Enhancing hospital protection measures reduces frontline medical workers' stress during the pandemic.

Frontline medical workers (FMWs) faced high stress levels in frontline clinics during the COVID-19 pandemic. This study aims to alleviate FMWs' psychological stress by enhancing protection measures, which includes refining the selection process, improving protective measures for their work in frontline clinics, and determining the appropriate time for evacuation. A Chinese-language-version stress questionnaire, covering stress-related issues and sociodemographic characteristics, was administered to FMWs in Shanghai during the COVID-19 pandemic in 2022, yielding 107 valid responses.

A soft electronic skin simulating the multi-scale human touch for the detection of fruit freshness.

Realizing biomimicry for human tactile perception is a meaningful challenge. In this work, a soft matter system with multi-scale energy dissipation structure is designed to realize flexible sensing and detection by biomimetic human touch. At the molecular scale, the supramolecular interactions are introduced into the hydrogel system, including the hydrophobic interaction and the ion attraction between macromolecular segments.

An integrally formed Janus supramolecular bio-gel with intelligent adhesion for multifunctional healthcare.

Despite the rapid development of Janus adhesive hydrogels, most of them still entail complex fabrication processes and have the inherent flaws, such as fragility and instability, thereby restricting their biomedical applications. In this study, a novel Janus bio-gel with strong mechanical and intelligent adhesion functions is facilely fabricated through a gravity-driven settlement strategy, employing poly-cyclodextrin microspheres (PCDMs). This strategy takes advantage of the sedimentation behavior of PCDMs with various diameters to establish structural disparities on both sides of the Janus bio-gel, thereby resolving multiple predicaments including the tedious synthesis steps and poor bonding of multilayer hydrogels.

Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis.

Background: Tuberous sclerosis complex (TSC) is one of the most common genetic causes of epilepsy. Identifying differentially expressed lipid metabolism related genes (DELMRGs) is crucial for guiding treatment decisions.

Methods: We acquired tuberous sclerosis related epilepsy (TSE) datasets, GSE16969 and GSE62019.

Bioinspired Adhesive Antibacterial Hydrogel with Self-Healing and On-Demand Removability for Enhanced Full-Thickness Skin Wound Repair.

Adhesive-caused injury is a great threat for extensive full-thickness skin trauma because extra-strong adhesion can incur unbearable pain and exacerbate trauma upon removal. Herein, inspired by the mussel, we designed and fabricated an adhesive antibacterial hydrogel dressing based on dynamic host-guest interaction that enabled on-demand stimuli-triggered removal to effectively care for wounds. In contrast with most hard-to-removable dressing, this adhesive antibacterial hydrogel exhibited strong adhesion property (85 kPa), which could achieve painless and noninvasive on-demand separation within 2 s through a host-guest competition mechanism (amantadine).

A novel multi-scale pressure sensing hydrogel for monitoring the physiological signals of long-term bedridden patients.

For long-term bedridden patients who need to wear diapers, the timely replacement of diapers is very important to ensure their quality of life. Therefore, it is urgent to develop a pressure sensor that can monitor the physiological conditions of patients in real time. Inspired by the multi-scale network structure of the multi-fiber protein in the muscle, a multi-scale hydrogel as a pressure sensor was prepared by introducing micron-scale hydrogel microspheres as physical crosslinking agents.

A Janus supramolecular hydrogel prepared by one-pot method for wound dressing.

Despite the adhesive hydrogels have gained progress and popularity, it is still an enormous challenge to develop a smart adhesion hydrogel for clinical medicine, which is an asymmetric adhesion hydrogel with on-demand detachment. Motivated by the thermal phase transition mechanism of gelatin, we have synthesized a Janus supramolecular hydrogel dressing with skin temperature-triggered adhesion by a simple one-pot process. This hydrogel has asymmetric and controllable adhesion, which not only can become the external objects barrier but also can achieve repeated adhesion and on-demand detachment triggered by temperature in tens of seconds.

Investigation on non-radioactive behavior of an acylhydrazone-based fluorescent probe: Coexistence of PET and TICT mechanisms.

A fluorescent probe (E)-((2,4-dihydroxybenzyl)diazenyl)(pyridin-2-yl)methanone (HL) to effectively and selectively detect Al was designed and synthesized in the experiment. Herein, we explained the excited state dynamics mechanism of HL by using density functional theory (DFT) and time-dependent density functional theory (TD-DFT). The potential energy surfaces (PESs) proved that the excited-state intramolecular proton transfer (ESIPT) process hardly occurs due to the high reaction barriers, so the fluorescence quenching behavior of HL was not based on ESIPT.

Modulating the performance of lipase-hydrogel microspheres in a "micro water environment".

In our previous work, we successfully stimulated lipase activity in an anhydrous reaction system using porous polyacrylamide hydrogel microsphere (PPAHM) as a carrier of lipase and free water. However, the effect of the existence state and content of water in lipase-porous polyacrylamide hydrogel microsphere (L-PPAHM) on the interfacial activation remained unclear. In this work, L-PPAHM with different water contents were obtained by water mist rehydration and were used to catalyze the synthesis of conjugated linoleic acid ethyl ester (CLA-EE).

Biomass-based hydrogels with high ductility, self-adhesion and conductivity inspired by starch paste for strain sensing.

Currently, hydrogel sensors for health monitoring require external tapes, bandages or adhesives to immobilize them on the surface of human skin. However, these external fixation methods easily lead to skin allergic reactions and the decline of monitoring accuracy. A simple strategy to solve this problem is to endow hydrogel sensors with good adhesion.

Polyionic liquids supramolecular hydrogel with anti-swelling properties for underwater sensing.

The preparation of hydrogel-based wearable sensors for underwater application with high mechanical properties and electrical conductivity is an urgent challenge. Here, a supramolecular hydrogel based on polyionic liquids was designed and prepared for underwater sensing. The introduction of functional ionic liquid structures effectively increased the supramolecular interaction in the hydrogel network, which made the hydrogel successfully resist the interference of external water molecules.

Pressure-sensitive antibacterial hydrogel dressing for wound monitoring in bed ridden patients.

Pressure ulcer is a common chronic injury in the bedridden population. The wound is easily subjected to secondary pressure injury due to the inconvenient mobility of patients, which greatly prolongs the hospital stay of patients and is highly prone to wound infection or other complications. It is urgent to develop a multifunctional wound dressing with pressure sensing, real-time monitoring, and wound therapy to overcome the secondary pressure injury during treatment.

A starch-regulated adhesive hydrogel dressing with controllable separation properties for painless dressing change.

The development of hydrogel dressings provides unprecedented opportunities for clinical medicine. However, the traditional hydrogel dressings cannot achieve controllable adhesion and separation, which often brings unbearable pain and secondary damage to patients during removal. In this work, a starch-regulated adhesive hydrogel dressing with controllable separation properties is reported.

Lipase-polydopamine magnetic hydrogel microspheres for the synthesis of octenyl succinic anhydride starch.

Octenyl succinic anhydride (OSA) starch is an important edible additive in the food field, and its synthesis method has attracted much attention. Lipase as a biocatalyst can improve the synthesis efficiency of OSA starch, and significantly inhibit the occurrence of side reactions. However, free lipase has not been widely applied in the synthesis of OSA starch due to the difficulty of separation from starch and poor reusability.

Exploring the influence of intermolecular hydrogen bonding on the fluorescence properties of HQCT and HQPH fluorescent chemosensors.

Recently, two trace water detection probes, 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazone(HQCT) and 8-hydroxyquinoline-2-carboxaldehyde (pyridine-2-carbonyl)-hydrazine(HQPH) have been successfully designed in the experiment. The original intramolecular proton transfer can be prevented by the water molecules, leading to fluorescence quenching. In order to investigate the fluorescence quenching mechanism, the effect of water molecules on the excited state proton transfer process will be studied in detail.

A lipase/poly (ionic liquid)-styrene microspheres/PVA composite hydrogel for esterification application.

Enzymes are particularly attractive as biocatalysts for the green synthesis of chemicals and pharmaceuticals. However, the traditional enzyme purification and separation process is complex and inefficient, which limits the wide application of enzyme catalysis. In this paper, an efficient strategy for enzyme purification and immobilization in one step is proposed.

A novel self-healing triple physical cross-linked hydrogel for antibacterial dressing.

The poor mechanical properties of wound dressings have always been a challenge in their application as wound protective barriers. In particular, when the hydrogel dressing absorbs the tissue fluid, the mechanical properties of the hydrogel will decrease greatly due to the swelling effect. In this study, an original antibacterial hydrogel dressing was prepared by a one-step process with acrylic acid, 1-vinyl-3-butylimidazolium, COOH-modified gum arabic, and aluminium chloride.

Exploring the relationship between the "ON-OFF" mechanism of fluorescent probes and intramolecular charge transfer properties.

In this study, the excited state charge distribution characteristics and fluorescence mechanism of HClO detection probes HN-ClO (weak fluorescence) and HN-ClO-F (strong fluorescence) probes were investigated based on density functional theory (DFT) and time-dependent density functional theory (TDDFT). The results of electrostatic potential (ESP) map and hole-electron analysis show that the HN-ClO and HN-ClO-F probes have obvious charge separation characteristics in the excited state. The excited state energy decomposition and Merz-Kollman charge analysis demonstrate the existence of distinct planar intramolecular charge transfer (PICT) features in HN-ClO and HN-ClO-F.

Hydrogen-bonded lipase-hydrogel microspheres for esterification application.

Lipase is the most widely used enzyme in industry. Due to its unique "lid" structure, lipase can only show high activity at the oil-water interface, which means that water is needed in the catalytic esterification process. However, the traditional lipase catalytic system cannot effectively control "micro-water" in the esterification environment, resulting in the high content of free water, which hinders the esterification reaction and reduces the yield.

Solvent effect on the excited-state intramolecular double proton transfer of 1,3-bis(2-pyridylimino)-4,7-dihydroxyisoindole.

Density functional theory (DFT) and time-dependent density functional theory (TDDFT) are used to study the solvatochromic effect and the excited-state intramolecular double proton transfer (ESIDPT) of 1,3-Bis(2-pyridylimino)-4,7-dihydroxyisoindole (BPI-OH) in different kinds of solvents. The hydrogen bonding parameters and IR spectra reveal that in the excited state, the strength of excited hydrogen bond increase with the decrease of solvent polarity. Furthermore, the reduction density gradient (RDG) analysis confirms the corresponding conclusion.

A ionic liquid enhanced conductive hydrogel for strain sensing applications.

Strain-sensitive and conductive hydrogels have attracted extensive research interest due to their potential applications in various fields, such as healthcare monitoring, human-machine interfaces and soft robots. However, low electrical signal transmission and poor tensile properties still limit the application of flexible sensing hydrogels in large amplitude and high frequency motion. In this study, a novel ionic liquid segmental polyelectrolyte hydrogel consisting of acrylic acid (AAc), 1-vinyl-3-butylimidazolium bromide (VBIMBr) and aluminum ion (Al) was prepared by molecular design and polymer synthesis.

The influence of intermolecular hydrogen bonds on single fluorescence mechanism of 1-hydroxy-11H-benzo [b]fluoren-11-one and 10-hydroxy-11H-benzo [b]fluoren-11-one.

Solvent effects usually have an essential effect on excited-state intramolecular proton transfer (ESIPT) processes and fluorescence mechanism. This contribution presents new insights into a newly synthesized compound, namely, 10-hydroxy-11H-benzo [b]fluoren-11-one (10-HHBF), and its analogue 1-hydroxy-11H-benzo [b]fluoren-11-one (1-HHBF), which exhibit single-fluorescence properties in protic solvents (methanol, MeOH), using time-dependent density functional theory (TDDFT). The results established four schemes, namely, MeOH-1, MeOH-2, MeOH-3, and MeOH-4, for 1-HHBF and 10-HHBF in MeOH.

Proteomic insights into protostane triterpene biosynthesis regulatory mechanism after MeJA treatment in Alisma orientale (Sam.) Juz.

Protostane triterpenes in Alisma orientale (Sam.) Juz. have unique structural features with distinct pharmacological activities.