Evaluation of the impact of COVID-19 pandemic on hospital admission related to common infections: Risk prediction models to tackle antimicrobial resistance in primary care.

Background: Antimicrobial resistance (AMR) is a multifaceted global challenge, partly driven by inappropriate antibiotic prescribing. The objectives of this study were to evaluate the impact of the COVID-19 pandemic on treatment of common infections, develop risk prediction models and examine the effects of antibiotics on infection-related hospital admissions.

Methods: With the approval of NHS England, we accessed electronic health records from The Phoenix Partnership (TPP) through OpenSAFELY platform.

Influence of ozone treatment on sensory quality, aroma active compounds, phytosterols and phytosterol oxidation products in stored rapeseed and flaxseed oils.

The effect of ozone treatment on the sensory quality, aroma compounds, phytosterols, and phytosterol oxidation products (POP) in stored plant oils was studied. Cold-pressed flaxseed, cold-pressed rapeseed, and refined rapeseed oils were treated with ozone, air, and nitrogen, then subjected to accelerated storage at 60 °C for 6 days. The sensory evaluation revealed that ozone significantly influenced the sensory profile, with notable cucumber and green-grassy aromas.

Strengthening Indonesia's health system through community and technological engagements in public health interventions.

The 7th International Symposium on Public Health (ISoPH 2023), was held on October 2-3, 2023, in Surabaya, Indonesia, which brought together a diverse array of public health professionals, researchers, and policymakers from around the globe. The purpose of the symposium was to facilitate the exchange of the latest information and ideas within the realm of public health. The symposium aspired to foster discussions and the exchange of insights regarding scientific issues in the field of public health globally and within the context of Indonesia.

The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle.

Multiple signaling pathways have been reported to be altered in Myotonic Dystrophy type 1 (DM1) skeletal muscle, contributing to pathogenicity. In particular, previous work established that AMPK signaling, a key sensor of energy metabolism, is repressed in DM1 mouse muscle and that activating AMPK through exercise and/or with pharmacological activators is beneficial for the DM1 muscle phenotype. Here, we explored the effects of a newer, more specific allosteric AMPK activator acting directly on AMPK.

Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach.

Purpose: Dopamine transporter imaging is routinely used in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) diagnosis. While [C]CFT PET is prevalent in Asia with a large APS database, Europe relies on [I]FP-CIT SPECT with limited APS data. Our aim was to develop a deep learning-based method to convert [C]CFT PET images to [I]FP-CIT SPECT images, facilitating multicenter studies and overcoming data scarcity to promote Artificial Intelligence (AI) advancements.

Crohn's Disease Confined to the Esophagus, with No Involvement of the Small or Large Bowel.

Unlabelled: Crohn's disease (CD) is a transmural inflammatory process that can affect any segment of the gastrointestinal tract. CD has a predilection for the colon and the small bowel, specifically the terminal ileum. Esophageal involvement of CD is exceedingly rare and there is a paucity of data regarding the disease phenotypes, course, complications and treatment.

Unraveling In vivo Potential of Curcumin-loaded Graphene Quantum Dots on Drug Delivery and Release Kinetics Aspects of Cancer Treatment.

This study introduces an innovative magnetic-based multifunctional anti-cancer drug carrier aiming to enhance the efficacy of curcumin in cancer therapy. The research investigates the potential of Graphene Quantum Dots (GQDs) as a curcumin drug delivery system for inhibiting cancer growth. GQDs with a particle diameter below 10 nm were synthesized via hydrothermal and Hummers methods, exhibiting homogeneity and crystalline structure according to AFM and XRD analyses.

Breast Cancer Chemoprevention from Nano Roscoe.

Background: After cardiovascular disease, cancer is one of the leading causes of death due to uncontrolled cell growth. Breast cancer is among the most prevalent types of cancer. Roscoe.

Locally Synthesized Zwitterionic Surfactants as EOR Chemicals in Sandstone and Carbonate.

Zwitterionic surfactants are found to be highly effective in reducing the IFT and changing the wettability. This work studied the solubility and wettability alteration performance of locally synthesized zwitterionic surfactants in Berea sandstone and Indiana limestone. Contact angle measurements were conducted to study the wettability under different conditions.

Bioinformatics design of peptide binding to the human cardiac troponin I (cTnI) in biosensor development for myocardial infarction diagnosis.

Cardiovascular disease has reached a mortality rate of 470,000 patients each year. Myocardial infarction accounts for 49.2% of these deaths, and the cTnI protein is a crucial target in diagnosing myocardial infarction.

Electrospun Smart Hybrid Nanofibers for Multifaceted Applications.

Smart electrospun hybrid nanofibers represent a cutting-edge class of functional nanostructured materials with unique collective properties. This review aims to provide a comprehensive overview of the applications of smart electrospun hybrid nanofibers in the fields of energy, catalysis, and biomedicine. Electrospinning is a powerful tool to fabricate different types of nanofibers' morphologies with precise control over structure and compositions.

Photothermal effectiveness of microporous carbon nanospheres incorporated with polysulfone in direct contact membrane distillation.

Carbon nano-spheres (CNS) were synthesized a hydrothermal method using d-glucose as a precursor, followed by pyrolysis in a nitrogen atmosphere. The resulting CNS were integrated into polysulfone (PSF) membranes to enhance their photothermal properties. Characterization using various techniques revealed improved thermal properties upon CNS inclusion, with a notable increase in membrane surface temperature and enhancement of contact angle (CA) and liquid entry pressure (LEP).

Liver hydatid cyst rupture into gallbladder and right hepatic duct: A case report.

Introduction And Importance: Concomitant rupture into the gallbladder and biliary tract is a very rare complication of liver hydatid cyst.

Presentation Of Case: We present the case of a young woman with rupture of liver hydatid cyst into gallbladder and right hepatic duct which was presented with abdominal pain and jaundice.

Clinical Discussion: While fistulization to the gallbladder is a rare complication of liver hydatid cyst, concomitant rupture of liver hydatid cyst into the gallbladder and biliary tract is very rare.

The Immunological Profile of Adipose Mesenchymal Stromal/Stem Cells after Cell Expansion and Inflammatory Priming.

Background: AT-MSCs display great immunoregulatory features, making them potential candidates for cell-based therapy. This study aimed to evaluate the "RBC lysis buffer" isolation protocol and immunological profiling of the so-obtained AT-MSCs.

Methods: We established an immune-comparative screening of AT-MSCs throughout in vitro cell expansion (PM, P1, P2, P3, P4) and inflammatory priming regarding the expression of 28 cell-surface markers, 6 cytokines/chemokines, and 10 TLR patterns.

Exploring Prior Antibiotic Exposure Characteristics for COVID-19 Hospital Admission Patients: OpenSAFELY.

Previous studies have demonstrated the association between antibiotic use and severe COVID-19 outcomes. This study aimed to explore detailed antibiotic exposure characteristics among COVID-19 patients. Using the OpenSAFELY platform, which integrates extensive health data and covers 40% of the population in England, the study analysed 3.

The impact of flipping class intervention on reading comprehension: Different approaches and proficiency levels.

Flipped classes can improve English language teaching and learning, especially reading outcomes, by enhancing student engagement and motivation through interactive and captivating educational materials. The goal of this study is to examine the effects of different schema activations in different English flipped class formats in pre-reading activities on the reading comprehension of students with different reading proficiency levels. A quasi-experimental research design was employed involving 30 first-year students from the first university and 28 first-year students from the second university in Surabaya, Indonesia, who were studying English as a general course at an intermediate level.

Three-dimensional Au-MnO nanostructure as an agent of synergistic cancer therapy: chemo-/photodynamic and photothermal approaches.

The design of multimodal cancer therapy was focused on reaching an efficient process and minimizing harmful effects on patients. In the present study, the Au-MnO nanostructures have been successfully constructed and produced as novel multipurpose photosensitive agents simultaneously for photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). The prepared AuNPs were conjugated with MnO NPs by its participation in the thermal decomposition process of KMnO confirmed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy (FT-IR).

Four new species of (Annelida, Eunicida, Eunicidae) from the east coast of Peninsular Malaysia.

Four new species of are described from Terengganu state on the east coast of Peninsular Malaysia, using morphological and molecular (cytochrome oxidase subunit I (COI) gene) data. These species belong to different groups of : belongs to Group A (Mossambica), and belong to Group B (Sanguinea) and belongs to Group E (Gravelyi). is characterised by having only limbate chaetae, absence of subacicular hooks, three types of pectinate chaetae including wide, thick isodont with short and slender inner teeth, and pectinate branchiae with up to nine branchial filaments.

Potential usage of boron modified carbon nanodots as a marker candidate for coronavirus disease (COVID-19) antibody detection.

The global outbreak of COVID-19 in December 2019 has highlighted rapid and accurate diagnostic tools for effective intervention. While the RT-PCR test offers 86 % sensitivity, uncertainties often require supplementary screening. This research investigates how carbon dots (CDs) can be utilized as markers for COVID-19 antibodies, taking advantage of their biocompatibility and low toxicity.