Pathogenic survivals were dramatically affected by Fe and Mn under freeze-thaw (FT), and the dissolutions of manganese and iron oxides (MIOs) were also accelerated under FT. But the mutual influences of pathogenic bacterial survival and MIOs under FT have not been profoundly explored yet. In this work, aqueous systems containing Escherichia coli as well as synthetic ferrihydrite (Fh) and manganese dioxide (MnO) were experimented under simulated FT cycles to study the mutual influences of metal oxides and bacteria survival while oxide dissolutions and appearances, bacterial morphology and activities (survival number, cell surface hydrophobicity (CSH) and superoxide dismutase (SOD)) were obtained.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate the potential utility of [Ga]Ga-FAPI-04 PET/CT for diagnosing primary and metastatic lesions in patients with liver cancer, as well as to compare it with contrast-enhanced CT (CE-CT), liver MRI, and [F]-FDG PET/CT.
Methods: We performed a single-center post hoc retrospective analysis of data obtained from a prospective parent study (NCT04416165). This study included 34 patients diagnosed with or suspected hepatic lesions who underwent concomitant [Ga]Ga-FAPI-04 and [F]-FDG/CT scans.
CRSP8 plays an important role in recruiting mediators to genes through direct interaction with various DNA-bound transactivators. In this study, we uncovered the unique function of CRSP8 in suppressing thyroid cancer differentiation and promoting thyroid cancer progression via targeting IKKα signaling. CRSP8 was highly expressed in human thyroid cancer cells and tissues, especially in anaplastic thyroid cancer (ATC).
View Article and Find Full Text PDFDoxycycline (DOX) is a key antimalarial drug thought to kill parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1-3 µM serum concentrations. DOX concentrations > 5 µM kill parasites with first-cycle activity but are thought to involve off-target mechanisms outside the apicoplast.
View Article and Find Full Text PDFTher Adv Psychopharmacol
October 2020
Compared with other inhaled anaesthetics, sevoflurane has a faster onset and offset, causes less irritation to the mucous membranes, and has a better safety profile. These characteristics warrant investigating the effect of sevoflurane in depression. In this Case Report, we describe that sevoflurane treatment was feasible and well tolerated by a patient with treatment-resistant depression (TRD).
View Article and Find Full Text PDFOur previous studies have reported that RFPL3 protein exerts its unique function as a transcriptional factor of hTERT promoter after being transported into the lung cancer cell nucleus. However, the detailed mechanism by which RFPL3 undergoes nuclear transport has not been reported yet. Here, we identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
View Article and Find Full Text PDFBackground: To quantitatively evaluate the contribution of plant roots to soil shear strength, the generalized equivalent confining pressure (GECP), which is the difference in confining pressure between the reinforced and un-reinforced soil specimens at the same shear strength, was proposed and considered in terms of the function of plant roots in soil reinforcement.
Methods: In this paper, silt loam soil was selected as the test soil, and the roots of were chosen as the reinforcing material. Different drainage conditions (consolidation drained (CD), consolidation undrained (CU), and unconsolidated undrained (UU)) were used to analyse the influences of different root distribution patterns (horizontal root (HR), vertical root (VR), and complex root (CR)) and root contents (0.
Background And Objectives: The 57 countries of the Organisation of Islamic Cooperation (OIC) are experiencing rapid increases in their burden of cancer. The First Ladies Against Cancer meeting at the 2016 OIC meeting in Istanbul committed to the importance of cancer control and the need for more evidence to support national cancer control planning (NCCP). Strong research systems are a crucial aspect of NCCP, but few data exist to support policy-makers across this political grouping.
View Article and Find Full Text PDFCancer Biother Radiopharm
October 2023
This study investigated irinotecan loading efficiency and release profiles of CalliSpheres . CalliSpheres with size of 50-150, 100-300, and 300-500 μm and irinotecan at different amounts (20, 40, 80, and 100 mg) and concentrations (5 and 10 mg/mL) were prepared for experiments. Dynamic light scattering and Agilent 1260 high-performance liquid chromatography system were used to quantify bead diameters and the efficiency of irinotecan loading and releasing properties, respectively.
View Article and Find Full Text PDFJ Pain Symptom Manage
March 2021
Context: There is rapidly increasing need for palliative care in Greater China because of rapidly aging populations.
Objectives: This study aimed to systematically review and appraise evidence for palliative care needs, models of care, interventions, and outcomes in Greater China.
Methods: Four databases (MEDLINE, EMBASE, CINAHL, and PsycINFO) were searched, with hand searching of local journals and databases.
Third-hand smoke (THS) is composed of surface-deposited remnants resulting from tabacco-smoking. Because THS components have properties of remaining on, re-emitting from and reacting on and with surfaces, in-situ analysis of the components on different surfaces is both in high demand and challenging. The aim of this study is to establish desorption corona beam ionization (DCBI)-MS/MS as an analytical tool for THS research.
View Article and Find Full Text PDFIt is extremely challenging to design photocontrolled molecular switches with absorption and fluorescence dual-mode outputs that are suited for a solid surface and interface. Herein, we report a group of furan-containing tetraarylethene derivatives with unique photophysical behavior of aggregation-induced emission (AIE) and distinct photochemical reaction-triggered photochromic behaviors by combining a photoactive furan or benzofuran group and an AIE-active triphenylethene molecule. The introduction of a furyl or benzofuryl group into the AIE luminogen endows the molecules with significant reversible photochromism and solid-state fluorescence.
View Article and Find Full Text PDFDNA-scaffolded silver nanoclusters (DNA/AgNC) probes are widely used to detect microRNAs (miRNAs) for diagnosing diseases. However, current available DNA/AgNC probes, which primarily based on fluorescence quenching (turn-off) method, suffer from low detection accuracy caused by bio-matrix interferences. Herein, we designed a new DNA/AgNC-cDNA probe to detect miRNA based on a fluorescence enhancing (turn-on) strategy.
View Article and Find Full Text PDFIn this study, the welded joints of dissimilar titanium alloys Ti600/Ti-22Al-25Nb were strengthened by isothermal forging. Different deformation parameters, including temperature, deformation speed, and reduction, were chosen. By isothermal forging, the original coarse dendritic grains of the welded joints were broken up effectively to form a large number of equiaxed grains.
View Article and Find Full Text PDFNon‑coding RNAs, including long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs), have significant regulatory effects on a number of biological processes in myocardial ischemia/reperfusion (I/R) injury, including cell differentiation, proliferation and apoptosis. In the present study, the expression levels of lncRNAs, miRNAs and mRNAs were evaluated in a mouse model of myocardial I/R injury. The potential functions of these differentially expressed genes were then analyzed via Gene Ontology and pathway analyses.
View Article and Find Full Text PDFAuris Nasus Larynx
December 2021
Objective: Pulsatile tinnitus (PT) caused by an aberrant artery is rare. We report an unprecedented cause of PT resulting from an aberrant artery coursing the mastoid surface, and qualitatively discuss the pathophysiology of PT.
Methods: This case study reports a 41-year-old woman who presented with persistent PT at her right retromastoid region.
Mol Ther Methods Clin Dev
September 2020
Physical titers for recombinant adeno-associated viral (rAAV) vectors are measured by quantifying viral genomes. It is generally perceived that AAV virions disassemble and release DNA upon thermal treatment. Here, we present data on enzymatic accessibility of rAAV genomes when AAV virions were subjected to thermal treatment.
View Article and Find Full Text PDFBackground: Care for people with progressive illness should be person centered and account for their cultural values and spiritual beliefs. There are an estimated 1.7 billion Muslims worldwide, largely living in low-income and middle-income countries.
View Article and Find Full Text PDFBackground And Aims: To identify the regulatory role of protein phosphatase 2A (PP2A) in the development of liver disease, we generated a mouse model with hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit).
Approach And Results: Homozygote (HO) mice and matched wild-type littermates were investigated at 3, 6, 9, 12, 15, and 18 months of age. Pathological examination showed that PP2A Aα deficiency in hepatocytes resulted in progressive liver fibrosis phenotype from 9 months of age.
PD-L1 is overexpressed in tumor cells and contributes to cancer immunoevasion. However, the role of the tumor cell-intrinsic PD-L1 in cancers remains unknown. Here we show that PD-L1 regulates lung cancer growth and progression by targeting the WIP and β-catenin signaling.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
October 2020
The booming construction industry has led to many environmental and occupational health and safety problems. Construction dust caused irreversible damage to the health of frontline workers and polluted the surrounding air environment, which has attracted the attention of researchers and practitioners. In this study, to systematically sort and analyze the distribution of construction dust (CD) research, its hot areas, and the evolution of its fronts, papers with "construction dust" as the subject term in the Web of Science Core Collection Database since 2010 are visually analyzed using CiteSpace.
View Article and Find Full Text PDFY-box binding protein 1 (YBX1) is involved in the development of multiple types of tumors. However, the relationship between YBX1 and autophagy in non-small cell lung cancer (NSCLC) remains unclear. In this study, we analyzed the expression and clinical significance of YBX1 and markers of autophagy (LC3I/II) in NSCLC and examined their roles in regulating sensitivity to cisplatin in NSCLC.
View Article and Find Full Text PDFLermoyez syndrome (LS) is a rare auditory disorder, the details of LS remain unclear. To investigate the grades of endolymphatic hydrops (ELH) and clinical characteristics of clinically diagnosed LS. Nine patients with clinically diagnosed LS were included.
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