Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In Vivo Results.

In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer / ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression method, and their hardness, diameter, thickness, friability, weight variation, content uniformity, and in vitro dissolution tests were assessed to determine 24-h drug release rates. The matrices with Ethocel 10 FP at a 10:4 ratio exhibited pseudo-zero-order kinetics (n-value of 0.

Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus.

Diabetes is a metabolic illness that increases protein glycosylation in hyperglycemic conditions, which can have an impact on almost every organ system in the body. The role of vitamin D in the etiology of diabetes under RAGE (receptor for advanced glycation end products) stress has recently received some attention on a global scale. Vitamin D's other skeletal benefits have generated a great deal of research.

Environmental friendly utilization of plant wastes in combination as a source of natural colorants for binary mordanted silk dyeing.

This study investigates the absorption behavior of natural dyes on silk fabric: madder roots (red dye) and amaltas (brown dye). The dyes were extracted under optimized conditions in an acidic medium. Binary mixtures of these dyes in different proportions were employed to develop various shades.

Anar Phali (Opuntia ficus) juice extract as a novel pollution-free source of natural betalain dye for wool yarn.

Green products such as plant pigments in all filed are gaining fame globally due to their excellent ayurvedic and biological characteristics. In this study, microwave rays have been employed for the isolation of colorants from Anar Phali while bio-mordant have been included to get color-fast shades. The colorant was isolated in an acidic medium before and after microwave rays for 2 min.

Development of extended-release metformin core tablet and synergistic coating of sitagliptin for the treatment of type-II diabetes mellitus - A comparative drug release evaluation with reference product.

Diabetes is getting a common disease and is spreading rapidly, affecting 6.6 percent world's population. Metformin HCl is an effective pharmacological treatment for type 2 diabetic patients because of its lowering blood glucose level ability, better weight-neutral effects and reduced risk of hypoglycemia.

Theoretical and Experimental Insights of Benzimidazole Catalyzed by the Epoxy-Acrylic Acid Reaction.

This study focuses on the experimental and molecular-level investigation of epoxy acrylate formation. Epoxy acrylate vinyl ester resin was prepared by a reaction of diglycidyl ether of bisphenol-A-based epoxy resin and acrylic acid, using benzimidazole as a catalyst. It was confirmed that benzimidazole can effectively catalyze this reaction.

GGA and GGA + U Study of ThMnSi and ThMnGe Compounds in a Body-Centered Tetragonal Ferromagnetic Phase.

Our study used the full-potential linearized augmented plane waves (FP-LAPW) method to conduct a first-principles evaluation of the structural, electronic, and magnetic properties of ThMnX (X = Si and Ge) compounds. To establish theoretical dependability with the currently available experimental results, computations for the structural findings of ternary intermetallic thorium (Th)-based compounds were achieved using the generalized gradient approximation in the scheme of Perdew-Burke-Ernzerhof (PBE-GGA) potential, while the generalized gradient approximation plus the Hubbard U (GGA + U) approach was employed to improve the electrical and magnetic properties. In contrast with both the paramagnetic (PM) and antiferromagnetic (AFM) phases, the ThMnX compounds were optimized in a stable ferromagnetic (FM) phase, which was more suited for studying and analyzing magnetic properties.

Assessment of wild turmeric-based eco-friendly yellow natural bio-colorant for dyeing of wool fabric.

The current study has been designed to observe the coloring efficacy of wild turmeric-based natural yellowish colorant for wool dyeing under microwave (MW) treatments. Extracts and fabrics have been exposed to MW treatment for up to 10 min. Surface morphology and changes in the fabric's chemical nature before and after radiation have been studied through SEM and FTIR, respectively.

Sustainable eco-friendly extraction of yellow natural dye from haar singhar (Nyctanthes arbor-tritis) for bio coloration of cotton fabric.

 The revival of natural dyes in different walks of life is due to stringent environmental standards imposed by many associations. For current studies, flowers of haar singhar (Nyctanthes arbor-tritis) has been chosen for bio-dyeing of cotton fabric using microwave irradiation techniques. For this purpose, liquid extracts and fabrics were exposed to microwave for 5 min at various conditions.

Waste black tea leaves (Camelia sinensis) as a sustainable source of tannin natural colorant for bio-treated silk dyeing.

Environmentally friendly products are the need of the hour, particularly in this pandemic situation because synthetic products need such toxic chemicals for their formulation and finishing which are carcinogenic for the globe. The current study is the utilization of waste black tea leaf (BT)-based tannin brown natural colorant for silk dyeing using microwave treatment. Dye (tannin) has been isolated in various media before and after microwave treatment up to 6 min and applied at various conditions.

Antioxidant and lipoxygenase inhibition studies of 4-(4-bromophenyl)-2,2'-bipyridine and its metal complexes Synthesis, characterization and biological screening.

Synthesis of new antioxidants and enzyme inhibitors is an active area of research in pharmaceutical sciences. This can be used for development of new active product ingredients which can prevent body from different diseases. This study comprises of preparation of transition metal complexes using 4-(4-bromophenyl)-2,2'-bipyridine (BPBP) and their screening for antioxidant and lipoxygenase inhibition properties.

Synthesis, lipoxygenase inhibition activity and molecular docking of oxamide derivative.

In this study, a range of oxamide ligands were synthesized by the reaction of amines with oxalyl chloride in basic medium. Spectroscopic and analytical techniques such as IR, 1H-NMR and ESI-MS techniques were used for characterization of the synthesized oxamides. The synthesized oxamides were screened for Lipoxygenase inhibition.

Microwave-assisted extraction and dyeing of chemical and bio-mordanted cotton fabric using harmal seeds as a source of natural dye.

The revival of cultural heritage in a form of natural colorants for textile dyeing is gaining popularity due to their soothing nature and bright shades. The present study was conducted to explore the coloring potential of harmala (Peganum harmala) seeds and to improve color strength of dye using microwave radiations followed by a mordanting process. The results showed that harmala plant seeds could be an excellent source of natural dyes for cotton dyeing if the irradiated acidified methanolic extract (RE, 4 min) is used to dye un-irradiated fabric (NRC) at 85 °C for 45 min using a dye bath of pH 9.

New carbazole linked 1,2,3-triazoles as highly potent non-sugar α-glucosidase inhibitors.

In the present study, a series of new carbazole linked 1H-1,2,3-triazoles (2-27) were synthesized via click reaction of N-propargyl-9H-carbazole (1) and azides of appropriate acetophenones and heterocycles. Synthesized carbazole triazoles including 7, 9, 10, 19, 20, and 23-26 (IC=0.8±0.

In vitro α-Glucosidase Inhibition by Non-sugar based Triazoles of Dibenzoazepine, their Structure-Activity Relationship, and Molecular Docking.

Background: α-Glucosidase inhibitors (AGIs) have been reported for their clinical potential against postprandial hyperglycemia, which is responsible for the risks associated with diabetes mellitus 2 and cardiovascular diseases (CVDs). Besides, a number of compounds have been reported as potent AGIs, several side effects are associated with them.

Methods: The aim of present work is to explore new and potent molecules as AGIs.

Removal of Heavy Metals by Adsorption onto Activated Carbon Derived from Pine Cones of Pinus roxburghii.

Activated carbon derived from cones of Pinus roxburghii (Himalayan Pine) was used as an adsorbent for the removal of copper, nickel and chromium ions from waste water. Surface analysis was carried out to determine the specific surface area and pore size distribution of the pine cone derived activated carbon. Optimal parameters, effect of adsorbent quantity, pH, equilibrium time, agitation speed and temperature were studied.

Modification of cellulosic fibers to enhance their dyeability using UV-irradiation.

Present research was proposed to evaluate the effect of UV radiation on the dyeing of cellulosic fabrics with direct dyes. The cellulosic fabric was irradiated by using UV radiation assembly (180 W) for different time intervals i.e.

Biodiversity and importance of floating weeds of Dara Ismail, Khan District of KPK, Pakistan.

The present paper is based on the results of taxonomic research work conducted in Dera Ismail Khan District of KPK, Pakistan, during 2005 - 2007. The area was extensively surveyed in order to collect floating aquatic weeds. From the study area 11 floating aquatic weed species belonging to 9 genera and 9 families were collected and identified in the light of available literature.

Analgesic and anti-inflammatory activities of 11-O-galloylbergenin.

Aims Of The Study: Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use.

Materials And Methods: 11-O-galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.

Structural insights to investigate Conypododiol as a dual cholinesterase inhibitor from Asparagus adscendens.

The main aim of the current study was to explore molecular insights for potentially new dual cholinesterase inhibitor(s) from Asparagus adscendens via molecular docking. This medicinal plant is traditionally used as a nerve tonic and remedy for memory impairments. Conypododiol was isolated from the chloroform fraction of methanolic extract of A.

Evaluation of a 3% surf solution (surf field mastitis test) for the diagnosis of subclinical bovine and bubaline mastitis.

Purpose: To evaluate a 3% solution of household detergent viz., Surf Excel (Surf field mastitis test, SFMT) vis-à-vis California mastitis test (CMT), Whiteside test (WST), somatic cell counts (SCC; cut off limit = 5 x 10(5) cells per millilitre) and bacteriological cultures for the detection of subclinical mastitis in quarter foremilk samples (n=800) of dairy cows and buffaloes.

Methods: Culture and SCC were used as gold standards.

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia.

The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than in any other region globally, but there is little direct evidence about its determinants. The Pakistan Risk of Myocardial Infarction Study (PROMIS) is an epidemiological resource to enable reliable study of genetic, lifestyle and other determinants of CHD in South Asia. By March 2009, PROMIS had recruited over 5,000 cases of first-ever confirmed acute myocardial infarction (MI) and over 5,000 matched controls aged 30-80 years.

A survey of infection control practices in the delivery room and nursery to investigate and control the high rate of neonatal sepsis: an experience at a secondary care hospital.

Objective: To survey the infection control practices in the delivery room and the nursery so that the ongoing high rate of neonatal sepsis can be controlled.

Method: A prospective study was conducted at the Department of Pathology, Paediatrics and Gynae/obst Combined Military Hospital, Gujranwala. Situation analysis was carried out, according to which a total of 56 cases of neonatal sepsis were diagnosed on the basis of clinical and lab criteria during a six month period from November 2005 to April 2006.

Indoor radon concentration measurement in the dwellings of Al-Jauf region of Saudi Arabia.

Indoor radon concentration measurement in the dwellings of Al-Jauf region of Saudi Arabia was carried out using passive radon dosemeters. The objective of this radon survey was to obtain representative indoor radon data of Al-Jauf region. The study is a continuation of radon survey in main cities of Saudi Arabia which constitutes a baseline for Saudi Arabia in the Radon World Atlas.

Anomalous indoor radon concentration in a dwelling in Qatif City, Saudi Arabia.

An indoor radon survey was carried out recently in nine cities of Saudi Arabia using nuclear track detectors (NTD)-based passive radon detectors. The survey included Qatif City in the Eastern Province of Saudi Arabia, where 225 detectors were collected back successfully. It was found that the average indoor radon concentration in the dwellings was 22 +/- 15 Bq m(-3).