to various emerging treatments, including chemical inhibitors, telomerase inhibitors, targeted therapy, and immunotherapies.

A Piezoelectric Nanogenerator-Driven Dual-Mode Platform for Visualization and Impedance Sensing.

Traditional visual biosensing platforms rely on color to display detection results, which can be influenced by individual visual abilities, equipment, parameters, and lighting conditions during photo capture. This limitation significantly impedes the advancement of next-generation portable electrochemical biosensors. Therefore, we propose a visual biosensing device that utilizes distance as an indicator, enabling the facile determination of the length of discoloration, which is inversely proportional to the concentration of the target analyte.

Real-world evidence of a novel tetravalent immunoglobulin Y effectiveness and safety in patients with the refractory Helicobacter pylori infection.

Background: Refractory Helicobacter pylori (H. pylori) infection inevitably increase the difficulty of drug selection. Here, we described our experience with the use of a novel tetravalent IgY against H.

Direct and specific detection of methyl-paraoxon using a highly sensitive fluorescence strategy combined with phosphatase-like nanozyme and molecularly imprinted polymer.

Methyl paraoxon (MP) is a highly toxic, efficient and broad-spectrum organophosphorus pesticide, which poses significant risks to ecological environment and human health. Many detection methods for MP are based on the enzyme catalytic or inhibition effect. But natural biological enzymes are relatively expensive and easy to be inactivated with a short service life.

Data fusion of near-infrared and mid-infrared spectroscopy for rapid origin identification and quality evaluation of Lonicerae japonicae flos.

A data fusion strategy based on near-infrared (NIR) and mid-infrared (MIR) spectroscopy techniques were developed for rapid origin identification and quality evaluation of Lonicerae japonicae flos (LJF). A high-level data fusion for origin identification was formed using the soft voting method. This data fusion model achieved accuracy, log-loss value and Kappa value of 95.

A potential-controlled electrochromic visual biosensor based on distance readout for zearalenone detection.

In this work, a potential-controlled electrochromic visual biosensor was developed for detecting zearalenone (ZEN) using a distance readout strategy. The sensor chip includes a square detection area and a folded signal output area created with laser etching technology. The detection area is modified with graphene oxide and ZEN aptamer, while Prussian blue (PB) is electrodeposited onto the signal output channel.

Uncertainty Quantification and Interpretability for Clinical Trial Approval Prediction.

Clinical trial is a crucial step in the development of a new therapy (e.g., medication) and is remarkably expensive and time-consuming.

High Value-Added Application of Natural Products in Crop Protection: Discovery and Exploration of Caffeoyl and Flavonoid Derivatives from DC. as Novel Insecticide Candidates.

Nine caffeoyl derivatives (), including two new dicaffeoyl glycosides, brevicaudatosides A and B ( and ), and six flavonoids (), were identified from overground DC. Compounds and exhibited significant oral toxicities against Harris with LC (half-lethal concentration) values of 0.12 and 0.

A perovskite-based electrochemiluminescence aptasensor for tetracycline screening.

Tetracyclines are currently the most commonly used class of antibiotics, and their residue issue significantly impacts public health safety. In this study, a surface modification of perovskite with cetyltrimethylammonium bromide led to the generation of stable electrochemiluminescence (ECL) emitters in aqueous systems and improved the biocompatibility of perovskite. A perovskite quantum dot-based ECL sensing strategy was developed.

Discovery of New Botanical Insecticides: Identification and Insecticidal Activity of Saponins from Maxim and Insights into the Stress Response of Harris.

To discover new botanical products-based insecticide candidates, 14 triterpenoid saponins (-) including four new ones, obscurosides A-D (-), were isolated from Maxim as potential agrochemicals against Harris and (L.). Compounds - were characterized by a rare ribose substitution at C-3, and was a bidesmoside glycosylated at the rare C-23 and C-28 positions of the oleanane aglycone.

Mesenchymal stem cell-derived extracellular vesicles: A novel promising neuroprotective agent for Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive loss of neurons in the brain. However, there are no effective drugs for AD. Mesenchymal stem cell-derived extracellular vesicles (MSCs-EVs), as a new mediator of intercellular communication, are associated with low immunogenicity, low risk of tumor formation, and good safety profile.