Synchronous enhancement of antimicrobial and mechanical properties of natural rubber by MXene functionalized with SiO.

The development of natural rubber (NR) gloves with superior antibacterial and enhanced mechanical properties is critical for safeguarding healthcare personnel. In this study, Ti-based MXene (TiCT) nanosheets were employed for the first time as an antibacterial agent to improve the antimicrobial performance of NR. Through SiO₂ intercalation via electronic assembly, the antibacterial efficacy of MXene was significantly boosted, achieving 100 % lethality against E.

Hypoxia-Inducible Factor-1α Regulates BNIP3-Dependent Mitophagy and Mediates Metabolic Reprogramming Through Histone Lysine Lactylation Modification to Affect Glioma Proliferation and Invasion.

Objective: Gliomas are the predominant form of malignant brain tumors. We investigated the mechanism of hypoxia-inducible factor-1α (HIF-1α) affecting glioma metabolic reprogramming, proliferation and invasion.

Methods: Human glioma cell U87 was cultured under hypoxia and treated with small interfering (si)HIF-1α, si-B cell lymphoma-2/adenovirus E1B 19-kDa interacting protein 3 (siBNIP3), si-YT521-B homology domain 2 (siYTHDF2), 3-methyladenine and 2-deoxyglucose, with exogenous sodium lactate-treated normally-cultured cells as a lactate-positive control.

A recurrence model for non-puerperal mastitis patients based on machine learning.

Objective: Non-puerperal mastitis (NPM) is an inflammatory breast disease affecting women during non-lactation periods, and it is prone to relapse after being cured. Accurate prediction of its recurrence is crucial for personalized adjuvant therapy, and pathological examination is the primary basis for the classification, diagnosis, and confirmation of non-puerperal mastitis. Currently, there is a lack of recurrence models for non-puerperal mastitis.

The Potential of Mesenchymal Stem Cell-Derived Exosomes in Cardiac Repair.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and effectively repairing the heart following myocardial injuries remains a significant challenge. Research has increasingly shown that exosomes derived from mesenchymal stem cells (MSC-Exo) can ameliorate myocardial injuries and improve outcomes after such injuries. The therapeutic benefits of MSC-Exo are largely due to their capacity to deliver specific cargo, including microRNAs and proteins.

N, O-Doped surface modulation of ZnInS with high hydrophilicity for enhanced photocatalytic hydrogen evolution.

Heteroatom doping is a promising strategy for optimizing the photocatalytic activity of semiconductors. However, relying solely on single-element doping often poses challenges in modulating the capabilities of semiconductors. Herein, we adopt a strategy of simultaneously modifying ZnInS with the double non-metallic elements nitrogen (N) and oxygen (O) to form (N, O)-ZnInS.

[Drift Correction Method of Wastewater Treatment Model Based on Transfer Learning Across Time Scales].

Data is the core foundation of intelligent operation and maintenance, but currently, there is generally insufficient data for wastewater treatment plants, and the status of wastewater treatment systems dynamically evolves with the changes in the internal and external environment. The intelligent operation and maintenance of wastewater plants face difficulties in modeling and model drift caused by system evolution. In response to this issue, the summer and winter seasons with significant differences in wastewater temperature, wastewater quality, and microbial status were selected as typical comparison scenarios.

UPLC-HDMS revealed numerous novel compounds in soybean crude oil.

Soybean crude oils (SCO) were detected by ultra-performance liquid chromatography-high-definition mass spectrometry (UPLC-HDMS) for discovering novel compounds. Numerous chromatographic peaks in ESI and ESI modes showed that SCO was rich in numerous compounds. A total of 215 potential compounds with accurate mass-to-charge ratio, MSMS spectrum and CCS value were detected in SCOs.

Research on the OFDR strain measurement method based on similarity features of dual-segment RSS.

Optical frequency domain reflectometry (OFDR) is a research hotspot in fiber optic sensing technology. This technology can be used for strain, vibration and temperature sensing and has great application prospects in fields such as deformation analysis of aerospace components and bridge monitoring. This article analyzes the reasons for strain demodulation errors under large strains.

A Mendelian randomization study on the association between systemic inflammatory regulators and essential and secondary hypertension.

Background: Inflammation is an important driver of hypertension with numerous components, and there is a paucity of research on the specific inflammatory factors that induce hypertension; therefore, we wanted to investigate the relationship between specific inflammatory factors and hypertension.

Purpose: A two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between systemic inflammatory regulators and hypertension (primary or secondary types).

Method: a large-scale, published genome-wide association study (GWAS) meta-analysis encompassing 41 cytokines (involved 8,293 Finnish participants from three independent population cohorts: the Cardiovascular Risk in Young Finns Study (YFS), FINRISK1997, and FINRISK2002.

Meso/Microporous Single-Atom Catalysts Featuring Curved Fe-N Sites Boost the Oxygen Reduction Reaction Activity.

Zeolitic-imidazolate frameworks (ZIFs) are among the most efficient precursors for the synthesis of atomically dispersed Fe-N/C materials, which are promising catalysts for enhancing the performance of Zn-air batteries (ZABs) and proton exchange fuel cells (PEMFCs). However, existing ZIF-derived Fe-N/C electrocatalysts mostly consist of microporous materials, leading to insufficient mass transport and inadequate battery/cell performance. In this study, we synthesize an atomically dispersed meso/microporous Fe-N/C material with curved Fe-N active sites, denoted as FeSA-N/TC, through the pyrolysis of hemin-modified ZIF films on ZnO nanorods, obtained from the self-assembly reaction between Zn from ZnO hydrolysis and 2-methylimidazole.

Enhanced Photocatalytic Hydrogen Production Activity Driven by TiO/(MoP/CdS): Insights from Powder Particles to Thin Films.

Transitioning from powder photocatalysts to thin film photocatalysts is one of the necessary steps toward industrializing photocatalytic hydrogen production. Herein, we reported the integration of non-noble metal cocatalyst MoP decorated with TiO and CdS, forming TiO/(MoP/CdS) for ultraviolet-visible light utilization. The designed powder TiO/(MoP/CdS) composites achieved a superior hydrogen production rate of 42.

Atomically Dispersed Palladium Catalyst for Chemoselective Hydrogenation of Quinolines.

Chemoselective hydrogenation of quinoline and its derivatives is a significant strategy to achieve the corresponding 1,2,3,4-tetrahydroquinolines (py-THQ) for various potential applications. Here, we precisely constructed a titanium carbide supported atomically dispersed Pd catalyst (Pd/TiC) for quinoline hydrogenation, delivering above 99% py-THQ selectivity at complete conversion with an outstanding turnover frequency (TOF) of 463 h. AC-HAADF-STEM and XAFS demonstrate that the atomic dispersion of Pd includes Pd-TiC single atoms and Pd clusters with atomic-layer thickness.

Diversified humoral immunity and impacts of booster vaccines: SARS-CoV-2 antibody profile and Omicron BA.2 neutralization before and after first or second boosters.

This study aims to investigate humoral immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and assess the impact of booster vaccines. We recruited individuals scheduled to receive either the first (original formula) or the second (bivalent) booster following the initial two-dose SARS-CoV-2 vaccination. We tested for IgG antibodies targeting the spike protein receptor-binding domain (RBD), S1, S2, and nucleocapsid protein, as well as for neutralizing antibodies against Omicron BA.

HBx integration in diffuse large B-cell lymphoma inhibits Caspase-3-PARP related apoptosis.

Diffuse large B-cell lymphoma (DLBCL) is the most common pathological type of non-Hodgkin lymphoma, and is closely associated with hepatitis B virus (HBV) infection status and hepatitis B X (HBx) gene integration. This project investigated the cellular biological effects and molecular mechanisms responsible for lymphomagenesis and the progression of HBx integration in DLBCL. The data showed that clinical DLBCL cells demonstrated HBx integration, and the sequencing analysis of integrated sites validated HBx integration in the constructed HBx-transfected cells.

Bone marrow cells contribute to seven different endothelial cell populations in the heart.

Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic strategies for myocardial ischemia. This study investigates the contribution of bone marrow-derived cells to endothelial cell populations in the heart, and their role in cardiac function and coronary circulation following repetitive ischemia (RI). Chimeric rats were created by transplanting BM cells from GFP female rats into irradiated male recipients.

Can digital economy foster synergistic increases in green innovation and corporate value? Evidence from China.

The rapid evolution of the digital economy has significantly accelerated progress towards achieving green and sustainable processes, particularly in the field of green production. While existing research has delved into the effects of the digital economy on Green Innovation (GI) and the consequences of digital transformation on Corporate Value (CV), there remains a notable gap in the literature regarding the potential for synergistic enhancements in firms' GI&CV through the ongoing digital revolution. This study utilizes an evolutionary game model and employs system dynamics methods to simulate the dynamic evolution trajectory of the influence of the digital economy on the synergy between GI&CV.

Resolving and correcting for kinetic biases on methane seep paleotemperature using carbonate ∆/∆ analysis.

Methane-derived authigenic carbonate often constitutes the sole remaining record of relic methane seeps. The clumped (∆) and oxygen isotopic composition of seep carbonates often yield inaccurate temperatures, attributed to kinetic isotope effects and modification of seawater isotope composition by hydrate water. Here, we analyzed the dual-clumped isotope (∆/∆) composition of authigenic carbonate from a modern methane seep.

A Multidisciplinary Hyper-Modeling Scheme in Personalized In Silico Oncology: Coupling Cell Kinetics with Metabolism, Signaling Networks, and Biomechanics as Plug-In Component Models of a Cancer Digital Twin.

The massive amount of human biological, imaging, and clinical data produced by multiple and diverse sources necessitates integrative modeling approaches able to summarize all this information into answers to specific clinical questions. In this paper, we present a hypermodeling scheme able to combine models of diverse cancer aspects regardless of their underlying method or scale. Describing tissue-scale cancer cell proliferation, biomechanical tumor growth, nutrient transport, genomic-scale aberrant cancer cell metabolism, and cell-signaling pathways that regulate the cellular response to therapy, the hypermodel integrates mutation, miRNA expression, imaging, and clinical data.

Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution.

DC inhibitory receptor (DCIR) is a C-type lectin receptor selectively expressed on myeloid cells, including monocytes, macrophages, DCs, and neutrophils. Its role in immune regulation has been implicated in murine models and human genome-wide association studies, suggesting defective DCIR function associates with increased susceptibility to autoimmune diseases such as rheumatoid arthritis, lupus, and Sjögren's syndrome. However, little is known about the mechanisms underlying DCIR activation to dampen inflammation.

Carbon-coated nickel phosphide enhances efficiently electron transfer of cadmium sulfide for photocatalytic hydrogen production.

The capacitance of a co-catalyst can be likened to a "double-edged sword". Α co-catalysts with high capacitance can store photoexcited electrons, thereby facilitating charge separation within the host catalyst. However, this property simultaneously restricts electron release.

MiR-204-5p may regulate oxidative stress in myopia.

The mechanisms underlying myopia remain not fully understood. We proposed to examine the function and underlying mechanisms of miR-204-5p in myopia development. The miR-204-5p expression level was assessed in the vitreous humor (VH) of a cohort consisting of 11 patients with high myopia (HM) and 16 control patients undergoing vitrectomy.

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency.

Background: Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spirometry, and cardiopulmonary exercise test (CPET) features of COPD patients with cardiac AD and the association of AD with CT-derived vascular and CPET-derived ventilatory efficiency metrics.

Methods: This observational cohort study included stable, non-severe COPD patients.