Xen 63 versus Preserflo MicroShunt implant in patients with primary open-angle glaucoma.

This study compared the efficacy safety profiles of the Xen 63 and Preserflo MicroShunt devices, both standalone, in patients with primary open-angle glaucoma (POAG). It is a retrospective and single-center study conducted on consecutive on patients with medically uncontrolled POAG who underwent either a standalone Xen 63 or a standalone Preserflo and had a 12-month follow-up visit. The primary outcome was the mean IOP at month-12.

Trends in glaucoma surgery in a tertiary hospital in Spain: 2010-2022.

Objective: This study aims to conduct an analysis glaucoma surgeries performed over a 13-year period at a tertiary hospital affiliated with the Spanish National Health System, with the goal of assessing temporal trends.

Methods: This retrospective observational study scrutinized surgeries undertaken in the glaucoma unit of a tertiary center in Spain between 2010 and 2022. Data collected included surgical dates, procedure performed, whether it was standalone or combined, as well as patient demographics including age, sex, and type of underlying glaucoma.

Easyton® transpalpebral versus Perkins applanation tonometry in different populations.

Objective:  To compare intraocular pressure (IOP) measurements obtained using the new transpalpebral Easyton® tonometer and Perkins applanation tonometer (PAT) in three different clinical populations.

Methods: The participants of this prospective study were 84 subjects divided into the groups: 22 healthy children (G1), 42 healthy adults (G2), and 20 adult patients with primary open angle glaucoma (G3). The data recorded in 84 eyes of these subjects were age, sex, gender, central corneal thickness (CCT), and axial length (AL).

Peripapillary and macular vascular parameters by optical coherence tomography angiography in primary congenital glaucoma.

Objective: To evaluate the differences in peripapillary and macular vascular parameters by optical coherence tomography angiography (OCTA) between patients with primary congenital glaucoma (PCG) and healthy controls; and to determine their diagnostic accuracy.

Material And Methods: Observational, cross-sectional study including 39 eyes with PCG and 78 healthy eyes. Only one eye per patient was included.

Destabilization of Black Holes and Stars by Generalized Proca Fields.

We demonstrate that black holes and stars in general relativity can be destabilized by perturbations of nonminimally coupled vector fields. Focusing on static and spherically symmetric backgrounds, our analysis shows that black holes with sufficiently small mass and stars with sufficiently high densities are subject to ghost- or gradient-type instabilities. This holds for a large class of Einstein-Proca theories with nonminimal couplings, including generalized Proca models that have sparked attention for their potential role in cosmology and astrophysics.

Clinical outcomes of combined Preserflo Microshunt implantation and cataract surgery in open-angle glaucoma patients.

To assess the effectiveness and safety of the Preserflo Microshunt (PMS) implantation combined with cataract surgery in open-angle glaucoma (OAG) patients. Retrospective, open-label study conducted on insufficiently controlled OAG patients, who underwent a PMS implant procedure with mitomycin-C 0.2%, either alone or in combination with cataract surgery, and were followed for at least 12 months.

Effects of Corneal Biomechanical Properties on Rebound Tonometry (Icare200) and Applanation Tonometry (Perkins) Readings in Patients With Primary Congenital Glaucoma.

Objective: The aim was to assess the influence of corneal biomechanics on intraocular pressure (IOP) measurements made with the Icare200 (IC200) rebound tonometer and the Perkins handheld applanation tonometer in patients with primary congenital glaucoma (PCG).

Materials And Methods: A total of 40 PCG patients and 40 healthy controls, age, and sex-matched, were recruited. IOP was measured with the Ocular Response Analyzer (IOPc, IOPg), IC200 and Perkins.

Agreement between rebound (Icare ic200) and applanation tonometry (Perkins) in patients with primary congenital glaucoma.

Purpose: To examine agreement between intraocular pressure (IOP) measurements made using the rebound tonometer Icare ic200 (RT200) and the Perkins handheld applanation tonometer (PAT) in patients with primary congenital glaucoma (PCG). The impacts of several covariables on measurements using the two devices were also assessed.

Materials And Methods: Intraocular pressure measurements were made in a single session in 86 eyes of 86 patients with PCG (46 under anaesthesia, 40 in the office).

Hyper-Non-Gaussianities in Inflation with Strongly Nongeodesic Motion.

Several recent proposals to embed inflation into high-energy physics rely on inflationary dynamics characterized by a strongly nongeodesic motion in negatively curved field space. This naturally leads to a transient instability of perturbations on sub-Hubble scales, and to their exponential amplification. Supported by first-principles numerical computations, and by the analytical insight provided by the effective field theory of inflation, we show that the bispectrum is enhanced in flattened configurations, and we argue that an analogous result holds for all higher-order correlation functions.

Scheie's line as a first sign of pigment dispersion syndrome.

A 50 year old woman was diagnosed with pigment dispersion syndrome (PDS) in the right eye and pigmentary glaucoma in the left eye in a routine medical examination. A line of pigment was observed in the vitreo-lenticular interface (Scheie's line) of the left eye and with an intraocular pressure of 26mmHg. The Scheie's line (SL) develops by the accumulation of detached iris pigment in PDS and accumulated in the ligament of Wieger that forms the vitreo-lenticular union.

Diagnostic capacity of SD-OCT segmented ganglion cell complex versus retinal nerve fiber layer analysis for congenital glaucoma.

Purpose: To compare the diagnostic performance of circumpapillary retinal nerve fiber layer (cpRNFL) analysis versus segmented ganglion cell complex analysis both by spectral-domain optical coherence tomography (SD-OCT) in children with primary congenital glaucoma (PCG).

Methods: Participants were 40 children diagnosed with PCG and 60 healthy children. Ophthalmological data collected (for one eye per child) were cup-disc ratio (C/D) and axial length (AL).

Visual snow in a paediatric patient.

Case Report: The case is presented of an 11 year-old girl referring to a one year history of photophobia and continuously seeing white spots in both eyes. The patient had a visual acuity of unity in both eyes, and a normal eye examination, and was referred to the Neuro-ophthalmology Unit. Once complete laboratory and imaging tests ruled out the possibility of any neurological pathology, she was diagnosed with visual snow (VS).

New technologies for measuring intraocular pressure.

The level of intraocular pressure (IOP) is the main known risk factor for the development and progression of glaucomatous optic neuropathy. Despite Goldmann applanation tonometry (GAT) being the gold standard for determining IOP since the last century, its limitations were obvious from the start and include substantial effects of several eye variables such as axial length, curvature, rigidity, and corneal thickness. These limitations have prompted the development of numerous formulas and nomograms designed to compensate for the ocular characteristics effect on GAT, but none of these methods has been entirely satisfactory.

[Non-organic visual loss. A series of 5 cases].

Non-organic visual loss is the presence of ocular symptoms without an organic base that justifies it, and can occur in up to 5% of the children attending Ophthalmology Outpatients. A suspicion and the management of this situation are essential for a proper diagnosis, not only to avoid unnecessary referrals to other specialties, but also to avoid health spending, in addition to reducing parental distress by the possible presence of eye disease in their children.

[Hypertension secondary to treatment with latanoprost].

Case Report: An 80 year old woman operated on by trabeculectomy for primary open-angle glaucoma due to increased pressure, who started treatment with latanoprost. Monitoring of blood pressure (BP) showed a statistically significant increase in both systolic and diastolic BP, coinciding with the use of topical hypotensive, which resolved by voluntarily suspending treatment, thus increasing again to reintroduce the prostaglandin.

Discussion: Prostaglandin analogs reduce intraocular pressure to produce vasodilation of the episcleral and ciliary arteries, increasing the outflow of aqueous humor.

Diplopia from pleomorphic lipoma of the orbit with lateral rectus muscle involvement.

A-55-year-old man with a 2-year history of left proptosis with painless swelling of the upper and lateral bulbar conjunctiva was referred. He had developed diplopia in left gaze. Orbital CT showed left proptosis with a mass measuring 2 × 1 cm in the superolateral and lateral left orbit, with lateral rectus muscle infiltration.

Serological markers in inflammatory bowel disease: a review of their clinical utility.

Background: Several antibodies, also called serological markers, are associated with specific forms, disease behavior and phenotype of inflammatory bowel disease (IBD).

Aim: Summarize and analyze the evidence of the utility of serologic markers in IBD, making emphasis on their clinical utility and behavior between populations.

Material And Methods: Relevant articles were located by computer-assisted search of PubMed (since January 1979 until December 2008).

[Bilateral third cranial nerve palsy secondary to lung carcinoma metastasis].

Clinical Case: A 58 year-old man with a known diagnosis of a large cell lung carcinoma, developed a progressive diplopia. His examination revealed a double oculomotor nerve palsy with dilated and poorly reactive pupils. A cranial magnetic resonance showed an unique and solitary lesion in the midbrain, which presumably affected to both oculomotor nucleus and fasciculus.

Lacrimal sac metastases from renal cell carcinoma.

Purpose: To report the first case of metastasis from renal cell carcinoma to the lacrimal sac and review the therapeutic options.

Methods: We have reviewed the case of a woman who was operated on for a renal cell carcinoma that developed epiphora and a lacrimal sac tumor, which corresponded to a metastasis from her previous tumor. Although renal cell carcinoma shows a great tendency for distant metastasis, this is the first reported case of metastasis to the lacrimal sac.

[Lower lip burn due to a fire during a blepharoplasty procedure].

Case Report: A 63-year-old woman underwent bilateral blepharoplasty under local anesthesia and sedation. During surgery a fire started due to an electrocautery spark. The fire resulted in cosmetic sequelae.