The Biphasic Activity of Auricularia Auricula-Judae Extract on Bone Homeostasis Through Inhibition of Osteoclastogenesis and Modulation of Osteogenic Activity.

Osteoporosis arises from the disturbance of bone homeostasis, a process regulated by osteoblasts and osteoclasts. The treatment and prevention of bone metabolic disorders resulting from an imbalance in bone homeostasis require the use of agents that effectively promote both bone formation and anti-resorptive effects. Therefore, an investigation was carried out to determine the potential of the edible mushroom in modulating bone remodeling by inhibiting RANKL-induced osteoclastogenesis and enhancing BMP-2-stimulated osteoblast differentiation.

Acorn Seed Coat Extract Promotes Wound Re-Epithelialization by Facilitating Fibroblast Migration and Inhibiting Dermal Inflammation.

The skin, recognized as the largest organ in the human body, serves a vital function in safeguarding against external threats. Severe damage to the skin can pose significant risks to human health. There is an urgent requirement for safe and effective therapies for wound healing.

Development of a wastewater based infectious disease surveillance research system in South Korea.

Wastewater-based epidemiology has been used in pathogen surveillance for microorganisms at the community level. This study was conducted to determine the occurrence and trends of infectious pathogens in sewage from Yongin city and the relationships between these pathogens and the incidence of infectious diseases in the community. From December 2022 to November 2023, we collected inflow water from six wastewater treatment plants in Yongin city twice a month.

3-Hydroxytanshinone Inhibits the Activity of Hypoxia-Inducible Factor 1-α by Interfering with the Function of α-Enolase in the Glycolytic Pathway.

Tumor cells in hypoxic conditions control cancer metabolism and angiogenesis by expressing HIF-1α. Tanshinone is a traditional Chinese medicine that has been shown to possess antitumor properties and exerts a therapeutic impact on angiogenesis. However, the precise molecular mechanism responsible for the antitumor activity of 3-Hydroxytanshinone (3-HT), a type of tanshinone, has not been fully understood.

Fabrication of a Fully Printed Ammonia Gas Sensor Based on ZnO/rGO Using Ultraviolet-Ozone Treatment.

In this study, a room-temperature ammonia gas sensor using a ZnO and reduced graphene oxide (rGO) composite is developed. The sensor fabrication involved the innovative application of reverse offset and electrostatic spray deposition (ESD) techniques to create a ZnO/rGO sensing platform. The structural and chemical characteristics of the resulting material were comprehensively analyzed using XRD, FT-IR, FESEM, EDS, and XPS, and rGO reduction was achieved via UV-ozone treatment.

Fully Printed Cellulose Nanofiber-Ag Nanoparticle Composite for High-Performance Humidity Sensor.

This paper reports a high-performance humidity sensor made using a novel cellulose nanofiber (CNF)-silver nanoparticle (AgNP) sensing material. The interdigital electrode pattern was printed via reverse-offset printing using Ag nano-ink, and the sensing layer on the printed interdigitated electrode (IDE) was formed by depositing the CNF-AgNP composite via inkjet printing. The structure and morphology of the CNF-AgNP layer are characterized using ultraviolet-visible spectroscopy, an X-ray diffractometer, field emission scanning electron microscopy, energy-dispersive X-ray analysis, and transmission electron microscopy.

Integrated Temperature-Humidity Sensors for a Pouch-Type Battery Using 100% Printing Process.

The performance, stability, and lifespan of lithium-ion batteries are influenced by variations in the flow of lithium ions with temperature. In electric vehicles, coolants are generally used to maintain the optimal temperature of the battery, leading to an increasing demand for temperature and humidity sensors that can prevent leakage and short circuits. In this study, humidity and temperature sensors were fabricated on a pouch film of a pouch-type battery.

The Psychomotor Cognition Test for Measurement of Sleepiness/Fatigue on a Touch Screen.

The Psychomotor Vigilance Test (PVT) is a simple and reliable performance test that measures sustained attention, alertness level, and fatigue level. The PVT is a convenient tool that can be used in real time in situ through a mobile device without the assistance of experts and therefore can be used to improve safety and prevent accidents. However, the original PVT is vulnerable to the subject's intentional concentration on the test, and the variance range among tests is narrow; these factors limit its usefulness in classifying the level of fatigue.

Bio-signals Collecting System for Fatigue Level Classification.

Fatigue is a risk factor that reduces quality of life and work efficiency, and threatens safety in a high-risk environment. However, fatigue is not yet precisely defined and is not a quantified concept as it relies on subjective evaluation. The purpose of this study is to manage risks, improve mission efficiency, and prevent accidents through the development of machine learning and deep learning based fatigue level classifier.

Humidity Sensors Based on Cellulose Nanofiber Fabricated on a Three-Dimensional (3D) Curved Surface.

Traditional printed electronics processes have recently been utilized within 3D-printed structures where components and interconnects are introduced during manufacturing disruptions. The dielectric performance of 3D-printed materials has a low-resolution problem, and many technologies have been proposed for direct printing on a 3D curved surface or structure. This paper reports a humidity sensor fabricated with a 3D-printed electrode and cellulose nanofibers on a curved surface.

Effect Sizes of Cognitive and Locomotive Behavior Tests in the 5XFAD-J Mouse Model of Alzheimer's Disease.

Alzheimer's disease (AD) is characterized by the accumulation of amyloid β (Aβ) plaques in the brain, leading to cognitive impairment and other clinical symptoms. The 5XFAD mouse model is commonly used in AD research because it expresses five human transgenes that result in the accumulation of Aβ plaques and cognitive decline at a relatively early age. Behavioral experiments are frequently conducted using this model; however, the effect size has not yet been reported.

Transferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain.

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases and a major contributor to dementia. Although the cause of this condition has been identified long ago as aberrant aggregations of amyloid and tau proteins, effective therapies for it remain elusive. The complexities of drug development for AD treatment are often compounded by the impermeable blood-brain barrier and low-yield brain delivery.

Inhibition of Osteoclast Differentiation and Promotion of Osteogenic Formation by Mycelium.

Osteoporosis, Greek for "porous bone," is a bone disease characterized by a decrease in bone strength, microarchitectural changes in the bone tissues, and an increased risk of fracture. An imbalance of bone resorption and bone formation may lead to chronic metabolic diseases such as osteoporosis. , known as "Bokryung" in Korea, is a fungus belonging to the family and has been used as a therapeutic food against various diseases.

Effect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer's Disease in High-Fat Diet-Fed Mice.

The typical pathological features of Alzheimer's disease (AD) are the accumulation of amyloid plaques in the brain and reactivity of glial cells such as astrocytes and microglia. Clinically, the development of AD and obesity are known to be correlated. In this study, we analyzed the changes in AD pathological characteristics in 5XFAD mice after obesity induction through a high-fat diet (HFD).

Deep learning-based system development for black pine bast scale detection.

The prevention of the loss of agricultural resources caused by pests is an important issue. Advances are being made in technologies, but current farm management methods and equipment have not yet met the level required for precise pest control, and most rely on manual management by professional workers. Hence, a pest detection system based on deep learning was developed for the automatic pest density measurement.

Four-step eco-friendly energy efficient recycling of contaminated NdFeB sludge and coercivity enhancement by reducing oxygen content.

Complete recycling of NdFeB sludge by chemical methods has gained significance in recent years, however, it is not easy to recycle highly contaminant sludge and obtain product with good magnetic properties. Herein we report a simple four-step process to recycle the NdFeB sludge containing ~ 10% of contaminants. Sludge was leached in HSO and selectively co-precipitated in two steps.

Novel eco-friendly low cost and energy efficient synthesis of (Nd-Pr-Dy)FeB magnetic powder from monazite concentrate.

Syntheses of NdFeB magnetic powder by conventional method is a complicated multi-step process, which produces harmful pollutants and consumes a huge amount of energy and resources. Herein we report a simple chemical route for the preparation of (Nd-Pr)FeB magnetic powder using monazite concentrate as a precursor. Th, U, Sm, and La impurities were removed from monazite leachate by roasting, solvent extraction and leaching the concentrate.

Disruption of the astrocyte-neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer's disease animal model.

The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte-neuron interactions on synapses are called tripartite synapses. These control the synaptic function in the central nervous system.

Enhancement of anisotropy energy of SmCo by ceasing the coupling at 2c sites in the crystal lattice with Cu substitution.

SmCo and SmCoCu magnetic particles were produced by co-precipitation followed by reduction diffusion. HRTEM confirmed the Cu substitution in the SmCo lattice. Non-magnetic Cu was substituted at "2c" site in the SmCo crystal lattice and effectively stopped the coupling in its surroundings.

The Value of Low Prostate Imaging-Reporting and Data System (PI-RADS) Scores in Preventing Unnecessary Prostate Biopsies.

: Magnetic resonance imaging (MRI) and the Prostate Imaging-Reporting and Data System (PI-RADS) have become essential tools for prostate cancer evaluation. We evaluated the ability of PI-RADS scores in identifying significant prostate cancer, which would help avoid unnecessary prostate biopsies. : Patients with prostate-specific antigen (PSA) levels ≤ 20 ng/mL, who underwent prostate MRI for evaluation from January 2018 to November 2019, were analyzed.

Determination of Dy substitution site in NdDyFeB by HAADF-STEM and illustration of magnetic anisotropy of "g" and "f" sites, before and after substitution.

NdFeB and NdDyFeB (x = 0.25, 0.50) particles were prepared by the modified co-precipitation followed by reduction-diffusion process.

Head and neck free tissue transfer in a patient with factor V Leiden: case report and review of the literature.

Hypercoagulable disorders can compromise success of free flap reconstruction. Factor V Leiden is one such disorder for which only one previously reported case of successful free tissue transfer in the head and neck has been described. We report a 70-year-old woman with factor V Leiden treated for stage IVA squamous cell carcinoma of the mandible with a composite resection and reconstruction with an osteocutaneous scapular free tissue transfer.

Honokiol ameliorates angiotensin II-induced hypertension and endothelial dysfunction by inhibiting HDAC6-mediated cystathionine γ-lyase degradation.

Hypertension and endothelial dysfunction are associated with various cardiovascular diseases. Hydrogen sulphide (H S) produced by cystathionine γ-lyase (CSE) promotes vascular relaxation and lowers hypertension. Honokiol (HNK), a natural compound in the Magnolia plant, has been shown to retain multifunctional properties such as anti-oxidative and anti-inflammatory activities.

Regulatory T Cells Conditioned Media Stimulates Migration in HaCaT Keratinocytes: Involvement of Wound Healing.

Purpose: Regulatory T (Treg) cells, a type of immune cell, play a very important role in the immune response as a subpopulation of T cells. In this study, we investigated the effects of Treg cells conditioned media (CM) on cell migration. Various cytokines and growth factors of Treg cells CM can effect on re-epithelialization stage during the wound healing.

Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol: a sub-group analysis of the BISO-CAD study.

Background: Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension.