The presence of angiotensin-converting enzyme activator in bovine tissues.

Recently we have revealed angiotensin-converting enzyme (ACE)-activating factor(s) in human neutrophils and blood. In this study the distribution of ACE-activating factor(s) was examined in various tissues. The effect of supernatants obtained from heated bovine tissue extracts on the activity of purified kidney ACE was studied.

Angiotensin-converting enzyme activator from purified human neutrophils.

An endogenous ACE activator has been revealed. Neutrophil-enriched human leucocyte preparations released in isotonic media a relatively thermostable factor, capable of increasing the angiotensin-converting enzyme activity 1.6-2.