Spatially Resolved Multiomics: Data Analysis from Monoomics to Multiomics.

Spatial monoomics has been recognized as a powerful tool for exploring life sciences. Recently, spatial multiomics has advanced considerably, which could contribute to clarifying many biological issues. Spatial monoomics techniques in epigenomics, genomics, transcriptomics, proteomics, and metabolomics can enhance our understanding of biological functions and cellular identities by simultaneously measuring tissue structures and biomolecule levels.

Unraveling the effectiveness of new media teaching strategies in pharmacology education under different educational backgrounds: Insights from 6447 students.

Background: Despite increasing studies underscoring the effectiveness of new media teaching strategies in pharmacology education, the influence of different educational backgrounds is still unclear. We aimed to evaluate the efficacy of new media teaching under various educational backgrounds in pharmacology education using network meta-analysis.

Methods: Literature databases were searched from their inception to February 28, 2024 for eligible trials.

Advancing detection of fungal and mycotoxins contamination in grains and oilseeds: Hyperspectral imaging for enhanced food safety.

Grains and oilseeds, including maize, wheat, and peanuts, are essential for human and animal nutrition but are vulnerable to contamination by fungi and their toxic metabolites, mycotoxins. This review provides a comprehensive investigation of the applications of hyperspectral imaging (HSI) technologies for the detection of fungal and mycotoxins contamination in grains and oilseeds. It explores the capability of HSI to identify specific spectral features of contamination and emphasized the critical role of sample properties and sample preparation techniques in HSI applications.

Leveraging logit uncertainty for better knowledge distillation.

Knowledge distillation improves student model performance. However, using a larger teacher model does not necessarily result in better distillation gains due to significant architecture and output gaps with smaller student networks. To address this issue, we reconsider teacher outputs and find that categories with strong teacher confidence benefit distillation more, while those with weaker certainty contribute less.

Role of del Nido Cardioplegia Solution in Prolonged Aortic Cross-clamp Cardiac Surgery: A Prospective Study.

Objectives: The myocardial-protective effect of del Nido cardioplegia solution was evaluated in adult patients undergoing prolonged aortic cross-clamping during cardiac surgery.

Design: Prospective cohort.

Setting: Single-center tertiary academic medical center.

Novel decision-level fusion strategies combined with hyperspectral imaging for the detection of soybean protein content.

Soybeans are used for human consumption or animal feed due to their abundant protein content. In this study, visible-near infrared (VNIR) hyperspectral imaging (HSI) and short-wave infrared HSI combined with three-levels data fusion methods were employed to detect the protein content of soybean seeds, including measurement-level fusion, feature-level fusion, and decision-level fusion. Additionally, three novel decision-level fusion methods were proposed, including binary linear regression, feature-based multiple linear regression (MLR), and model-based MLR.

Luminol/PtCo@rGO and Au@CNTs-based electrochemiluminescence cytosensor for ultrasensitive detection of breast cancer CTCs.

Background: Breast cancer CTCs have recently been recognized as an emerging biomarker for liquid biopsy of breast cancer. In this work, based on two-dimensional (2D) noble metal PtCo@rGO nanozymes and Au@CNTs bioconjugates, a novel electrochemiluminescence (ECL) cytosensor was developed in order to detect breast cancer CTCs (MCF-7) ultrasensitively.

Results: The PtCo@rGO nanozymes possessed large specific surface area and high efficiency peroxidase-like activity, which can be used as nanocarriers to anchor and catalyze luminol ECL emission efficiently.

The Divergent and Bidirectional Relationships Between Narcissistic Admiration and Rivalry and Prosocial Behaviors.

Previous studies have identified narcissism as one of the dark triad personalities. However, contradictory findings were found regarding the relationship between grandiose narcissism and prosocial behaviors. The present research further explored their relationships and reconciled the contradictions by distinguishing between narcissistic admiration and rivalry facets, as well as investigating the bidirectional relationships between narcissism and prosocial behaviors, and the mediating effect of basic psychological needs satisfaction/frustration.

Analysis of the spatio-temporal evolutionary characteristics of myopia among students aged 7-18 years in China: based on panel data analysis.

Myopia is a major important public health concern and has huge burden on health system across the world. This study aimed to explore the spatial and temporal analysis of the prevalence of myopia among students aged 7-18 years to identify the potential clusters and the trends of myopia in China. Spatial autocorrelation analysis, temporal and spatial scan analysis and beta convergence test were performed using ArcGIS10.

a-SiC heteromorphic immersion nanocavities enabling wide-field real-time single-molecule detection.

Real-time single-molecule detection via fluorescence exhibits advantages of non-contact and specificity, especially in illustrating the dynamic heterogeneity of living substances. However, wide-field view and signal-to-noise ratio (SNR) are always contradictory in real-time single-molecule detection with fluorescence labels, owing to the limitation of the omnidirectional radiation characteristics of fluorophores. Herein, we propose a nano optical sensing device based on a-SiC heteromorphic immersion nanocavities (aHINCs), enabling wide-field real-time single-molecule imaging without sacrificing SNR.

Nevus-associated acral melanoma has lower risk of recurrence and mortality than de novo acral melanoma: A multicenter, retrospective analysis of 482 patients.

Background: It is unknown whether acral melanomas (AMs) associated with pre-existing nevi have similar risk to other AMs.

Objective: To compare risk of recurrence and death between AMs associated with pre-existing nevi and de novo AMs.

Methods: We conducted a multicenter retrospective cohort study involving patients diagnosed with AMs between February 2011 and November 2022.

Peripheral microvessel area better predicts the severity of coronary stenosis of acute myocardial infarction patients over pulse wave velocity.

Microvascular obstruction (MVO) is linked with adverse clinical outcome in acute coronary syndrome (ACS) patients, therefore, early prediction of MVO with non-invasive peripheral microcirculation is crucial in facilitating optimal treatment. Current study aims to analyze the significance of opisthenar microvessel area (OMA, measured using optical coherence tomography, OCT) in predicting coronary stenosis (Gensini score, GS) and short-term cardiac recovery of ACS patients and the results were compared to those of arterial stiffness parameters (Pulse Wave Velocity, PWV; Ankle-Brachial Index; ABI). Results showed that cardiac functional parameters (e.

Balancing the Charge Separation and Surface Reaction Dynamics in Twin-Interface Photocatalysts for Solar-to-Hydrogen Production.

Solar-driven photocatalytic green hydrogen (H) evolution reaction presents a promising route toward solar-to-chemical fuel conversion. However, its efficiency has been hindered by the desynchronization of fast photogenerated charge carriers and slow surface reaction kinetics. This work introduces a paradigm shift in photocatalyst design by focusing on the synchronization of charge transport and surface reactions through the use of twin structures as a unique platform.

Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells.

Hepatocellular carcinoma (HCC) circulating tumor cells (CTCs) exhibit significant phenotypic heterogeneity and diverse gene expression profiles due to epithelial-mesenchymal transition (EMT). However, current detection methods lack the capacity for simultaneous quantification of multidimensional biomarkers, impeding a comprehensive understanding of tumor biology and dynamic changes. Here, the CTC Digital Simultaneous Cross-dimensional Output and Unified Tracking (d-SCOUT) technology is introduced, which enables simultaneous quantification and detailed interpretation of HCC transcriptional and phenotypic biomarkers.

Automated measurement and correlation analysis of fundus tessellation and optic disc characteristics in myopia.

This study aims to quantify fundus tessellated (FT) density and optic disc (OD) morphology using deep learning (DL) techniques and to investigate the correlations between these fundus characteristics and refractive function in young patients with myopia. We constructed two DL-based segmentation models to delineate the FT, OD, peripapillary atrophy (PPA), and macula at a pixel-level resolution. The study sought to identify differences in fundus characteristics between eyes categorized as having high myopia versus mild or moderate myopia.

An Online Multimodal Food Data Exploration Platform for Specific Population Health: Development Study.

Background: Nutrient needs vary over the lifespan. Improving knowledge of both population groups and care providers can help with healthier food choices, thereby promoting population health and preventing diseases. Providing evidence-based food knowledge online is credible, low cost, and easily accessible.

Pim1 inactivating induces RUNX3 upregulation that improves/alleviates airway inflammation and mucus hypersecretion in vitro and in vivo.

Purpose: Our research aimed to evaluate whether proto-oncogene serine/threonine-protein kinase Pim-1 (Pim1) inactivation could attenuate asthma by promoting runt-related transcription factor 3 (Runx3) expression and explore the underlying molecular mechanism.

Method: Phorbol 12-myristate 13-acetate (PMA, 50 nM) was used to induce inflammation in BEAS-2B human airway epithelial cells. ELISA and immunofluorescence double staining confirmed inflammation modelling and differential expression of Pim1 and Runx3.

Clinicopathologic characterization of secretory carcinoma of salivary gland.

Background: To investigate the clinicopathologic characteristics, therapeutic methods, and prognosis of secretory carcinoma of salivary gland (SCSG).

Methods: The clinicopathologic data of 13 patients with SCSG admitted to Shanxi Cancer Hospital from January 2018 to June 2023 were retrospectively analyzed, and a literature review was performed.

Results: A total of eight males and five females aged 22-78 years old were enrolled, and they commonly presented with painless masses in the parotid or submandibular gland.

Meta-analysis of prediction models for predicting lymph node metastasis in thyroid cancer.

Background: The purpose of this systematic review and meta-analysis is to assess the efficacy of various machine learning (ML) techniques in predicting preoperative lymph node metastasis (LNM) in patients diagnosed with papillary thyroid carcinoma (PTC). Although prior studies have investigated the potential of ML in this context, the current evidence is not sufficiently strong. Hence, we undertook a thorough analysis to ascertain the predictive accuracy of different ML models and their practical relevance in predicting preoperative LNM in PTC patients.

Exploring the Mechanism of Centipeda minima in Treating Nasopharyngeal Carcinoma Based on Network Pharmacology.

Background: Centipeda minima (CM) is a traditional Chinese herbal medicine used for the treatment of sinusitis and rhinitis, and it possesses anti-cancer properties. However, the mechanism of CM in the treatment of nasopharyngeal carcinoma (NPC) remains unclear.

Objective: This study aimed to explore the mechanism of CM in the treatment of NPC using a network pharmacology approach.

Plasma-derived Exosomal miR-25-3p and miR-23b-3p as Predictors of Response to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma.

Background: Exosomal miRNAs have emerged as promising biomarkers for cancer. However, little is known about the role of exosomal miRNAs in the response prediction of esophageal squamous cell carcinoma (ESCC) patients treated with chemoradiotherapy (CRT).

Methods: In this prospective study, 40 ESCC patients treated by CRT were enrolled from January 2021 to June 2022.