Publications by authors named "Fanampe"
Article Synopsis
- Rifampicin-resistant tuberculosis (RR-TB) is a significant health issue worldwide, and personalized treatment based on complete drug-resistance profiles is mainly practiced in wealthy countries, with low-income regions lacking access to advanced technologies like whole genome sequencing (WGS).
- A clinical trial in South Africa aims to evaluate a WGS-guided automated treatment strategy for RR-TB, comparing it to standard treatment protocols to determine its effectiveness and feasibility.
- The trial will assess various outcomes, including the speed of improvement in patients, cure and relapse rates, safety, and cost-effectiveness, ultimately aiming to gather evidence that supports the integration of WGS technology into routine care for RR-TB in low and middle-income countries.
Background/aims: Obesity has increased rapidly in South African children and adolescents. Genes involved in appetite regulation have been extensively studied worldwide, but their role in the obesity phenotype in South African Black and mixed-ancestry school adolescents is unknown.
Methods: Seven common polymorphisms in LEP, GHRL, CART and LEPR were analysed for genotype and haplotype association with anthropometric obesity phenotype indicators in South African Black and mixed-ancestry adolescent school learners.
Background: Human and animal studies support the role of MC4R and MC3R in human obesity, but limited data are available on the genetic contribution to obesity in South African populations.
Objective: To screen obese-overweight South African pupils for MC3R and MC4R polymorphisms that may play a role in the development of obesity.
Design: A cross-sectional study screened 227 obese-overweight (115 black and 112 coloured) and 204 normal weight (94 black, 110 coloured) school pupils for the presence of MC4R and MC3R polymorphisms using a single strand conformation polymorphism, subsequent sequencing, and allele specific restriction enzyme analysis.
Background: The Ectonucleotide Pyrophosphatase Phosphodiesterasel (ENPP1) polymorphisms have been associated with metabolic traits. There is no data on the effect of ENPP1 in South African children or adults.
Objective: To investigate the role of K121Q (rs1044498), rs997509 and rs9402349 in obesity and other components of the metabolic syndrome.