Publications by authors named "Gaurav"

Objective: Spinocerebellar ataxias (SCA) are neurodegenerative diseases with widespread lesions across the central nervous system. Ataxia and spasticity are usually predominant, but patients may also present with parkinsonism. We aimed to characterize substantia nigra pars compacta (SNc) degeneration in SCA2 and 7 using neuromelanin-sensitive imaging.

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The present study aimed to detect the prevalence, virulence and antimicrobial resistance genes profile of Escherichia coli isolated from diarrhoeic lambs. A total of 61 faecal samples were collected from diarrhoeic lambs. The presence of various virulence and antimicrobial resistance genes in E.

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Vulvovaginal enterobiasis is underreported and an often-missed diagnosis in prepubertal girls presenting with isolated nocturnal vulvar pruritus. An 8-year-old-girl with intense nocturnal vulvar itching for 4 months was diagnosed with enterobiasis after microscopy of a vaginal swab revealed Enterobius vermicularis (pinworm) ova. The child and her family were treated with two doses of oral albendazole, 2 weeks apart, resulting in symptom resolution.

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Purpose: The present study was carried out to evaluate the radioprotective activities of N-acetyl-L-tryptophan (L-NAT) using rodent and non-human primate (NHP) models.

Materials And Methods: The antagonistic effect of L-NAT on the Transient receptor potential vanilloid-1 (TRPV1) receptor and substance P inhibition was determined using molecular docking and Elisa assays. The in radioprotective activity of L-NAT was evaluated using whole-body survival assays in mice and NHPs.

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Drought is a natural disaster that can affect a larger area over time. Damage caused by the drought can only be reduced through its accurate prediction. In this context, we proposed a hybrid stacked model for rainfall prediction, which is crucial for effective drought forecasting and management.

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Article Synopsis
  • * Enhanced exposure-response and pharmacokinetic/pharmacodynamic modeling revealed that higher concentrations of sotatercept improve key clinical outcomes including 6MWD and the likelihood of achieving lower NT-proBNP levels, while maintaining safety measures like hemoglobin levels.
  • * Key factors influencing the treatment's response include patient age and iron supplementation, but their overall impact on outcomes was minimal, supporting the selected dosing strategy of 0.7 mg/kg administered subcutaneously every three weeks as effective and safe.
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Motivation: Genome-wide association studies (GWAS) have been remarkably successful in identifying associations between genetic variants and imaging-derived phenotypes. To date, the main focus of these analyses has been on established, clinically-used imaging features. We sought to investigate if deep learning approaches can detect more nuanced patterns of image variability.

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Objectives: Morphine is the cornerstone of pain management in a palliative care setting. Nausea with or without vomiting usually occurs when patients are initiated on morphine for the 1 time or when the dose is substantially increased.

Materials And Methods: A total of 90 patients fulfilling the inclusion criteria were randomly allocated into two groups of 45 each.

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Objective: Current postgraduate curriculum in India lacks practical training in ultrasound for residents in obstetrics and gynecology. The objective of this study was to develop and assess impact of a capacity building program utilizing clinical teaching and simulation to enhance knowledge and skills of residents at a healthcare facility in India.

Methods: A training program comprising of 14 modules on basic obstetric ultrasounds was created over 3 months.

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Article Synopsis
  • Laparoscopic cholecystectomy is the standard treatment for gallbladder stones, but occasionally needs to be converted to open surgery due to intra-operative difficulties, with conversion rates ranging from 1% to 13%.
  • A study conducted in India analyzed factors such as age, gender, and ultrasound findings in 93 gallstone patients to predict the likelihood of needing this conversion.
  • Key predictors for conversion included the presence of acute cholecystitis, multiple previous gallbladder attacks, and certain ultrasound results indicating a contracted gallbladder.
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Background Ileal perforations represent one of the most common surgical emergencies in India, associated with significant morbidity and mortality rates. The causes of these perforations include infections such as tuberculosis and enteric fever, as well as malignancy and trauma. Management options encompass ileostomy, resection with anastomosis, and primary closure.

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Aims: There is a shortage of livers for transplantation in the United Kingdom; despite this, more than a fifth of those retrieved are not transplanted. Normothermic machine perfusion (NMP) allows a functional assessment of marginal organs using biochemical parameters. This study describes the histological changes in livers undergoing NMP.

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Background: Choledocholithiasis, or stones in the common bile duct (CBD), has two types: primary stones that form in the CBD and secondary stones that migrate from the gallbladder. Management includes endoscopic, laparoscopic, and open surgical methods. In India, the availability of endoscopic retrograde cholangiopancreatography (ERCP) and laparoscopic surgery is limited often necessitating open procedures.

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  • Cancer stem cells (CSCs), marked by CD24 and CD44, are linked to aggressive behavior and poor outcomes in breast cancer, with a study examining 75 tissue samples revealing significant correlations between these markers and clinical parameters, therapy response, and metastasis risks.* -
  • Analysis indicated that patients expressing CD24-/CD44+/ALDH1A3+ had higher tumor stages and worse treatment responses, while those with either CD24 or CD44 positivity showed larger tumors and increased nodal burden at younger ages.* -
  • The study emphasizes the importance of these CSC markers as predictors of adverse outcomes, suggesting that their presence is associated with higher rates of distant metastasis and reduced effectiveness of chemotherapy in breast cancer patients.*
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We report a rare case of furuncular myiasis in a 7-year-old boy presenting with a discharging nodule over the scalp. The report details the clinical presentation, examination findings, and dermoscopic features of furuncular myiasis. To the best of our knowledge, Chrysomya bezziana has never been reported to cause furuncular myiasis.

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