Completely medial access by page-turning approach for laparoscopic right hemi-colectomy: 6-year-experience in single center.

Background: To investigate the safety and feasibility of the completely medial access by page-turning approach (CMAP) for laparoscopic right hemi-colectomy.

Methods: In this retrospective study, the data from 72 patients who underwent laparoscopic right hemi-colectomy with CMAP were analyzed and compared with data from 124 patients who underwent the conventional medial approach performed by the same surgical team from September 2011 to March 2017.

Result: Complete mesocolic excision (CME) was achieved in 67 of 72 patients (93.

PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.

Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus, identification of epigenetic modifiers essential for oncogenic transcriptional programs is a key to designing effective therapeutics for this deadly disease. Here we report that Protein Arginine Methyltransferase 2 (PRMT2) is highly expressed in GBM and correlated with poor prognosis.

Cardioprotection during ischemia by coronary collateral growth.

Ischemic heart diseases (IHD) cause millions of deaths around the world annually. While surgical and pharmacological interventions are commonly used to treat patients with IHD, their efficacy varies from patient to patient and is limited by the severity of the disease. One promising, at least theoretically, approach for treating IHD is induction of coronary collateral growth (CCG).

Hierarchical fibrous microfiltration membranes by self-assembling DBS nanofibrils in solution-blown nanofibers.

A novel hierarchical nanofibrous membrane was demonstrated via in situ self-assembly of 1,3:2,4-dibenzylidene-d-sorbitol (DBS) supramolecular fibrils in solution-blown polyacrylonitrile (PAN) nanofibers. The formed DBS fibrils were interconnected into networks and anchored onto the PAN nanofibers, which decreased the pore sizes and enhanced the mechanical properties, the filtration efficiency, and particularly the flux.

Can Environmental Quality Improvement and Emission Reduction Targets Be Realized Simultaneously? Evidence from China and A Geographically and Temporally Weighted Regression Model.

The reductions of industrial pollution and greenhouse gas emissions are important actions to create an ecologically stable civilization. However, there are few reports on the interaction and variation between them. In this study, the vertical and horizontal scatter degree method is used to calculate a comprehensive index of industrial pollution emissions.

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies.

New therapeutic biological entities such as bispecific antibodies targeting tissue or specific cell populations form an increasingly important part of the drug development portfolio. However, these biopharmaceutical agents bear the risk of extensive target-mediated drug disposition or atypical pharmacokinetic properties as compared to canonical antibodies. Pharmacokinetics and bio-distribution studies become therefore more and more important during lead optimization.

Review of mobile applications for optimizing the follow-up care of patients with diabetes.

Background: Several smartphone applications aim at facilitating communication between patients and healthcare providers. In this review, we evaluate and compare the most promising applications in the field of diabetes mellitus (DM) and obesity. Most applications monitor body weight, fasting or postprandial blood glucose, glycosylated hemoglobin (Hgb) A1c (HgbA1c), and units and types of insulin used.

Mediation of Flower Induction by Gibberellin and its Inhibitor Paclobutrazol: mRNA and miRNA Integration Comprises Complex Regulatory Cross-Talk in Apple.

Guaranteeing successful flowering is very important in economic plant species, especially apple (Malus domestica Borkh.), which is difficult to induce to flower. However, the gene expression and networks involved in flowering have not been totally characterized.

Drivers Analysis of CO₂ Emissions from the Perspective of Carbon Density: The Case of Shandong Province, China.

Against the backgrounds of emission reduction targets promised by China, it is crucial to explore drivers of CO₂ emissions comprehensively for policy making. In this study, Shandong Province in China is taken as an example to investigate drivers in carbon density by using an extended Kaya identity and a logarithmic mean Divisia index model (LMDI) with two layers. It is concluded that there are eight positive driving factors of carbon density during 2000⁻2015, including traffic congestion, land urbanization, etc.

Multiple Heterotopic Ossification of the Intestine Detected by 99mTc-MDP Bone Scan in a Patient With Primary Peritoneal Cancer.

Heterotopic ossification is a rare phenomenon that refers to formation of bone outside the skeletal system. We present a 61-year-old woman who suffered from peritoneal cancer surgery 2 years ago, referred for Tc-MDP bone scan because of higher serum CA-125 level, which showed multiple intense tracer activities in her abdominal and pelvic region without other abnormalities. SPECT/CT revealed the activities were loaded in the intestine but not in the bone.

Identification and Characterization of miRNAs in Self-Rooted and Grafted Reveals Critical Networks Associated with Flowering.

Grafting can improve the agricultural traits of crop plants, especially fruit trees. However, the regulatory networks and differentially expressed microRNAs (miRNAs) related to grafting in apple remain unclear. Herein, we conducted high-throughput sequencing and identified differentially expressed miRNAs among self-rooted Fuji, self-rooted M9, and grafted Fuji/M9.

MyHealthAvatar lifestyle management support for cancer patients.

MyHealthAvatar (MHA) is built on the latest information and communications technology with the aim of collecting lifestyle and health data to promote citizen's wellbeing. According to the collected data, MHA offers visual analytics of lifestyle data, contributes to individualised disease prediction and prevention, and supports healthy lifestyles and independent living. The iManageCancer project aims to empower patients and strengthen self-management in cancer diseases.

Transcriptome Analysis Reveals Multiple Hormones, Wounding and Sugar Signaling Pathways Mediate Adventitious Root Formation in Apple Rootstock.

Adventitious roots (AR) play an important role in the vegetative propagation of apple rootstocks. The potential role of hormone, wounding, and sugar signalling pathways in mediating AR formation has not been adequately explored and the whole co-expression network in AR formation has not been well established in apple. In order to identify the molecular mechanisms underlying AR formation in 'T337' apple rootstocks, transcriptomic changes that occur during four stages of AR formation (0, 3, 9 and 16 days) were analyzed using high-throughput sequencing.

Genome Identification of B-BOX Gene Family Members in Seven Rosaceae Species and Their Expression Analysis in Response to Flower Induction in Malus domestica.

BBX proteins play important roles in regulating plant growth and development including photomorphogenesis, photoperiodic regulation of flowering, and responses to biotic and abiotic stresses. At present, the genomes of seven fruit species have been fully sequenced. However, little is known about the gene family and their evolutionary history in these species.

Mitochondrial regulation of [Ca]i oscillations during cell cycle resumption of the second meiosis of oocyte.

Oocyte is arrested at metaphase of the second meiosis until fertilization switching on [Ca]i oscillations. Oocyte activation inefficiency is the most challenging problem for failed fertilization and embryonic development. Mitochondrial function and intracellular [Ca]i oscillations are two critical factors for the oocyte's developmental potential.

Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules.

Xuezhikang capsule (XZK) is a traditional Chinese medicine that contains lovastatin (Lv) for hyperlipidemia treatment, although it has fewer side effects than Lv. However, the pharmacokinetic mechanisms contributing to its distinct efficacy and low side effects are unclear. Mice were fed a high-fat diet (HFD) for 6 weeks to induce hyperlipidemia.

Anomalous Capillary Rise under Nanoconfinement: A View of Molecular Kinetic Theory.

Understanding the capillary filling behaviors in nanopores is crucial for many science and engineering problems. Compared with the classical Bell-Cameron-Lucas-Washburn (BCLW) theory, anomalous coefficient is always observed because of the increasing role of surfaces. Here, a molecular kinetics approach is adopted to explain the mechanism of anomalous behaviors at the molecular level; a unified model taking account of the confined liquid properties (viscosity and density) and slip boundary condition is proposed to demonstrate the macroscopic consequences, and the model results are successfully validated against the published literature.

Targeting of BMI-1 with PTC-209 inhibits glioblastoma development.

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. Here we showed that BMI-1 is highly expressed in GBM and especially enriched in glioblastoma stem cells (GSCs).

Fast photocatalytic degradation of dyes using low-power laser-fabricated CuO-Cu nanocomposites.

In this study, we report a simple method to controllably synthesize CuO-Cu nanocomposites by using a low-power CO laser, and application of these nanomaterials for photocatalytic degradation of methylene blue (MB). Our experiments demonstrate that efficient tailoring of the CuO-Cu nanocomposites can be realized by accurate control and optimization of the ambient parameters, such as laser energy and NaOH concentration. Compared to hydrothermally fabricated CuO-Cu catalysts, the laser-reduced composites exhibit better visible-light photocatalytic activity for MB degradation, which could be attributed to the formation of special catalytically active structures on the nanocomposite surface.

Electricity generation from banana peels in an alkaline fuel cell with a CuO-Cu modified activated carbon cathode.

Low-cost and highly active catalyst for oxygen reduction reaction is of great importance in the design of alkaline fuel cells. In this work, CuO-Cu composite catalyst has been fabricated by a facile laser-irradiation method. The addition of CuO-Cu composite in activated carbon air-cathode greatly improves the performance of the cathode.

Multi-frequency difference method for intracranial hemorrhage detection by magnetic induction tomography.

Objective: Frequency-difference magnetic induction tomography (fdMIT) is a promising technique for the continuous monitoring of intracranial hemorrhage. The dual-frequency difference MIT (dfdMIT) will sometimes produce artefacts in the reconstructed images. To overcome this problem, a multi-frequency difference MIT (mfdMIT) method is proposed.

Application of liquid chromatography-tandem mass spectrometry to study the effect of docetaxel on pharmacokinetics and tissue distribution of apatinib in mice.

Apatinib, a highly selective small-molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), has attracted many attentions due to its anticancer activity in various malignancies containing non-small-cell lung cancer (NSCLC). Our previous preclinical study confirmed the enhanced anti-tumor efficacy of combined treatment between apatinib and docetaxel for NSCLC. However, the effects of docetaxel on pharmacokinetics and tissue distribution of apatinib are not clear.

The mitochondrial genome of the deep-sea tubeworm (Siboglinidae, Annelida) and its phylogenetic implications.

is a conspicuous annelid living in the cold seeps and hydrothermal vents of the Western Pacific region and relying on their endosymbiont bacteria as a source of energy and organic carbon. We report the complete mitochondrial genome of , which is 15,280 bp in length, containing 13 protein-coding genes, two ribosomal RNA genes, 22 tRNA genes and a putative control region. The overall base composition is AT-biased.