Environmental factors ultraviolet a and ozone exacerbate the repeated inhalation toxicity of 6PPD in mice via accelerating the aging reaction.

The burden of N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidized products on human health can no longer be ignored due to the detection types and concentrations in the environment continue to increase. Environmental ozone (O) and ultraviolet A (UVA) may induce ozonation and photoaging of 6PPD to produce toxic products. However, the impact of specific environmental conditions on the aging and toxic effects of 6PPD is unclear.

Unpacking greenwashing: The impact of environmental attitude, proactive strategies, and network embeddedness on corporate environmental performance.

Though there are considerable attention given to the consequences of greenwashing, however companies efforts to reduce greenwashing is still underexplored. Beside mounting pressures of stakeholders asking firms to revise their environmental orientation in order to reduce perceived greenwashing. Hence, the purpose of current study is to examine the impact of firms' environmental attitude, proactive environmental strategy, and network embeddedness on corporate environmental performance through perceived greenwashing.

Study of conveyor belt deviation detection based on improved YOLOv8 algorithm.

Conveyor belt deviation is a commmon and severe type of fault in belt conveyor systems, often resulting in significant economic losses and potential environment pollution. Traditional detection methods have obvious limitations in fault localization precision and analysis accuracy, unable to meet the demands of efficient and real-time fault detection in complex industrial scenarios. To address these issues, this paper proposes an improved detection algorithm based on YOLOv8, aiming to achieve efficient and accurate detection during the operation of the belt.

Study on the Impact of Porous Media on Condensate Gas Depletion: A Case Study of Reservoir in Xihu Sag.

During the depletion and pressure reduction process in condensate gas reservoirs, the precipitation of condensate oil transforms the single-phase gas flow into a two-phase gas-liquid flow, significantly reducing the permeability. Currently, microscopic studies of the phase behavior of condensate gas in porous media mainly focus on observing and describing the occurrence of condensate oil, lacking quantitative calculations and direct observations of condensate oil throughout the entire depletion cycle. This paper uses a microvisualization method to simulate the depletion process of condensate gas reservoirs.

Genomics-driven integrative analysis highlights immune-related plasma proteins for psychiatric disorders.

Background: Genome-wide association studies (GWAS) have identified numerous variants associated with psychiatric disorders. However, it remains largely unknown on how GWAS risk variants contribute to psychiatric disorders.

Methods: Through integrating two largest, publicly available, independent protein quantitative trait loci datasets of plasma protein and nine large-scale GWAS summary statistics of psychiatric disorders, we first performed proteome-wide association study (PWAS) to identify psychiatric disorders-associated plasma proteins, followed by enrichment analysis to reveal the underlying biological processes and pathways.

An arithmetic operation P system based on symmetric ternary system.

Nowadays, electronic computers use a "binary" numbering system, as opposed to "ternary" logic, which is closer to the way the human brain thinks. In this paper, the symmetric ternary system is applied to membrane computing for the first time. By combining the symmetric ternary system with membrane computing, this paper provides a more suitable arithmetic operation method for bio-computers, which breaks through the limitations of the traditional binary system in complex operations, and has a great potential for application in artificial intelligence and automatic learning in particular.

Mendelian randomization reveals that abnormal lipid metabolism mediates the causal relationship between body mass index and keratoconus.

Previous studies suggest that a high body mass index (BMI) may be a risk factor for keratoconus (KC), but the causal relationship remains unclear. This study used Mendelian randomization (MR) to investigate this connection and explore the mediating role of circulating serum metabolites and inflammatory factors in this association. Two-sample MR analysis was conducted to assess the relationship between BMI and KC.

Driving mechanism of land use and landscape pattern to phytoplankton and zooplankton community and their trophic interactions in river ecosystems.

The trophic interactions between phytoplankton and zooplankton communities are essential for maintaining river ecosystem integrity and health. However, the driving mechanisms of land use and landscape patterns (LULP) affecting their trophic interactions are not fully understood. Therefore, the research objective of this study was to reveal the driving mechanisms of LULP on the interaction of phytoplankton with zooplankton through remote sensing interpretation of LULP in different buffer scales (500 m, 1000 m, 1500 m, and catchment), combined with water environment factors and plankton community structures analyzed.

Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study.

Background: Dyslipidemia is prominently associated with adverse outcomes in patients with coronary artery disease (CAD). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel comprehensive lipid index. However, limited evidence exists on the relationship of the NHHR with the risk of adverse outcomes in patients with CAD.

Programming Hydrogen Bonds for Reversible Elastic-Plastic Phase Transition in a Conductive Stretchable Hydrogel Actuator with Rapid Ultra-High-Density Energy Conversion and Multiple Sensory Properties.

Smart hydrogels have recently garnered significant attention in the fields of actuators, human-machine interaction, and soft robotics. However, when constructing large-scale actuated systems, they usually exhibit limited actuation forces (≈2 kPa) and actuation speeds. Drawing inspiration from hairspring energy conversion mechanism, an elasticity-plasticity-controllable composite hydrogel (PCTA) with robust contraction capabilities is developed.

Insights into the interactions of plant-associated bacteria and their role in the transfer of antibiotic resistance genes from soil to plant.

This study discussed the role of plant-associated microbiome in regulating ARG transfer in soil-plant systems. Results showed that target ARGs in plants were mainly derived from rhizosphere soil. Cooperative interactions among bacteria in rhizosphere soil, plant-roots, plant-shoots, and soil-roots-shoots systems occurred during ARG transfer.

C-FOS inhibition promotes pancreatic cancer cell ferroptosis by transcriptionally regulating the expression of SLC7A11.

Cellular proto-oncogene C-Fos forms the AP-1 transcription factor by dimerizing with proto-oncogene c-Jun; this factor upregulates the transcription of genes associated with different malignancies. However, its functions in pancreatic adenocarcinoma (PAAD) remain poorly understood. In this study, the c-Fos was increased in PAAD cells and tissues through bioinformatic analysis, RT-PCR, and WB.

Applications of Machine Learning in Meniere's Disease Assessment Based on Pure-Tone Audiometry.

Objective: To apply machine learning models based on air conduction thresholds of pure-tone audiometry for automatic diagnosis of Meniere's disease (MD) and prediction of endolymphatic hydrops (EH).

Study Design: Retrospective study.

Setting: Tertiary medical center.

'Picking up the pieces': primary care practitioners' experiences of cancer care reviews.

Background: The number of people who are living with and beyond cancer is increasing in England. Primary care delivers cancer care via structured proactive conversations which are incentivised through the Quality and Outcomes Framework (QoF): 'cancer care reviews' (CCRs). Declining workforce numbers, increasing patient demand, CCR policy changes in 2020 and the onset of the coronavirus disease 2019 (COVID-19) pandemic, highlight a need to explore how staff deliver CCRs.

Urolithin A attenuates hexavalent chromium-induced small intestinal injury by modulating PP2A/Hippo/YAP1 pathway.

Hexavalent chromium (Cr(VI)) exposure has been linked with gastrointestinal toxicity, whereas the molecular pathways and key targets remain elusive. Computational toxicology analysis predicted the correlation between protein phosphatase 2A (PP2A) and genes regarding Cr(VI)-induced intestinal injury. Here, we generated a mouse model with intestinal epithelium-specific knock out of Ppp2r1a (encoding PP2A Aα subunit) to investigate the mechanisms underlying Cr(VI)-induced small intestinal toxicity.

TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence.

Osteoarthritis (OA) pain is often associated with the expression of tumor necrosis factor alpha (TNF-α), suggesting that TNF-α is one of the main contributing factors that cause inflammation, pain, and OA pathology. Thus, inhibition of TNF-α could potentially improve OA symptoms and slow disease progression. Anti-TNF-α treatments with antibodies, however, require multiple treatments and cannot entirely block TNF-α.

Sustainable flood control strategies under extreme rainfall: Allocation of flood drainage rights in the middle and lower reaches of the yellow river based on a new decision-making framework.

Climate change has exacerbated the frequency and magnitude of extreme rainfall, which has led to the perpetuation of flooding as a hazard to humans and society. China has begun to consider introducing Flood drainage rights (FDR), a sustainable flood control measure, into non-engineering measures as a complement to engineering measures for flood control. FDR represent the right of regions to discharge regional floodwaters caused by extreme rainfall into the river, and are the primary means of controlling the amount of floodwaters from regions when regional flood capacity is exceeded.

Intergenerational engagement with Asian residents in long-term care facilities: a mixed method systematic review.

Introduction: Asian countries are experiencing a rapid rise in their aging populations. Cognitive and physical decline associated with aging can limit social interaction. This particularly impacts on those residing in long-term care facilities and engagement with children and young people.

A comprehensive study of Tianma Toutong Tablets from the dual dimensions of quality and efficacy using fingerprint techniques and network pharmacology.

Background: The quality of traditional Chinese medicine (TCM) is the prerequisite for ensuring its safe and effective clinical application. With the increasing popularity of TCM worldwide, the quality control of TCM products has become increasingly crucial. Tianma toutong tablet (TMTTT) is mainly used for migraine caused by external wind and cold, blood stasis, or deficiency of blood and nourishment.

Setting Regional Priorities for Palliative and End-of-Life Care Research Using a Delphi Technique Approach.

Objective: Identifying research priorities is very important for palliative and end-of-life care to ensure research is focused on evidence gaps. This project aimed to identify and prioritise palliative and end-of-life care research areas within the West Midlands region in United Kingdom (UK).

Methods: A modified Delphi technique approach was used with palliative care stakeholders.

Exploring the causal relationship between body mass index and keratoconus: a Mendelian randomization study.

Background: Despite reports suggesting a link between obesity and keratoconus, the causal relationship is not fully understood.

Methods: We used genome-wide association study (GWAS) data from public databases for a two-sample Mendelian randomization analysis to investigate the causal link between body mass index (BMI) and keratoconus. The primary method was inverse variance weighted (IVW), complemented by different analytical techniques and sensitivity analyses to ensure result robustness.